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X-WR-CALDESC:Events for Simons Foundation
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DTSTART:20120311T070000
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DTSTART;TZID=America/New_York:20130918T080000
DTEND;TZID=America/New_York:20130918T170000
DTSTAMP:20260417T061847
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T160933Z
UID:440-1379491200-1379523600@www.simonsfoundation.org
SUMMARY:The Energetic Ear
DESCRIPTION:A. James Hudspeth\, M.D.\, Ph.D.\nInvestigator\, Howard Hughes Medical Institute\nF.M. Kirby Professor and Laboratory of Sensory Neuroscience Head\, the Rockefeller University \nAs the gateway to human communication\, the sense of hearing is of enormous importance in our lives.  Research on hearing has recently been revolutionized by the demonstration that the ear is not simply a passive receiver for sound\, but also an amplifier that augments\, filters\, and compresses its inputs.  Hair cells\, the ear’s sensory receptors\, use two processes to implement an active process that endows our hearing with these remarkable properties.  First\, the vibration-sensitive structures of the ear\, which are termed hair bundles\, display a mechanical instability that underlies their capacity to oscillate in response to stimulation.  And second\, the membranes of hair cells are replete with proteins that contract in response to electrical stimuli\, thus enabling the cells to act like tiny muscles.  The exuberant activity of these two motile processes can even cause sounds to be emitted from normal ears. \nReading Material (pdf)\nLecture Slides (pdf)
URL:https://www.simonsfoundation.org/event/the-energetic-ear/
LOCATION:NY
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181132/hudspeth_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130911T160000
DTEND;TZID=America/New_York:20130911T180000
DTSTAMP:20260417T061848
CREATED:20140617T040000Z
LAST-MODIFIED:20211207T160923Z
UID:241-1378915200-1378922400@www.simonsfoundation.org
SUMMARY:Quantitative Biology: Frontier at the Interface of the Physical and Life Sciences
DESCRIPTION:The 21st century holds promise for designed manipulation of biological organisms for engineering\, and for informed personalized medical intervention. A prerequisite for realizing these dreams is a quantitative\, predictive understanding of living systems\, which in turn requires a new type of science that combines biological expertise with novel methodologies and theoretical abstraction. In this talk\, Terry Hwa will explore the opportunities that exist at this new frontier using several examples at the molecular\, cellular and population levels.
URL:https://www.simonsfoundation.org/event/quantitative-biology-frontier-at-the-interface-of-the-physical-and-life-sciences/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Theory and Biology
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130911T160000
DTEND;TZID=America/New_York:20130911T180000
DTSTAMP:20260417T061848
CREATED:20130906T040000Z
LAST-MODIFIED:20211207T160914Z
UID:1918-1378915200-1378922400@www.simonsfoundation.org
SUMMARY:September 11\, 2013: Quantitative Biology: Frontier at the Interface of the Physical and Life Sciences
DESCRIPTION:September 11\, 2013 \nThe 21st century holds promise for designed manipulation of biological organisms for engineering\, and for informed personalized medical intervention. A prerequisite for realizing these dreams is a quantitative\, predictive understanding of living systems\, which in turn requires a new type of science that combines biological expertise with novel methodologies and theoretical abstraction. In this talk\, Terry Hwa will explore the opportunities that exist at this new frontier using several examples at the molecular\, cellular and population levels. \nSpeaker \nTerry Hwa\, Ph.D.\nUniversity of California\, San Diego \nLocation \nGerald D. Fischbach Auditorium\, Simons Foundation\n160 5th Avenue\nNew York\, NY 10010 \nWednesday\, September 11\, 2013 from 4:00 PM to 6:00 PM (EDT) \nTo RSVP for this event\, please do so at Eventbrite. \nClick here to learn more about the Theory and Biology Lectures.
URL:https://www.simonsfoundation.org/event/september-11-2013-quantitative-biology-frontier-at-the-interface-of-the-physical-and-life-sciences-2/
LOCATION:NY
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200225/terrence_hwa_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130911T000000
DTEND;TZID=America/New_York:20130911T000000
DTSTAMP:20260417T061848
CREATED:20131031T040000Z
LAST-MODIFIED:20211207T160903Z
UID:1821-1378857600-1378857600@www.simonsfoundation.org
SUMMARY:September 11\, 2013: Quantitative Biology: Frontier at the Interface of the Physical and Life Sciences
DESCRIPTION:September 11\, 2013 \nThe 21st century holds promise for designed manipulation of biological organisms for engineering\, and for informed personalized medical intervention. A prerequisite for realizing these dreams is a quantitative\, predictive understanding of living systems\, which in turn requires a new type of science that combines biological expertise with novel methodologies and theoretical abstraction. In this talk\, Terry Hwa will explore the opportunities that exist at this new frontier using several examples at the molecular\, cellular and population levels. \nSpeaker \nTerry Hwa\, Ph.D.\nUniversity of California\, San Diego \nLocation \nGerald D. Fischbach Auditorium\, Simons Foundation\n160 5th Avenue\nNew York\, NY 10010 \nWednesday\, September 11\, 2013 from 4:00 PM to 6:00 PM (EDT) \nClick here to learn more about the Theory and Biology Lectures.
URL:https://www.simonsfoundation.org/event/september-11-2013-quantitative-biology-frontier-at-the-interface-of-the-physical-and-life-sciences/
LOCATION:NY
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200225/terrence_hwa_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20130903
DTEND;VALUE=DATE:20130908
DTSTAMP:20260417T061848
CREATED:20130903T040000Z
LAST-MODIFIED:20250813T163220Z
UID:1915-1378166400-1378598399@www.simonsfoundation.org
SUMMARY:Foundation Hosts Symposium: Foliation Theory in Algebraic Geometry
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/foundation-hosts-symposium-foliation-theory-in-algebraic-geometry/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Ave\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205128/foliation_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130619T170000
DTEND;TZID=America/New_York:20130619T180000
DTSTAMP:20260417T061848
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T160851Z
UID:438-1371661200-1371664800@www.simonsfoundation.org
SUMMARY:Stem Cells: Our Lifelong Tissue Rejuvenators  And Their Promise for Regenerative Medicine
DESCRIPTION:Most of our cells are specialized to serve as muscle\, nerve\, blood\, skin\, or one of the body’s many other differentiated tissues. When these cells die in the course of disease\, injury\, or normal cellular aging\, the body issues “911 calls” that are answered by stem cells\, versatile companions that reside within each tissue\, with the potential to replenish specialized cells lost during normal wear and tear. How do stem cells retain their remarkable capacity to regenerate tissue? Why are some stem cells\, such as those of the skin\, so extraordinarily good at making new tissue? And why are other stem cells\, such as those of the heart and brain\, more limited in their potential? These are some of the many questions that fascinate Rockefeller University’s Rebecca C. Lancefield Professor Elaine Fuchs\, Ph.D. \nDr. Fuchs’s influential research on the biology of skin is clarifying the roles that stem cells play in building and regenerating tissues. Her laboratory has uncovered various molecular signals that tell skin stem cells when to make hair\, when to rejuvenate the skin surface (epidermis)\, and when to focus instead on repairing tissue after the skin is wounded. By focusing on fundamental mechanisms\, her work is shedding light on the mysteries of the body’s “fountain of youth” cells.  Although skin stem cells typically replenish only the skin and hair’s lost or dying cells\, they are closely related to other stem cells\, such as those of the cornea\, breast\, prostate\, and lung. Studies by Dr. Fuchs and her collaborators have begun to reveal unforeseen opportunities for therapies involving skin stem cells\, for example\, turning them into corneal stem cells that may be able to correct certain kinds of blindness. \nDr. Fuchs is also pursuing the theory that tumors result from stem cells gone awry\, raising the possibility that scientists could intervene in this process for cancer therapy. Her investigations are elucidating the broad questions of what happens to stem cells as we grow older\, and whether changes in stem cells raise the risk of cancer as we age.  She will touch on all of these topics in her presentation. \nAbout the Speaker \nElaine Fuchs is the Rebecca C. Lancefield Professor in Mammalian Cell Biology and Development at The Rockefeller University. She is also an Investigator\, Howard Hughes Medical Institute. Fuchs has published more than 280 papers and is internationally known for her research in skin biology\, its stem cells and its associated human genetic disorders. Fuchs’ pioneered “reverse genetics\,” a method of starting with protein and working one’s way up to elucidating the genetic basis of the human disorder that is caused by its mutations. Fuchs has applied her strategy to elucidate the genetic bases of a number of blistering skin disorders and tumors. Her current research focuses on the molecular mechanisms that underlie how stem cells of the skin are able to both self-renew long-term and to maintain and regenerate epidermis\, sweat glands and hair follicles. She studies how stem cells make tissues by responding to signals from their neighbors\, adjusting their program of gene expression and adopting specific fates. In addition to dissecting how these pathways are regulated in normal homeostasis\, Fuchs also explores how stem cells are mobilized in wound repair and how abnormalities in stem cell behavior can lead to cancers. Overall\, for over three decades\, Fuchs has continued to devise and employ innovative and imaginative approaches to biomedical research\, with emphasis on the skin. \nFuchs received her Ph.D. in Biochemistry from Princeton University\, and after her postdoctoral research with Dr. Howard Green at the Massachusetts Institute of Technology\, she joined the faculty at the University of Chicago in 1980. She stayed there until 2002 when she relocated to The Rockefeller University. Fuchs’ past awards and honors include the Presidential Young Investigator Award\, the Richard Lounsbery Award from the National Academy of Sciences\, the Novartis-Drew Award for Biomedical Research\, the Dickson Prize in Medicine\, the FASEB Award for Scientific Excellence\, the Beering Award\, the National Medal of Science\, the L’Oreal-UNESCO Award and Charlotte Friend Memorial Award from the American Association for Cancer Research. In 2011\, she received the Madison Medal\, Passano Award\, and Albany Prize in Medicine (with Shinya Yamanaka and James Thompson)\, and in 2012 received the March of Dimes Prize (with Howard Green). This year\, she has received the Kligman-Frost Leadership Award from the Society of Investigative Dermatology\, the Lifetime Achievement Award from the American Skin Foundation and the Pasarow Award for Cancer Research. Fuchs is an elected member of the National Academy of Sciences\, The Institute of Medicine\, American Academy of Arts and Sciences\, American Philosophical Society\, European Molecular Biology Organization (foreign member) and Academy of the American Association for Cancer Research. She holds honorary doctorates from Mt. Sinai/New York University School of Medicine and from the University of Illinois\, Champaign-Urbana. Fuchs is also a past President of the American Society of Cell Biology\, a recent President of the International Society for Stem Cell Research and is on the Board of Governors of the New York Academy of Sciences. She has trained over 25 graduate students and 100 postdoctoral fellows\, many of whom are now independent researchers at major academic universities and medical schools throughout the world.
URL:https://www.simonsfoundation.org/event/stem-cells-our-lifelong-tissue-rejuvenators-and-their-promise-for-regenerative-medicine/
LOCATION:NY
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181130/elainefuchs_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130530T163000
DTEND;TZID=America/New_York:20130530T183000
DTSTAMP:20260417T061848
CREATED:20140611T040000Z
LAST-MODIFIED:20211207T161039Z
UID:215-1369931400-1369938600@www.simonsfoundation.org
SUMMARY:Antibodies\, behavior and cognition
DESCRIPTION:About the lecture: \nAs neutralizers of microbial agents\, antibodies are major contributors to immune competence. Occasionally\, however\, they act as autoantibodies\, which bind to a person’s own tissue\, triggering autoimmune disease. In adults\, the blood-brain barrier protects the brain against autoantibodies\, but that barrier is not fully competent in fetuses\, allowing maternal antibodies to penetrate the fetal brain and potentially alter its development. This mechanism may contribute to some cases of autism. \nAbout the speaker: \nBetty Diamond is head of the Center for Autoimmune and Musculoskeletal Diseases at the Feinstein Institute for Medical Research in New York. Her research has focused on the induction and pathogenicity of anti-DNA antibodies in systemic lupus erythematosus. She received the American College of Rheumatology’s Distinguished Investigator Award in 2001\, the Lee C. Howley Sr. Prize from the Arthritis Foundation in 2002\, and the Recognition Award from the National Association of M.D.-Ph.D. Programs in 2004. Diamond was elected to the Institute of Medicine in 2006. \nAbout the commentator: \nAlan S. Brown is professor of psychiatry and epidemiology at Columbia University and director of the Unit in Birth Cohort Studies at the New York State Psychiatric Institute. His research has focused on prenatal exposure to infectious\, immunologic\, nutritional and toxic factors\, and its association with risk of schizophrenia\, bipolar disorder and autism. He demonstrated earlier this year that elevated maternal C-reactive protein\, an inflammatory biomarker\, is related to a significantly increased risk of autism in the child. He is leading large\, multi-site national birth cohort studies of prenatal biomarkers\, developmental pathways and familial vulnerability based on an archived biobank and nationwide registries in Finland.
URL:https://www.simonsfoundation.org/event/antibodies-behavior-and-cognition/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130530T163000
DTEND;TZID=America/New_York:20130530T183000
DTSTAMP:20260417T061848
CREATED:20130530T040000Z
LAST-MODIFIED:20211207T161029Z
UID:2037-1369931400-1369938600@www.simonsfoundation.org
SUMMARY:May 30\, 2013: Antibodies\, behavior and cognition
DESCRIPTION:Betty Diamond\n    \nAbout the lecture:\nAs neutralizers of microbial agents\, antibodies are major contributors to immune competence. Occasionally\, however\, they act as autoantibodies\, which bind to a person’s own tissue\, triggering autoimmune disease. In adults\, the blood-brain barrier protects the brain against autoantibodies\, but that barrier is not fully competent in fetuses\, allowing maternal antibodies to penetrate the fetal brain and potentially alter its development. This mechanism may contribute to some cases of autism. \nAbout the speaker:\nBetty Diamond is head of the Center for Autoimmune and Musculoskeletal Diseases at the Feinstein Institute for Medical Research in New York. Her research has focused on the induction and pathogenicity of anti-DNA antibodies in systemic lupus erythematosus. She received the American College of Rheumatology’s Distinguished Investigator Award in 2001\, the Lee C. Howley Sr. Prize from the Arthritis Foundation in 2002\, and the Recognition Award from the National Association of M.D.-Ph.D. Programs in 2004. Diamond was elected to the Institute of Medicine in 2006. \nAbout the commentator:\nAlan S. Brown is professor of psychiatry and epidemiology at Columbia University and director of the Unit in Birth Cohort Studies at the New York State Psychiatric Institute. His research has focused on prenatal exposure to infectious\, immunologic\, nutritional and toxic factors\, and its association with risk of schizophrenia\, bipolar disorder and autism. He demonstrated earlier this year that elevated maternal C-reactive protein\, an inflammatory biomarker\, is related to a significantly increased risk of autism in the child. He is leading large\, multi-site national birth cohort studies of prenatal biomarkers\, developmental pathways and familial vulnerability based on an archived biobank and nationwide registries in Finland.
URL:https://www.simonsfoundation.org/event/may-30-2013-antibodies-behavior-and-cognition/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Ave\, New York\, NY\, 10010\, United States
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130522T170000
DTEND;TZID=America/New_York:20130522T180000
DTSTAMP:20260417T061848
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T161018Z
UID:436-1369242000-1369245600@www.simonsfoundation.org
SUMMARY:Parking Cars\, Rolling Balls\, and Falling Cats: The Concept of Holonomy
DESCRIPTION:The mathematical concept of ‘holonomy’ was gradually developed in the late 19th and early 20th centuries in a number of different contexts\, and it was found to lie at the base of many everyday phenomena. Anyone who has ever tried to control the orientation of a 3-dimensional object on a computer screen using a trackball has dealt with the problem of trying to control three parameters (yaw\, pitch\, and roll) with an object that can only accept essentially two inputs (the direction and speed of rotation of the ball). That we can actually do this (and many other similar feats\, such as parallel parking a car or a trailer or\, for a cat\, the ability to turn itself in the air so as to land on its feet) is due to the phenomenon of ‘non-holonomy’ of mechanical systems. \nThe problem of how to make this somewhat vague concept precise\, so that it can be put to use\, has occupied engineers and mathematicians for more than a century\, and new things about it continue to be discovered today. It turns out to be deeply geometrical in nature. Even as simple a system as a ball rolling over a surface without slipping or twisting turns out to have surprising connections with other parts of mathematics\, including the so-called ‘exceptional’ groups. ‘Holonomy’ is used to detect the curvature of space\, and constraints on it are used to describe systems that are important in string theory and particle physics. \nIn this talk\, I’ll describe some basic aspects of this concept\, starting with simple physical problems and illustrating the ideas using familiar objects (including the Platonic solids). \nAbout the Speaker \nRobert Bryant is the Director of the Mathematical Sciences Research Institute in Berkeley\, California. Born and educated in North Carolina\, he has held positions in mathematics departments at Rice University\, Duke University\, and\, currently\, at the University of California at Berkeley. He is a member of the National Academy of Sciences and a Fellow of the American Mathematical Society. \nBryant’s research is in the area of differential geometry and its applications\, particularly to the study of partial differential equations\, control theory\, and the calculus of variations. While continuing to develop techniques pioneered by Elie Cartan and Shiing-shen Chern in the early and middle 20th century for studying these problems\, his work has produced results in the theory of holonomy of Riemannian manifolds (particularly\, showing the existence of the so-called ‘exceptional’ holonomies that turn up in string theory)\, minimal surfaces\, integrable systems\, and several related areas.
URL:https://www.simonsfoundation.org/event/parking-cars-rolling-balls-and-falling-cats-the-concept-of-holonomy/
LOCATION:NY
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181128/robert_bryant.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130508T160000
DTEND;TZID=America/New_York:20130508T180000
DTSTAMP:20260417T061848
CREATED:20140616T040000Z
LAST-MODIFIED:20211207T161007Z
UID:239-1368028800-1368036000@www.simonsfoundation.org
SUMMARY:Climate Projections over North America in the Coming Decades
DESCRIPTION:Earth’s climate trajectory over the next few decades will be influenced both by human-induced climate change and by internally generated variability in the climate system. This lecture highlights the substantial contribution of internal variability to projected climate trends over North America in the next 50 years. \nAbout the Speaker \nClara Deser\, Ph.D. is the head of the Climate Analysis Section within the Climate and Global Dynamics Division at NCAR. Her research interests include diagnostic analysis of observed climate variability in the coupled atmosphere-ocean-ice system\, as well as future climate change. She is also a co-chair of the CESM Climate Variability and Change Working Group.
URL:https://www.simonsfoundation.org/event/climate-projections-over-north-america-in-the-coming-decades/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:The Science of Climate
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180734/ClaraDeser_video11.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130425T163000
DTEND;TZID=America/New_York:20130425T183000
DTSTAMP:20260417T061848
CREATED:20140611T040000Z
LAST-MODIFIED:20211207T160957Z
UID:217-1366907400-1366914600@www.simonsfoundation.org
SUMMARY:New Genetic Insights into the Pathophysiology of Autism Spectrum Disorders
DESCRIPTION:The genetics and genomics of autism spectrum disorders have reached a tipping point. The recent focus on de novo mutations has led to systematic\, highly productive gene discovery efforts. These have begun to clarify a tremendously heterogeneous allelic architecture as well as specific genes contributing to social disability syndromes. This lecture will review these recent discoveries and address the challenges facing the path forward from reliable gene discovery to an actionable understanding of the molecular pathophysiology of autism spectrum disorders. \nAbout the Speaker \nMatthew State\, M.D.\, Ph.D.\, received his undergraduate and medical degrees from Stanford University\, and completed his residency in psychiatry and fellowship in child psychiatry at the University of California\, Los Angeles Neuropsychiatric Institute. He received his Ph.D. in genetics from Yale University and was a faculty member there from 2001-2013. He is currently chairman of the psychiatry department at the University of California\, San Francisco. \nState’s lab has a longstanding interest in the contribution of rare genetic mutations to childhood neuropsychiatric disorders\, including autism and Tourette syndrome. State is currently leading a large\, multi-site\, genome-wide study of autism spectrum disorder funded by the Simons Foundation\, and is playing a leadership role in the Tourette International Collaborative for Genetics and the Autism Sequencing Consortium. Among many professional honors\, this past year he was awarded the Ruane Prize for Outstanding Research in Child and Adolescent Psychiatry by the Brain and Behavior Research Foundation.
URL:https://www.simonsfoundation.org/event/new-genetic-insights-into-the-pathophysiology-of-autism-spectrum-disorders/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130425T000000
DTEND;TZID=America/New_York:20130425T000000
DTSTAMP:20260417T061848
CREATED:20130425T040000Z
LAST-MODIFIED:20211207T160947Z
UID:2044-1366848000-1366848000@www.simonsfoundation.org
SUMMARY:New Genetic Insights into the Pathophysiology of Autism Spectrum Disorders
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/april-25-2013-new-genetic-insights-into-the-pathophysiology-of-autism-spectrum-disorders/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130424T160000
DTEND;TZID=America/New_York:20130424T180000
DTSTAMP:20260417T061848
CREATED:20140616T040000Z
LAST-MODIFIED:20211207T154453Z
UID:237-1366819200-1366826400@www.simonsfoundation.org
SUMMARY:Water: Climate's Great Orchestrator
DESCRIPTION:The mighty water molecule\, with its voracious appetite for infrared radiation\, is responsible for much of what we know about climate and climate change\, and even more of what we don’t know. Trapped for most of its life in large surface reservoirs\, every few thousand years it escapes to the atmosphere for a short sojourn of a little over a week\, during which it helps to create\, quite literally\, the world as we know it. \nAbout the Speaker \nBjorn B. Stevens\, Ph.D. leads the department “The Atmosphere in the Earth System” as well as the International Max Planck Research School on Earth System Modelling at the Max Planck Institute for Meteorology. \nProf. Stevens has published ground-breaking research papers dealing with the theory\, modelling and observation of “low” clouds\, which is one of the most important problems in meteorology and climate research.
URL:https://www.simonsfoundation.org/event/water-climates-great-orchestrator/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:The Science of Climate
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180731/BjornStevens_video1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130410T160000
DTEND;TZID=America/New_York:20130410T180000
DTSTAMP:20260417T061848
CREATED:20140616T040000Z
LAST-MODIFIED:20211207T154515Z
UID:235-1365609600-1365616800@www.simonsfoundation.org
SUMMARY:Climate Feedbacks: Magnitude & Uncertainty in Global Warming
DESCRIPTION:Most of the changes in climate that are projected to occur over the 21st century will not result directly from the human emission of greenhouse gases\, but from natural feedbacks within the climate system that amplify its sensitivity to these emissions. Some of these feedbacks are well constrained by theory and observations\, while others are not. This lecture outlines our understanding of the main feedback processes in the climate system and how they impact both the magnitude of future changes in Earth’s climate and the uncertainty in our predictions of these changes. \nAbout the Speaker \nBrian J. Soden\, Ph.D. is Professor of Meteorology and Physical Oceanography at the Rosenstiel School for Marine and Atmospheric Science\, University of Miami. Dr. Soden specializes in the use of satellite observations to test and improve computer model simulations of climate change. He has published over 80 publications on a variety of topics\, but most often related to the response of the climate system to global warming.
URL:https://www.simonsfoundation.org/event/climate-feedbacks-magnitude-uncertainty-in-global-warming/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:The Science of Climate
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20130331
DTEND;VALUE=DATE:20130407
DTSTAMP:20260417T061848
CREATED:20170911T222211Z
LAST-MODIFIED:20250813T163108Z
UID:25738-1364688000-1365292799@www.simonsfoundation.org
SUMMARY:Non-Archimedean and Tropical Geometry (2013)
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/non-archimedean-and-tropical-geometry-2013/
LOCATION:NY
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130327T170000
DTEND;TZID=America/New_York:20130327T180000
DTSTAMP:20260417T061848
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T154544Z
UID:434-1364403600-1364407200@www.simonsfoundation.org
SUMMARY:The Most Random of All Possible Worlds
DESCRIPTION:The talk will be about the law of large numbers\, in its various manifestations. This is a real cornerstone of probability and\, in English\, it says that a random system of a very large size is typically not random: its deterministic state is the one that has the largest probability to occur. Maximizing the probability
to occur is a variational problem that can be analyzed and sometimes solved. As for any variational problem\, there is always something special about the solution\, which translates into special and beautiful forms created by pure luck of the draw. \nSuggested Reading \nOkounkov’s AMS colloquim lectures (2007) will serve as an introduction to his lecture. \nAbout the Speaker \nAndrei Okounkov is the Samuel Eilenberg Professor of Mathematics at Columbia University. Born and educated in Moscow\, he came to the U.S. in 1995 and held positions at the University of Chicago\, University of California at Berkeley\, and Princeton University before joining the faculty of Columbia University. His work on representation theory and its applications to algebraic geometry\, mathematical physics\, and other fields was recognized by the Packard fellowship\, the European Mathematical Society prize\, the Fields medal of the International Mathematical Union\, and other distinctions. \n 
URL:https://www.simonsfoundation.org/event/the-most-random-of-all-possible-worlds/
LOCATION:NY
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181126/andrei_okounkov_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130313T160000
DTEND;TZID=America/New_York:20130313T180000
DTSTAMP:20260417T061848
CREATED:20140616T040000Z
LAST-MODIFIED:20211207T154558Z
UID:233-1363190400-1363197600@www.simonsfoundation.org
SUMMARY:Hurricanes: Present and Future
DESCRIPTION:Some 90 tropical cyclones develop each year. In this lecture\, Professor Kerry Emanuel will review the theory of tropical cyclones and how it informs observed variability. He will also discuss how these storms may have important feedbacks on such phenomena as El Niño-Southern Oscillation and global climate change. \nAbout the Speaker \nKerry A. Emanuel\, Ph.D. is Professor of Atmospheric Science in the Department of Earth\, Atmospheric\, and Planetary Sciences at Massachusetts Institute of Technology.
URL:https://www.simonsfoundation.org/event/hurricanes-present-and-future/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:The Science of Climate
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180728/kerry_emanuel1.jpeg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130310T170000
DTEND;TZID=America/New_York:20130310T180000
DTSTAMP:20260417T061848
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T154614Z
UID:432-1362934800-1362938400@www.simonsfoundation.org
SUMMARY:Autism\, Oxytocin\, and Neural Signaling
DESCRIPTION:Genetics tells us that abnormal synaptic and nuclear proteins are often at the root of major neuropsychiatric disorders. Autism\, a prominent and often debilitating disorder of the brain\, has been traced to small contributions of hundreds of genes\, creating a formidable challenge for those interested in exploring pathophysiology and possible therapeutic interventions. A major interest of our laboratory is a form of autism known as Timothy Syndrome (TS)\, which arises from a point mutation in a signaling protein. Though rare\, the mutation causes autism spectrum disorder (ASD) with 3:1 odds. The gene\, known as CACNA1C\, encodes a particular kind of calcium channel known as “L-type”. We have studied the behavior of mice bearing the TS mutation and find persistent behavior\, altered communication\, and reduced social interaction relative to their unaffected sibs\, features reminiscent of the three characteristic hallmarks of autism. The mutation leads to over-activity of the ion channel\, raising the prospect that it might be counteracted pharmacologically. Interestingly\, the same CACNA1C gene has been repeatedly implicated in schizophrenia and in Major Depressive Disorder. The possibility arises that work on diverse neuropsychiatric diseases will prove more synergistic than previously appreciated. \nWhy does miscoding in CACNA1C exert such strong effects? Like its close relatives\, this particular L-type calcium channel plays a central role in allowing a neuron to track its own activity.  In a process called excitation-transcription coupling\, neuronal firing drives the opening of the L-type channel\, flow of calcium into the cell\, activation of transcription factors\, and expression of specific sets of genes. Ultimately\, this supports neuronal autoregulation and plasticity. We are currently working out critical details of how the L-type channel transmits a packet of information to control nuclear gene transcription. Interestingly\, elements of this signaling pathway are encoded by genes that have also been implicated in causing neuropsychiatric disorders. \nDisorders at the cellular level are thought to engender aberrant function of neuronal circuits. Oxytocin is a key neuromodulator whose influence on neuronal circuitry has been linked to social memory and maternal behavior in animals\, as well trust\, emotion recognition and parenting in humans. Multiple clinical trials have uncovered promising actions of oxytocin on autistic behavior in teenagers\, including processing of information about faces. By examining oxytocin actions in brain slices\, we have found that activation of oxytocin receptors sharpens the responses of a canonical hippocampal circuit. The peptide increases the fidelity of signal transmission through the network\, while simultaneously suppressing the noise of background spontaneous activity. These seemingly contradictory actions are both mediated through a selective depolarization of the fast-spiking interneurons by oxytocin. The resulting increase in inhibitory tone in principal cells dampens their spontaneous activity. Meanwhile\, a use-dependent depression of the feed-forward inhibitory synapses permits enhanced spike transmission. By activating fast-spiking neurons with cholecystokinin\, or with channelrhodopsin-2\, we demonstrate that this novel circuit mechanism is generally applicable to any manipulation that elicits the firing of fast-spiking basket cells. We have begun testing the action of oxytocin agonists on reversal learning\, to determine if perseverative behavior can be ameliorated. The prospect looms that actions of oxytocin at the circuit level might contribute to its behavioral impact in autistic individuals\, but at the moment this is merely a hypothesis. \nSuggested Reading \n\nCaV1 and CaV2 Channels Engage Distinct Modes of Ca2+ Signaling to Control CREB-Dependent Gene Expression \n\n\n\n\nMouse model of Timothy syndrome recapitulates triad of autistic traits \n\n\n\nAbout the Speaker \nRichard W. Tsien\, DPhil\, is Director of the Neuroscience Institute\, Druckenmiller Professor of Neuroscience\, and Chair of the Physiology and Neuroscience Department at the NYU School of Medicine. Prior to joining NYU in August 2011\, Dr. Tsien served as the George D. Smith Professor of Molecular Genetic Medicine at Stanford University. While there\, Dr. Tsien founded and served as the inaugural chair of the Department of Molecular and Cellular Physiology. After a six-year term as chair\, in 1994 he co-led a successful Stanford-wide movement to establish an institute for neuroscience\, the Stanford Brain Research Center\, which he co-directed from 2000 through 2005. He served a 10-year term as the director and principal investigator at Stanford’s Silvio Conte Center for Neuroscience Research. As a scientist\, Dr. Tsien is a world leader in the study of calcium channels and their signaling targets\, particularly at pre- and postsynaptic sites. He studies how synapses contribute to neuronal computations and network function in both healthy and diseased brains. His research\, generously supported by the NIH and private foundations\, has contributed substantially to understanding how neurotransmitters\, drugs and molecular alterations regulate calcium channels and has implications for diverse clinical areas such as pain and autism. His research has been published in over 200 peer-reviewed journal articles\, and he has served on editorial boards for numerous journals. He has also served as section chair for the American Association for the Advancement of Science (Neuroscience Section) and the National Academy of Sciences (Neurobiology Section) and has been a member of scientific advisory boards for several institutes\, including the Howard Hughes Medical Institute. Dr. Tsien received both an undergraduate and graduate degree in electrical engineering from the Massachusetts Institute of Technology. He was a Rhodes Scholar\, graduating with his doctorate in biophysics from Oxford University\, England after which he joined the faculty at Yale University School of Medicine and served for nearly two decades. He is a member of both the Institute of Medicine and National Academy of Sciences. He was awarded the Julius Axelrod Prize by the Society for Neuroscience in 2012. \n 
URL:https://www.simonsfoundation.org/event/autism-oxytocin-and-neural-signaling/
LOCATION:NY
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181124/richardtsien2_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130224T000000
DTEND;TZID=America/New_York:20130302T000000
DTSTAMP:20260417T061848
CREATED:20150908T040000Z
LAST-MODIFIED:20250813T162959Z
UID:4075-1361664000-1362182400@www.simonsfoundation.org
SUMMARY:The Kardar-Parisi-Zhang Equation and Universality Class (2013)
DESCRIPTION:February 24-March 2\, 2013 \nOrganizers: Alexei Borodin\, Jeremy Quastel\, Herbert Spohn \nThe Kardar-Parisi-Zhang equation is a nonlinear stochastic partial differential equation widely used in the physics literature as a model of randomly growing interfaces\, but until recently very poorly understood from the mathematical point of view. In one dimension\, it is a member of a large universality class containing directed random polymers\, stochastic Hamilton-Jacobi-Bellman equations\, stochastically perturbed reaction-diffusion equations\, stochastic Burgers equations and interacting particle models. The class is characterized by the unusual dynamic scaling exponent z=3/2. A number of breakthroughs about 10 years ago led to exact distributions of fluctuations for a few models\, with conjectural extrapolation to the whole class. The distributions\, surprisingly\, turned out to be those recently discovered in random matrix theory. In the last few years there have been a second group of breakthroughs. Several models with adjustable asymmetry have recently been solved through which one can obtain\, by scaling limits\, exact distributions for various initial conditions for the KPZ equation itself. In addition\, there have been breakthroughs in the well-posedness of the KPZ equation. \nThe goal of this workshop is to build on these advances in two directions. 1. Studying the integrability properties and statistics of the KPZ equation\, as well as other models in the KPZ universality class. 2. Extending the universality of the KPZ equation. The new well-posedness theory should provide a route to proving scaling limits to the KPZ equation for a wider class of physical models. \nParticipants \nFedor Bogomolov\, NYU/Courant \nMark Adler\, Brandeis University \nGerard Ben Arous\, NYU/Courant \nAlexei Borodin\, MIT \nPasquale Calabrese\, Universita di Pisa \nReda Chhaibi\, Universitat Zurich \nIvan Corwin\, MIT/Microsoft Research \nPercy Deift\, NYU/Courant \nVictor Dotsenko\, University of Paris 6 \nPatrik Ferrari\, University of Bonn \nAlan Hammond\, University of Oxford \nKurt Johnasson\, KTH \nKostya Khanin\, University of Toronto \nPierre Le Doussal\, ENS\, Paris \nPierre van Moerbeke\, Université catholique de Louvain \nNeil O’Connell\, Warwick University \nJeremy Quastel\, University of Toronto \nTomohiro Sasamoto\, Chiba University \nTimo Seppalainen\, University of Wisconsin-Madison \nSenya Shlosman\, University of Marseilles \nHerbert Spohn\, Technische Universitat Munchen \nCraig Tracy\, UC Davis \nJon Warren\, Warwick University
URL:https://www.simonsfoundation.org/event/the-kardar-parisi-zhang-equation-and-universality-class-february-24-march-2-2013/
LOCATION:NY
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130216T170000
DTEND;TZID=America/New_York:20130216T180000
DTSTAMP:20260417T061848
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T155527Z
UID:430-1361034000-1361037600@www.simonsfoundation.org
SUMMARY:Probability & Intuition
DESCRIPTION:Probability theory was devised in order to understand gambling\, but now is the underpinning of statistics\, without which we would be clueless in our complex society.  Yet probability itself is a mysterious quantity\, hard to define\, and awkward for our human intuition to cope with.  Does it even exist\, except in our minds? \nThrough stories and puzzles\, we will attempt to get a slightly better grip on probability and to identify some of the ways in which our intuition tends to lead us astray. \n  \nSuggested Reading: \nGrinstead and Snell’s Introduction to Probability \nAbout the Speaker:\n \nPeter Winkler is the William Morrill Professor of Mathematics and Computer Science at Dartmouth College. His research interests lie in discrete mathematics and the theory of computing\, probability theory\, and applications. \nPeter Winkler is author of more than 125 research papers and the holder of eight patents. Winkler studied Mathematics at Harvard University and received his Ph.D. in from Yale University. He has also published two books on mathematical puzzles. \nHomepage: http://www.math.dartmouth.edu/~pw/ \n 
URL:https://www.simonsfoundation.org/event/probability-intuition/
LOCATION:NY
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181122/peter_winkler_large_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130203T000000
DTEND;TZID=America/New_York:20130209T000000
DTSTAMP:20260417T061848
CREATED:20141022T040000Z
LAST-MODIFIED:20250813T162813Z
UID:3935-1359849600-1360368000@www.simonsfoundation.org
SUMMARY:Simons Symposium on Quantum Entanglement (2013)
DESCRIPTION:February 3-9\, 2013 \nThe goal of our meeting will be to explore exotic quantum states of matter\, with a particular focus on the role of quantum entanglement. A variety of new tools arising from both the study of quantum field theoretic techniques in condensed matter physics\, and from the “holographic” duality between field theories and gravity theories coming out of string theory\, make this an excellent time to try and rise to the challenge of understanding exotic quantum states. \nParticipants \nSean Hartnoll\, Stanford University \nGary Horowitz\, UC Santa Barbara \nLiza Huijse\, Harvard University \nShamit Kachru\, Stanford University \nIgor Klebanov\, Princeton University \nSung-Sik Lee\, McMaster University \nHong Liu\, MIT \nJohn McGreevy\, MIT \nAndy Millis\, Simons Foundation \nRobert Myers\, Perimeter Institute \nHirosi Ooguri\, Caltech \nMasaki Oshikawa\, University of Tokyo \nJoe Polchinski\, KITP \nSubir Sachdev\, Harvard University \nEva Silverstein\, Stanford University \nJulian Sonner\, MIT \nAndy Strominger\, Harvard University \nBrian Swingle\, Harvard University \nSenthil Todadri\, MIT \nSandip Trivedi\, Tata Institute of Fundamental Research \nHerman Verlinde\, Princeton University \nAshvin Vishwanath\, UC Berkeley \nX.G. Wen\, MIT/Perimeter Institute \nJan Zaanen\, University of Leiden \n 
URL:https://www.simonsfoundation.org/event/quantum-entanglement-2013/
LOCATION:NY
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130131T123000
DTEND;TZID=America/New_York:20130131T173000
DTSTAMP:20260417T061848
CREATED:20140612T040000Z
LAST-MODIFIED:20170818T184156Z
UID:221-1359635400-1359653400@www.simonsfoundation.org
SUMMARY:Resting State fMRI
DESCRIPTION:This Biotech Symposium will focus on resting-state fMRI\, a neuroimaging technique that uses dynamic changes in oxygenated blood flow to explore the brain’s functional organization when a person is at rest and not performing an explicit task. \nSpeakers: \nRandy Buckner\, Harvard University: The Basics of Functional Connectivity MRI \n \nSteven Petersen\, Washington University: Network Analysis of Functional Connectivity MRI Can Identify Systems and Vulnerable Locations \n \nMichael Milham\, Child Mind Institute: An Emerging Big Data Resource for Imaging-Based Biomarker Identification \n \n 
URL:https://www.simonsfoundation.org/event/resting-state-fmri/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Biotech Symposia
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130131T000000
DTEND;TZID=America/New_York:20130131T000000
DTSTAMP:20260417T061848
CREATED:20131220T050000Z
LAST-MODIFIED:20170823T200432Z
UID:1994-1359590400-1359590400@www.simonsfoundation.org
SUMMARY:January 31\, 2013: Resting State fMRI
DESCRIPTION:January 31\, 2013\, 12:30-5:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nThis Biotech Symposium will focus on resting-state fMRI\, a neuroimaging technique that uses dynamic changes in oxygenated blood flow to explore the brain’s functional organization when a person is at rest and not performing an explicit task. \n  \n  \n  \n  \nSpeakers: \nRandy Buckner\, Harvard University: The Basics of Functional Connectivity MRI \n\nSteven Petersen\, Washington University: Network Analysis of Functional Connectivity MRI Can Identify Systems and Vulnerable Locations \n \nMichael Milham\, Child Mind Institute: An Emerging Big Data Resource for Imaging-Based Biomarker Identification \n \n 
URL:https://www.simonsfoundation.org/event/january-31-2013-resting-state-fmri/
LOCATION:NY
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20130129T080000
DTEND;TZID=America/New_York:20131008T170000
DTSTAMP:20260417T061848
CREATED:20140618T040000Z
LAST-MODIFIED:20211207T155538Z
UID:200-1359446400-1381251600@www.simonsfoundation.org
SUMMARY:Mathematics of Planet Earth 2013 Simons Public Lecture Series
DESCRIPTION:The Simons Foundation is pleased to support the Mathematics of Planet Earth 2013 (MPE2013) Simons Public Lecture Series as a part of Mathematical Sciences Research Institute’s MPE2013 project. \nThese lectures showcase the relevance of mathematics in meeting the global challenges facing our planet today. The Simons Foundation\, along with others\, has worked to create a comprehensive and accessible series featuring some of today’s most pressing issues. This series will not only inform the public about the connection between math and sustainability but will also encourage progress toward solving some of planet Earth’s fundamental problems and foster communication between science and mathematics educators. \nThough the MPE2013 lectures are targeted to a mathematically literate audience\, they are also intended to be accessible to a broad lay audience. The lectures\, now begun\, will be held in nine locations around the world and cover a broad range of topics. MPE2013 features top researchers in mathematics\, climate science and sustainability\, who will discuss themes ranging from the relevance of mathematical models in climate prediction to the importance of social cooperation in overcoming global sustainability problems. \nThe series launched with an inaugural lecture on January 29\, 2013\, at the Sidney Myer Asia Centre in Melbourne\, Australia. Geoff Prince\, director of the Australia Mathematical Sciences Institute\, and Ian Chubb\, Australia’s chief scientist\, introduced speaker Professor Simon Levin\, George M. Moffett Professor of Biology and director of the Center for BioComplexity at Princeton University. \nLevin’s lecture\, “The Challenge of Sustainability and the Promise of Mathematics\,” focused on how mathematical models may be used to explore and predict behavior within financial\, ecological and governmental systems. The Melbourne lecture was attended by a combination of mathematicians and the general public\, and it was followed by an engaging question and answer session with the speakers. \nPast lectures:\n \nQuantum mechanics and the future of the planet\nSpeaker: Emily Carter\nNovember 4\, 2013\nHosted by: Institute for Pure and Applied Mathematics\nLos Angeles\, California \n  \nThe challenge of sustainability and the promise of mathematics\nSpeaker: Simon Levin\nJanuary 29\, 2013\nHosted by: Australian Mathematical Sciences Institute (AMSI)\nMelbourne\, Australia\nSimon Levin\, director of the Center for BioComplexity at Princeton University\, considered how mathematical tools can help us understand systems from bacterial biofilms to the biosphere and how mathematical models can predict various human behaviors. \n  \nClimate disruption: What math and science have to say\nSpeaker: Emily Shuckburgh\nMarch 4\, 2013\nHosted by: American Institute of Mathematics and Mathematical Science Research Institute\, San Francisco\, California\nRenowned climate scientist Emily Shuckburgh discussed the implications of climate disruption and how mathematical and scientific models can be used to predict scenarios for the Earth’s future. \n \n  \nClimate Math\nSpeaker: Inez Fung\nMarch 26\, 2013\nHosted by: African Institute for Mathematical Sciences (AIMS)\nCape Town\, South Africa\nInez Fung\, a leading climate expert\, reviewed the basis of climate modeling and discussed new challenges to projecting future climate change. \n \n  \nLes mathématiques pour faire parler la Terre (Images\, Earthquakes and Plumes)\nSpeaker: Ingrid Daubechies\nApril 10\, 2013\nHosted by Centre de recherches mathématiques (CRM)\nMontréal\, CanadaMathematician\nIngrid Daubechies discussed how she has developed methods to extract information about Earth’s structure from global seismic data.\n \n  \nThe Public Health Impact of Air Pollution and Climate Change\nSpeaker: Francesca Dominici\nApril 24\, 2013\nHosted by: Statistical and Applied Mathematical Sciences Institute (SAMSI)\nChapel Hill\, North Carolina\nBiostatistician and public health expert Francesca Dominici reviewed statistical modeling methods for estimating the public health impact of air pollution and extreme heat. \n  \nCliMathematics: Models\, data\, structures\nSpeaker: Rupert Klein\nMay 23\, 2013\nHosted by: Berlin Mathematical Network\nBerlin\, Germany\nRupert Klein\, who has made a career of finding connections between mechanical engineering and climate\, explained how physics\, informatics and statistics can quantitatively characterize observational data about our planet. \n  \nOn growth and form: Mathematics\, physics and biology\nSpeaker: L. Magadevan\nSeptember 24\, 2013\nHosted by: Institute for Computational and Experimental Research in Mathematics\nProvidence Rhode Island \n  \nThe evolution of cooperation: Why we need each other to succeed\nSpeaker: Martin Nowak\nOctober 8\, 2013\nHosted by: Institute for Mathematics and its Applications\nMinneapolis\, Minnesota
URL:https://www.simonsfoundation.org/event/mathematics-of-planet-earth-2013-simons-public-lecture-series/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:MPE2013 Simons Public Lecture Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180655/mpe1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20130127
DTEND;VALUE=DATE:20130203
DTSTAMP:20260417T061848
CREATED:20141022T040000Z
LAST-MODIFIED:20250813T162504Z
UID:3934-1359244800-1359849599@www.simonsfoundation.org
SUMMARY:New Directions in Approximation Algorithms (2013)
DESCRIPTION:Organizers: Sanjeev Arora\, Uriel Feige\, Michel Goemans & David Shmoys \nMany of the striking advances in theoretical computer science over the past two decades concern
 approximation algorithms\, which compute provably near-optimal solutions to NP-hard optimization problems.
 Yet the approximability of several fundamental problems such as TSP\, Graph Coloring\, Graph Partitioning etc.
remains an open question. For other problems the so-called PCP Theorems and more recently\, the Unique Games
Conjecture (UGC)\, provide a complexity-theoretic explanation for the failure to design better algorithms. \nA quick succession of papers in the past 5 years or so has yielded new ideas for algorithmic approaches that show
promise of leading to a resolution of the classic open problems\, as well as possibly a refutation of the UGC itself.
 These new approaches use structural insights gained from mathematical programming relaxations\, either linear
programming (LP) or semidefinite programming (SDP). They draw upon a more complete arsenal of techniques
than had been seen earlier in math programming: Markov Chain Monte Carlo sampling\, spectral techniques
(focusing especially on higher eigenvalues of the graph spectrum)\, high dimensional geometry\, local vs global
geometric theorems\, etc. Within the past year\, approximation techniques have also been used to make progress on
semirandom complexity\, which is an important — and largely nonunderstood — notion between worst-case and
average-case complexity. \n\nParticipants\n\n\n\nSanjeev Arora\nPrinceton University\n\n\nBoaz Barak\nMicrosoft Research\, New England\n\n\nJulia Chuzhoy\nToyota Technological Institute at Chicago\n\n\nUriel Feige\nWeizmann Institute\n\n\nMichel X. Goemans\nMIT\n\n\nVenkatesan Guruswami\nCarnegie Mellon University\n\n\nJohan Hastad\nKTH\n\n\nSampath Kannan\nSimons Foundation\n\n\nJonathan Kelner\nMIT\n\n\nSubhash Khot\nNYU/Chicago\n\n\nMonique Laurent\nCentrum Wiskunde & Informatica\n\n\nJames Lee\nWashington University\n\n\nLaszlo Lovasz\nEötvös Loránd University\n\n\nYury Makarychev\nToyota Technological Institute at Chicago\n\n\nClaire Matthieu\nENS/Brown\n\n\nAssaf Naor\nNYU\n\n\nShayan Oveis-Gharan\nStanford University\n\n\nPrasad Raghavendra\nGeorgia Tech\n\n\nDavid B. Shmoys\nCornell University\n\n\nMohit Singh\nMSR-Redmond\n\n\nDavid Steurer\nMSR-NERD/Cornell\n\n\nOla Svensson\nEPFL\n\n\nLuca Trevisan\nStanford University\n\n\nAnke Van Zuijlen\nMPI/William & Mary
URL:https://www.simonsfoundation.org/event/new-directions-in-approximation-algorithms-2013/
LOCATION:NY
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20121221T170000
DTEND;TZID=America/New_York:20121221T180000
DTSTAMP:20260417T061848
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T155554Z
UID:428-1356109200-1356112800@www.simonsfoundation.org
SUMMARY:Animation\, Teeth and Skeletons
DESCRIPTION:The talk describes (dis)similarity distances between pairs of two-dimensional surfaces (embedded in three-dimensional space) that use both local structures and global information in the surfaces. This is work done in collaboration with Yaron Lipman. \nThese are motivated by the need of biological morphologists to compare different phenotypical structures. At present\, scientists using physical traits to study evolutionary relationships among living and extinct animals analyze data extracted from carefully defined anatomical correspondence points (landmarks). Identifying and recording these landmarks is time consuming and can be done accurately only by trained morphologists. This necessity renders these studies inaccessible to non-morphologists and causes phenomics to lag behind genomics in elucidating evolutionary patterns. \nUnlike other algorithms presented for morphological correspondences\, our approach does not require any preliminary marking of special features or landmarks by the user. It also differs from other seminal work in computational geometry in that our algorithms are polynomial in nature and thus faster\, making pairwise comparisons feasible for significantly larger numbers of digitized surfaces. \nThe approach is illustrated using three datasets representing teeth and different bones of primates and humans; it is shown that it leads to highly accurate results. \nSuggested Reading: \nAlgorithms to automatically quantify the geometric similarity of anatomical surfaces \nAbout the Speaker: \nIngrid Daubechies is a member of the United States’ National Academy of Sciences\, was a MacArthur Fellow\, and is President of the International Mathematical Union. \nProfessor Daubechies was born and educated in Belgium. She moved to the United States in 1987 where she first worked for Bell Laboratories and then at Princeton University where she was full Professor of Mathematics from 1993-2011. She is best known for her discovery and mathematical analysis of compactly supported wavelets\, which are used in image compression\, for example in JPEG 2000 for both both lossless and lossy compression. She was awarded the Steele Prize for mathematical exposition in 1994 for her book\, Ten Lectures on Wavelets. \nOne focus of Daubechies’ current research is the development of analytic and geometric tools for the comparison of surfaces. Her new approach\, developed with Yaron Lipmon uses conformal mapping to define a metric between surfaces. Comparison of surfaces plays a central role in many scientific disciplines and in the construction of video animations\, and it is also a crucial step in many medical and biological applications. In an earlier collaboration\, she worked with paleontologists to develop a quantitative method to characterize the complexity of molar tooth surfaces\, in an effort to reconstruct the diet of various extinct taxa. \nHomepage: https://web.math.princeton.edu/~ingrid/
URL:https://www.simonsfoundation.org/event/animation-teeth-and-skeletons/
LOCATION:NY
CATEGORIES:Simons Science Series
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20120919T170000
DTEND;TZID=America/New_York:20120919T180000
DTSTAMP:20260417T061848
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T155607Z
UID:426-1348074000-1348077600@www.simonsfoundation.org
SUMMARY:The Mathematics of Mind and Brain
DESCRIPTION:The mind and brain can be thought of as computational systems — but what kinds of computations do they carry out\, and what kinds of mathematics can best characterize these computations? The last sixty years have seen several prominent proposals: the mind/brain should be viewed as a logic engine\, or a probability engine\, or a high-dimensional vector processer\, or a nonlinear dynamical system. Yet none of these proposals appears satisfying on its own. The most important lessons learned concern the central role of mathematics in bridging different perspectives and levels of analysis — different views of the mind\, or how the mind and the brain relate — and the need to integrate traditionally disparate branches of mathematics and paradigms of computation in order to build these bridges. \nI will discuss three case studies in integration\, two recent successes and one that is more wide open. The first success has come in bridging two different ways to descibe the mind\, as a logic engine (dominant from the 1950s through the 1970s)\, and as a probability engine (dominant since the 1990s). The recent development of probabilistic programs offers a way to combine the expressiveness of symbolic logic for representing abstract and composable knowledge with the capacity of probability theory to support useful inferences and decisions from incomplete and noisy data. Probabilistic programs let us build the first quantitatively predictive mathematical models of core capacities of human common-sense thinking: intuitive physics and intuitive psychology\, or how people reason about the dynamics of objects and infer the mental states of others from their behavior. A second success has come from using the mathematics of probability to bridge the cognitive and neural levels of analysis\, unifying models of inference and decision in mind and brain. But what we do not yet understand is how to connect the mathematics of logic\, symbols\, and programs\, essential for describing knowledge at the cognitive level\, with the mathematics of high-dimensional vector spaces and nonlinear dynamics that has been most influential in describing how the brain learns and computes. How can symbols and logic be embedded in or effectively emerge from the mathematics of vector spaces and dynamical systems? This is the twenty-first century version of the mind-body problem\, and arguably the greatest outstanding theoretical question in neuroscience. \nSuggested Reading: \nHow to Grow a Mind: Statistics\, Structure\, and Abstraction \nAbout the Speaker: \nJosh Tenenbaum is a Professor in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology. Tenenbaum and his colleagues in the Computational Cognitive Science group study one of the most basic and distinctively human aspects of cognition: the ability to learn so much about the world\, rapidly and flexibly. Given just a few relevant experiences\, even young children can infer the meaning of a new word\, the hidden properties of an object or substance\, or the existence of a new causal relation or social rule. These inferences go far beyond the data given: after seeing three or four examples of “horses”\, a two-year-old will confidently judge whether any new entity is a horse or not\, and she will be mostly correct\, except for the occasional donkey or camel. \nWe want to understand these everyday inductive leaps in computational terms. What is the underlying logic that supports reliable generalization from so little data? What are its cognitive and neural mechanisms\, and how can we build more powerful learning machines based on the same principles? \nThese questions demand a multidisciplinary approach. Tenenbaum and his group’s research combines computational models (drawing chiefly on Bayesian statistics\, probabilistic generative models\, and probabilistic programming) with behavioral experiments in adults and children. Their models make strong quantitative predictions about behavior\, but more importantly\, they attempt to explain why cognition works\, by viewing it as an approximation to ideal statistical inference given the structure of natural tasks and environments. \nWhile their core interests are in human learning and reasoning\, they also work actively in machine learning and artificial intelligence. These two programs are inseparable: bringing machine-learning algorithms closer to the capacities of human learning should lead to more powerful AI systems as well as more powerful theoretical paradigms for understanding human cognition. \nCurrent research in Ketterle’s group explores the computational basis of many aspects of human cognition: learning concepts\, judging similarity\, inferring causal connections\, forming perceptual representations\, learning word meanings and syntactic principles in natural language\, noticing coincidences and predicting the future\, inferring the mental states of other people\, and constructing intuitive theories of core domains\, such as intuitive physics\, psychology\, biology\, or social structure. \nHomepage: http://web.mit.edu/cocosci/josh.html
URL:https://www.simonsfoundation.org/event/the-mathematics-of-mind-and-brain/
LOCATION:NY
CATEGORIES:Simons Science Series
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20120422T000000
DTEND;TZID=America/New_York:20120428T000000
DTSTAMP:20260417T061848
CREATED:20141022T040000Z
LAST-MODIFIED:20250813T162322Z
UID:3937-1335052800-1335571200@www.simonsfoundation.org
SUMMARY:Knot Homologies and BPS States (2012)
DESCRIPTION:In recent years\, homological knot invariants have been gaining momentum in both mathematics and physics\, and recent developments promise it will only be growing. Therefore\, a symposium on “the physics of knot homologies” is very timely. \nMoreover\, this subject is intimately connected with another active area of research at the interface of geometry and physics: the study of BPS invariants and their behavior under wall crossing. The relation between quantum invariants of knots and 3-manifolds on one hand\, and wall crossing of refined BPS invariants on the other\, is currently a very active area of research. The underlying reason for this interesting connection is that\, in a physical realization of knot homologies as spaces of BPS states\, the basic operations in knot theory (such as skein relations) correspond to changes of the (brane) system under which the spectrum of BPS states jumps. \n\nParticipants\n\n\n\nMina Aganacic\nUC Berkeley\n\n\nIvan Cherednik\nUniversity of North Carolina at Chapel Hill\n\n\nRobbert Dijkgraaf\nUniversiteit van Amsterdam\n\n\nDavide Gaiotto\nInstitute for Advanced Study\n\n\nSergei Gukov\nCalifornia Institute of Technology\n\n\nMikhail Khovanov\nColumbia University\n\n\nPeter Kronheimer\nHarvard University\n\n\nCiprian Manolescu\nUCLA\n\n\nHiraku Nakajima\nKyoto University\n\n\nAndrew Neitzke\nUniversity of Texas at Austin\n\n\nAlexei Oblomkov\nUniversity of Massachusetts\n\n\nAndrei Okounkov\nColumbia University\n\n\nHirosi Ooguri\nCalifornia Institute of Technology\n\n\nPeter Ozsvath\nMIT\n\n\nJacob Rasmussen\nUniversity of Cambridge\n\n\nLev Rozansky\nImperial College London\n\n\nVivek Shende\nPrinceton University\n\n\nYan Soibelman\nKansas State University\n\n\nCumrun Vafa\nHarvard University\n\n\nJohannes Walcher\nCERN\n\n\nAgenda & Slides\n\nMonday\, April 23\n\nMikhail Khovanov	Link Homology for Tangles and Cobordisms\nLev Rozansky   	Khovanov Homology of a Unicolored B-adequate Link Has a Tail\nMina Aganagic  	 Refined Chern-Simons Theory\, Topological Strings and Knot Homology (PDF)\nIvan Cherednik 	Hyperpolynomials of torus knots via DAHA (PDF)\n\nTuesday\, April 24\n\nHirosi Ooguri  	Introduction and Overview by a Physicist\nCumrun Vafa    	Knot Homology\, Mirror Symmetry & Topological Strings\nSergei Gukov   	What is Superpolynomial? (PDF)\n\nWednesday\, April 25\n\nAlexei Oblomkov	Khovanov-Rozansky homology\, Hilbert schemes of points on planar curves and rational Cherednik algebras.\nVivek Shende   	Large N duality\, singular curves\, Hitchin fibres\, and knot homology\nAndrei Okounkov	The Index & the Vertex\n\nThursday\, April 26\n\nCiprian Manolescu	Knot Homologies and Tor Groups\nJacob Rasmussen	DAHA and Differentials\nJohannes Walcher	On the Arithmetic of BPS states\n\nFriday\, April 27\n\nHiraku Nakajima	AGT Conjecture\, perverse sheaves on instanton moduli and what I learned this week (PDF)\nYan Soibelman  	Motovic Donaldson-Thomas Invariants\, Hall Algebras & Knot Invariants\nAndrew Neitzke 	Spectral Networks\nRobbert Dijkgraaf	Topological Strings\, Quantum Curves\, and Knot Invariants
URL:https://www.simonsfoundation.org/event/knot-homologies-and-bps-states-april-22-april-28-2012/
LOCATION:NY
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20120418T170000
DTEND;TZID=America/New_York:20120418T180000
DTSTAMP:20260417T061848
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T155626Z
UID:424-1334768400-1334772000@www.simonsfoundation.org
SUMMARY:What Has the Brain Evolved to Know About the Natural Olfactory World?
DESCRIPTION:Most sensory stimuli in the natural world exhibit strong statistical regularities. For example\, if a given pixel in a visual scene is dark\, there is a high chance that adjacent pixels will also be dark. A proposed general principle of sensory neuroscience is that the brain’s circuitry is designed to take advantage of these statistical regularities. In particular\, stimuli with natural statistics appear to be unusually good at recruiting mutually antagonistic interactions between nearby neurons. Mutual antagonism (or “lateral inhibition”) is thought to increase the efficiency by which natural stimuli are encoded by neural populations. Historically\, these ideas have been explored mostly in the context of the visual system. In this talk\, I will re-examine these ideas in the context of a much less well-studied sensory modality – namely\, the sense of smell. I ask whether the olfactory world exhibits statistical regularities\, and if so\, what these “natural odor statistics” might look like. I will also critically explore the idea that the circuitry of the brain’s olfactory processing centers could be adapted to exploit such natural statistics. \nSuggested Reading: \nOdor plumes and how insects use them.pdf \nThe odor coding system of Drosophila.pdf \nAbout the Speaker: \nRachel Wilson is an HHMI Early Career Scientist at Harvard Medical School. Rachel Wilson is using Drosophila to study how neural circuits transform sensory signals\, with a special emphasis on the olfactory system. \nInsects\, Rachel Wilson says\, may be closer cousins than we imagine\, at least in terms of their brain power. “Of course they’re not terribly smart. But unlike simpler invertebrates like slugs or worms\, the way they interact with the world is relatively flexible. They can play a lot of games with only about a hundred thousand brain cells.” This balance between simplicity and complexity is what attracted Wilson to studying the fruit fly Drosophila as a model for investigating neural circuit function. \nHomepage: http://www.hhmi.org/research/ecs/wilson_bio.html
URL:https://www.simonsfoundation.org/event/what-has-the-brain-evolved-to-know-about-the-natural-olfactory-world/
LOCATION:NY
CATEGORIES:Simons Science Series
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20120314T170000
DTEND;TZID=America/New_York:20120314T180000
DTSTAMP:20260417T061848
CREATED:20170428T040000Z
LAST-MODIFIED:20170428T040000Z
UID:422-1331744400-1331748000@www.simonsfoundation.org
SUMMARY:New Technologies for Measuring Neural Circuit Dynamics
DESCRIPTION:At the microscopic scale\, the brain consists of vast networks of neurons that are wired together with synaptic connections to form neural circuits. Neurons are individuals\, in that each neuron can have electrical and chemical activity that is different from that of its neighbors. But the activity of each neuron is also dependent on that of the others in the circuit\, through the synaptic connections that define the circuit’s architecture. A thinking brain can therefore be viewed as an immensely complex pattern of activity distributed across the circuit. As different neurons become silent or active\, the pattern of activity shifts in space and time. These shifting patterns define what is known as neural circuit dynamics. The key to understanding how the brain works is to determine how the neural dynamics across these vast networks represent and process information relevant to behavior. Huge technical challenges exist in performing measurements of neural circuit dynamics in the awake brain. This talk will present recent advances in methods and instrumentation that combine genetically encoded molecular sensors\, optical imaging\, and virtual reality systems to measure neural circuit dynamics in the mouse brain during virtual navigation and decision-making. \nAbout the Speaker: \nDavid Tank is the Henry L. Hillman professor of neuroscience and molecular biology at Princeton University and Co-Director of the Princeton Neuroscience Institute. He also directs the Bezos Center for Neural Circuit Dynamics. \nDr. Tank earned his B.S. in Physics and Mathematics at Case Western Reserve University in 1976 and a Ph.D. degree in Physics from Cornell University in 1983. From 1983-2001 he was a research scientist at Bell Laboratories in Murray Hill\, NJ\, and became a Bell Laboratories Fellow in 1999. From 1991-2001 he served as Department Head of the Biological Computation Research Department. In 2001\, he moved to Princeton University\, becoming a founding Co-Director of the Princeton Neuroscience Institute in 2005. His research interests include the measurement\, analysis\, and modeling of neural circuit dynamics. At Bell Laboratories he contributed to the development of attractor network models of neural decision-making\, the development of functional MRI imaging\, and the development of cellular resolution optical imaging of neural dynamics. More recently\, his work has focused on the mechanisms of persistent neural activity and the development and application of rodent virtual reality systems combined with optical imaging and electrophysiology to study neural circuit dynamics during navigation. \nDr. Tank has received several awards and honors for his research including election to the National Academy of Sciences and the American Academy of Arts and Sciences. He is a fellow of the American Physical Society and a recipient of the W. Alden Spencer Award from Columbia University and the Lawrence Katz Prize from Duke University. \nHomepage: http://genomics.princeton.edu/tank/Index.html
URL:https://www.simonsfoundation.org/event/new-technologies-for-measuring-neural-circuit-dynamics/
LOCATION:NY
CATEGORIES:Simons Science Series
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