BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Simons Foundation - ECPv6.6.3//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Simons Foundation
X-ORIGINAL-URL:https://www.simonsfoundation.org
X-WR-CALDESC:Events for Simons Foundation
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20130310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20131103T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20131014T000000
DTEND;TZID=America/New_York:20131014T000000
DTSTAMP:20260417T085450
CREATED:20131007T040000Z
LAST-MODIFIED:20170823T194854Z
UID:1779-1381708800-1381708800@www.simonsfoundation.org
SUMMARY:October 14\, 2013: The Search for Early Life on Earth and Mars
DESCRIPTION:14 October 2013\, 4:30-6:30 p.m. Eastern\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nNo one knows when life first colonized planet Earth\, nor if or when Mars ever supported life. We see numerous\, unequivocal lines of evidence for life on Earth from some 2.5 billion years ago to the present day. But the further back in time we look\, the more clues about our earliest ancestors are clouded by doubts\, uncertainties and controversies. \nSimilarly\, the search for life on Mars is challenging\, risky and controversial. Because it is improbable that any fossils are preserved on Mars\, researchers must study the chemistry of its rocks to gain insights into potential habitable environments there. Scientists can do this using the instrument payload of the Curiosity rover now operating on the surface of Mars. \n  \n 
URL:https://www.simonsfoundation.org/event/october-14-2013-the-search-for-early-life-on-earth-and-mars/
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200129/Origins.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20131010
DTEND;VALUE=DATE:20131012
DTSTAMP:20260417T085450
CREATED:20131209T050000Z
LAST-MODIFIED:20250813T163426Z
UID:1974-1381363200-1381535999@www.simonsfoundation.org
SUMMARY:Foundation Hosts First MPS Annual Meeting
DESCRIPTION:On October 10 and 11 the Simons Foundation’s Mathematics and Physical Sciences (MPS) division held its inaugural Annual Meeting. This gathering of Simons Investigators and Simons Fellows was an opportunity for foundation staff to become acquainted with the outstanding mathematicians\, theoretical physicists and theoretical computer scientists whom the foundation supports\, and for the awardees to get to know each other and their work\, stimulating the flow of ideas across disciplines\, and perhaps encouraging new interactions and collaborations. \nThe meeting featured nine lectures over two days\, all held in the Gerald D. Fischbach Auditorium at the Simons Foundation in New York City\, and represented the full breadth of the science that MPS supports. “We heard wonderful lectures and it was extremely educational for me personally and\, I believe\, for many others\,” says MPS director Yuri Tschinkel. \nEqually important were the opportunities for casual discussion\, evolution of ideas and\, perhaps\, the beginnings of collaborations. \n“The feeling of intensity in the auditorium and during coffee breaks and lunches was very impressive\,” says associate director of physics Andy Millis. “We hope the meeting leads to the creation of a strong community in these fields — and it looks like that’s starting to happen.” \nAttending the meeting were 74 Investigators and Fellows from MPS’ three areas of focus — mathematics\, theoretical physics and theoretical computer science. MPS intends this meeting to be an annual event\, bringing the foundations ‘family’ of scientific leaders together for two days of discussion of the most exciting ideas at the research frontier. \n Download the 2013 Annual Meeting booklet (PDF).
URL:https://www.simonsfoundation.org/event/foundation-hosts-first-mps-annual-meeting/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Ave\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205832/thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20131009T160000
DTEND;TZID=America/New_York:20131009T180000
DTSTAMP:20260417T085450
CREATED:20140612T040000Z
LAST-MODIFIED:20211207T160836Z
UID:198-1381334400-1381341600@www.simonsfoundation.org
SUMMARY:Neural Codes for Representation and Memory
DESCRIPTION:The fundamental components of representation and communication in the brain are forgetful and noisy. How does the brain overcome these features to perform accurate computation and generate reliable short-term memory? Ila Fiete will discuss how recent discoveries finally substantiate classical theoretical ideas\, while simultaneously showing that neural codes go far beyond our current theoretical understanding. She will argue that it is time to develop and apply information-theoretic principles specific to coding in the noisy brain.
URL:https://www.simonsfoundation.org/event/neural-codes-for-representation-and-memory/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Theory and Biology
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180653/ila_fiete_thumb1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20131009T160000
DTEND;TZID=America/New_York:20131009T180000
DTSTAMP:20260417T085450
CREATED:20130906T040000Z
LAST-MODIFIED:20170823T192312Z
UID:1919-1381334400-1381341600@www.simonsfoundation.org
SUMMARY:October 9\, 2013: Neural Codes for Representation and Memory
DESCRIPTION:October 9\, 2013 \nThe fundamental components of representation and communication in the brain are forgetful and noisy. How does the brain overcome these features to perform accurate computation and generate reliable short-term memory? Ila Fiete will discuss how recent discoveries finally substantiate classical theoretical ideas\, while simultaneously showing that neural codes go far beyond our current theoretical understanding. She will argue that it is time to develop and apply information-theoretic principles specific to coding in the noisy brain. \nSpeaker \nIla Fiete\, Ph.D.\nUniversity of Texas at Austin \nLocation \nGerald D. Fischbach Auditorium\, Simons Foundation\n160 5th Avenue\nNew York\, NY 10010 \nWednesday\, October 9\, 2013 from 4:00 PM to 6:00 PM (EDT) \nTo RSVP for this event\, please do so at Eventbrite. \nClick here to learn more about the Theory and Biology Lectures. \n 
URL:https://www.simonsfoundation.org/event/october-9-2013-neural-codes-for-representation-and-memory-2/
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200227/ila_fiete_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20131009T000000
DTEND;TZID=America/New_York:20131009T000000
DTSTAMP:20260417T085450
CREATED:20131031T040000Z
LAST-MODIFIED:20170823T195732Z
UID:1823-1381276800-1381276800@www.simonsfoundation.org
SUMMARY:October 9\, 2013: Neural Codes for Representation and Memory
DESCRIPTION:October 9\, 2013 \nThe fundamental components of representation and communication in the brain are forgetful and noisy. How does the brain overcome these features to perform accurate computation and generate reliable short-term memory? Ila Fiete will discuss how recent discoveries finally substantiate classical theoretical ideas\, while simultaneously showing that neural codes go far beyond our current theoretical understanding. She will argue that it is time to develop and apply information-theoretic principles specific to coding in the noisy brain. \nSpeaker \nIla Fiete\, Ph.D.\nUniversity of Texas at Austin \nLocation \nGerald D. Fischbach Auditorium\, Simons Foundation\n160 5th Avenue\nNew York\, NY 10010 \nWednesday\, October 9\, 2013 from 4:00 PM to 6:00 PM (EDT) \nClick here to learn more about the Theory and Biology Lectures.
URL:https://www.simonsfoundation.org/event/october-9-2013-neural-codes-for-representation-and-memory/
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200227/ila_fiete_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20131005T100000
DTEND;TZID=America/New_York:20131005T180000
DTSTAMP:20260417T085450
CREATED:20130913T040000Z
LAST-MODIFIED:20250813T163314Z
UID:1921-1380967200-1380996000@www.simonsfoundation.org
SUMMARY:Celebrating the Mathematics of Pierre Deligne: October 5\, 2013
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/celebrating-the-mathematics-of-pierre-deligne-october-5-2013/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205138/deligne_thumb2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130926T163000
DTEND;TZID=America/New_York:20130926T183000
DTSTAMP:20260417T085450
CREATED:20140611T040000Z
LAST-MODIFIED:20211207T160825Z
UID:196-1380213000-1380220200@www.simonsfoundation.org
SUMMARY:Evolving Perspectives on Autism
DESCRIPTION:Clinical psychologist Catherine Lord and neuroscientist Steven Hyman present their conceptual frameworks of autism\, and their recommendations for moving the field forward. \nCommentator Eric London\, of the New York State Institute for Basic Research in Developmental Disabilities\, provides post-discussion commentary from a physician’s perspective.
URL:https://www.simonsfoundation.org/event/evolving-perspectives-on-autism/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180651/Cathy-Lord-Photo-web1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130926T000000
DTEND;TZID=America/New_York:20130926T000000
DTSTAMP:20260417T085450
CREATED:20131030T040000Z
LAST-MODIFIED:20170823T195045Z
UID:1801-1380153600-1380153600@www.simonsfoundation.org
SUMMARY:September 26\, 2013: Evolving Perspectives on Autism
DESCRIPTION:September 26\, 2013\, 4:30-6:30 p.m. Eastern\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nClinical psychologist Catherine Lord and neuroscientist Steven Hyman present their conceptual frameworks of autism\, and their recommendations for moving the field forward. \nCommentator Eric London\, of the New York State Institute for Basic Research in Developmental Disabilities\, provides post-discussion commentary from a physician’s perspective. \nIf this lecture was videotaped\, it will be posted here after production.
URL:https://www.simonsfoundation.org/event/september-26-2013-evolving-perspectives-on-autism/
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200157/Cathy-Lord-Photo-web.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130920T003000
DTEND;TZID=America/New_York:20130920T173000
DTSTAMP:20260417T085450
CREATED:20140612T040000Z
LAST-MODIFIED:20211207T160624Z
UID:225-1379637000-1379698200@www.simonsfoundation.org
SUMMARY:Diffusion Tensor Imaging
DESCRIPTION:The Neuroimaging Symposia provide a venue for presenting and discussing the latest technical approaches\, methods and algorithms in neuroimaging. The symposia are intended to inform and engage those interested in understanding and applying these techniques. Attendees will include New York City area faculty\, postdoctoral and clinical fellows\, students and technical staff. Guests are invited to meet the speakers and mingle during the mid-afternoon break. \nTo view slides from Karla Miller’s lecture\, DTI Image Acquisition\, click here. \nTo view slides from Brian Wandell’s lecture\, DTI Analysis and Tractography\, click here. \nTo view slides from Stephen Smith’s lecture\, Human Connectome Project\, click here.
URL:https://www.simonsfoundation.org/event/diffusion-tensor-imaging/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Biotech Symposia
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180720/diffusion_thumb21.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130920T000000
DTEND;TZID=America/New_York:20130920T000000
DTSTAMP:20260417T085450
CREATED:20131002T040000Z
LAST-MODIFIED:20170823T192529Z
UID:1764-1379635200-1379635200@www.simonsfoundation.org
SUMMARY:September 20\, 2013: Diffusion Tensor Imaging
DESCRIPTION:20 September 2013\, 12:30-5:30 p.m. Eastern\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nThe Neuroimaging Symposia provide a venue for presenting and discussing the latest technical approaches\, methods and algorithms in neuroimaging. The symposia are intended to inform and engage those interested in understanding and applying these techniques. Attendees will include New York City area faculty\, postdoctoral and clinical fellows\, students and technical staff. Guests are invited to meet the speakers and mingle during the mid-afternoon break. \n \nTo view slides from Karla Miller’s lecture\, DTI Image Acquisition\, click here. \nTo view slides from Brian Wandell’s lecture\, DTI Analysis and Tractography\, click here. \nTo view slides from Stephen Smith’s lecture\, Human Connectome Project\, click here. \n 
URL:https://www.simonsfoundation.org/event/september-20-2013-diffusion-tensor-imaging/
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200113/diffusion_thumb2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130918T080000
DTEND;TZID=America/New_York:20130918T170000
DTSTAMP:20260417T085450
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T160933Z
UID:440-1379491200-1379523600@www.simonsfoundation.org
SUMMARY:The Energetic Ear
DESCRIPTION:A. James Hudspeth\, M.D.\, Ph.D.\nInvestigator\, Howard Hughes Medical Institute\nF.M. Kirby Professor and Laboratory of Sensory Neuroscience Head\, the Rockefeller University \nAs the gateway to human communication\, the sense of hearing is of enormous importance in our lives.  Research on hearing has recently been revolutionized by the demonstration that the ear is not simply a passive receiver for sound\, but also an amplifier that augments\, filters\, and compresses its inputs.  Hair cells\, the ear’s sensory receptors\, use two processes to implement an active process that endows our hearing with these remarkable properties.  First\, the vibration-sensitive structures of the ear\, which are termed hair bundles\, display a mechanical instability that underlies their capacity to oscillate in response to stimulation.  And second\, the membranes of hair cells are replete with proteins that contract in response to electrical stimuli\, thus enabling the cells to act like tiny muscles.  The exuberant activity of these two motile processes can even cause sounds to be emitted from normal ears. \nReading Material (pdf)\nLecture Slides (pdf)
URL:https://www.simonsfoundation.org/event/the-energetic-ear/
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181132/hudspeth_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130911T160000
DTEND;TZID=America/New_York:20130911T180000
DTSTAMP:20260417T085450
CREATED:20140617T040000Z
LAST-MODIFIED:20211207T160923Z
UID:241-1378915200-1378922400@www.simonsfoundation.org
SUMMARY:Quantitative Biology: Frontier at the Interface of the Physical and Life Sciences
DESCRIPTION:The 21st century holds promise for designed manipulation of biological organisms for engineering\, and for informed personalized medical intervention. A prerequisite for realizing these dreams is a quantitative\, predictive understanding of living systems\, which in turn requires a new type of science that combines biological expertise with novel methodologies and theoretical abstraction. In this talk\, Terry Hwa will explore the opportunities that exist at this new frontier using several examples at the molecular\, cellular and population levels.
URL:https://www.simonsfoundation.org/event/quantitative-biology-frontier-at-the-interface-of-the-physical-and-life-sciences/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Theory and Biology
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180735/terrence_hwa_thumb1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130911T160000
DTEND;TZID=America/New_York:20130911T180000
DTSTAMP:20260417T085450
CREATED:20130906T040000Z
LAST-MODIFIED:20211207T160914Z
UID:1918-1378915200-1378922400@www.simonsfoundation.org
SUMMARY:September 11\, 2013: Quantitative Biology: Frontier at the Interface of the Physical and Life Sciences
DESCRIPTION:September 11\, 2013 \nThe 21st century holds promise for designed manipulation of biological organisms for engineering\, and for informed personalized medical intervention. A prerequisite for realizing these dreams is a quantitative\, predictive understanding of living systems\, which in turn requires a new type of science that combines biological expertise with novel methodologies and theoretical abstraction. In this talk\, Terry Hwa will explore the opportunities that exist at this new frontier using several examples at the molecular\, cellular and population levels. \nSpeaker \nTerry Hwa\, Ph.D.\nUniversity of California\, San Diego \nLocation \nGerald D. Fischbach Auditorium\, Simons Foundation\n160 5th Avenue\nNew York\, NY 10010 \nWednesday\, September 11\, 2013 from 4:00 PM to 6:00 PM (EDT) \nTo RSVP for this event\, please do so at Eventbrite. \nClick here to learn more about the Theory and Biology Lectures.
URL:https://www.simonsfoundation.org/event/september-11-2013-quantitative-biology-frontier-at-the-interface-of-the-physical-and-life-sciences-2/
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200225/terrence_hwa_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130911T000000
DTEND;TZID=America/New_York:20130911T000000
DTSTAMP:20260417T085450
CREATED:20131031T040000Z
LAST-MODIFIED:20211207T160903Z
UID:1821-1378857600-1378857600@www.simonsfoundation.org
SUMMARY:September 11\, 2013: Quantitative Biology: Frontier at the Interface of the Physical and Life Sciences
DESCRIPTION:September 11\, 2013 \nThe 21st century holds promise for designed manipulation of biological organisms for engineering\, and for informed personalized medical intervention. A prerequisite for realizing these dreams is a quantitative\, predictive understanding of living systems\, which in turn requires a new type of science that combines biological expertise with novel methodologies and theoretical abstraction. In this talk\, Terry Hwa will explore the opportunities that exist at this new frontier using several examples at the molecular\, cellular and population levels. \nSpeaker \nTerry Hwa\, Ph.D.\nUniversity of California\, San Diego \nLocation \nGerald D. Fischbach Auditorium\, Simons Foundation\n160 5th Avenue\nNew York\, NY 10010 \nWednesday\, September 11\, 2013 from 4:00 PM to 6:00 PM (EDT) \nClick here to learn more about the Theory and Biology Lectures.
URL:https://www.simonsfoundation.org/event/september-11-2013-quantitative-biology-frontier-at-the-interface-of-the-physical-and-life-sciences/
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200225/terrence_hwa_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20130903
DTEND;VALUE=DATE:20130908
DTSTAMP:20260417T085450
CREATED:20130903T040000Z
LAST-MODIFIED:20250813T163220Z
UID:1915-1378166400-1378598399@www.simonsfoundation.org
SUMMARY:Foundation Hosts Symposium: Foliation Theory in Algebraic Geometry
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/foundation-hosts-symposium-foliation-theory-in-algebraic-geometry/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Ave\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205128/foliation_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130619T170000
DTEND;TZID=America/New_York:20130619T180000
DTSTAMP:20260417T085450
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T160851Z
UID:438-1371661200-1371664800@www.simonsfoundation.org
SUMMARY:Stem Cells: Our Lifelong Tissue Rejuvenators  And Their Promise for Regenerative Medicine
DESCRIPTION:Most of our cells are specialized to serve as muscle\, nerve\, blood\, skin\, or one of the body’s many other differentiated tissues. When these cells die in the course of disease\, injury\, or normal cellular aging\, the body issues “911 calls” that are answered by stem cells\, versatile companions that reside within each tissue\, with the potential to replenish specialized cells lost during normal wear and tear. How do stem cells retain their remarkable capacity to regenerate tissue? Why are some stem cells\, such as those of the skin\, so extraordinarily good at making new tissue? And why are other stem cells\, such as those of the heart and brain\, more limited in their potential? These are some of the many questions that fascinate Rockefeller University’s Rebecca C. Lancefield Professor Elaine Fuchs\, Ph.D. \nDr. Fuchs’s influential research on the biology of skin is clarifying the roles that stem cells play in building and regenerating tissues. Her laboratory has uncovered various molecular signals that tell skin stem cells when to make hair\, when to rejuvenate the skin surface (epidermis)\, and when to focus instead on repairing tissue after the skin is wounded. By focusing on fundamental mechanisms\, her work is shedding light on the mysteries of the body’s “fountain of youth” cells.  Although skin stem cells typically replenish only the skin and hair’s lost or dying cells\, they are closely related to other stem cells\, such as those of the cornea\, breast\, prostate\, and lung. Studies by Dr. Fuchs and her collaborators have begun to reveal unforeseen opportunities for therapies involving skin stem cells\, for example\, turning them into corneal stem cells that may be able to correct certain kinds of blindness. \nDr. Fuchs is also pursuing the theory that tumors result from stem cells gone awry\, raising the possibility that scientists could intervene in this process for cancer therapy. Her investigations are elucidating the broad questions of what happens to stem cells as we grow older\, and whether changes in stem cells raise the risk of cancer as we age.  She will touch on all of these topics in her presentation. \nAbout the Speaker \nElaine Fuchs is the Rebecca C. Lancefield Professor in Mammalian Cell Biology and Development at The Rockefeller University. She is also an Investigator\, Howard Hughes Medical Institute. Fuchs has published more than 280 papers and is internationally known for her research in skin biology\, its stem cells and its associated human genetic disorders. Fuchs’ pioneered “reverse genetics\,” a method of starting with protein and working one’s way up to elucidating the genetic basis of the human disorder that is caused by its mutations. Fuchs has applied her strategy to elucidate the genetic bases of a number of blistering skin disorders and tumors. Her current research focuses on the molecular mechanisms that underlie how stem cells of the skin are able to both self-renew long-term and to maintain and regenerate epidermis\, sweat glands and hair follicles. She studies how stem cells make tissues by responding to signals from their neighbors\, adjusting their program of gene expression and adopting specific fates. In addition to dissecting how these pathways are regulated in normal homeostasis\, Fuchs also explores how stem cells are mobilized in wound repair and how abnormalities in stem cell behavior can lead to cancers. Overall\, for over three decades\, Fuchs has continued to devise and employ innovative and imaginative approaches to biomedical research\, with emphasis on the skin. \nFuchs received her Ph.D. in Biochemistry from Princeton University\, and after her postdoctoral research with Dr. Howard Green at the Massachusetts Institute of Technology\, she joined the faculty at the University of Chicago in 1980. She stayed there until 2002 when she relocated to The Rockefeller University. Fuchs’ past awards and honors include the Presidential Young Investigator Award\, the Richard Lounsbery Award from the National Academy of Sciences\, the Novartis-Drew Award for Biomedical Research\, the Dickson Prize in Medicine\, the FASEB Award for Scientific Excellence\, the Beering Award\, the National Medal of Science\, the L’Oreal-UNESCO Award and Charlotte Friend Memorial Award from the American Association for Cancer Research. In 2011\, she received the Madison Medal\, Passano Award\, and Albany Prize in Medicine (with Shinya Yamanaka and James Thompson)\, and in 2012 received the March of Dimes Prize (with Howard Green). This year\, she has received the Kligman-Frost Leadership Award from the Society of Investigative Dermatology\, the Lifetime Achievement Award from the American Skin Foundation and the Pasarow Award for Cancer Research. Fuchs is an elected member of the National Academy of Sciences\, The Institute of Medicine\, American Academy of Arts and Sciences\, American Philosophical Society\, European Molecular Biology Organization (foreign member) and Academy of the American Association for Cancer Research. She holds honorary doctorates from Mt. Sinai/New York University School of Medicine and from the University of Illinois\, Champaign-Urbana. Fuchs is also a past President of the American Society of Cell Biology\, a recent President of the International Society for Stem Cell Research and is on the Board of Governors of the New York Academy of Sciences. She has trained over 25 graduate students and 100 postdoctoral fellows\, many of whom are now independent researchers at major academic universities and medical schools throughout the world.
URL:https://www.simonsfoundation.org/event/stem-cells-our-lifelong-tissue-rejuvenators-and-their-promise-for-regenerative-medicine/
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181130/elainefuchs_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130530T163000
DTEND;TZID=America/New_York:20130530T183000
DTSTAMP:20260417T085450
CREATED:20140611T040000Z
LAST-MODIFIED:20211207T161039Z
UID:215-1369931400-1369938600@www.simonsfoundation.org
SUMMARY:Antibodies\, behavior and cognition
DESCRIPTION:About the lecture: \nAs neutralizers of microbial agents\, antibodies are major contributors to immune competence. Occasionally\, however\, they act as autoantibodies\, which bind to a person’s own tissue\, triggering autoimmune disease. In adults\, the blood-brain barrier protects the brain against autoantibodies\, but that barrier is not fully competent in fetuses\, allowing maternal antibodies to penetrate the fetal brain and potentially alter its development. This mechanism may contribute to some cases of autism. \nAbout the speaker: \nBetty Diamond is head of the Center for Autoimmune and Musculoskeletal Diseases at the Feinstein Institute for Medical Research in New York. Her research has focused on the induction and pathogenicity of anti-DNA antibodies in systemic lupus erythematosus. She received the American College of Rheumatology’s Distinguished Investigator Award in 2001\, the Lee C. Howley Sr. Prize from the Arthritis Foundation in 2002\, and the Recognition Award from the National Association of M.D.-Ph.D. Programs in 2004. Diamond was elected to the Institute of Medicine in 2006. \nAbout the commentator: \nAlan S. Brown is professor of psychiatry and epidemiology at Columbia University and director of the Unit in Birth Cohort Studies at the New York State Psychiatric Institute. His research has focused on prenatal exposure to infectious\, immunologic\, nutritional and toxic factors\, and its association with risk of schizophrenia\, bipolar disorder and autism. He demonstrated earlier this year that elevated maternal C-reactive protein\, an inflammatory biomarker\, is related to a significantly increased risk of autism in the child. He is leading large\, multi-site national birth cohort studies of prenatal biomarkers\, developmental pathways and familial vulnerability based on an archived biobank and nationwide registries in Finland.
URL:https://www.simonsfoundation.org/event/antibodies-behavior-and-cognition/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180710/betty-diamond-thumbnail1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130530T163000
DTEND;TZID=America/New_York:20130530T183000
DTSTAMP:20260417T085450
CREATED:20130530T040000Z
LAST-MODIFIED:20211207T161029Z
UID:2037-1369931400-1369938600@www.simonsfoundation.org
SUMMARY:May 30\, 2013: Antibodies\, behavior and cognition
DESCRIPTION:Betty Diamond\n    \nAbout the lecture:\nAs neutralizers of microbial agents\, antibodies are major contributors to immune competence. Occasionally\, however\, they act as autoantibodies\, which bind to a person’s own tissue\, triggering autoimmune disease. In adults\, the blood-brain barrier protects the brain against autoantibodies\, but that barrier is not fully competent in fetuses\, allowing maternal antibodies to penetrate the fetal brain and potentially alter its development. This mechanism may contribute to some cases of autism. \nAbout the speaker:\nBetty Diamond is head of the Center for Autoimmune and Musculoskeletal Diseases at the Feinstein Institute for Medical Research in New York. Her research has focused on the induction and pathogenicity of anti-DNA antibodies in systemic lupus erythematosus. She received the American College of Rheumatology’s Distinguished Investigator Award in 2001\, the Lee C. Howley Sr. Prize from the Arthritis Foundation in 2002\, and the Recognition Award from the National Association of M.D.-Ph.D. Programs in 2004. Diamond was elected to the Institute of Medicine in 2006. \nAbout the commentator:\nAlan S. Brown is professor of psychiatry and epidemiology at Columbia University and director of the Unit in Birth Cohort Studies at the New York State Psychiatric Institute. His research has focused on prenatal exposure to infectious\, immunologic\, nutritional and toxic factors\, and its association with risk of schizophrenia\, bipolar disorder and autism. He demonstrated earlier this year that elevated maternal C-reactive protein\, an inflammatory biomarker\, is related to a significantly increased risk of autism in the child. He is leading large\, multi-site national birth cohort studies of prenatal biomarkers\, developmental pathways and familial vulnerability based on an archived biobank and nationwide registries in Finland.
URL:https://www.simonsfoundation.org/event/may-30-2013-antibodies-behavior-and-cognition/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Ave\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205954/betty-diamond-thumbnail2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130522T170000
DTEND;TZID=America/New_York:20130522T180000
DTSTAMP:20260417T085450
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T161018Z
UID:436-1369242000-1369245600@www.simonsfoundation.org
SUMMARY:Parking Cars\, Rolling Balls\, and Falling Cats: The Concept of Holonomy
DESCRIPTION:The mathematical concept of ‘holonomy’ was gradually developed in the late 19th and early 20th centuries in a number of different contexts\, and it was found to lie at the base of many everyday phenomena. Anyone who has ever tried to control the orientation of a 3-dimensional object on a computer screen using a trackball has dealt with the problem of trying to control three parameters (yaw\, pitch\, and roll) with an object that can only accept essentially two inputs (the direction and speed of rotation of the ball). That we can actually do this (and many other similar feats\, such as parallel parking a car or a trailer or\, for a cat\, the ability to turn itself in the air so as to land on its feet) is due to the phenomenon of ‘non-holonomy’ of mechanical systems. \nThe problem of how to make this somewhat vague concept precise\, so that it can be put to use\, has occupied engineers and mathematicians for more than a century\, and new things about it continue to be discovered today. It turns out to be deeply geometrical in nature. Even as simple a system as a ball rolling over a surface without slipping or twisting turns out to have surprising connections with other parts of mathematics\, including the so-called ‘exceptional’ groups. ‘Holonomy’ is used to detect the curvature of space\, and constraints on it are used to describe systems that are important in string theory and particle physics. \nIn this talk\, I’ll describe some basic aspects of this concept\, starting with simple physical problems and illustrating the ideas using familiar objects (including the Platonic solids). \nAbout the Speaker \nRobert Bryant is the Director of the Mathematical Sciences Research Institute in Berkeley\, California. Born and educated in North Carolina\, he has held positions in mathematics departments at Rice University\, Duke University\, and\, currently\, at the University of California at Berkeley. He is a member of the National Academy of Sciences and a Fellow of the American Mathematical Society. \nBryant’s research is in the area of differential geometry and its applications\, particularly to the study of partial differential equations\, control theory\, and the calculus of variations. While continuing to develop techniques pioneered by Elie Cartan and Shiing-shen Chern in the early and middle 20th century for studying these problems\, his work has produced results in the theory of holonomy of Riemannian manifolds (particularly\, showing the existence of the so-called ‘exceptional’ holonomies that turn up in string theory)\, minimal surfaces\, integrable systems\, and several related areas.
URL:https://www.simonsfoundation.org/event/parking-cars-rolling-balls-and-falling-cats-the-concept-of-holonomy/
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181128/robert_bryant.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130508T160000
DTEND;TZID=America/New_York:20130508T180000
DTSTAMP:20260417T085450
CREATED:20140616T040000Z
LAST-MODIFIED:20211207T161007Z
UID:239-1368028800-1368036000@www.simonsfoundation.org
SUMMARY:Climate Projections over North America in the Coming Decades
DESCRIPTION:Earth’s climate trajectory over the next few decades will be influenced both by human-induced climate change and by internally generated variability in the climate system. This lecture highlights the substantial contribution of internal variability to projected climate trends over North America in the next 50 years. \nAbout the Speaker \nClara Deser\, Ph.D. is the head of the Climate Analysis Section within the Climate and Global Dynamics Division at NCAR. Her research interests include diagnostic analysis of observed climate variability in the coupled atmosphere-ocean-ice system\, as well as future climate change. She is also a co-chair of the CESM Climate Variability and Change Working Group.
URL:https://www.simonsfoundation.org/event/climate-projections-over-north-america-in-the-coming-decades/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:The Science of Climate
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180734/ClaraDeser_video11.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130425T163000
DTEND;TZID=America/New_York:20130425T183000
DTSTAMP:20260417T085450
CREATED:20140611T040000Z
LAST-MODIFIED:20211207T160957Z
UID:217-1366907400-1366914600@www.simonsfoundation.org
SUMMARY:New Genetic Insights into the Pathophysiology of Autism Spectrum Disorders
DESCRIPTION:The genetics and genomics of autism spectrum disorders have reached a tipping point. The recent focus on de novo mutations has led to systematic\, highly productive gene discovery efforts. These have begun to clarify a tremendously heterogeneous allelic architecture as well as specific genes contributing to social disability syndromes. This lecture will review these recent discoveries and address the challenges facing the path forward from reliable gene discovery to an actionable understanding of the molecular pathophysiology of autism spectrum disorders. \nAbout the Speaker \nMatthew State\, M.D.\, Ph.D.\, received his undergraduate and medical degrees from Stanford University\, and completed his residency in psychiatry and fellowship in child psychiatry at the University of California\, Los Angeles Neuropsychiatric Institute. He received his Ph.D. in genetics from Yale University and was a faculty member there from 2001-2013. He is currently chairman of the psychiatry department at the University of California\, San Francisco. \nState’s lab has a longstanding interest in the contribution of rare genetic mutations to childhood neuropsychiatric disorders\, including autism and Tourette syndrome. State is currently leading a large\, multi-site\, genome-wide study of autism spectrum disorder funded by the Simons Foundation\, and is playing a leadership role in the Tourette International Collaborative for Genetics and the Autism Sequencing Consortium. Among many professional honors\, this past year he was awarded the Ruane Prize for Outstanding Research in Child and Adolescent Psychiatry by the Brain and Behavior Research Foundation.
URL:https://www.simonsfoundation.org/event/new-genetic-insights-into-the-pathophysiology-of-autism-spectrum-disorders/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
ATTACH;FMTTYPE=image/png:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180712/mattstate1.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130425T000000
DTEND;TZID=America/New_York:20130425T000000
DTSTAMP:20260417T085450
CREATED:20130425T040000Z
LAST-MODIFIED:20211207T160947Z
UID:2044-1366848000-1366848000@www.simonsfoundation.org
SUMMARY:New Genetic Insights into the Pathophysiology of Autism Spectrum Disorders
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/april-25-2013-new-genetic-insights-into-the-pathophysiology-of-autism-spectrum-disorders/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/png:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11210006/mattstate.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130424T160000
DTEND;TZID=America/New_York:20130424T180000
DTSTAMP:20260417T085450
CREATED:20140616T040000Z
LAST-MODIFIED:20211207T154453Z
UID:237-1366819200-1366826400@www.simonsfoundation.org
SUMMARY:Water: Climate's Great Orchestrator
DESCRIPTION:The mighty water molecule\, with its voracious appetite for infrared radiation\, is responsible for much of what we know about climate and climate change\, and even more of what we don’t know. Trapped for most of its life in large surface reservoirs\, every few thousand years it escapes to the atmosphere for a short sojourn of a little over a week\, during which it helps to create\, quite literally\, the world as we know it. \nAbout the Speaker \nBjorn B. Stevens\, Ph.D. leads the department “The Atmosphere in the Earth System” as well as the International Max Planck Research School on Earth System Modelling at the Max Planck Institute for Meteorology. \nProf. Stevens has published ground-breaking research papers dealing with the theory\, modelling and observation of “low” clouds\, which is one of the most important problems in meteorology and climate research.
URL:https://www.simonsfoundation.org/event/water-climates-great-orchestrator/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:The Science of Climate
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180731/BjornStevens_video1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130410T160000
DTEND;TZID=America/New_York:20130410T180000
DTSTAMP:20260417T085450
CREATED:20140616T040000Z
LAST-MODIFIED:20211207T154515Z
UID:235-1365609600-1365616800@www.simonsfoundation.org
SUMMARY:Climate Feedbacks: Magnitude & Uncertainty in Global Warming
DESCRIPTION:Most of the changes in climate that are projected to occur over the 21st century will not result directly from the human emission of greenhouse gases\, but from natural feedbacks within the climate system that amplify its sensitivity to these emissions. Some of these feedbacks are well constrained by theory and observations\, while others are not. This lecture outlines our understanding of the main feedback processes in the climate system and how they impact both the magnitude of future changes in Earth’s climate and the uncertainty in our predictions of these changes. \nAbout the Speaker \nBrian J. Soden\, Ph.D. is Professor of Meteorology and Physical Oceanography at the Rosenstiel School for Marine and Atmospheric Science\, University of Miami. Dr. Soden specializes in the use of satellite observations to test and improve computer model simulations of climate change. He has published over 80 publications on a variety of topics\, but most often related to the response of the climate system to global warming.
URL:https://www.simonsfoundation.org/event/climate-feedbacks-magnitude-uncertainty-in-global-warming/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:The Science of Climate
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180730/brian_soden1.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20130331
DTEND;VALUE=DATE:20130407
DTSTAMP:20260417T085450
CREATED:20170911T222211Z
LAST-MODIFIED:20250813T163108Z
UID:25738-1364688000-1365292799@www.simonsfoundation.org
SUMMARY:Non-Archimedean and Tropical Geometry (2013)
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/non-archimedean-and-tropical-geometry-2013/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130327T170000
DTEND;TZID=America/New_York:20130327T180000
DTSTAMP:20260417T085450
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T154544Z
UID:434-1364403600-1364407200@www.simonsfoundation.org
SUMMARY:The Most Random of All Possible Worlds
DESCRIPTION:The talk will be about the law of large numbers\, in its various manifestations. This is a real cornerstone of probability and\, in English\, it says that a random system of a very large size is typically not random: its deterministic state is the one that has the largest probability to occur. Maximizing the probability to occur is a variational problem that can be analyzed and sometimes solved. As for any variational problem\, there is always something special about the solution\, which translates into special and beautiful forms created by pure luck of the draw. \nSuggested Reading \nOkounkov’s AMS colloquim lectures (2007) will serve as an introduction to his lecture. \nAbout the Speaker \nAndrei Okounkov is the Samuel Eilenberg Professor of Mathematics at Columbia University. Born and educated in Moscow\, he came to the U.S. in 1995 and held positions at the University of Chicago\, University of California at Berkeley\, and Princeton University before joining the faculty of Columbia University. His work on representation theory and its applications to algebraic geometry\, mathematical physics\, and other fields was recognized by the Packard fellowship\, the European Mathematical Society prize\, the Fields medal of the International Mathematical Union\, and other distinctions. \n 
URL:https://www.simonsfoundation.org/event/the-most-random-of-all-possible-worlds/
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181126/andrei_okounkov_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130313T160000
DTEND;TZID=America/New_York:20130313T180000
DTSTAMP:20260417T085450
CREATED:20140616T040000Z
LAST-MODIFIED:20211207T154558Z
UID:233-1363190400-1363197600@www.simonsfoundation.org
SUMMARY:Hurricanes: Present and Future
DESCRIPTION:Some 90 tropical cyclones develop each year. In this lecture\, Professor Kerry Emanuel will review the theory of tropical cyclones and how it informs observed variability. He will also discuss how these storms may have important feedbacks on such phenomena as El Niño-Southern Oscillation and global climate change. \nAbout the Speaker \nKerry A. Emanuel\, Ph.D. is Professor of Atmospheric Science in the Department of Earth\, Atmospheric\, and Planetary Sciences at Massachusetts Institute of Technology.
URL:https://www.simonsfoundation.org/event/hurricanes-present-and-future/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:The Science of Climate
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180728/kerry_emanuel1.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130310T170000
DTEND;TZID=America/New_York:20130310T180000
DTSTAMP:20260417T085450
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T154614Z
UID:432-1362934800-1362938400@www.simonsfoundation.org
SUMMARY:Autism\, Oxytocin\, and Neural Signaling
DESCRIPTION:Genetics tells us that abnormal synaptic and nuclear proteins are often at the root of major neuropsychiatric disorders. Autism\, a prominent and often debilitating disorder of the brain\, has been traced to small contributions of hundreds of genes\, creating a formidable challenge for those interested in exploring pathophysiology and possible therapeutic interventions. A major interest of our laboratory is a form of autism known as Timothy Syndrome (TS)\, which arises from a point mutation in a signaling protein. Though rare\, the mutation causes autism spectrum disorder (ASD) with 3:1 odds. The gene\, known as CACNA1C\, encodes a particular kind of calcium channel known as “L-type”. We have studied the behavior of mice bearing the TS mutation and find persistent behavior\, altered communication\, and reduced social interaction relative to their unaffected sibs\, features reminiscent of the three characteristic hallmarks of autism. The mutation leads to over-activity of the ion channel\, raising the prospect that it might be counteracted pharmacologically. Interestingly\, the same CACNA1C gene has been repeatedly implicated in schizophrenia and in Major Depressive Disorder. The possibility arises that work on diverse neuropsychiatric diseases will prove more synergistic than previously appreciated. \nWhy does miscoding in CACNA1C exert such strong effects? Like its close relatives\, this particular L-type calcium channel plays a central role in allowing a neuron to track its own activity.  In a process called excitation-transcription coupling\, neuronal firing drives the opening of the L-type channel\, flow of calcium into the cell\, activation of transcription factors\, and expression of specific sets of genes. Ultimately\, this supports neuronal autoregulation and plasticity. We are currently working out critical details of how the L-type channel transmits a packet of information to control nuclear gene transcription. Interestingly\, elements of this signaling pathway are encoded by genes that have also been implicated in causing neuropsychiatric disorders. \nDisorders at the cellular level are thought to engender aberrant function of neuronal circuits. Oxytocin is a key neuromodulator whose influence on neuronal circuitry has been linked to social memory and maternal behavior in animals\, as well trust\, emotion recognition and parenting in humans. Multiple clinical trials have uncovered promising actions of oxytocin on autistic behavior in teenagers\, including processing of information about faces. By examining oxytocin actions in brain slices\, we have found that activation of oxytocin receptors sharpens the responses of a canonical hippocampal circuit. The peptide increases the fidelity of signal transmission through the network\, while simultaneously suppressing the noise of background spontaneous activity. These seemingly contradictory actions are both mediated through a selective depolarization of the fast-spiking interneurons by oxytocin. The resulting increase in inhibitory tone in principal cells dampens their spontaneous activity. Meanwhile\, a use-dependent depression of the feed-forward inhibitory synapses permits enhanced spike transmission. By activating fast-spiking neurons with cholecystokinin\, or with channelrhodopsin-2\, we demonstrate that this novel circuit mechanism is generally applicable to any manipulation that elicits the firing of fast-spiking basket cells. We have begun testing the action of oxytocin agonists on reversal learning\, to determine if perseverative behavior can be ameliorated. The prospect looms that actions of oxytocin at the circuit level might contribute to its behavioral impact in autistic individuals\, but at the moment this is merely a hypothesis. \nSuggested Reading \n\nCaV1 and CaV2 Channels Engage Distinct Modes of Ca2+ Signaling to Control CREB-Dependent Gene Expression \n\n\n\n\nMouse model of Timothy syndrome recapitulates triad of autistic traits \n\n\n\nAbout the Speaker \nRichard W. Tsien\, DPhil\, is Director of the Neuroscience Institute\, Druckenmiller Professor of Neuroscience\, and Chair of the Physiology and Neuroscience Department at the NYU School of Medicine. Prior to joining NYU in August 2011\, Dr. Tsien served as the George D. Smith Professor of Molecular Genetic Medicine at Stanford University. While there\, Dr. Tsien founded and served as the inaugural chair of the Department of Molecular and Cellular Physiology. After a six-year term as chair\, in 1994 he co-led a successful Stanford-wide movement to establish an institute for neuroscience\, the Stanford Brain Research Center\, which he co-directed from 2000 through 2005. He served a 10-year term as the director and principal investigator at Stanford’s Silvio Conte Center for Neuroscience Research. As a scientist\, Dr. Tsien is a world leader in the study of calcium channels and their signaling targets\, particularly at pre- and postsynaptic sites. He studies how synapses contribute to neuronal computations and network function in both healthy and diseased brains. His research\, generously supported by the NIH and private foundations\, has contributed substantially to understanding how neurotransmitters\, drugs and molecular alterations regulate calcium channels and has implications for diverse clinical areas such as pain and autism. His research has been published in over 200 peer-reviewed journal articles\, and he has served on editorial boards for numerous journals. He has also served as section chair for the American Association for the Advancement of Science (Neuroscience Section) and the National Academy of Sciences (Neurobiology Section) and has been a member of scientific advisory boards for several institutes\, including the Howard Hughes Medical Institute. Dr. Tsien received both an undergraduate and graduate degree in electrical engineering from the Massachusetts Institute of Technology. He was a Rhodes Scholar\, graduating with his doctorate in biophysics from Oxford University\, England after which he joined the faculty at Yale University School of Medicine and served for nearly two decades. He is a member of both the Institute of Medicine and National Academy of Sciences. He was awarded the Julius Axelrod Prize by the Society for Neuroscience in 2012. \n 
URL:https://www.simonsfoundation.org/event/autism-oxytocin-and-neural-signaling/
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181124/richardtsien2_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130224T000000
DTEND;TZID=America/New_York:20130302T000000
DTSTAMP:20260417T085450
CREATED:20150908T040000Z
LAST-MODIFIED:20250813T162959Z
UID:4075-1361664000-1362182400@www.simonsfoundation.org
SUMMARY:The Kardar-Parisi-Zhang Equation and Universality Class (2013)
DESCRIPTION:February 24-March 2\, 2013 \nOrganizers: Alexei Borodin\, Jeremy Quastel\, Herbert Spohn \nThe Kardar-Parisi-Zhang equation is a nonlinear stochastic partial differential equation widely used in the physics literature as a model of randomly growing interfaces\, but until recently very poorly understood from the mathematical point of view. In one dimension\, it is a member of a large universality class containing directed random polymers\, stochastic Hamilton-Jacobi-Bellman equations\, stochastically perturbed reaction-diffusion equations\, stochastic Burgers equations and interacting particle models. The class is characterized by the unusual dynamic scaling exponent z=3/2. A number of breakthroughs about 10 years ago led to exact distributions of fluctuations for a few models\, with conjectural extrapolation to the whole class. The distributions\, surprisingly\, turned out to be those recently discovered in random matrix theory. In the last few years there have been a second group of breakthroughs. Several models with adjustable asymmetry have recently been solved through which one can obtain\, by scaling limits\, exact distributions for various initial conditions for the KPZ equation itself. In addition\, there have been breakthroughs in the well-posedness of the KPZ equation. \nThe goal of this workshop is to build on these advances in two directions. 1. Studying the integrability properties and statistics of the KPZ equation\, as well as other models in the KPZ universality class. 2. Extending the universality of the KPZ equation. The new well-posedness theory should provide a route to proving scaling limits to the KPZ equation for a wider class of physical models. \nParticipants \nFedor Bogomolov\, NYU/Courant \nMark Adler\, Brandeis University \nGerard Ben Arous\, NYU/Courant \nAlexei Borodin\, MIT \nPasquale Calabrese\, Universita di Pisa \nReda Chhaibi\, Universitat Zurich \nIvan Corwin\, MIT/Microsoft Research \nPercy Deift\, NYU/Courant \nVictor Dotsenko\, University of Paris 6 \nPatrik Ferrari\, University of Bonn \nAlan Hammond\, University of Oxford \nKurt Johnasson\, KTH \nKostya Khanin\, University of Toronto \nPierre Le Doussal\, ENS\, Paris \nPierre van Moerbeke\, Université catholique de Louvain \nNeil O’Connell\, Warwick University \nJeremy Quastel\, University of Toronto \nTomohiro Sasamoto\, Chiba University \nTimo Seppalainen\, University of Wisconsin-Madison \nSenya Shlosman\, University of Marseilles \nHerbert Spohn\, Technische Universitat Munchen \nCraig Tracy\, UC Davis \nJon Warren\, Warwick University
URL:https://www.simonsfoundation.org/event/the-kardar-parisi-zhang-equation-and-universality-class-february-24-march-2-2013/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130216T170000
DTEND;TZID=America/New_York:20130216T180000
DTSTAMP:20260417T085450
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T155527Z
UID:430-1361034000-1361037600@www.simonsfoundation.org
SUMMARY:Probability & Intuition
DESCRIPTION:Probability theory was devised in order to understand gambling\, but now is the underpinning of statistics\, without which we would be clueless in our complex society.  Yet probability itself is a mysterious quantity\, hard to define\, and awkward for our human intuition to cope with.  Does it even exist\, except in our minds? \nThrough stories and puzzles\, we will attempt to get a slightly better grip on probability and to identify some of the ways in which our intuition tends to lead us astray. \n  \nSuggested Reading: \nGrinstead and Snell’s Introduction to Probability \nAbout the Speaker:\n \nPeter Winkler is the William Morrill Professor of Mathematics and Computer Science at Dartmouth College. His research interests lie in discrete mathematics and the theory of computing\, probability theory\, and applications. \nPeter Winkler is author of more than 125 research papers and the holder of eight patents. Winkler studied Mathematics at Harvard University and received his Ph.D. in from Yale University. He has also published two books on mathematical puzzles. \nHomepage: http://www.math.dartmouth.edu/~pw/ \n 
URL:https://www.simonsfoundation.org/event/probability-intuition/
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181122/peter_winkler_large_thumb.jpg
END:VEVENT
END:VCALENDAR