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DTSTART:20140309T070000
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DTSTART:20141102T060000
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DTSTART;TZID=America/New_York:20150909T161500
DTEND;TZID=America/New_York:20150909T181500
DTSTAMP:20260409T062528
CREATED:20150811T040000Z
LAST-MODIFIED:20211207T165311Z
UID:303-1441815300-1441822500@www.simonsfoundation.org
SUMMARY:Visualizing Quantum Matter
DESCRIPTION:Everything around us — everything each of us has ever experienced and virtually everything underpinning our technological society and economy — is governed by quantum mechanics. Yet this most fundamental physical theory of nature often feels like a set of somewhat eerie and counterintuitive ideas of no direct relevance to our lives. Why is this? One reason is that we cannot perceive the strangeness (and astonishing beauty) of the quantum mechanical phenomena all around us by using our own senses. \nDr. Davis will describe the recent development of techniques that allow the imaging of electronic quantum phenomena directly at the atomic scale. As examples\, he will visually explore the previously unseen and very beautiful forms of quantum matter making up electronic liquid crystals [1\,2] and high-temperature superconductors [3\,4] and find that they are closely relayed. The implications for fundamental physics research\, and also for advanced materials and new technologies\, arising from development and application of these quantum matter visualization techniques will be discussed. \nJ.C. Séamus Davis is the J.G. White Distinguished Professor of Physical Sciences at Cornell University; he is also the SUPA Distinguished Research Professor of Physics at St. Andrews University\, Scotland\, and a senior physicist at Brookhaven National Laboratory in Upton\, New York. Between 2009 and 2014 he was the Director of the Center for Emergent Superconductivity\, an Energy Frontier Research Center of the U.S. Department of Energy. Davis’ active research is focused upon macroscopic quantum physics of emergent quantum matter\, including studies of superconductors\, superfluids\, supersolids\, spin liquids\, monopole liquids and heavy fermions. Davis has been the recipient of the the Outstanding Performance Award of the Lawrence Berkeley National Laboratory (2001)\, the Science and Technology Award of Brookhaven National Laboratory (2013)\, the Fritz London Memorial Prize (2005)\, and the H. Kamerlingh-Onnes Memorial Prize (2009). Davis is a fellow of the Institute of Physics (U.K.)\, the American Physical Society (U.S.)\, and a member of the U.S. National Academy of Sciences. \n  \n[1] Science 315\, 1380 (2007)\n[2] Science 327\, 181 (2010)\n[3] Science 336\, 563 (2012)\n[4] Science 344\, 612 (2014)
URL:https://www.simonsfoundation.org/event/visualizing-quantum-matter/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:New Directions in Imaging
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150515T170000
DTEND;TZID=America/New_York:20150515T181500
DTSTAMP:20260409T062528
CREATED:20150331T040000Z
LAST-MODIFIED:20211207T165259Z
UID:300-1431709200-1431713700@www.simonsfoundation.org
SUMMARY:Solving the 3-D Puzzle of Rotation Assignment in Single Particle Cryo-Electron Microscopy
DESCRIPTION:Single particle cryo-electron microscopy (EM) recently joined X-ray crystallography and nuclear magnetic resonance spectroscopy as a high-resolution structural method for biological macromolecules. In single particle cryo-EM\, the 3-D structure needs to be determined from many noisy 2-D projection images of individual\, ideally identical frozen-hydrated macromolecules whose orientations and positions are random and unknown. \nThis lecture will explore algorithms for estimating the unknown pose parameters. The main focus will be on algorithms that are based on semidefinite programming relaxations that can be viewed as extensions to existing approximation algorithms to max-cut and unique games\, two fundamental problems in theoretical computer science. \nAmit Singer is a professor of mathematics and a member of the executive committee of the Program in Applied and Computational Mathematics (PACM) at Princeton University. He joined Princeton as an assistant professor in 2008. From 2005 to 2008 he was a Gibbs Assistant Professor in Applied Mathematics at the Department of Mathematics\, Yale University. \nSinger received his B.Sc. degree in Physics and Mathematics and his Ph.D. degree in applied mathematics from Tel Aviv University\, Israel\, in 1997 and 2005\, respectively. He was awarded the Moore Investigator in Data-Driven Discovery Award (2014)\, the Simons Investigator Award (2012)\, the Presidential Early Career Award for Scientists and Engineers (2010)\, the Alfred P. Sloan Research Fellowship (2010) and the Haim Nessyahu Prize in Mathematics (2007). His current research in applied mathematics focuses on theoretical and computational aspects of data science\, and on developing computational methods for structural biology.
URL:https://www.simonsfoundation.org/event/solving-the-3-d-puzzle-of-rotation-assignment-in-single-particle-cryo-electron-microscopy/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:New Directions in Imaging
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20150515
DTEND;VALUE=DATE:20150516
DTSTAMP:20260409T062528
CREATED:20190411T200328Z
LAST-MODIFIED:20250813T172253Z
UID:48212-1431648000-1431734399@www.simonsfoundation.org
SUMMARY:Simons Collaboration on Algorithms and Geometry 2015 Annual Meeting
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/simons-collaboration-on-algorithms-and-geometry-2015-annual-meeting/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150513T170000
DTEND;TZID=America/New_York:20150513T181500
DTSTAMP:20260409T062528
CREATED:20150309T040000Z
LAST-MODIFIED:20211207T165249Z
UID:298-1431536400-1431540900@www.simonsfoundation.org
SUMMARY:Extra-Solar Planets: Search\, Characterization and Population Inferences
DESCRIPTION:The NASA Kepler mission vastly increased the number of planets around other stars that we know about. In this lecture\, David W. Hogg will explore how planets are discovered in the Kepler dataset\, how the data are understood and how researchers can make inferences about the full population of planets in the galaxy. Key questions in this area revolve around the formation of planetary systems\, along with the typicality of the Earth and our solar system. Because extra-solar planets imprint such tiny signals — measured in parts per million — on the carrier signals from their host stars\, research projects require extremely high levels of precision. Hogg and his team use concepts from data science to obtain calibrations and measurements at the required levels. \nDavid W. Hogg is professor of physics and data science at New York University (NYU). He is deputy director of the NYU Center for Data Science and executive director of the Moore-Sloan Data Science Environment at NYU. His research centers on astrophysics problems in which the challenges of data analysis are of greatest importance.
URL:https://www.simonsfoundation.org/event/extra-solar-planets-search-characterization-and-population-inferences/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Frontiers of Data Science
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180842/HOGG.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150506T170000
DTEND;TZID=America/New_York:20150506T181500
DTSTAMP:20260409T062528
CREATED:20150331T040000Z
LAST-MODIFIED:20211207T165240Z
UID:301-1430931600-1430936100@www.simonsfoundation.org
SUMMARY:Bell Labs’ Role in Programming Languages and Algorithms
DESCRIPTION:Bell Labs is deservedly renowned for its invention of the transistor\, but this talk will demonstrate that its contributions to programming languages and algorithms have been equally instrumental to the flowering of the Information Age. \nIn this lecture\, Alfred V. Aho will discuss the role that software plays in the modern world. Few people appreciate what software really is\, how critical software systems are to the functioning of society\, how much software there actually is and how much investment there is in the software infrastructure. Programming languages and algorithms are at the heart of all software. Aho will discuss the development of some key ideas in programming languages and algorithms that were invented at Bell Labs\, ideas that are now routinely used throughout the world. \nAlfred V. Aho is Lawrence Gussman Professor of Computer Science at Columbia University. Prior to working at Columbia\, he was vice president of the Computing Sciences Research Center at Bell Labs\, the center that created the Unix operating system and the C and C++ programming languages. Aho is a member of the National Academy of Engineering and of the American Academy of Arts and Sciences. He won the IEEE John von Neumann Medal for his contributions to computer science.
URL:https://www.simonsfoundation.org/event/bell-labs-role-in-programming-languages-and-algorithms/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Frontiers of Data Science
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180846/AhoPic.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150429T170000
DTEND;TZID=America/New_York:20150429T181500
DTSTAMP:20260409T062528
CREATED:20150305T050000Z
LAST-MODIFIED:20211207T165230Z
UID:296-1430326800-1430331300@www.simonsfoundation.org
SUMMARY:Tracing the Unseen Majority: Insights Into the Critical Role Microbes Play in the Ocean
DESCRIPTION:There is a vast sea of microbes — invisible to all but the most powerful microscopes — that drives ocean chemistry\, affects climate and even produces the fish we eat and the air we breathe. Ocean microbes make the planet habitable\, but major uncertainties still exist about the distribution and activity of key groups of microbes. \nIn this lecture\, Sonya Dyhrman will focus on photosynthetic microbes called phytoplankton\, highlighting the critical and beneficial roles that phytoplankton play in marine systems. These phytoplankton form the base of the marine food web and drive carbon and nitrogen cycling\, yet major uncertainties exist regarding how key groups are distributed and what controls their activities in different systems. Leveraging new species-specific molecular approaches\, Dyhrman will highlight examples of how this unseen microbial world both shapes and is shaped by our changing planet. \nSonya Dyhrman is an oceanographer who studies photosynthetic microbes and their role in shaping marine ecosystem structure\, function and biogeochemistry. She received her Ph.D. from the Scripps Institution of Oceanography and did her postdoctoral training at the Woods Hole Oceanographic Institute\, where she was a tenured member of the scientific staff until 2013\, when she moved to Columbia University. Dyhrman spends much of her time at sea on research expeditions ranging from the tropics to Antarctica.
URL:https://www.simonsfoundation.org/event/tracing-the-unseen-majority-insights-into-the-critical-role-microbes-play-in-the-ocean/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Interdisciplinary
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180840/DyhrmanPIC.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150422T170000
DTEND;TZID=America/New_York:20150422T181500
DTSTAMP:20260409T062528
CREATED:20150204T050000Z
LAST-MODIFIED:20211207T165221Z
UID:292-1429722000-1429726500@www.simonsfoundation.org
SUMMARY:Climate Change and Sea Level Rise: Projecting\, Reducing and Managing the Risk
DESCRIPTION:As the world warms over this century\, the level of the oceans will rise almost everywhere in a non-uniform pattern. The increasing risk of flooding from higher sea levels\, combined with potentially stronger coastal storms\, poses a risk to urban areas along all coasts\, particularly the U.S. Northeast coast. \nIn this lecture\, Michael Oppenheimer will describe the physical mechanisms causing observed increases in sea level. He will describe sea level rise projections and their relation to increases in atmospheric greenhouse gases. The credibility of projections is limited by our modest comprehension of the dynamics of the Greenland and Antarctic ice sheets. This lecture presents an emerging approach to projecting sea level rise in the absence of fully credible models\, along with resulting projections of regional sea level and flood risk increases worldwide. The talk will conclude with a discussion of lessons learned about managing and reducing coastal flood risk from recent episodes of extreme flooding\, including a look at New York City’s response following Hurricane Sandy. \nMichael Oppenheimer is director of Princeton University’s Program in Science\, Technology and Environmental Policy. He is a long-time participant in the Intergovernmental Panel on Climate Change\, serves on the National Academy of Sciences’ Board on Energy and Environmental Systems\, and is a science advisor to the Environmental Defense Fund\, where he formerly served as chief scientist. His research addresses climate change broadly\, including mechanisms causing sea level rise\, projection of flood probabilities and policy responses.
URL:https://www.simonsfoundation.org/event/climate-change-and-sea-level-rise-projecting-reducing-and-managing-the-risk/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:The Science of Climate
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150420T170000
DTEND;TZID=America/New_York:20150420T180000
DTSTAMP:20260409T062528
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T165410Z
UID:469-1429549200-1429552800@www.simonsfoundation.org
SUMMARY:Human Neurodegenerative Disease: Insight from Drosophila
DESCRIPTION:The Bonini laboratory focuses on applying the extraordinary power of a very simple model organism — the fruit fly Drosophila — to the complex problem of human neurodegenerative disease. Many human neurodegenerative diseases\, like the dementia-causing Alzheimer’s disease and the motor neuron disease ALS\, are associated with the abnormal accumulation of key proteins in which mutations are found in inherited situations; these same proteins accumulate in sporadic disease as well. Although disease mechanisms have classically been studied in systems like the mouse or in cell culture\, instead we developed the much simpler system Drosophila for this end. Drosophila shares genes and pathways with humans\, including basic aspects of brain structure. Our studies illustrate how remarkable insight can be gleaned from Drosophila by recreating the features of the human disease in the fly\, and then employing the range of genetic approaches available to uncover surprising molecular mechanisms. Importantly\, the genetics of the animal also holds promise to reveal the foundation for unsuspected and new therapeutic approaches. In this way\, this very simple system can contribute important insight toward an understanding of the basic biology of human disease\, as well as outline approaches to intervention. \nNancy Bonini is the Florence R.C. Murray Professor of Biology at the University of Pennsylvania and a Howard Hughes Medical Institute Investigator. Her laboratory focuses on using Drosophila melanogaster as a tool to define genes important for human brain disease. A class of human neurodegenerative diseases involves expansion of a polyglutamine repeat within the various disease proteins. This polyglutamine expansion results in a dominant\, toxic property of the disease protein\, leading to neural degeneration. Huntington’s disease is of this class. We have recreated this class of human neurodegenerative disease in Drosophila by expressing in flies one of these human disease proteins with an expanded polyglutamine run. Whereas expression of the protein with a normal polyglutamine repeat has no effect\, expression of the protein with an expanded polyglutamine repeat results in late onset\, progressive degeneration in the nervous system. This indicates that the molecular mechanisms of human polyglutamine disease are conserved in Drosophila. Hence\, we are now using Drosophila to define genes involved in the mechanisms and progression of polyglutamine disease\, to identify suppressor mutations that can prevent or delay brain degeneration\, and to extend these studies to additional diseases\, like Parkinson’s disease and other motor neuron diseases. The Bonini lab is also expanding into neural injury and aging models in Drosophila by analyzing the nervous system with age. They hope that these studies will lead to insight into neural decline with aging\, providing an approach for new treatments.
URL:https://www.simonsfoundation.org/event/human-neurodegenerative-disease-insight-from-drosophila/
CATEGORIES:Simons Science Series
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20150417
DTEND;VALUE=DATE:20150418
DTSTAMP:20260409T062528
CREATED:20170811T205547Z
LAST-MODIFIED:20251202T213748Z
UID:15093-1429228800-1429315199@www.simonsfoundation.org
SUMMARY:2015 Conference on Theory & Biology
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/2015-conference-on-theory-biology/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Ave\, New York\, NY\, 10010\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150415T170000
DTEND;TZID=America/New_York:20150415T180000
DTSTAMP:20260409T062528
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T165401Z
UID:467-1429117200-1429120800@www.simonsfoundation.org
SUMMARY:Illuminating Biology at the Nanoscale with Super-Resolution Florescence Microscopy
DESCRIPTION:Dissecting the inner workings of a cell requires imaging methods with molecular specificity\, molecular-scale resolution and dynamic imaging capability such that molecular interactions inside the cell can be directly visualized. Fluorescence microscopy is a powerful imaging modality for investigating cells largely owning to its molecular specificity and dynamic imaging capability. However\, the spatial resolution of light microscopy\, classically limited by the diffraction of light to a few hundred nanometers\, is substantially larger than typical molecular-length scales in cells. Hence many subcellular structures and dynamics cannot be resolved by conventional fluorescence microscopy. We developed a super-resolution fluorescence microscopy method\, stochastic optical reconstruction microscopy (STORM)\, which breaks the diffraction limit. STORM uses single-molecule imaging and photo-switchable fluorescent probes to temporally separate the spatially overlapping images of individual molecules. This approach has allowed multicolor and three-dimensional imaging of living cells with nanometer-scale resolution and enabled discoveries of novel sub-cellular structures. In this talk\, I will discuss the technological development and biological applications of STORM. \nThe Zhuang research lab works on the forefront of single-molecule biology and bioimaging\, developing and applying advanced optical imaging techniques to study the behavior of individual biological molecules and molecular assemblies in vitro and in live cells. Students and postdoctoral fellows in the Zhuang lab apply their diverse backgrounds in chemistry\, physics\, biology and engineering to develop new imaging probes and methods and use these tools to study a variety of interesting biological systems. Our current research is focused on three major directions: (1) Developing super-resolution optical microscopy that allows cell and tissue imaging with nanoscopic-scale resolution and applying this technology to cell biology and neurobiology\, (2) investigating how biomolecules function\, especially how proteins and nucleic acids interact\, using single-molecule fluorescence imaging and spectroscopy\, (3) investigating how viruses and cells interact using imaging techniques with high spatiotemporal resolution.
URL:https://www.simonsfoundation.org/event/illuminating-biology-at-the-nanoscale-with-super-resolution-florescence-microscopy/
CATEGORIES:Simons Science Series
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150408T170000
DTEND;TZID=America/New_York:20150408T181500
DTSTAMP:20260409T062528
CREATED:20150121T050000Z
LAST-MODIFIED:20211207T165350Z
UID:288-1428512400-1428516900@www.simonsfoundation.org
SUMMARY:Imaging as Exploration
DESCRIPTION:Advances in modern digital imaging methods are revolutionizing a wide range of scientific disciplines. They facilitate the acquisition of huge amounts of data that allow the visualization\, measurement\, reconstruction\, and archiving of complex\, multi-dimensional images. At the same time\, advances in computing technologies enable the deployment of tremendous computing resources. This permits numerical modeling of a broad swath of scientific phenomena\, and results in the production of vast quantities of numerical data. These data are just the beginning of the scientific exploration that modern computational and visualization methods will allow. But these advanced data generation capabilities require other enhanced abilities — with increasing data size and complexity\, the development of more efficient acquisition and analysis methods is essential. \nIn this lecture\, Lawrence R. Frank will discuss how this new paradigm of imaging exploration is manifest. He will explore how the increasing generality of approaches has led to dynamic methods for data analysis applicable to disparate fields\, from brain imaging to severe weather. \nLawrence R. Frank received his Ph.D. in physics from the Massachusetts Institute of Technology. He is founder and director of the University of California\, San Diego Center for Scientific Computation in Imaging (CSCI). His primary focus has been on the development of novel methods of magnetic resonance imaging (MRI) used in conjunction with computational methods. Used together\, these methods address research questions in a variety of topics\, such as cardiac biomechanics\, evolutionary biology and characterization of neural architecture. The work at CSCI has recently expanded to the development of theoretical frameworks and computational methods for the analysis of spatial-temporal data in imaging for applications\, from dynamic imaging of brain activity with functional MRI to severe weather meteorology.
URL:https://www.simonsfoundation.org/event/imaging-as-exploration/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Frontiers of Data Science
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150401T170000
DTEND;TZID=America/New_York:20150401T181500
DTSTAMP:20260409T062528
CREATED:20141218T050000Z
LAST-MODIFIED:20211207T165340Z
UID:282-1427907600-1427912100@www.simonsfoundation.org
SUMMARY:Reproducible Research and the Common Task Method
DESCRIPTION:The ‘Reproducible Research’ idea posits that publishing data and code\, not just statistical summaries\, makes for better and faster science. In particular\, shared datasets and shared evaluation metrics lower barriers to entry\, and allow meaningful comparison of scientific hypotheses with engineering algorithms. \nIn this lecture\, Mark Liberman will describe the origins and development of the ‘Common Task’ method in DARPA’s human language technology program\, its broader influence on recent research and development practices\, and its lessons for the future. Large\, shared datasets and well-defined evaluation metrics allow the steady improvement of technologies a decade or more in advance of commercial viability. There are important opportunities to apply similar ideas in a wide variety of areas\, from autism research to STEM education and writing instruction. \nMark Liberman is the Christopher H. Browne Professor of Linguistics at the University of Pennsylvania\, with positions in the department of computer science and in the psychology graduate group. He is also founder and director of the Linguistic Data Consortium. Before coming to the University of Pennsylvania\, he was head of the linguistics research department at AT&T Bell Laboratories.
URL:https://www.simonsfoundation.org/event/reproducible-research-and-the-common-task-method/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Frontiers of Data Science
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150327T123500
DTEND;TZID=America/New_York:20150327T173000
DTSTAMP:20260409T062528
CREATED:20150206T050000Z
LAST-MODIFIED:20211207T165330Z
UID:294-1427459700-1427477400@www.simonsfoundation.org
SUMMARY:Genomics in Single Cells and Microbiomes
DESCRIPTION:Speakers: Curtis Huttenhower\, Aviv Regev\, Dana Pe’er\, Michael Schatz \nCurtis Huttenhower \nHigh-precision Functional Profiling of Microbial Communities and the Human Microbiome \n \nAviv Regev \nTowards a Human Cell Atlas \n \nDan Pe’er \nSingle Cell Mapping of Developmental Trajectories Underlying Health and Disease \n \nMichael Schatz \nAlgorithms for Single Cell and Single Molecule Biology
URL:https://www.simonsfoundation.org/event/genomics-in-single-cells-and-microbiomes/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Biotech Symposia
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150325T170000
DTEND;TZID=America/New_York:20150325T184500
DTSTAMP:20260409T062528
CREATED:20150115T050000Z
LAST-MODIFIED:20211207T165320Z
UID:286-1427302800-1427309100@www.simonsfoundation.org
SUMMARY:Trends in Prevalence and Future Directions of the Epidemiology of Autism: The Impact of Social and Cultural Factors
DESCRIPTION:Once considered an extremely rare childhood mental disorder\, autism is now recognized as a common neurodevelopmental disability\, affecting more than 1 percent of the population in the U.S. Reasons for the rise in prevalence are not fully understood\, but they are likely associated with societal and cultural influences\, and the expansion of the concept of autism to a spectrum disorder: autism spectrum disorder (ASD) \nIn this lecture\, Maureen Durkin will discuss trends in the prevalence of ASD\, focusing on the role of intellectual disability — both as a co-occurring condition with ASD and in terms of using ASD as a diagnostic substitute for intellectual disability. She will also explore evidence of socioeconomic disparities in access to ASD diagnostic and therapeutic services\, the cultural and financial barriers underlying these disparities\, and the need to incorporate modern concepts of disability into the epidemiology of ASD\, placing emphasis not only on primary prevention of impairments but also on enhancement of functioning and social inclusion of people with ASD. \nMaureen Durkin is an epidemiologist\, professor of population health sciences and pediatrics\, and Waisman Center investigator at the University of Wisconsin-Madison. She received her Ph.D. in anthropology from the University of Wisconsin-Madison\, and her M.P.H. and Dr.P.H. degrees in epidemiology from Columbia University. She conducts studies on the epidemiology of neurodevelopmental disabilities and is currently principal investigator of the Wisconsin site of the Centers for Disease Control and Prevention’s Autism and Developmental Disabilities Monitoring Network.
URL:https://www.simonsfoundation.org/event/trends-in-prevalence-and-future-directions-of-the-epidemiology-of-autism-the-impact-of-social-and-cultural-factors/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150323T170000
DTEND;TZID=America/New_York:20150323T183000
DTSTAMP:20260409T062528
CREATED:20141126T050000Z
LAST-MODIFIED:20211207T164246Z
UID:278-1427130000-1427135400@www.simonsfoundation.org
SUMMARY:Light to Life
DESCRIPTION:4:15 pm: Tea\n5:00 pm: Lecture \nAll life on Earth is based on electron transfer reactions far from thermodynamic equilibrium. Increasingly high-resolution protein structure imagery provides an opportunity to glimpse into the deep past. \nIn this talk\, Paul Falkowski will examine the origins of biologically catalyzed electron transfer reactions\, which form the basis of all life on Earth. He will focus on evolution of the structures responsible for these reactions. The structural analyses of extant oxidoreductases — enzymes that catalyze the transfer of electrons — provide clues to how the earliest life forms evolved increasingly intricate bioelectronic devices. Using experimental analyses of the photochemical reactivity of common minerals\, he will go on to explore how photobiochemical reactions could have evolved to provide the long-term power supply for life. \nPaul Falkowski is the Bennett L. Smith Chair in Business and Natural Resources at Rutgers University. His scientific interests include evolution of the Earth’s systems\, paleoecology\, photosynthesis\, biophysics\, biogeochemical cycles\, symbiosis and sustainability. Falkowski has written more than 350 papers and several books\, and has received recognition and distinguished awards for his work\, including a Guggenheim Fellowship\, the A.G. Huntsman Award\, the G. Evelyn Hutchinson Award and the Vernadsky Medal from the European Geosciences Union. He is a member of the National Academy of Sciences. \n  \n 
URL:https://www.simonsfoundation.org/event/light-to-life/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Origins of Life
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150322T000000
DTEND;TZID=America/New_York:20150328T000000
DTSTAMP:20260409T062528
CREATED:20141002T040000Z
LAST-MODIFIED:20250813T172158Z
UID:3801-1426982400-1427500800@www.simonsfoundation.org
SUMMARY:Geometry Over Nonclosed Fields: Geometry and Arithmetic of Holomorphic Symplectic Varieties (2015)
DESCRIPTION:March 22–28\, 2015\n\n \nOrganizing committee:\nFedor Bogomolov\, Courant Institute of Mathematical Sciences\nBrendan Hassett\, Rice University\nYuri Tschinkel\, Simons Foundation \nThe second Simons Symposium on Geometry over Nonclosed Fields took place March 22-28. The first symposium in this series focused on rational curves on higher-dimensional algebraic varieties and outlined applications of the theory of curves to arithmetic problems. Since then\, there has been significant progress in this field\, with major new results obtained by participants: \n\nProof of the Tate conjecture for K3 surfaces by Maulik and Madapusi Pera\,\nProof of the integral Tate conjecture for cubic fourfolds over finite fields by Charles and Pirutka\,\nProof of the ample and effective cone conjecture for deformations of punctual Hilbert schemes of K3 surfaces by Bayer-Macrì and Bayer-Hassett-Tschinkel\,\nProof of the Morrison-Kawamata cone conjecture for general hyperkähler manifolds\, by Verbitsky\,\nProof of vanishing of Kobayashi pseudo-metric on hyperkähler manifolds\, by Kamenova\, Lu\, and Verbitsky.\n\nSome of these developments were discussed at the Symposium by Pirutka\, Kamenova\, and Verbitsky. These results have given new impetus to the study of rational curves and spaces of rational curves on K3 surfaces and their higher-dimensional generalizations. One of the main recent insights is that the geometry of rational curves is tightly coupled to properties of derived categories of sheaves on K3 surfaces. The implementation of this idea led to proofs of long-standing conjectures concerning birational properties of holomorphic symplectic varieties\, which in turn should yield new theorems in arithmetic. The Symposium featured several talks concerning the derived categories approach\, by Bayer\, Katzarkov\, Macrì\, and Stellari. It is expected that this approach will lead to deeper understanding of arithmetic properties of K3 surfaces over local fields\, number fields\, and function fields. Some of these ideas were outlined in talks by Liedtke and Olsson. Another source of ideas comes from Galois theory: distribution properties of Frobenius classes in Galois representations attached to curves or surfaces have striking geometric applications. This was the topic of talks by Charles\, Katz\, and Zarhin. Finally\, moduli spaces continue to play an important role in arithmetic. The talks by Farkas\, Hulek\, and Várilly-Alvarado introduced the participants to new theorems in this area. \n  \n\nAgenda & Lecture Notes\n\n\n\n\nMonday\nK3 Surfaces\n\n\n\nChristian Liedtke Good Reduction of K3 Surfaces (PDF)\n\n\n\nDaniel HuybrechtCurves and Cycles on K3 Surfaces (PDF)\n\n\n\nMartin OlssonThe Derived Torelli Theorem for K3 Surfaces and Applications (PDF)\n\n\n\nArend BayerDerived Automorphism Groups of K3 Surfaces of Picard Rank One (PDF)\n\n\n\nTuesday\nModuli Spaces\n\n\n\nGavril FarkasA Uniformization for the Moduli Space of Abelian Varieties of Dimension Six\n\n\n\nKlaus HulekModuli of Enriques Surfaces (PDF)\n\n\n\nAnthony Várilly-AlvaradoKodaira Dimension of Moduli of special cubic fourfolds (PDF)\n\n\nWednesday\nGeometry of Holomorphic Symplectic Varieties\n\n\n\nLjudmila KamenovaVanishing of the Kobayashi Pseudometric on K3 Surfaces and Hyperkähler Manifolds (PDF)\n\n\n\nMisha VerbitskyProof of Morrison-Kawamata cone conjecture for holomorphically symplectic manifolds (PDF)\n\n\n\nThursday\nArithmetic Problems\n\n\n\nFrancois CharlesExceptional isogenies of Elliptic Curves and Frobenius Distribution\n\n\n\nAlena PirutkaIntegral Tate Conjecture for Cubic Fourfolds (PDF)\n\n\n\nNick KatzSimple Things We Don’t Know (PDF)\n\n\n\nYuri ZarhinFamilies of Abelian Varieties with Big ℓ-adic Monodromy\n\n\n\nFriday\nCategorical Approaches\n\n\n\nLudmil Katzarkov Sheaf of Categories and 4-Dimensional Cubics (PDF)\n\n\n\nEmanuele MacrìStability Conditions on Threefolds (PDF)\n\n\n\nPaolo Stellari Stability Conditions on Threefolds 2 (PDF)\n\n\n	 Download full agenda PDF \n\nParticipants\n\n\n\n\nArend Bayer\nUniversity of Edinburgh\n\n\nFedor Bogomolov\nNew York University\n\n\nFrançois Charles\nOrsay\n\n\nIvan Cheltsov\nUniversity of Edinburgh\n\n\nIzzet Coskun\nUniversity of Illinois\, Chicago\n\n\nOlivier Debarre\nUniversité Paris Diderot\n\n\nGavril Farkas\nUniversity of Berlin\n\n\nBrendan Hassett\nRice University\n\n\nKlaus Hulek\nInstitute for Advanced Study\n\n\nDaniel Huybrechts\nUniversity of Bonn\n\n\nLjudmila Kamenova\nSUNY Stony Brook\n\n\nNick Katz\nPrinceton University\n\n\nLudmil Katzarkov\nMiami & Vienna\n\n\nChristian Liedtke\nUniversity of Munich\n\n\nEmanuele Macri\nOhio State University\n\n\nMartin Olsson\nUC Berkeley\n\n\nAlena Pirutka\nÉcole polytechnique\n\n\nJason Starr\nSUNY Stony Brook\n\n\nPaolo Stellari\nUniversità degli Studi di Milano\n\n\nYuri Tschinkel\nSimons Foundation\n\n\nRavi Vakil\nStanford University\n\n\nAnthony Várilly-Alvarado\n Rice University \n\n\nMisha Verbitsky\n Higher School of Economics \n\n\nYuri Zarhin\n Penn State University \n\n\n	 Download Participants PDF\n\nPhotographs\n\n	(Photo credit: Prof. Debarre)\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n	\n\n\n  \n \n« Back to Simons Symposia
URL:https://www.simonsfoundation.org/event/geometry-over-nonclosed-fields-geometry-and-arithmetic-of-holomorphic-symplectic-varieties/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150318T170000
DTEND;TZID=America/New_York:20150318T180000
DTSTAMP:20260409T062528
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T164237Z
UID:465-1426698000-1426701600@www.simonsfoundation.org
SUMMARY:Online Social Systems
DESCRIPTION:People spend hours a day interacting in online settings\, ranging from social media sites to a broad range of digital communities designed for work\, education and entertainment. Such systems are generally intended to elicit particular activities or forms of engagement\, yet we have relatively little understanding of the resulting behaviors or of how system design may contribute to those behaviors. In this talk\, I will discuss some of our work that aims to develop models of human behavior in online settings\, both to inform system design but also to address fundamental questions in the social sciences. In particular\, I will discuss some results regarding the diffusion of ideas and products\, participation in massive online courses\, the use of badges as incentives\, the inadvertent disclosure of social ties\, and effects of homophily\, or “birds of a feather” principle\, in online communities. These results include the study of large sites such as Coursera\, Flickr\, LinkedIn\, and Stack Overflow. \nDaniel Huttenlocher is the founding dean and vice provost of Cornell Tech. As dean\, he has overall responsibility for the new campus\, including the academic quality and direction of the campus’ degree programs and research. Huttenlocher has a mix of academic and industry background\, having worked at the Xerox Palo Alto Research Center (PARC) and served as CTO of Intelligent Markets\, as well as being a faculty member at Cornell for over two decades. He received his bachelor’s degree from the University of Michigan and both his master’s and doctorate degrees from Massachusetts Institute of Technology (MIT). He currently serves as a trustee of the John D. and Catherine T. MacArthur Foundation.
URL:https://www.simonsfoundation.org/event/online-social-systems/
CATEGORIES:Simons Science Series
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150315T000000
DTEND;TZID=America/New_York:20150321T000000
DTSTAMP:20260409T062528
CREATED:20141002T040000Z
LAST-MODIFIED:20250813T172127Z
UID:3800-1426377600-1426896000@www.simonsfoundation.org
SUMMARY:Quantum Entanglement (2015)
DESCRIPTION:March 15-21\, 2015\n\n \nOrganizers:\nShamit Kachru\, Stanford University\nHirosi Ooguri\, Caltech\nSubir Sachdev\, Harvard University \nSince our last symposium\, quantum entanglement has become even more important in areas of theoretical physics ranging from condensed matter physics and quantum information to quantum gravity. In quantum gravity\, it is playing a key role in elucidating the mechanism of the holographic duality between field theories and gravity theories. In condensed matter physics\, entanglement has become a key organizing principle in new approaches to performing lattice simulations of quantum systems (like DMRG and MERA).  It also acts as one of the few `tags’ for topologically ordered states – novel phases of matter not characterized by conventional order parameters. These developments make it an excellent time to bring together theorists in these areas to share their insights and tools.\n  \n\nSlides\n\n	Ashvin Vishwanath\, UC Berkeley:\n	Topology + Localization: Quantum Coherence In “Hot” Matter (PDF) \n	Tarun Grover\, KITP:\n	Universal Aspects of Many Body Localization Transition & Eigenstate Thermalization (PDF)\n\nAgenda\n\n\n\n\nMonday\n\n\n\n\nSubir Sachdev\n\n\n\nXiao-Liang Qi\n\n\n\nAshvin Vishwanath\n\n\n\nHong Liu\n\n\n\nShamit Kachru\n\n\nTuesday\n\n\n\n\nTadashi Takayanagi\n\n\n\nMatt Headrick\n\n\n\nHirosi Ooguri\n\n\n\nVeronika Hubeny\n\n\n\nMukund Rangamani\n\n\nWednesday\n\n\n\n\nDavid Huse\n\n\n\nMax Melitski\n\n\n\nTarun Grover\n\n\nThursday\n\n\n\n\nDaniel Harlow\n\n\n\nBrian Swingle\n\n\n\nBeni Yoshida\n\n\n\nRobert Myers\n\n\n\nDam Son\n\n\nFriday\n\n\n\n\nHoracio Casini\n\n\n\nEva Silverstein\n\n\n\nSean Hartnoll\n\n\n\nLiam Fitzpatrick\n\n\n\nSun-Sik Lee\n\n\n	→ Download full agenda PDF \n\nParticipants\n\n\n\nHoracio Casini\nCentro Atómico Bariloche\n\n\nLiam Fitzpatrick\nStanford University\n\n\nTarun Grover\nKITP\n\n\nDaniel Harlow\nPrinceton University\n\n\nSean Hartnoll\nStanford University\n\n\nMatt Headrick\nBrandeis University\n\n\nVeronika Hubeny\nDurham Uiversity\n\n\nDavid Huse\nPrinceton University\n\n\nShamit Kachru\nStanford University\n\n\nSung-Sik Lee\nMcMaster University/Perimeter Institute\n\n\nHong Liu\nMIT\n\n\nMax Metlitski\nKITP\n\n\nRobert Myers\nPerimeter Institute\n\n\nHirosi Ooguri\nCaltech\n\n\nXiao-Liang Qi\nStanford University\n\n\nMukund Rangamani \nDurham University\n\n\nSubir Sachdev\nHarvard University\n\n\nEva Silverstein\nStanford University\n\n\nDam Son\nUniversity of Chicago\n\n\nBrian Swingle\nHarvard University\n\n\nTadashi Takayanagi\nKyoto University\n\n\nAshvin Vishwanath\nUC Berkeley\n\n\nBeni Yoshida\nCaltech\n\n\n	(Download Participants PDF)\n\n\n  \n \n« Back to Simons Symposia
URL:https://www.simonsfoundation.org/event/quantum-entanglement-2015/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150311T170000
DTEND;TZID=America/New_York:20150311T181500
DTSTAMP:20260409T062528
CREATED:20150203T050000Z
LAST-MODIFIED:20211207T164226Z
UID:290-1426093200-1426097700@www.simonsfoundation.org
SUMMARY:Mineral Evolution and Ecology\, and the Co-evolution of Life and Rocks
DESCRIPTION:Earth’s geological and biological evolution are intertwined in remarkable ways that are coming into sharper focus thanks to studies of the diversity and distribution of minerals. Robert Hazen will explore the emerging field of ‘mineral evolution’ and reveal how Earth\, which is unique among known worlds in its biosphere\, is unique in its geosphere as well. \nIn this lecture\, Robert Hazen will examine how Earth’s near-surface environment has evolved as a consequence of selective physical\, chemical and biological processes — an evolution that is preserved in the mineralogical record. Recent studies of mineral diversification through time reveal correlations with major geochemical\, tectonic and biological events\, including large changes in ocean chemistry\, the supercontinent cycle\, the origins of life\, the increase in atmospheric oxygen and the rise of the terrestrial biosphere. Growing data resources also point to new opportunities for applying statistical methods and visualization strategies for deep-time — or geologic time — data. Among our most provocative findings: Earth is mineralogically unique in the cosmos. \nRobert Hazen received degrees in geology from the Massachusetts Institute of Technology and a Ph.D. in earth science from Harvard University. A senior staff scientist at the Carnegie Institution’s Geophysical Laboratory\, Hazen is also executive director of the Deep Carbon Observatory and author of numerous articles and books\, including “The Story of Earth”. Hazen’s recent research focuses on possible roles of minerals in the origin of life\, mineral evolution and the coevolution of the geosphere and biosphere.
URL:https://www.simonsfoundation.org/event/mineral-evolution-and-ecology-and-the-co-evolution-of-life-and-rocks/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Interdisciplinary
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150304T170000
DTEND;TZID=America/New_York:20150304T181500
DTSTAMP:20260409T062528
CREATED:20141218T050000Z
LAST-MODIFIED:20211207T164218Z
UID:280-1425488400-1425492900@www.simonsfoundation.org
SUMMARY:A Dark Matter Hunter’s Guide to the Universe
DESCRIPTION:Dark matter is a new\, mysterious form of matter that holds the universe together. It is responsible for the growth of structures in our universe as large as the Milky Way that can ultimately support life. While we know that dark matter is important for the evolution of our universe\, and that it is much more prevalent than ordinary matter (such as electrons and nuclei)\, the underlying nature of dark matter remains unknown. Still\, by using theoretical ideas exploring what dark matter may be\, we can search for experimental evidence about its nature. \nKathryn Zurek will review evidence for the presence of dark matter in our universe and the need for a new theory to describe the dark matter sector. She will discuss how dark matter hunters are searching for dark matter through observations on galactic and extra-galactic scales\, as well as in terrestrial experiments. She will focus on the connections among these various kinds of searches\, from the cosmic microwave background to observations of high-energy gamma rays in our galaxy\, as well as terrestrial experiments such as those involving the Large Hadron Collider. \n  \nKathryn Zurek received her Ph.D. in particle astrophysics from the Institute for Nuclear Theory at the University of Washington in 2006. She was then a postdoctoral fellow at the University of Wisconsin-Madison\, working on physics beyond the Standard Model\, and then the David Schramm Fellow in the theoretical astrophysics group at Fermi National Accelerator Laboratory. In 2009\, she became an assistant and then associate professor at the University of Michigan\, before moving to the Lawrence Berkeley National Laboratory. In 2014\, she began working as a member of the Joint Particle Theory Group at the Berkeley Center for Theoretical Physics. Her interests lie primarily at the boundary between particle physics\, and astrophysics and cosmology. \n  \n 
URL:https://www.simonsfoundation.org/event/a-dark-matter-hunters-guide-to-the-universe/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Astronomy, Cosmology and Particle Physics
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150225T170000
DTEND;TZID=America/New_York:20150225T184500
DTSTAMP:20260409T062528
CREATED:20150107T050000Z
LAST-MODIFIED:20211207T164204Z
UID:284-1424883600-1424889900@www.simonsfoundation.org
SUMMARY:Molecular and Neural Architecture of Circuits Underlying Social Behavior in the Mouse
DESCRIPTION:4:15 pm: Tea\n5:00 pm: Lecture\n6:15 pm: Reception \nMore information coming soon.
URL:https://www.simonsfoundation.org/event/molecular-and-neural-architecture-of-circuits-underlying-social-behavior-in-the-mouse/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150222T000000
DTEND;TZID=America/New_York:20150228T000000
DTSTAMP:20260409T062528
CREATED:20141002T040000Z
LAST-MODIFIED:20250813T172052Z
UID:3799-1424563200-1425081600@www.simonsfoundation.org
SUMMARY:New Directions in Approximations Algorithms (2015)
DESCRIPTION:February 22-28\, 2015\n\n \nOrganizers:\nSanjeev Arora\, Princeton University\nUriel Feige\, Weizmann Institute\nMichel Goemans\, Massachusetts Institute of Technology\nDavid Shmoys\, Cornell University \nThis is the second Simons Symposium on Approximation Algorithms for NP-hard problems. The first\, in January 2013\, focused on core techniques and problems of this field. The upcoming meeting is expected to also highlight how the notion of approximation has found uses in other areas\, including mechanism design\, combinatorial optimization\, online algorithms\, machine learning\, big-data algorithms\, differential privacy and discrepancy theory. \nThe schedule will be a mix of surveys and talks about new results. The structure will be informal and provide time for intense group discussions about open problems. Not all attendees will be expected to give long talks.\n  \n\nAgenda & Lecture Slides\n\n\n\n\n Monday \n\n\n\n Tim Roughgarden		Approximation and Algorithmic Game Theory \n\n\n\n Constantinos Daskalakis	Removing Mechanism to Algorithm Design (PDF) \n\n\n\n Bobby Kleinberg		Security Problems with Non-uniform Arrival Order (PDF) \n\n\n\n Mohit Singh    		Linear Programs & Algorithms for Capacitated Facility Location (PDF) \n\n\n\n Tuesday \n\n\n\n Prasad Raghavendra		Lower Bounds on the Size of Semidefinite Programs (PDF) \n\n\n\n David Steurer  		Lower Bounds on Semidefinite Programming Relaxations \n\n\n\n Raghu Meka     		Sum-of-Squares and Planted Clique (PDF) \n\n\n\n Moses Charikar 		Spectral Embedding of k-cliques\, Graph Partitioning and k-Means (PDF) \n\n\n\n Uriel Fiege    		A Prediction Game (PDF) \n\n\n Wednesday \n\n\n\n Avrim Blum     		Connections Between Learning and Approximation \n\n\n\n Sanjeev Arora  		Linear Algebra ++ and Unsupervised Machine Learning \n\n\n\n Satish Rao     		Sherman’s Algorithm for Approximate Maximum Flow: Cut Approximation\, Preconditioning and Multiplicative Weights \n\n\n Thursday \n\n\n\n Nikhil Bansal & Thomas Rothvoss  		Discrepency and Approximation  (PDFs: Part I\, Part II)\n\n\n\n Konstantin Makarychev		Solving Optimization Problems with Diseconomies of Scale via Decoupling (PDF) \n\n\n\n Ola Svensson   		Approximating ATSP by Relaxing Connectivity (PDF) \n\n\n\n Julia Chuzoy   		Excluded Grid Theorem: Improved and Simplified (PDF) \n\n\n\n Friday \n\n\n\n Kunal Talwar   		Approximation Algorithms and Differential Privacy \n\n\n\n Shuchi Chawla   		Approximate Optimality via Simple Tuthful Mechanisms \n\n\n\n Roy Schwartz    		Fast and Simple Algorithms for Submodular Maximization (PDF) \n\n\n\n Nikhil Bansal   		Independent Sets in Sparse Graphs (PDF) \n\n\n	→ View/download full agenda PDF \n\nParticipants\n\n\n\nSanjeev Arora\nPrinceton University\n\n\nNikhil Bansal\nEindhoven University of Technology\n\n\nAvrim Blum\nCarnegie Mellon University\n\n\nMoses Charikar\nPrinceton University\n\n\nShuchi Chawla\nUniversity of Wisconsin\n\n\nJulia Chuzhoy\nToyota Technological Institute at Chicago\n\n\nCostis Daskalakis\nMIT\n\n\nIrit Dinur\nWeizmann Institute of Science\n\n\nUriel Feige\nWeizmann Institute of Science\n\n\nMichel Goemans\nMIT\n\n\nBobby Kleinberg\nCornell University\n\n\nKonstantin Makarychev\nMicrosoft Research\n\n\nRaghu Meka\nInstitute for Advanced Study\n\n\nPrasad Raghavendra\nUC Berkeley\n\n\nSatish Rao\nUC Berkeley\n\n\nThomas Rothvoss\nUniversity of Washington\n\n\nTim Roughgarden\nStanford University\n\n\nRoy Schwartz\nPrinceton University\n\n\nDavid Shmoys\nCornell University\n\n\nMohit Singh\nMicrosoft Research\n\n\nDavid Steurer\nCornell University\n\n\nOla Svensson\nÉcole Polytechnique Fédérale de Lausanne\n\n\nKunal Talwar\nMicrosoft Research\n\n\n	(Download Participants PDF)\n\n\n  \n \n« Back to Simons Symposia
URL:https://www.simonsfoundation.org/event/new-directions-in-approximations-algorithms-2015/
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150218T170000
DTEND;TZID=America/New_York:20150218T180000
DTSTAMP:20260409T062528
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T164155Z
UID:464-1424278800-1424282400@www.simonsfoundation.org
SUMMARY:The Origin of Specificity in Regulated Protein Degradation
DESCRIPTION:One of the characteristic features of life is specificity. It emerges in metabolism\, information transfer from DNA to protein\, embryology\, immunology and virtually every other process. Its explanation on the molecular level is thermodynamic stability and structural complementarity. Yet one disturbing issue persists: the protein and nucleic acid sequences coding for that specificity are generally too small to distinguish actual partners from competitors. Similarly\, protein degradation conveys specificity through very short sequences. The process is so kinetically complex that bulk kinetic experiments and a few molecular structures are insufficient to explain how specificity is achieved. Using single molecule kinetic measurements\, we have deconvolved much of that specificity. The results reveal a novel process based loosely on some original ideas of kinetic proofreading\, by John Hopfield and Jacques Ninio. The unraveling of the details of the ubiquitin mechanism has led us to think more generally about the tradeoffs in biology between specificity and speed and the limits to which energy consumption can optimize that tradeoff. These conclusions based on understanding the mechanism of protein degradation may be relevant to other biochemical processes\, such as phosphorylation and transcription. \nMarc W. Kirschner\, Ph.D. graduated from Northwestern University in 1966 and received his Ph.D. from the University of California\, Berkeley in 1971. Following postdoctoral research at Berkeley and at the University of Oxford\, he was appointed as Assistant Professor at Princeton University in 1972 and full Professor in 1978. In 1978\, he moved to the Department of Biochemistry and Biophysics at the University of California\, San Francisco as a Professor. After fifteen years at the University of California\, San Francisco\, Dr. Kirschner moved to Harvard Medical School in 1993 to become the founding Chair of the Department of Cell Biology. In 2003\, he established the Department of Systems Biology at Harvard Medical School and became its first Chair. In 2009 he was named University Professor\, Harvard’s highest professorial distinction. \nDr. Kirschner’s laboratory investigates three broad\, diverse areas: regulation of the cell cycle\, the role of cytoskeleton in cell morphogenesis\, and mechanisms of establishing the basic vertebrate body plan.
URL:https://www.simonsfoundation.org/event/the-origin-of-specificity-in-regulated-protein-degradation/
CATEGORIES:Simons Science Series
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20150213
DTEND;VALUE=DATE:20150215
DTSTAMP:20260409T062528
CREATED:20150226T050000Z
LAST-MODIFIED:20250813T171855Z
UID:2557-1423785600-1423958399@www.simonsfoundation.org
SUMMARY:Simons Collaboration on the Many Electron Problem Annual Meeting 2015
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/foundation-hosts-annual-meeting-of-many-electron-collaboration/
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150211T170000
DTEND;TZID=America/New_York:20150211T181500
DTSTAMP:20260409T062528
CREATED:20141028T040000Z
LAST-MODIFIED:20211207T164349Z
UID:276-1423674000-1423678500@www.simonsfoundation.org
SUMMARY:Cosmic Microwave Background: Observational Tests of Theories of the Early Universe
DESCRIPTION:We live in a remarkable era. We can directly see what our universe was like 13.8 billion years ago. We use observations to test some of our wildest imaginings about how our universe began. Eiichiro Komatsu will summarize the current observational results and the state of affairs on theories of the early universe. \nIn this lecture\, Komatsu will describe the ‘cosmic microwave background\,’ the light remnants of the Big Bang. With this light\, we can directly see the physical state of the universe when it was very young. Detailed analyses of this light show a remarkable fact: All the cosmic structures\, including galaxies\, stars\, planets and ourselves\, originate from small quantum mechanical fluctuations present in the early universe. Such extraordinary claims require extraordinary evidence\, and Komatsu and his group believe they have such evidence. He will describe the physics of the cosmic microwave background\, discuss observational results and explain what they mean for our understanding of how the universe began. \nEiichiro Komatsu uses theoretical physics and experimental data to study the origin\, evolution and constituents of our universe. He received his Ph.D. from Tohoku University in Japan in 2001. After being a postdoctoral researcher at Princeton University and spending nine years at the University of Texas as faculty\, he moved to the Max Planck Institute for Astrophysics in Germany in 2012 to serve as a director. He has received numerous awards\, including the American Astronomical Society’s Lancelot Berkeley Prize in 2013.
URL:https://www.simonsfoundation.org/event/cosmic-microwave-background-observational-tests-of-theories-of-the-early-universe/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Astronomy, Cosmology and Particle Physics
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20150201
DTEND;VALUE=DATE:20150208
DTSTAMP:20260409T062528
CREATED:20170911T221817Z
LAST-MODIFIED:20250813T171752Z
UID:25733-1422748800-1423353599@www.simonsfoundation.org
SUMMARY:Non-Archimedean and Tropical Geometry (2015)
DESCRIPTION:February 1-7\, 2015\n\n \nOrganizers:\nMatt Baker\, Georgia Institute of Technology\nSame Payne\, Yale University \nThis symposium focused on setting a clear agenda for future developments in the related fields of tropical and nonarchimedean analytic geometry. One of the goals of the meeting was to produce high-quality expository material presenting the methods\, results and ambitions of these active research areas. Another was to identify problems in other fields of mathematics that could be amenable to tropical and nonarchimedean analytic methods and establish new rigorous links with those neighboring fields. \nTopics discussed included: \n\nConnections between birational geometry\, minimal model program\, and skeletons of Berkovich spaces \nThe recent work of Mustata\, Nicaise\, and Xu\, which relates Kontsevich-Soibelman skeletons of Berkovich spaces to skeletons of SNC formal models\nExistence and uniqueness of solutions to nonarchimedean Monge Ampere by Boucksom\, Favre and Jonsson\, and Yuan and Zhang \nPossible applications of existence and uniqueness for nonarchimedean partial differential equations in birational and arithmetic geometry\nRelations between as well as applications of various notions of higher dimensional potential theory on Berkovich spaces\n\n\nAgenda\, Notes & Materials\n\nOrganizers Matt Baker and Sam Payne provided the following documents that highlight open problems and topics discussed at the Non-Archimedean and Tropical Geometry symposium. \n• Summary (PDF)\n	   • Problem Session Notes (PDF) \nOrganizers’ site: http://users.math.yale.edu/~sp547/SimonsSymposium2015.html \n\n\nMonday\n\n\n\n\n\nJohan de Jong\nA remark on a paper of Thuillier\n\n\n\nDustin Cartwright\nOn homotopy types of analytifications. (PDF)\n\n\n\nYuri Tschinkel\nIgusa integrals and volume asymptotics in analytic and adelic geometry (joint work with A. Chambert-Loir) (PDF) \n\n\n\n\nOpen Problem Session\nModerator: Ravi Vakil\n\n\n\nJune Huh\nA tropical approach to a Hodge conjecture for positive currents (PDF)\n\n\nTuesday\n\n\n\n\n\nMircea Mustata\nWeight functions and skeleta (PDF)\n\n\n\nChenyang Xu\nSkeleton and dual complex (PDF)\n\n\n\nJohannes Nicaise\nPoles of maximal order of Igusa zeta functions (PDF)\n\n\n\nMichael Temkin\nMetrization of differential pluriforms on Berkovich spaces (PDF)\n\n\n\nWednesday\n\n\n\n\n\nMattias Jonsson\nSolution to a non-Archimedean Monge-Ampere equation I (PDF)\n\n\n\nSebastien Boucksom\nSolution to a non-Archimedean Monge-Ampere equation II (PDF)\n\n\n\nWalter Gubler\nA tropical approach to non-archimedean Arakelov theory (PDF)\n\n\nThursday\n\n\n\n\n\nSam Payne\nTropical Brill–Noether theory and its applications I (PDF)\n\n\n\nDavid Jensen\nTropical Brill–Noether theory and its applications II (PDF)\n\n\n\nOpen Problem Session\nModerator: Antoine Chambert-Loir\n\n\n\nVladimir Berkovich\nComplex analytic vanishing cycles for formal schemes (PDF)\n\n\n\nFriday\n\n\n\n\n\nAntoine Ducros\nPiecewise monomial skeleta (PDF)\n\n\n\nKiran Kedlaya\nConvergence polygons for connections on nonarchimedean curves (PDF)\n\n\n\nAnnette Werner\nSkeletons and tropicalizations (PDF)\n\n\n\nDan Abramovich\nArtin fans (PDF)\n\n\n	→ Download full agenda PDF\n\nParticipants\n\n\n\nDan Abramovich\nBrown University\n\n\nMatt Baker\nGeorgia Tech\n\n\nVladimir Berkovich\nWeizman Institute\n\n\nSebastian Boucksom\nParis 6\n\n\nDustin Cartwright\nYale University\n\n\nAntoine Chambert-Loir\nUniversité Paris-Sud\n\n\nJohan de Jong\nColumbia University\n\n\nAntoine Ducros\nParis 6\n\n\nTyler Foster\nUniversity of Michigan\n\n\nWalter Gubler\nUniversity of Regensburg\n\n\nJune Huh\nPrinceton / IAS / Clay Math Institute\n\n\nDavid Jensen\nUniversity of Kentucky\n\n\nMattias Jonsson\nUniversity of Michigan\n\n\nKiran Kedlaya\nUC San Diego\n\n\nKlaus Künnemann\nUniversität Regensburg \n\n\nMircea Mustata\nUniversity of Michigan\n\n\nJohannes Nicaise\nKU Leuven\n\n\nSam Payne\nYale University\n\n\nJoe Rabinoff\nGeorgia Tech University\n\n\nMichael Temkin\nEinstein Institute of Mathematics\n\n\nYuri Tschinkel\nSimons Foundation\n\n\nRavi Vakil\nStanford University\n\n\nAnnette Werner\nGoethe-Universität Frankfurt\n\n\nChenyang Xu\nBeijing International Center of Mathematics Research\n\n\n	→ Download Participants PDF\n\n\n  \n \n« Back to Simons Symposia
URL:https://www.simonsfoundation.org/event/non-archimedean-and-tropical-geometry-2015/
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20150128T170000
DTEND;TZID=America/New_York:20150128T184500
DTSTAMP:20260409T062528
CREATED:20141024T040000Z
LAST-MODIFIED:20211207T164337Z
UID:274-1422464400-1422470700@www.simonsfoundation.org
SUMMARY:One Brain\, Many Genomes: Somatic Mutation and Genomic Variability in the Human Cerebral Cortex
DESCRIPTION:Due to the winter storm\, the Wednesday\, January 28\, 2015 5:00 p.m. Autism: Emerging Concepts lecture “One Brain\, Many Genomes: Somatic Mutation and Genomic Variability in the Human Cerebral Cortex” by Christopher A. Walsh is canceled and will be rescheduled. \n4:15 pm: Tea\n5:00 pm: Lecture\n6:15 pm: Reception \nChristopher Walsh and his team are interested in genetic mechanisms of cerebral cortical development and abnormalities of cortical development resulting in intellectual disability\, autism and epilepsy. The lab pioneered the analysis of recessive causes of autism by studying children with autism whose parents share ancestry. \nWalsh will review recent work on ‘somatic mutations’ — de novo mutations that are present in some brain cells but not in all cells of the body — in several neurological conditions associated with intellectual disability and seizures. The talk will also cover the extent to which somatic mutations are an inevitable part of normal brain development\, such that the neurons in the human brain are a tapestry of cells with distinct genomes. He will briefly discuss the possible relevance of somatic mutations to autism. \n  \nChristopher A. Walsh is chief of the genetics and genomics division at Boston Children’s Hospital\, Bullard Professor of Pediatrics and Neurology at Harvard Medical School\, and an investigator at the Howard Hughes Medical Institute. He completed his M.D. and Ph.D. degrees at the University of Chicago\, trained in neurology at Massachusetts General Hospital and has worked at Boston Children’s Hospital since 2006. \nIf this lecture is videotaped\, it will be posted here after production.
URL:https://www.simonsfoundation.org/event/one-brain-many-genomes-somatic-mutation-and-genomic-variability-in-the-human-cerebral-cortex/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
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DTSTART;TZID=America/New_York:20141212T123000
DTEND;TZID=America/New_York:20141212T173000
DTSTAMP:20260409T062528
CREATED:20140819T040000Z
LAST-MODIFIED:20211207T164326Z
UID:269-1418387400-1418405400@www.simonsfoundation.org
SUMMARY:MEG/EEG Part 2: Analysis\, Application and Interpretation
DESCRIPTION:Speakers:\nJonathan Simon\, University of Maryland\nTimothy Roberts\, Children’s Hospital of Philadelphia\nJonathan Winawer\, New York University \n  \n \nSignal Analysis Primer and Applications\nJonathan Z. Simon\, University of Maryland \nModern cognitive neuroscientists using electrocorticography (ECoG)\, MEG and electroencephalography (EEG) are under substantial pressure to use advanced signal processing and analysis techniques\, but typically receive little formal training in their usage. \nJonathan Simon\, whose departmental affiliations are with both electrical engineering and biology\, will provide a signal analysis tutorial aimed at cognitive neuroscientists who wish to better understand their own signal analysis methods. The tutorial will be a mix of an elementary primer with a collection of useful tips and tricks\, all aimed at cognitive neuroscientists who routinely analyze ECoG\, MEG or EEG signals. \nThe goal will be to expand signal-processing intuition by bridging the gap between mathematical abstractions (e.g.\, complex numbers\, Fourier transforms and functional analysis) and their applications (e.g.\, phase relationships\, frequency bands\, and desirable and undesirable filter properties)\, using a mix of mathematical and illustrative examples. \n  \n \nApplications of Timing and Spectro-temporal Analysis\nTimothy Roberts\, Children’s Hospital of Philadelphia \nMagnetoencephalography (MEG) offers intrinsic capabilities afforded by high temporal resolution. Not only can subtle shifts in response timing be resolved\, but higher frequency oscillatory brain activity can also be precisely defined. Combined with advanced spatial localization algorithms\, this offers a powerful five-dimensional modality capable of interrogating the ‘where?’\, ‘when?’ and\, indeed\, ‘what?’ of brain function. \nBecause spatially resolved signals can be obtained\, each rich with spectro-temporal features\, analysis of both spatial (regional) functional connectivity\, and cross-spectral coupling\, this technique presents insight into the dynamics and regional interplay of brain networks. \nTimothy Roberts will discuss these technical capabilities and examine the clinical research opportunities they afford\, especially in the field of neuropsychiatric disorders\, in which disruptions of neural systems\, circuitry and connectivity may be implicated. The talk will focus on the field of autism\, but will also illustrate the relevance of the spatio-spectro-temporal approach to other disorders\, such as attention deficit hyperactivity disorder\, schizophrenia and mild traumatic brain injury. \nAdditionally\, integration of MEG characteristics with converging evidence from multimodal studies (e.g.\, magnetic resonance imaging and magnetic resonance spectroscopy) will augment the neurobiologic interpretation of the observed MEG features\, and thus define a path toward the development of ‘biological markers’ for use in diagnosis\, prognosis and treatment development and evaluation. \n  \n \nSpectral Analysis of ECoG in Humans\nJonathan Winawer\, New York University \nThere are many tools available to measure activity in the living human brain. The two most widely studied human brain responses are the blood-oxygen-level-dependent (BOLD)signal\, typically measured with functional magnetic resonance imaging (fMRI)\, and perturbations in electromagnetic fields\, measured with magnetoencephalography and electroencephalography (EEG)\, including subdural electroencephalography (ECoG). \nBoth the BOLD response and field perturbations arise from the activity of large populations of neurons. Understanding how each of these two signals depends on neural activity\, and how the signals relate to one another\, is a matter of considerable importance in human neuroscience. Jonathan Winawer will review methods and empirical findings in the spectral analyses of ECoG data\, and propose links between components of the ECoG signal\, the BOLD signal and the underlying cortical circuitry.
URL:https://www.simonsfoundation.org/event/megeeg-part-2-analysis-application-and-interpretation/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Biotech Symposia
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DTSTART;TZID=America/New_York:20141210T170000
DTEND;TZID=America/New_York:20141210T180000
DTSTAMP:20260409T062528
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T164316Z
UID:462-1418230800-1418234400@www.simonsfoundation.org
SUMMARY:Why Prove Theorems?
DESCRIPTION:Since at least the time when it was understood that the circumference of a circle is pi multiplied by its diameter\, the applications of mathematics have raced on far ahead of the foundations of the subject itself. By considering a variety of examples\, principally from the 19th century\, we will explore the tension between mathematics and its applications\, and reasons why it remains a valuable and rewarding occupation to develop the necessary framework for existing and “well understood” theories. If time permits\, I will give a short discussion of recent work I have done on the mathematical foundations for diffusion models in population genetics. \n\nView/Download slides (PDF)\nView/Download “Poincaré on: Why do Analysis?” (PDF)\n\nCharles L. Epstein received his Ph.D. from New York University in 1983. After three years as a postdoctoral fellow at Princeton University\, he joined the faculty of the Department of Mathematics at the University of Pennsylvania\, where he currently holds the Thomas A. Scott Chair in Mathematics. He has worked in spectral theory\, hyperbolic geometry\, univalent function theory\, microlocal analysis\, several complex variables and index theory. For more than a decade\, he has also worked on a range of problems in medical imaging\, image analysis\, computational electromagnetics and mathematical aspects of population genetics. He was a Sloan Foundation Fellow in 1988–90. In 2007\, he founded the Graduate Group in Applied Mathematics and Computational Science at the University of Pennsylvania\, which he continues to chair.
URL:https://www.simonsfoundation.org/event/why-prove-theorems/
CATEGORIES:Simons Science Series
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20141203T170000
DTEND;TZID=America/New_York:20141203T184500
DTSTAMP:20260409T062528
CREATED:20140611T040000Z
LAST-MODIFIED:20211207T164305Z
UID:194-1417626000-1417632300@www.simonsfoundation.org
SUMMARY:Learning to Move
DESCRIPTION:Basic motor skills such as looking\, reaching and walking do not simply appear as the result of maturation. Rather\, infants must learn to move. Learning entails discovering new forms of movements to suit the task at hand and using perceptual information to select and modify movements adaptively. \nIn this lecture\, Karen E. Adolph will discuss how infants learn to generate and control their motor actions. Learning to move involves more than merely lifting the limbs against gravity. Adaptive action requires that movements be constructed\, selected and modified in accordance with the constraints and opportunities provided by the physical and social environment. The learning process is geared toward flexibility rather than rote performance: Infants are ‘learning to learn’ rather than acquiring fixed solutions. \nJames C. Galloway will provide post-lecture commentary on how research on typical development can inform motor functioning in autism. \nKaren E. Adolph is professor of psychology at the Center for Neuroscience at New York University\, as well as a fellow of the American Psychological Association and the American Psychological Society. She is incoming president of the International Society for Infant Studies and is leading the Databrary.org project to enable open sharing of video data among developmental scientists. \nAdolph has pioneered research on motor skill acquisition in infants\, and in particular how infants learn to use perceptual and social information to guide actions adaptively. Her research also examines effects of body growth\, exploratory activity\, environmental and social supports\, and culture on perceptual-motor learning and development. \nJames C. (Cole) Galloway is director of the Pediatric Mobility Lab and Design Studio\, and professor of physical therapy at the University of Delaware. Galloway began focusing on young children following a postdoctoral fellowship with Esther Thelen. His research focuses on how multiple biological\, psychological and environmental factors contribute to the emergence of exploratory behaviors. Current projects focus on advancing the technology and training to assist children in maximizing their daily exploration.
URL:https://www.simonsfoundation.org/event/learning-to-move/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
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