CCB Brown Bag Seminar

  • Speakers
  • Natalie Sauerwald, Ph.D.Flatiron Research Fellow, Genomics, CCB, Flatiron Institute
  • Adam Lamson, Ph.D.Flatiron Research Fellow, Biophysical Modeling, CCB, Flatiron Institute
Date & Time

1st Presenter: Natalie Sauerwald, Ph.D., Flatiron Research Fellow, Genomics

Topic: Differences in response to SARS-CoV-2 infection in male and female young adults

Abstract: Male sex is a major risk factor for SARS-CoV-2 infection severity and death. To understand the basis for this sex difference, we studied SARS-CoV-2 infection in a young adult cohort of United States Marine recruits. We identified sex differences in symptoms, viral load, blood transcriptome, RNA splicing, and proteomic signatures. Mediation analysis implicated some of these pre-existing differences in infection outcomes, indicating that the antiviral innate immunity set point contributes to sex differences in response to SARS-CoV-2 infection.

2nd Presenter: Adam Lamson, Ph.D., Flatiron Research Fellow, CCB

Topic: Exploring overlooked physical principles that can coordinate chromatin organization

Abstract: Polymer simulations have become increasingly effective at interpreting the often beautiful hierarchical patterns that arise in chromatin conformation capture (3C,Hi-C) assays. While a number of models and theories can reconstruct these patterns in silco, many use highly coarse-grained potentials and ignore the microscopic mechanisms behind the interactions between chromatin, transcription factors(TFs), and the surrounding fluid. Here, I investigate how steric interactions between TFs expand and isolate genomic regions, while microscopically modeled crosslinking proteins specifically condense others domains. Furthermore, I will show how hydrodynamic forces couple chromatin and TF motion, providing an unrecognized avenue of nuclear organization.

Advancing Research in Basic Science and MathematicsSubscribe to Flatiron Institute announcements and other foundation updates