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DTSTART;TZID=America/New_York:20141008T161500
DTEND;TZID=America/New_York:20141008T184500
DTSTAMP:20260413T081442
CREATED:20140819T040000Z
LAST-MODIFIED:20211207T163134Z
UID:266-1412784900-1412793900@www.simonsfoundation.org
SUMMARY:Urban Social Science Au Naturel
DESCRIPTION:The enormous amount of information that is now available about cities and the people who live in them offers intriguing opportunities for better understanding human behavior. That understanding can be applied to optimize urban policy and operations. Steven Koonin will discuss examples of and prospects for gaining insight into human behavior within the context of work at New York University’s Center for Urban Science and Progress. \nSteven E. Koonin was appointed founding director of New York University’s Center for Urban Science and Progress in April 2012. That consortium of academic\, corporate and government partners pursues research and educational activities to develop and demonstrate informatics technologies for urban problems in the ‘living laboratory’ of New York City. He previously served as the U.S. Department of Energy’s second Senate-confirmed under secretary for science. As chief scientist at BP\, Koonin developed a long-range technology strategy for alternative and renewable energy sources. \nKoonin joined the faculty of the California Institute of Technology (Caltech) in 1975\, was a research fellow at the Niels Bohr Institute from 1976 to 1977\, and was an Alfred P. Sloan Foundation fellow from 1977 to 1979. He became professor of theoretical physics at Caltech in 1981 and served as chairman of the faculty from 1989 to 1991. From 1995 to 2004\, Koonin was the seventh provost of Caltech.
URL:https://www.simonsfoundation.org/event/urban-social-science-au-naturel/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Data Analysis in the Social Sciences
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180802/Koonin.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20141001T161500
DTEND;TZID=America/New_York:20141001T184500
DTSTAMP:20260413T081442
CREATED:20140819T040000Z
LAST-MODIFIED:20211207T163125Z
UID:257-1412180100-1412189100@www.simonsfoundation.org
SUMMARY:Testing the Cortical Column Conjecture
DESCRIPTION:Many contemporary theories of neural information processing suggest that the neocortex employs algorithms composed of repeated instances of a limited set of computing primitives. There is a recognized need for tools that interrogate the structure of the cortical microcircuits believed to embody these primitives. The cortical column conjecture suggests that neurons in the neocortex are connected in a graph that exhibits motifs representing repeated processing modules. Carey Priebe and his collaborators will present a notional demonstration of how statistical inference on graphs can inform our understanding of cortical computing. \nBy modeling the cortical graph as a hierarchical stochastic block model (HSBM)\, with induced subgraphs\, which are themselves independent stochastic block models\, a natural question is to estimate the extent to which identified subgraphs share common structure. This will require addressing the problem of identifying candidate subgraphs\, and of determining the impact of imperfect subgraph identification on subsequent inference. The application of this connectomics theory and the associated methods will be demonstrated via a bio-inspired\, large-scale simulation study. \nCarey E. Priebe received a B.S. in mathematics from Purdue University in Indiana\, an M.S. in computer science from San Diego State University\, and a Ph.D. in information technology (computational statistics) from George Mason University in Washington\, D.C. He worked as a mathematician and scientist in the U.S. Navy research and development laboratory system until he became a professor in the department of applied mathematics and statistics at the Whiting School of Engineering at Johns Hopkins University. At Johns Hopkins\, Priebe holds joint appointments in the department of computer science\, the department of electrical and computer engineering\, the Center for Imaging Science\, the Human Language Technology Center of Excellence and the Whitaker Biomedical Engineering Institute. \nHis research interests include computational statistics\, kernel and mixture estimates\, statistical pattern recognition\, statistical image analysis\, dimensionality reduction\, model selection and statistical inference for high-dimensional and graph data. Priebe is a senior member of the Institute of Electrical and Electronics Engineers\, a lifetime member of the Institute of Mathematical Statistics\, an elected member of the International Statistical Institute and a fellow of the American Statistical Association. He received an Office of Naval Research Young Investigator Award in 1995\, the 2010 American Statistical Association Distinguished Achievement Award\, the 2011 McDonald Award for Excellence in Mentoring and Advising\, and in 2008 was named one of six inaugural National Security Science and Engineering Faculty Fellows.
URL:https://www.simonsfoundation.org/event/testing-the-cortical-column-conjecture/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Frontiers of Data Science
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180752/Priebe.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140923T161500
DTEND;TZID=America/New_York:20140923T184500
DTSTAMP:20260413T081442
CREATED:20140819T040000Z
LAST-MODIFIED:20211207T163112Z
UID:253-1411488900-1411497900@www.simonsfoundation.org
SUMMARY:The Social Brain: A Hypothesis Space for Understanding Autism
DESCRIPTION:Humans are a highly social species\, allocating numerous brain regions to distinct aspects of social cognition. These regions and corresponding mental abilities serve as tools for understanding which functions are lost and which are preserved in autism. \nAutism is characterized by a highly uneven cognitive profile in which some mental functions are preserved or enhanced\, whereas others are disrupted. An important asset in the search to understand this complex disorder comes from the study of the typical human mind and brain. Behavioral\, developmental and neural data from control subjects support a modular architecture\, with distinct cognitive functions implemented in distinct cognitive and neural mechanisms. In this talk\, Nancy Kanwisher will consider the functional architecture of the social brain in typical subjects as an avenue for considering which functions are affected and which are preserved in autism. \nNancy Kanwisher is a professor in the Department of Brain & Cognitive Sciences at Massachusetts Institute of Technology (MIT) and an investigator at MIT’s McGovern Institute for Brain Research. After receiving her B.S. and Ph.D. from MIT\, Kanwisher served on the faculty at the University of California\, Los Angeles\, and Harvard\, before returning to MIT in 1997. Kanwisher has received the Troland Research Award\, MacVicar Faculty Fellow teaching award and Golden Brain Award. She is a member of the National Academy of Sciences and the American Academy of Arts and Sciences.
URL:https://www.simonsfoundation.org/event/the-social-brain-a-hypothesis-space-for-understanding-autism/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180747/nancy-kanwisher-feature.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140917T170000
DTEND;TZID=America/New_York:20140917T180000
DTSTAMP:20260413T081442
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T163102Z
UID:456-1410973200-1410976800@www.simonsfoundation.org
SUMMARY:Strategies to Prolong Vision in Inherited Forms of Blindness
DESCRIPTION:Photoreceptor cells are a highly specialized cell type in the eye. They capture light and transform the light signals into chemical signals that are delivered to other types of neurons in the eye. Vision is thus initiated by photoreceptors and relies completely upon proper photoreceptor survival. In many inherited diseases that lead to blindness\, the disease gene directly affects photoreceptor cells. One such disease\, retinitis pigmentosa (RP)\, has disease genes that directly affect rods\, the photoreceptor type that mediates vision in dim light. People born with RP are thus night blind. Subsequent to rod dysfunction and death\, the cone photoreceptors\, which mediate color and daylight vision\, also lose function and die. We have suggested a model wherein cones are affected due to dysregulated metabolism\, which occurs after rods die. Cones do not express most RP disease genes\, but they do experience a greatly altered environment following rod death. The outer segments of the cone collapse lose their intimate association with their support cells and are exposed to a hyperoxic environment. We have begun to develop gene therapy to combat some of these problems. Our approach is to use adenovirus-associated vectors (AAV) to deliver genes that help cones fight oxidation and other forms of stress. Our progress in treating RP mice using such vectors will be presented. \n• View/Download Slides (PDF)\nDr. Cepko is the Bullard Professor of Genetics and Neuroscience at Harvard Medical School and an Investigator of the Howard Hughes Medical Institute. She received her Ph.D. degree from the Massachusetts Institute of Technology\, working with Phillip Sharp\, and remained at MIT as a postdoctoral fellow in the laboratory of Richard Mulligan\, where she helped develop the technology of retrovirus-mediated gene transduction. Her current research is focused on the development of the central nervous system\, with an emphasis on the retina. Her laboratory has also been working to develop gene therapy for prolonging vision in genetic forms of blindness\, and in developing viral vectors for tracing neuronal circuitry. She is a member of the National Academy of Sciences and the American Academy of Arts and Sciences.
URL:https://www.simonsfoundation.org/event/strategies-to-prolong-vision-in-inherited-forms-of-blindness/
LOCATION:NY
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181147/Connie_Cepko.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140912T123000
DTEND;TZID=America/New_York:20140912T173000
DTSTAMP:20260413T081442
CREATED:20140819T040000Z
LAST-MODIFIED:20211207T163030Z
UID:263-1410525000-1410543000@www.simonsfoundation.org
SUMMARY:Complex Data Visualization: Approach and Application
DESCRIPTION:This Biotech Symposium will focus on the visualization and representation of analytic results from complex data sets. Dropping costs of DNA sequencing coupled with the development of various sequencing modalities are driving the generation of large\, complex genomics datasets. In addition\, longitudinal sampling and the pairing of genomics data with real-time data collection from wearable devices promise to increase the complexity of analyses. In this context\, visualization techniques are likely to play a crucial role in making results understandable. \n  \nSpeakers: \nÇağatay Demiralp\, Ph.D.\nStanford University\nVisualize First\, Ask Questions Later: How to Explore Thousands of Genomic Sequences Interactively \n \nNils Gehlenborg\, Ph.D.\nHarvard Medical School\nVisual Exploration of Clinical and Genomic Data for Patient Stratification \n \nCydney Nielsen\, Ph.D.\nBritish Columbia Cancer agency\nVisualizing Cancer Genomes: Techniques and Challenges \n(Video forthcoming) \nNikolaus Schultz\, Ph.D.\nMemorial Sloan-Kettering Cancer Center\nThe cBioPortal for Cancer Genomics
URL:https://www.simonsfoundation.org/event/complex-data-visualization-approach-and-application/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Biotech Symposia
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140910T161500
DTEND;TZID=America/New_York:20140910T181500
DTSTAMP:20260413T081442
CREATED:20140819T040000Z
LAST-MODIFIED:20211207T163257Z
UID:264-1410365700-1410372900@www.simonsfoundation.org
SUMMARY:Living with Uncertainty but Still Learning: Anti-Abortion Democrats\, Jimmy Carter Republicans and the Missing Leap Day Babies
DESCRIPTION:To learn about the human world\, we should accept uncertainty and embrace variation. Andrew Gelman will illustrate this concept with various examples from his recent research and discuss more generally how statistical methods can help or hinder the scientific process. \nAndrew Gelman received his Ph.D. in statistics from Harvard University in 1990. His books include Bayesian Data Analysis; Teaching Statistics: A Bag of Tricks; A Quantitative Tour of the Social Sciences; and Red State\, Blue State\, Rich State\, Poor State: Why Americans Vote the Way They Do. He is currently professor of statistics and political science\, as well as director of the Applied Statistics Center\, at Columbia University.
URL:https://www.simonsfoundation.org/event/living-with-uncertainty-but-still-learning-anti-abortion-democrats-jimmy-carter-republicans-and-the-missing-leap-day-babies/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Data Analysis in the Social Sciences
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180759/Gelman.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140904T080000
DTEND;TZID=America/New_York:20140905T170000
DTSTAMP:20260413T081442
CREATED:20190508T204940Z
LAST-MODIFIED:20250813T171544Z
UID:49273-1409817600-1409936400@www.simonsfoundation.org
SUMMARY:Simons Collaboration on the Many Electron Problem Annual Meeting 2014
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/simons-collaboration-on-the-many-electron-problem-annual-meeting-2014/
LOCATION:NY
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140710T080000
DTEND;TZID=America/New_York:20140710T170000
DTSTAMP:20260413T081442
CREATED:20140710T040000Z
LAST-MODIFIED:20211207T163248Z
UID:212-1404979200-1405011600@www.simonsfoundation.org
SUMMARY:November 6\, 2013: Infants’ Grasp of Others’ Intentions: The Development of Social Understanding
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/november-6-2013-infants-grasp-of-others-intentions-the-development-of-social-understanding/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140530T000000
DTEND;TZID=America/New_York:20140530T000000
DTSTAMP:20260413T081442
CREATED:20140501T040000Z
LAST-MODIFIED:20250813T170925Z
UID:3638-1401408000-1401408000@www.simonsfoundation.org
SUMMARY:Symposium on Evidence in the Natural Sciences
DESCRIPTION:FRIDAY\, MAY 30\, 2014\nScientific Program: 8:00 AM – 3:15 PM\nEvening Program: 4:30 – 7:45 PM \nGerald D. Fischbach Auditorium\n160 5th Avenue\, New York\, New York\, 10010 \n\nWhat is the difference between evidence\, fact\, and proof? Can we quantify evidence; is something more evident than something else? What does it take to convince a scientist\, a scientific community\, and the general public of the correctness of a scientific result in the era of very complicated experiments\, big data\, and weak signals? \nThis symposium\, co-hosted by the Simons Foundation and John Templeton Foundation and in collaboration with the World Science Festival\, addressed these and related questions\, during a scientific program suited for for established researchers\, postdoctoral fellows and graduate students working in the natural sciences and allied fields\, and during an evening program aimed at the above scientists in addition to the well-informed general public. \nSee the foundation news feature on the symposium for further information and photographs.\nSPEAKERS\n\nJim Baggott\, Science Writer\nCharles Bennett\, IBM Research\nDavid Donoho\, Stanford University\nPeter Galison\, Harvard University\nBrian Greene\, Columbia University\nThomas Hales\, Pittsburgh University\nTim Maudlin\, New York University\nAmber Miller\, Columbia University\nWilliam Press\, University of Texas at Austin \n\nAGENDA\n\nDownload Agenda PDF \n\n\n\n \n\n\nEvidence in the Natural Sciences\nFriday\, May 30\, 2014\n\n\n8:00 – 9.00 AM\nBreakfast & Check-in\n\n\n9:00 – 9:05 AM\nWelcome & Introduction\nYuri Tschinkel\nSimons Foundation\nVladimir Buzek\nTempleton Foundation\n\n\n9:05 – 9:45 AM\nThe Verification of the Proof of the Kepler Conjecture\nThomas Hales\nPittsburgh University\n\n\n9:45 – 10:25 AM\nCan We Believe Our Published Research? Systemic Failures\, Their Causes\, a Solution\nDavid Donoho\nStanford University\n\n\n10:25 – 10:55 AM\nBreak\n\n\n\n10:55 – 11:35 AM\nReproducibility Now at Risk?\nWilliam Press\nThe University of Texas at Austin\n\n\n11:35 AM -12:15 PM\nHow Can We Know What Happened Almost 14 Billion Years Ago?\nAmber Miller\nColumbia University\n\n\n12:15 – 12:55 PM\nEvidence\, Computation\, and Ethics\nCharles Bennett\nIBM Research\n\n\n12:55 – 1:55 PM\nLunch\n\n\n\n1:55 – 2:35 PM\nNew Evidence\nPeter Galison\nHarvard University\n\n\n2:35 – 3:15 PM\nEvidence and Theory in Physics\nTim Maudlin\nNew York University\n\n\n4:30 – 5:15 PM\nTea\n\n\n5:15 – 6:45 PM\nPanel Discussion\nBrian Greene\, Columbia University\nPeter Galison\, Harvard University\nJim Baggott\, Science Writer\n\n\n6:45 – 7:45 PM\nReception\n\n\n\n\n\nTALKS\n\nDownload PDF file of the abstracts below \nPanel Discussion\nBrian Greene\, Columbia University\nPeter Galison\, Harvard University\nJim Baggott\, Science Writer \n \nThe Verification of the Proof of the Kepler Conjecture\nThomas Hales\, Pittsburgh University \n \nView/Download Slides (pdf)\nIn 1998\, Sam Ferguson and Tom Hales announced the proof of a 400-year-old conjecture made by Kepler. The Kepler conjecture asserts that the most efficient arrangement of balls in space is the familiar pyramid arrangement used to stack oranges at markets. \nTheir mathematical proof relies heavily on long computer calculations. Checking this proof turned out to be a particular challenge for referees. The verification of the correctness of this single proof has now continued for more than 15 years and is still unfinished at the formal level. This long process has fortified standards of computer-assisted mathematical proofs. \nCan We Believe Our Published Research? Systemic Failures\, Their Causes\, a Solution\nDavid Donoho\, Stanford University \n \nView/Download Slides (pdf)\nStatistical evidence has served as a central component of the scientific method for centuries. The proper calculation and interpretation of statistical evidence is now crucial for interpretation of the one million or more research articles published yearly that purport to discover new effects by data analysis. \nTraditional practices\, which aligned nicely with rigorous statistical analysis\, are slipping away. One of these was the idea of defining\, in advance of any data gathering\, the entire pipeline of data processing and analysis\, so the data itself would not affect its own analysis\, and theoretical assumptions would hold. Another was the idea of carefully describing post facto the full set of analyses that led to a conclusion\, including dead ends and reports left in the file drawer. \nA great deal of mischief can be\, and has been\, unloosed by the spread of less rigorous practices\, traceable ultimately to the ease with which data and analyses can be ‘tweaked.’ John Ioannidis suggests that half or more of all published research findings are false. \nIn this talk\, we reviewed some of the validity problems becoming evident in the combined corpus of scientific knowledge at a global scale and how this is detected. \nReproducibility Now at Risk?\nWilliam H. Press\, The University of Texas at Austin \n \nView/Download Slides (pdf)\nThe reproducibility of experimental results is a central tenet of science\, related to equally central notions of causality. Yet irreproducibility occurs all the time in the scientific enterprise\, ranging in cause from the fundamentally statistical nature of quantum mechanics and chaotic classical systems to the long list of human fallibilities that can cause experiments to go bad or even mathematical proofs to contain obscure flaws. It has recently been alleged that biomedical experiments are becoming less reproducible\, to the point of stymieing new cancer drug development. Are researchers today just sloppier\, or is there a more fundamental explanation? What should we do about it? \nHow Can We Know What Happened Almost 14 Billion Years Ago?\nAmber Miller\, Columbia University \n \nView/Download Slides (pdf)\nHow do we go about uncovering the history of the universe\, and what evidentiary standards are required in order to leap the bar from theoretical idea to established scientific framework? Of particular importance in this field is the distinction between a model simply capable of explaining observed phenomena\, and one with the power to generate unique and testable predictions. However\, the application of properly predictive modeling in the theoretical framework is only one side of the coin. Equally important is the rigor with which the experimental investigations are conducted. Perhaps counter-intuitively to those working outside the field\, there are powerful sociological forces at work in the cosmological community that play a constructive role in ensuring this intellectual rigor. \nIn this talk\, Professor Miller discussed the manner and degree to which this affects the debate. \nEvidence\, Computation\, and Ethics\nCharles Bennett\, IBM Research \n \nView/Download Slides (pdf)\nOur world contains abundant evidence of a nontrivial past\, and archaeological artifacts are deemed valuable according to how much of this long history they contain evidence of\, evidence that cannot be found elsewhere. Nevertheless some important aspects of the past\, like the lost literature of antiquity and the fate of Jimmy Hoffa\, have resisted discovery for a long time\, and there is reason to believe that some of this information has been irretrievably lost\, so by now it is as objectively ambiguous as the most indeterminate aspects of the future\, e.g.\, which of two radioactive atoms will decay first. Notions of evidence and history can be formalized by a modern version of the old idea of a monkey accidentally typing Shakespeare. A modern monkey boosts its chances by typing at a general-purpose computer instead of a typewriter. The behavior of such a randomly programed computer turns out to be a rather subtle mathematical question\, whose answer contains the seeds of a non-anthropocentric ethics\, in which objects (such as a book\, a DNA sequence\, or the whole biosphere)\, are deemed valuable and worthy of preservation if they contain internal evidence\, unavailable elsewhere\, of a nontrivial causal history requiring a long time for a computer to recapitulate. \nNew Evidence\nPeter Galison\, Harvard University \n \nPerhaps the greatest lesson that the history of physics can offer us is this: the development of science is not just about the discovery of new theories and phenomena; it is about the creation of novel forms of evidence and argument. Statistical inference\, error bars\, golden events — along with argument by diagrams\, symmetry\, simulation\, and Gedankenexperiment — these and other forms of evidence are so much a part of our armamentarium that it is easy to think they are part of the eternal firmament of physics. But they\, like the objects and laws they helped establish\, are very much the product of hard-fought battles in the development of the discipline. And the evolution of the very form of our evidence is a sign of the dynamic\, changing nature of physics itself. \nEvidence and Theory in Physics\nTim Maudlin\, New York University \n \nView/Download Slides (pdf)\nAs an empirical science\, physics must imply some testable predictions. And since physics proposes to offer a complete description of the physical world\, those empirical consequences must follow from the theory all by itself. The main interpretational problem of quantum theory (the measurement problem or Schrödinger cat problem) arises exactly because it is unclear how to connect in a principled way the language of the theory to the language of the empirical data. John Bell offered a solution to this problem\, which he called the “theory of local beables.” Professor Maudlin discussed Bell’s general solution\, and a few of the exact detailed forms it might take.
URL:https://www.simonsfoundation.org/event/symposium-on-evidence-in-the-natural-sciences/
LOCATION:NY
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/12031745/kepler5_258x216.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140528T163000
DTEND;TZID=America/New_York:20140528T183000
DTSTAMP:20260413T081442
CREATED:20140508T040000Z
LAST-MODIFIED:20211207T163233Z
UID:208-1401294600-1401301800@www.simonsfoundation.org
SUMMARY:Keeping Your Brain in Balance: Do Defects in Neuronal Homeostasis Contribute to Autism Spectrum Disorders?
DESCRIPTION:May 28\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Gina Turrigiano will describe the plasticity mechanisms that allow our brains to ‘tune themselves up’ and remain both plastic and stable. These mechanisms include a family of ‘homeostatic’ plasticity mechanisms that allow neurons to adjust their excitability to maintain constant firing rates in the face of outside perturbations. Recently\, Turrigiano has investigated the role of homeostatic plasticity in the experience-dependent development of the visual cortex\, especially how homeostatic mechanisms interact with classical forms of synaptic plasticity to allow experience-dependent circuit refinement. A major goal of Turrigiano’s lab is to determine the molecular and biophysical mechanisms of homeostatic plasticity and use this knowledge to perturb these mechanisms in intact cortex. These studies are generating insights into the normal function of cortical microcircuits and into how the failure of homeostatic plasticity mechanisms might contribute to developmental defects in brain wiring that contribute to autism spectrum disorders. \nGina Turrigiano received her her Ph.D. from the University of California\, San Diego. She trained as a postdoc with Eve Marder at Brandeis University before joining the Brandeis faculty in 1994. She is now a full professor in the department of biology\, the Volen Center for Complex Systems and the Center for Behavioral Genomics at Brandeis. \nTurrigiano has received numerous awards for her research\, including a National Institutes of Health (NIH) career development award\, a Sloan Foundation fellowship\, a MacArthur Foundation fellowship\, McKnight Foundation Technological Innovation and Neurobiology of Disease awards\, an NIH director’s pioneer award\, the HFSP Nakasone Award\, election to the American Academy of Arts and Sciences and election to the National Academy of Sciences. Her scientific interests include mechanisms of synaptic and intrinsic plasticity and the experience-dependent refinement of neocortical microcircuitry.
URL:https://www.simonsfoundation.org/event/keeping-your-brain-in-balance-do-defects-in-neuronal-homeostasis-contribute-to-autism-spectrum-disorders/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180702/Turrigiano1-pic-copy1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140528T000000
DTEND;TZID=America/New_York:20140528T000000
DTSTAMP:20260413T081442
CREATED:20140224T050000Z
LAST-MODIFIED:20211207T163224Z
UID:2034-1401235200-1401235200@www.simonsfoundation.org
SUMMARY:May 28\, 2014: Keeping Your Brain in Balance: Do Defects in Neuronal Homeostasis Contribute to Autism Spectrum Disorders?
DESCRIPTION:May 28\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Gina Turrigiano will describe the plasticity mechanisms that allow our brains to ‘tune themselves up’ and remain both plastic and stable. These mechanisms include a family of ‘homeostatic’ plasticity mechanisms that allow neurons to adjust their excitability to maintain constant firing rates in the face of outside perturbations. Recently\, Turrigiano has investigated the role of homeostatic plasticity in the experience-dependent development of the visual cortex\, especially how homeostatic mechanisms interact with classical forms of synaptic plasticity to allow experience-dependent circuit refinement. A major goal of Turrigiano’s lab is to determine the molecular and biophysical mechanisms of homeostatic plasticity and use this knowledge to perturb these mechanisms in intact cortex. These studies are generating insights into the normal function of cortical microcircuits and into how the failure of homeostatic plasticity mechanisms might contribute to developmental defects in brain wiring that contribute to autism spectrum disorders. \nGina Turrigiano received her her Ph.D. from the University of California\, San Diego. She trained as a postdoc with Eve Marder at Brandeis University before joining the Brandeis faculty in 1994. She is now a full professor in the department of biology\, the Volen Center for Complex Systems and the Center for Behavioral Genomics at Brandeis. \nTurrigiano has received numerous awards for her research\, including a National Institutes of Health (NIH) career development award\, a Sloan Foundation fellowship\, a MacArthur Foundation fellowship\, McKnight Foundation Technological Innovation and Neurobiology of Disease awards\, an NIH director’s pioneer award\, the HFSP Nakasone Award\, election to the American Academy of Arts and Sciences and election to the National Academy of Sciences. Her scientific interests include mechanisms of synaptic and intrinsic plasticity and the experience-dependent refinement of neocortical microcircuitry. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production.
URL:https://www.simonsfoundation.org/event/may-28-2014-keeping-your-brain-in-balance-do-defects-in-neuronal-homeostasis-contribute-to-autism-spectrum-disorders/
LOCATION:NY
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205949/Turrigiano1-pic-copy.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140521T154500
DTEND;TZID=America/New_York:20140521T181500
DTSTAMP:20260413T081442
CREATED:20140612T040000Z
LAST-MODIFIED:20211207T163214Z
UID:227-1400687100-1400696100@www.simonsfoundation.org
SUMMARY:Probabilistic Topic Models of Text and Users
DESCRIPTION:In this talk\, David Blei will review the basics of topic modeling and describe his recent research on collaborative topic models—models that simultaneously analyze documents and the corresponding reader behavior. Blei will explain how using collaborative topic models to discover patterns in how people read can help point readers to relevant new documents. Finally\, he will discuss the broader field of probabilistic modeling\, which gives data scientists both a rich language for expressing statistical assumptions and scalable algorithms for using those assumptions to uncover hidden patterns in massive data. \nDavid Blei is associate professor of computer science at Princeton University. Blei’s research focuses on developing methods for finding patterns in large datasets. He has received awards including a Sloan Fellowship (2010)\, the Office of Naval Research Young Investigator Award (2011)\, the Presidential Early Career Award for Scientists and Engineers (2011)\, the Blavatnik Faculty Award (2013) and the ACM-Infosys Foundation Award (2013). Blei earned his Ph.D. in computer science from the University of California\, Berkeley.
URL:https://www.simonsfoundation.org/event/probabilistic-topic-models-of-text-and-users/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Frontiers of Data Science
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180722/blei-hi-res-426x6401.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140521T000000
DTEND;TZID=America/New_York:20140521T000000
DTSTAMP:20260413T081442
CREATED:20140411T040000Z
LAST-MODIFIED:20211207T163205Z
UID:2079-1400630400-1400630400@www.simonsfoundation.org
SUMMARY:May 21\, 2014: Probabilistic Topic Models of Text and Users
DESCRIPTION:May 21\, 2014\, 3:45-6:00 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this talk\, David Blei will review the basics of topic modeling and describe his recent research on collaborative topic models—models that simultaneously analyze documents and the corresponding reader behavior. Blei will explain how using collaborative topic models to discover patterns in how people read can help point readers to relevant new documents. Finally\, he will discuss the broader field of probabilistic modeling\, which gives data scientists both a rich language for expressing statistical assumptions and scalable algorithms for using those assumptions to uncover hidden patterns in massive data. \nDavid Blei is associate professor of computer science at Princeton University. Blei’s research focuses on developing methods for finding patterns in large datasets. He has received awards including a Sloan Fellowship (2010)\, the Office of Naval Research Young Investigator Award (2011)\, the Presidential Early Career Award for Scientists and Engineers (2011)\, the Blavatnik Faculty Award (2013) and the ACM-Infosys Foundation Award (2013). Blei earned his Ph.D. in computer science from the University of California\, Berkeley. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production.
URL:https://www.simonsfoundation.org/event/may-21-2014-probabilistic-topic-models-of-text-and-users/
LOCATION:NY
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11210056/blei-hi-res.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140507T170000
DTEND;TZID=America/New_York:20140507T180000
DTSTAMP:20260413T081442
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T163420Z
UID:454-1399482000-1399485600@www.simonsfoundation.org
SUMMARY:Big Data Analytics and a Path to Enhancing Our Understanding of Human Disease
DESCRIPTION:Dr. Schadt provides an overview of how his team organizes very large scale data across many different types\, and then integrates these data using sophisticated mathematical algorithms to construct predictive network models of disease. This approach well complements the type of natural artificial intelligence/machine learning approaches that have become nearly standard in the life and biomedical sciences for building classifiers for a whole range of problems (disease classification\, subtype classification\, drug response classification\, and so on). By building a causal network model that spans multiple scales (from the molecular to the cellular\, to the tissue/organ\, to the organism and community) we can understand the flow of information and how best to modulate that flow to improve human wellbeing\, whether better diagnosing and treating disease or improving overall health. Examples of building these predictive network models across a range of diseases are given\, covering areas such as Alzheimer’s disease\, inflammatory bowel disease\, and diabetes. \nDr. Schadt also discusses the application of this type of modeling in the cancer arena where interpreting any given cancer case in the context of the digital universe of information relating to the cancer of interest is carried out using predictive network models to inform on personalized treatment options for a given patient\, including personalized vaccines or novel drug combinations. \nView/Download Slides (PDF)\nAbout the Speaker \nDr. Schadt is Chair of the Department of Genetics and Genomic Sciences\, Director of the Icahn Institute for Genomics and Multiscale Biology\, and Jean C. & James W. Crystal Professor of Genomics at the Icahn School of Medicine at Mount Sinai. Dr. Schadt’s lab and broader efforts at the Icahn Institute focus on the integration of diverse\, very large scale data to build predictive models of disease that can aid in providing more accurate diagnoses of disease and how best to treat it. \nDr. Schadt is an expert on the generation and integration of very large-scale sequence variation\, molecular profiling and clinical data in disease populations for constructing molecular networks that define disease states and link molecular biology to physiology. He is known for calling for a shift in molecular biology toward a network-oriented view of living systems to complement the reductionist\, single-gene approaches that currently dominate biology in order to more accurately model the complexity of biological systems. Dr. Schadt’s research has provided novel insights into what is needed to master diverse\, large-scale data collected on normal and disease populations in order to elucidate the complexity of disease and make more informed decisions in the drug discovery arena. He has published more than 200 peer-reviewed papers in leading scientific journals\, and contributed to a number of discoveries relating to the genetic basis of common human diseases such as diabetes\, obesity\, and Alzheimer’s disease. \nDr. Schadt is also a founding member of Sage Bionetworks\, an open-access genomics initiative designed to build and support databases and an accessible platform for creating innovative dynamic disease models. Prior to joining Mount Sinai in 2011\, he was Chief Scientific Officer at Pacific Biosciences\, the next-generation sequencing technology provider. Previously\, Dr. Schadt was Executive Scientific Director of Genetics at Rosetta Inpharmatics\, a subsidiary of Merck & Co.\, Inc. in Seattle\, and before Rosetta\, Dr. Schadt was a Senior Research Scientist at Roche Bioscience. He received his B.A. in applied mathematics and computer science from California Polytechnic State University\, his M.A. in pure mathematics from University of California\, Davis\, and his Ph.D. in bio-mathematics from University of California\, Los Angeles (requiring Ph.D. candidacy in molecular biology and mathematics).
URL:https://www.simonsfoundation.org/event/big-data-analytics-and-a-path-to-enhancing-our-understanding-of-human-disease/
LOCATION:NY
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181145/Eric_Schadt.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140430T154500
DTEND;TZID=America/New_York:20140430T180000
DTSTAMP:20260413T081442
CREATED:20140617T040000Z
LAST-MODIFIED:20211207T163407Z
UID:243-1398872700-1398880800@www.simonsfoundation.org
SUMMARY:Where is Fundamental Physics Heading?
DESCRIPTION:In recent decades\, physicists and astronomers have discovered two beautiful standard models\, one for the quantum world of extremely short distances and one for the universe as a whole. Both models have had spectacular success\, but there are also strong arguments for new physics beyond these models. \nIn this lecture\, Nathan Seiberg will review these models\, their successes and their shortfalls. He will describe how experiments in the near future could point to new physics to suggest a profound conceptual revolution in our understanding of the world. \nSeiberg received his Ph.D. in 1982 from the Weizmann Institute of Science in Israel\, where he worked from 1985 to 1991 as senior scientist\, associate professor and professor. From 1989 to 1997\, he was a professor at Rutgers University in New Jersey. He joined the faculty at the Institute for Advanced Study in New Jersey in 1997. \nSeiberg has received many awards and honors\, including a MacArthur Fellowship\, the Oskar Klein Medal\, the Dannie Heineman Prize for Mathematical Physics of the American Physical Society and the American Institute of Physics\, and the Fundamental Physics Prize. He is a member of both the American Academy of Arts and Sciences and the National Academy of Sciences. \n 
URL:https://www.simonsfoundation.org/event/where-is-fundamental-physics-heading/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180737/Seiberg-Nathan_20121.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140430T000000
DTEND;TZID=America/New_York:20140430T000000
DTSTAMP:20260413T081442
CREATED:20140307T050000Z
LAST-MODIFIED:20211207T163354Z
UID:2056-1398816000-1398816000@www.simonsfoundation.org
SUMMARY:April 30\, 2014: Where is Fundamental Physics Heading?
DESCRIPTION:April 30\, 2014\, 3:45-6:00 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn recent decades\, physicists and astronomers have discovered two beautiful standard models\, one for the quantum world of extremely short distances and one for the universe as a whole. Both models have had spectacular success\, but there are also strong arguments for new physics beyond these models. \nIn this lecture\, Nathan Seiberg will review these models\, their successes and their shortfalls.  He will describe how experiments in the near future could point to new physics to suggest a profound conceptual revolution in our understanding of the world. \nSeiberg received his Ph.D. in 1982 from the Weizmann Institute of Science in Israel\, where he worked from 1985 to 1991 as senior scientist\, associate professor and professor.  From 1989 to 1997\, he was a professor at Rutgers University in New Jersey. He joined the faculty at the Institute for Advanced Study in New Jersey in 1997. \nSeiberg has received many awards and honors\, including a MacArthur Fellowship\, the Oskar Klein Medal\, the Dannie Heineman Prize for Mathematical Physics of the American Physical Society and the American Institute of Physics\, and the Fundamental Physics Prize. He is a member of both the American Academy of Arts and Sciences and the National Academy of Sciences. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production.
URL:https://www.simonsfoundation.org/event/april-30-2014-where-is-fundamental-physics-heading/
LOCATION:NY
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11210023/Seiberg-Nathan_2012.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140423T163000
DTEND;TZID=America/New_York:20140423T183000
DTSTAMP:20260413T081442
CREATED:20140508T040000Z
LAST-MODIFIED:20211207T163345Z
UID:206-1398270600-1398277800@www.simonsfoundation.org
SUMMARY:New Insights and Approaches for Studying Rett Syndrome\, an Autism-Associated Disorder
DESCRIPTION:In this lecture\, Gail Mandel will provide a general introduction to Rett syndrome (RTT)\, a neurodevelopmental disease of girls that results from defects in the gene encoding of the transcription factor methyl-CpG-binding protein 2 (MeCP2). She will provide evidence that the pathology is complex\, involving defects in both neurons and astrocytes in conventional RTT mouse models. She will discuss emerging ideas about the normal function of the MeCP2 protein and her recent findings that point to a role for MeCP2 in 3-D chromatin architecture. Finally\, she will discuss whether Rett syndrome could be amenable to gene replacement strategies. \nGail Mandel holds a Ph.D. in immunology from the University of California\, Los Angeles (UCLA) and did postdoctoral work in biochemistry and molecular biology at UCLA; the University of California\, San Diego; and Harvard Medical School. She began her career at Tufts Medical School in Boston\, where she was one of the first investigators to clone and express mammalian voltage-dependent ion channels. In the department of neurobiology and behavior at Stony Brook University\, she identified the protein REST\, which is responsible for regulation of sodium channel expression and the acquisition of cellular excitability. These discoveries have helped unlock the mechanisms through which embryonic cell types differentiate specifically into neurons. Currently\, Mandel is a senior scientist in the Vollum Institute at Oregon Health & Science University. She is an Investigator of the Howard Hughes Medical Institute and a member of the American Academy of Sciences and National Academy of Sciences. \n 
URL:https://www.simonsfoundation.org/event/new-insights-and-approaches-for-studying-rett-syndrome-an-autism-associated-disorder/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180700/mandel1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140423T000000
DTEND;TZID=America/New_York:20140423T000000
DTSTAMP:20260413T081442
CREATED:20140224T050000Z
LAST-MODIFIED:20211207T163333Z
UID:2032-1398211200-1398211200@www.simonsfoundation.org
SUMMARY:April 23\, 2014: New Insights and Approaches for Studying Rett Syndrome\, an Autism-Associated Disorder
DESCRIPTION:April 23\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Gail Mandel will provide a general introduction to Rett syndrome (RTT)\, a neurodevelopmental disease of girls that results from defects in the gene encoding of the transcription factor methyl-CpG-binding protein 2 (MeCP2). She will provide evidence that the pathology is complex\, involving defects in both neurons and astrocytes in conventional RTT mouse models. She will discuss emerging ideas about the normal function of the MeCP2 protein and her recent findings that point to a role for MeCP2 in 3-D chromatin architecture. Finally\, she will discuss whether Rett syndrome could be amenable to gene replacement strategies. \nGail Mandel holds a Ph.D. in immunology from the University of California\, Los Angeles (UCLA) and did postdoctoral work in biochemistry and molecular biology at UCLA; the University of California\, San Diego; and Harvard Medical School. She began her career at Tufts Medical School in Boston\, where she was one of the first investigators to clone and express mammalian voltage-dependent ion channels. In the department of neurobiology and behavior at Stony Brook University\, she identified the protein REST\, which is responsible for regulation of sodium channel expression and the acquisition of cellular excitability. These discoveries have helped unlock the mechanisms through which embryonic cell types differentiate specifically into neurons. Currently\, Mandel is a senior scientist in the Vollum Institute at Oregon Health & Science University. She is an Investigator of the Howard Hughes Medical Institute and a member of the American Academy of Sciences and National Academy of Sciences. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production.
URL:https://www.simonsfoundation.org/event/april-23-2014-new-insights-and-approaches-for-studying-rett-syndrome-an-autism-associated-disorder/
LOCATION:NY
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205946/mandel.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140415T163000
DTEND;TZID=America/New_York:20140415T183000
DTSTAMP:20260413T081442
CREATED:20140617T040000Z
LAST-MODIFIED:20211207T163308Z
UID:245-1397579400-1397586600@www.simonsfoundation.org
SUMMARY:Von Neumann Machines and Molecular Darwinism
DESCRIPTION:In this lecture\, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines)\, especially those with the capacity to self-reproduce\, and molecular Darwinian systems that maintain heritable ‘bits’ of information\, which are refined through evolution. Such molecular machines have been constructed in the laboratory and are able to reproduce themselves indefinitely. \nJoyce is professor of chemistry and molecular biology\, and an investigator at the Skaggs Institute for Chemical Biology at the Scripps Research Institute in La Jolla\, California. \nJoyce’s research involves the test-tube evolution of nucleic acids and the application of these methods to the development of novel RNA and DNA enzymes. He also has a longstanding interest in the origins of life and the role of RNA in the early history of life on Earth. His laboratory recently described the first example\, outside of biology\, of a self-replicating molecule that is capable of undergoing Darwinian evolution. This so-called ‘immortal molecule’ has been the subject of extensive news coverage\, including by The New York Times\, Scientific American\, CNN and the BBC. \nJoyce received his M.D. and Ph.D. from the University of California\, San Diego in 1984.
URL:https://www.simonsfoundation.org/event/von-neumann-machines-and-molecular-darwinism/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Origins of Life
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180739/joyce1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140415T000000
DTEND;TZID=America/New_York:20140415T000000
DTSTAMP:20260413T081442
CREATED:20140610T040000Z
LAST-MODIFIED:20211207T163523Z
UID:2128-1397520000-1397520000@www.simonsfoundation.org
SUMMARY:April 15\, 2014: Von Neumann Machines and Molecular Darwinism
DESCRIPTION:April 15\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines)\, especially those with the capacity to self-reproduce\, and molecular Darwinian systems that maintain heritable ‘bits’ of information\, which are refined through evolution. Such molecular machines have been constructed in the laboratory and are able to reproduce themselves indefinitely. \nJoyce is professor of chemistry and molecular biology\, and an investigator at the Skaggs Institute for Chemical Biology at the Scripps Research Institute in La Jolla\, California. \nJoyce’s research involves the test-tube evolution of nucleic acids and the application of these methods to the development of novel RNA and DNA enzymes. He also has a longstanding interest in the origins of life and the role of RNA in the early history of life on Earth. His laboratory recently described the first example\, outside of biology\, of a self-replicating molecule that is capable of undergoing Darwinian evolution. This so-called ‘immortal molecule’ has been the subject of extensive news coverage\, including by The New York Times\, Scientific American\, CNN and the BBC. \nJoyce received his M.D. and Ph.D. from the University of California\, San Diego in 1984. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production.
URL:https://www.simonsfoundation.org/event/april-15-2014-von-neumann-machines-and-molecular-darwinism-2/
LOCATION:NY
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11210206/joyce.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140415T000000
DTEND;TZID=America/New_York:20140415T000000
DTSTAMP:20260413T081442
CREATED:20140207T050000Z
LAST-MODIFIED:20211207T163513Z
UID:2001-1397520000-1397520000@www.simonsfoundation.org
SUMMARY:April 15\, 2014: Von Neumann Machines and Molecular Darwinism
DESCRIPTION:April 15\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY\nIn this lecture\, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines)\, especially those with the capacity to self-reproduce\, and molecular Darwinian systems that maintain heritable ‘bits’ of information\, which are refined through evolution. Such molecular machines have been constructed in the laboratory and are able to reproduce themselves indefinitely. \nJoyce is professor of chemistry and molecular biology\, and an investigator at the Skaggs Institute for Chemical Biology at the Scripps Research Institute in La Jolla\, California. \nJoyce’s research involves the test-tube evolution of nucleic acids and the application of these methods to the development of novel RNA and DNA enzymes. He also has a longstanding interest in the origins of life and the role of RNA in the early history of life on Earth. His laboratory recently described the first example\, outside of biology\, of a self-replicating molecule that is capable of undergoing Darwinian evolution. This so-called ‘immortal molecule’ has been the subject of extensive news coverage\, including by The New York Times\, Scientific American\, CNN and the BBC. \nJoyce received his M.D. and Ph.D. from the University of California\, San Diego in 1984. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production.
URL:https://www.simonsfoundation.org/event/april-15-2014-von-neumann-machines-and-molecular-darwinism/
LOCATION:NY
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205904/Gerry-joyce.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140411T000000
DTEND;TZID=America/New_York:20140411T000000
DTSTAMP:20260413T081442
CREATED:20140331T040000Z
LAST-MODIFIED:20211207T163501Z
UID:2068-1397174400-1397174400@www.simonsfoundation.org
SUMMARY:April 11\, 2014: Conference on Theory & Biology
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/april-11-2014-conference-on-theory-biology/
LOCATION:NY
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20140411
DTEND;VALUE=DATE:20140412
DTSTAMP:20260413T081442
CREATED:20170811T205831Z
LAST-MODIFIED:20190416T175336Z
UID:15096-1397174400-1397260799@www.simonsfoundation.org
SUMMARY:2014 Conference on Theory & Biology
DESCRIPTION:
URL:https://www.simonsfoundation.org/event/2014-conference-on-theory-biology/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Ave\, New York\, NY\, 10010\, United States
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140409T170000
DTEND;TZID=America/New_York:20140409T180000
DTSTAMP:20260413T081442
CREATED:20170428T040000Z
LAST-MODIFIED:20211207T163452Z
UID:452-1397062800-1397066400@www.simonsfoundation.org
SUMMARY:Transcriptional and Epigenetic Mechanisms of Depression
DESCRIPTION:Eric J. Nestler\, M.D.\, Ph.D.\nNash Family Professor and Chairman\, Department of Neuroscience\nDirector\, Friedman Brain Institute\nIcahn School of Medicine at Mount Sinai\nDepression is a common\, chronic\, and debilitating disease. Although many patients benefit from antidepressant medications or other therapies\, only about half show complete remission. Factors that precipitate depression\, such as stress\, are incompletely understood. \nWe have used chronic social defeat stress as an animal model of depression. Prolonged exposure to an aggressor induces lasting changes in behavior such as social avoidance and anhedonia-like symptoms\, which are reversed by chronic (but not acute) treatment with available antidepressants. Roughly one-third of mice subjected to social defeat stress do not exhibit these deleterious behaviors and appear “resilient.” We are exploring the molecular basis of defeat-induced behavioral pathology\, antidepressant action\, and resilience by analyzing genome-wide changes in gene expression and chromatin modifications in several limbic brain regions. One area of focus is the nucleus accumbens\, a key brain reward region implicated in aspects of depression. \nWe have identified sets of genes that remain altered one month after defeat stress. Many of these changes are reversed by chronic antidepressant treatment. Interestingly\, a large subset of these genes\, whose abnormalities are corrected by antidepressants\, appear normal in resilient mice. These findings suggest that antidepressants work in part by inducing changes in gene and chromatin regulation in nucleus accumbens that occur naturally in more resilient individuals. Current studies are underway to investigate the genes and molecular pathways involved in these various responses. Specific genes that control susceptibility\, resilience\, and antidepressant responses will be discussed. \nTogether\, this work provides novel insight into the molecular mechanisms by which chronic stress produces lasting changes in specific brain areas\, and associated changes in the functioning of neural circuits\, to cause depression-like symptoms. The findings also suggest novel leads for the development of new antidepressant treatments. \nAbout the Speaker \n\n\nDr. Nestler is the Nash Family Professor of Neuroscience at the Mount Sinai School of Medicine in New York\, where he serves as Chair of the Department of Neuroscience and Director of the Friedman Brain Institute. He received his B.A.\, Ph.D.\, and M.D. degrees\, and psychiatry residency training\, from Yale University. He served on the Yale faculty from 1987-2000\, where he was the Elizabeth Mears and House Jameson Professor of Psychiatry and Neurobiology\, and Director of the Division of Molecular Psychiatry. He moved to Dallas in 2000 where he served as the Lou and Ellen McGinley Distinguished Professor and Chair of the Department of Psychiatry at The University of Texas Southwestern Medical Center until moving to New York in 2008. Dr. Nestler is a member of the Institute of Medicine and a Fellow of the American Academy of Arts and Sciences. The goal of Dr. Nestler’s research is to better understand the molecular mechanisms of addiction and depression based on work in animal models\, and to use this information to develop improved treatments of these disorders. \n“Transcriptional and Epigenetic Mechanisms of Depression” lecture slides (pdf) \n“Hidden Switches in the Mind” (pdf) \n“Epigenetic Mechanisms of Depression and Antidepressant Action” (pdf)
URL:https://www.simonsfoundation.org/event/transcriptional-and-epigenetic-mechanisms-of-depression/
LOCATION:NY
CATEGORIES:Simons Science Series
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181144/Nestler-MSSM_709_thumb.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140326T163000
DTEND;TZID=America/New_York:20140326T183000
DTSTAMP:20260413T081442
CREATED:20140508T040000Z
LAST-MODIFIED:20211207T163441Z
UID:204-1395851400-1395858600@www.simonsfoundation.org
SUMMARY:An Attempt at Redefining Autism for the Biological Sciences: Implications and Translational Opportunities
DESCRIPTION:In this presentation\, Ami Klin will present infant and toddler data on two behavioral assays measuring highly conserved and developmentally early emerging social adaptive behaviors. His findings suggest that these measures are more proximal to gene expression\, better capture unfolding social adaptive developmental mechanisms and are more presymptomatic and more highly quantitative than prior work. The findings have the potential to bridge genetic determinants and symptomatic outcomes\, create a common framework for gene-brain-behavior research and constrain future models of pathogenesis. \nThese concepts also have translational value in addressing autism as a public health challenge via efforts to develop community-viable systems to reduce age of diagnosis and improve access to early care in the general population. Klin’s programmatic goal at the Marcus Autism Center research enterprise is to capitalize on new science in order to address still-intractable health care challenges. \nAmi Klin\, Ph.D.\, is Georgia Research Alliance Eminent Scholar Professor and director of the division of autism and developmental disabilities at Emory University School of Medicine\, and chief of the Marcus Autism Center\, Children’s Healthcare of Atlanta. He earned his Ph.D. from the University of London and completed clinical and research work at Yale University’s Child Study Center. Until 2010\, he directed the autism program at the Yale Child Study Center\, Yale University School of Medicine\, and was Harris Professor of Child Psychology and Psychiatry there. \nKlin’s primary research focuses on the social mind and brain\, and on the developmental aspects of autism from infancy through adulthood. He is the author of over 180 publications in the field of autism and related conditions and the co-editor of Asperger Syndrome\, Autism Spectrum Disorders in Infants and Toddlers\, the third edition of the Handbook of Autism and Pervasive Developmental Disorders and several special issues of professional journals focused on autism spectrum disorders.
URL:https://www.simonsfoundation.org/event/an-attempt-at-redefining-autism-for-the-biological-sciences-implications-and-translational-opportunities/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180658/Klin1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140326T000000
DTEND;TZID=America/New_York:20140326T000000
DTSTAMP:20260413T081442
CREATED:20140224T050000Z
LAST-MODIFIED:20211207T163432Z
UID:2030-1395792000-1395792000@www.simonsfoundation.org
SUMMARY:March 26\, 2014: An Attempt at Redefining Autism for the Biological Sciences: Implications and Translational Opportunities
DESCRIPTION:March 26\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this presentation\, Ami Klin will present infant and toddler data on two behavioral assays measuring highly conserved and developmentally early emerging social adaptive behaviors. His findings suggest that these measures are more proximal to gene expression\, better capture unfolding social adaptive developmental mechanisms and are more presymptomatic and more highly quantitative than prior work. The findings have the potential to bridge genetic determinants and symptomatic outcomes\, create a common framework for gene-brain-behavior research and constrain future models of pathogenesis. \nThese concepts also have translational value in addressing autism as a public health challenge via efforts to develop community-viable systems to reduce age of diagnosis and improve access to early care in the general population. Klin’s programmatic goal at the Marcus Autism Center research enterprise is to capitalize on new science in order to address still-intractable health care challenges. \nAmi Klin\, Ph.D.\, is Georgia Research Alliance Eminent Scholar Professor and director of the division of autism and developmental disabilities at Emory University School of Medicine\, and chief of the Marcus Autism Center\, Children’s Healthcare of Atlanta. He earned his Ph.D. from the University of London and completed clinical and research work at Yale University’s Child Study Center. Until 2010\, he directed the autism program at the Yale Child Study Center\, Yale University School of Medicine\, and was Harris Professor of Child Psychology and Psychiatry there. \nKlin’s primary research focuses on the social mind and brain\, and on the developmental aspects of autism from infancy through adulthood. He is the author of over 180 publications in the field of autism and related conditions and the co-editor of Asperger Syndrome\, Autism Spectrum Disorders in Infants and Toddlers\, the third edition of the Handbook of Autism and Pervasive Developmental Disorders and several special issues of professional journals focused on autism spectrum disorders. \nTo attend this event\, sign up here.
URL:https://www.simonsfoundation.org/event/march-26-2014-an-attempt-at-redefining-autism-for-the-biological-sciences-implications-and-translational-opportunities/
LOCATION:NY
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DTSTART;TZID=America/New_York:20140323T000000
DTEND;TZID=America/New_York:20140329T000000
DTSTAMP:20260413T081442
CREATED:20150908T040000Z
LAST-MODIFIED:20250813T163845Z
UID:4080-1395532800-1396051200@www.simonsfoundation.org
SUMMARY:Galactic Superwinds: Beyond Phenomenology (2014)
DESCRIPTION:March 23 – 29\, 2014 \nOrganizers:\nAndrew Benson\, Carnegie Observatories\nJuna Kollmeier\, Carnegie Observatories \nThe goal of this symposium was to bring together leading experts in the theory and observation of galactic superwinds — outflows of mass\, momentum and energy from galaxies thought to be driven by radiation and winds from stars\, and by supernova explosions. The major topic of discussion was the physics of cold gas flows ejected at high velocity into a low density\, hot circumgalactic medium\, specifically what physics (magnetic fields\, thermal conduction\, etc.) must be incorporated to accurately model the evolution of these clouds\, and whether these physical processes\, with characteristic length scales on the order of 1 parsec\, can be resolved in cosmological simulations at any point in the foreseeable future. An alternative to fully resolving cloud physics was suggested. In this approach\, a detailed sub-grid model of cloud evolution would be solved for each gas particle in the wind\, computing mass\, energy and momentum mixing rates with the surroundings. These rates would then be applied to the macroscopic gas distribution in the simulation. \nThe symposium also addressed the question of how best to compare theory and observation. Quantities that theorists would like to know can be derived from observations only through the addition of many extra assumptions\, all adding uncertainty to the measurements. For example\, a basic quantity of interest is the mass flux in the wind. Inferring this from observations requires assumptions about the isotropy of the wind\, the radius from which it is launched\, etc.\, leading to uncertainties of 1 to 2 orders of magnitude. A major discussion point arising from this issue was\, where should theory and observations meet? Should observers attempt to estimate mass fluxes using all of the assumptions described above\, or should theorists attempt to model the ionization structure of the outflows in their simulations and extract line profiles from their models that can be compared directly with the observables? Each approach requires assumptions\, and it is unclear which approach (or perhaps some middle ground) is optimal. Therefore\, attempting both approaches and comparing results would be advisable. \n  \nMaterials: \nPublications\n\n	 \n	Publications and preprints resulting from the Simons Symposium on Galactic Superwinds: \n\nThe Systematic Properties of the Warm Phase of Starburst-Driven Galactic Winds; T. Heckman\, R. Alexandroff\, S. Borthakur; in preparation.\nIndirect Evidence for Escaping Lyman Continuum Photons in Local Lyman Break Galaxy Analogs; R. Alexandroff\, T. Heckman\, et al.; submitted to ApJ (2015): http://adsabs.harvard.edu/abs/2015AAS…22525109A.\nConnection Between the Circumgalactic Medium and the Atomic Hydrogen Disk in Galaxies; S. Borthakur\, T. Heckman\, et al.; submitted to ApJ (2015): http://adsabs.harvard.edu/abs/2015AAS…22542701B.\nThe Launching of Cold Clouds by Galaxy Outflows I: Hydrodynamic Interactions with Radiative Cooling; E. Scannapieco & M. Brüggen; (2015): http://arxiv.org/pdf/1503.06800v1.pdf.\nGalaxy Outflows Without Supernovae; S. Sur\, E. Scannapieco\, E. C. Ostriker; in preparation.\nEntrainment in Trouble: Cool Cloud Acceleration and Destruction in Hot Supernova-Driven Galactic Winds; D. Zhang\, T. A. Thompson\, N. Murray\, E. Quataert; to be submitted to MNRAS (2015).\nMagnetized gas clouds can survive acceleration by a hot wind; M. McCourt\, R. O’Leary\, A-M. Madigan\, E. Quataert; MNRAS Letters (2015) 449 (1)\, 2–7: http://dx.doi.org/10.1093/mnras/stv355.\nSub-Eddington Star-Forming Regions Are Super-Eddington: Momentum Driven Outflows from Supersonic Turbulence; A. Thompson & M. R. Krumholz; submitted to MNRAS (2014): http://arxiv.org/abs/1411.1769.\nThe Lyα Line Profiles of Ultraluminous Infrared Galaxies: Fast Winds and Lyman Continuum Leakage; C. L. Martin\, M. Dijkstra\, A. Henry\, K. T. Soto\, C. W. Danforth\, J. Wong; submitted to ApJ (2015): http://arxiv.org/abs/1501.05946.\nBaryon Cycling in the Low-Redshift Circumgalactic Medium: A Comparison of Simulations to the COS-Halos Survey; A. B. Ford\, J. K. Werk\, R. Davé\, J. Tumlinson\, R. Bordoloi\, N. Katz\, J. A. Kollmeier\, B. D. Oppenheimer\, M. S. Peeples\, J. X. Prochaska\, D. H. Weinberg; submitted to MNRAS (2015): http://arxiv.org/abs/1503.02084.\nThe EAGLE project: simulating the evolution and assembly of galaxies and their environments; J. Schaye\, R. A. Crain\, R. G. Bower\, M. Furlong\, M. Schaller\, T. Theuns\, C. D. Vecchia\, C. S. Frenk\, I. G. McCarthy\, J. C. Helly\, A. Jenkins\, Y. M. Rosas-Guevara\, S. D. M. White\, M. Baes\, C. M. Booth\, P. Camps\, J. F. Navarro\, Y. Qu\, A. Rahmati\, T. Sawala\, P. A. Thomas\, J. Trayford; MNRAS (2015) 446 (1)\, 521–554: http://dx.doi.org/10.1093/mnras/stu2058.\nThe EAGLE simulations of galaxy formation: calibration of subgrid physics and model variations; R. A. Crain\, J. Schaye\, R. G. Bower\, M. Furlong\, M. Schaller\, T. Theuns\, C. D. Vecchia\, C. S. Frenk\, I. G. McCarthy\, J. C. Helly\, A. Jenkins\, Y. M. Rosas-Guevara\, S. D. M. White\, J. W. Trayford; submitted to MNRAS (2015): http://arxiv.org/abs/1501.01311.\nEvolution of galaxy stellar masses and star formation rates in the EAGLE simulations; M. Furlong\, R. G. Bower\, T. Theuns\, J. Schaye\, R. A. Crain\, M. Schaller\, C. D. Vecchia\, C. S. Frenk\, I. G. McCarthy\, J. Helly\, A. Jenkins\, Y. M. Rosas-Guevara\, submitted to MNRAS (2014): http://arxiv.org/abs/1410.3485.\nOn the interplay between star formation and feedback in galaxy formation simulations; O. Agertz & A. V. Kravtsov; submitted to and in press at ApJ (2015): http://arxiv.org/abs/1404.2613.\nStellar feedback driven winds and galaxy morphology; O. Agertz & A. Kravtsov; to be submitted.\nThe distribution of neutral hydrogen around high-redshift galaxies and quasars in the EAGLE simulation;  Rahmati\, J. Schaye\, R. G. Bower\, R. A. Crain\, M. Furlong\, M. Schaller\, T. Theuns; submitted to MNRAS (2015): http://arxiv.org/abs/1503.05553.\nGalaxies that shine: radiation-hydrodynamical simulations of disk galaxies; Rosdahl\, J. Schaye\, R. Teyssier\, O. Agertz; submitted to MNRAS (2015): http://arxiv.org/abs/1501.04632.\nDetection of hot\, metal-enriched outflowing gas around z ≈ 2.3 star-forming galaxies in the Keck Baryonic Structure Survey;  L. Turner\, J. Schaye\, C. C. Steidel\, G. C. Rudie\, A. L. Strom; submitted to MNRAS (2014): http://arxiv.org/abs/1410.8214.\n\n\nPresentation Slides\n\n	Rob Crain\, Leiden Observatory\n	Download Slides \n	Romeel Davé\, Arizona State University\n	Download Slides \n	Nick Gnedin\, University of Chicago/Fermilab\n	Download Slides \n	Mark Krumholz\, UC Santa Cruz\n	Download Slides \n	Eliot Quataert\, UC Berkeley\n	Download Slides \n	Joop Schaye\, Leiden Observatory\n	Download Slides \n	David Weinberg\, Ohio State\n	Download Slides\n\n$(‘#presentation-slides’).toggle(0);\nSession Slides\n\nRichard Bower\, University of Durham\nOutflow Questions \nRob Crain\, Leiden Observatory\nPre-SNe Stellar Winds\, Intermediate Age Populations\, Momentum Driving Relevance on Scales Beyond GMCs\, 1051 erg/SN\, Short AGN Duty Cycles\, Accuracy of Models (SAM/hydro)\, Dwarf Galaxy Simulation Parameters v. Observational Constraints \nRomeel Davé\, Arizona State University\nWind Propagation & Mixing \nNick Gnedin\, University of Chicago/Fermilab\nHow We Should Think About Star Formation \nNeal Katz\, University of Massachusetts\nPhenomenologically Obtained Winds (POW) \nDusan Keres\, University of San Diego\nChallenges in (Numerical) Galactic Wind Modeling \nMark Krumholz\, UC Santa Cruz\nGalactic Winds: The “Last pc” Problem \nCrystal Martin\, UC Santa Barbara\nWhat Is the Mass Flux in Galactic Winds? \nEliot Quataert\, UC Berkeley\nGalactic Winds (impact of star formation vs. AGNs\, role of cosmic rays\, level of detail needed/feasible for predictive galaxy formation models) \nBrant Robertson\, University of Arizona\nPhysical Coupling of Winds to the Turbulent Interstellar Medium \nEvan Scannapieco\, Arizona State University\nWhat are the Turbulent Velocity and Scale Height in Starbursting Galaxies? \nJoop Schaye\, Leiden Observatory\nKey Challenges in Wind Modeling \nSijing Shen\, UC Santa Cruz\nChallenges in Galactic Wind Modeling \nChuck Steidel\, Cal Tech\nNon-Exhaustive List of Questions \nGreg Stinson\, Max-Planck-Institut für Astronomie\nHow Do Outflows Work? \nTodd Thompson\, Ohio State\nTheoretical & Observational Challenges \nFreeke van de Voort\, UC Berkeley\nAspects in Need of Simulation and Study \nDavid Weinberg\, Ohio State\nPrimary Questions of Galaxy Formation / What Happens to Gas After it is Ejected? / Other Key Isssues \n\nSymposium Agenda\n\nDownload PDF \nGalactic Superwinds: Beyond Phenomenology\nMarch 23 – 29\, 2014 \n\n\n\n\n	\n\nMONDAY: ISM\n\n\n9:00 – 10:30 AM\nStar Formation\nModerators: Gnedin & Krumholz\n\n\n11:00 AM – 12:30 PM\nTurbulence\nModerators: Robertson & Scannapieco\n\n\n4:00 – 5:30 PM\nStellar Populations / Stellar Winds / Supernovae\nModerators: Crain & Schaye\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n8:30 – 10:00 PM\nNumerics @ Night\nModerator: Krumholz\n\n\n \n\n\nTUESDAY: Energy Input\n\n\n9:00 – 10:30 AM\nAGN/Preventative Feedback\nModerators: Quataert & Katz\n\n\n11:00 AM – 12:30 PM\nKnown Unknowns(Magnetics Fields\, Cosmic Rays\, etc.)\nModerators: Stinson\, Keres & Schaye\n\n\n4:00 – 5:30 PM\nCoupling to ISM\nModerators: Thompson & Krumholz\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n8:30 – 10:00 PM\nNumerics @ Night\nModerator: Katz\n\n\n \n\n\nWEDNESDAY: Wind Structure\n\n\n9:00 – 10:30 AM\nMass\, Energy\, Momentum & Metal Fluxes\nModerators: Davé & Martin\n\n\n11:00 AM – 12:30 PM\nMultiphase Wind Structure\nModerators: Keres & Steidel\n\n\n2:30 – 4:00 PM\nCoupling to the CGM\nModerators: Shen & Heckman\n\n\n \n\n\nTHURSDAY: Diagnostics\nÜber Moderators: Steidel\, Heckman\, Martin\n\n\n9:00 – 10:30 AM\nISM\nModerator: Murray\n\n\n11:00 AM – 12:30 PM\nGalactic\nModerator: van de Voort\n\n\n4:00 – 5:30 PM\nCGM\nModerator: Weinberg\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n8:30 – 10:00 PM\nNumerics @ Night\nModerator: Shen & Keres\n\n\n \n\n\nFRIDAY: Synthesis\n\n\n9:00 – 10:30 AM\nObservational\nModerators: Steidel\, Heckman & Martin\n\n\n11:00 AM – 12:30 PM\nTheoretical/Numerical\nModerators: Bower\, Kravtsov & Murray\n\n\n4:00 – 5:30 PM\nRoadmap\nModerators: Benson\, Kollmeier\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n\n \nParticipants: \nAndrew Benson\, Carnegie Observatories\nRichard Bower\, University of Durham\nRob Crain\, Leiden Observatory\nRomeel Dave\, Arizona State University\nNick Gnedin\, University of Chicago/Fermilab\nTim Heckman\, Johns Hopkins University\nNeal Katz\, University of Massachusetts\nDusan Keres\, University of San Diego\nJuna Kollmeier\, Carnegie Observatories\nAndrey Kravtsov\, University of Chicago\nMark Krumholz\, UC Santa Cruz\nCrystal Martin\, UC Santa Barbara\nNorman Murray\, Canadian Institute of Theoretical Astrophysics\nEliot Quataert\, UC Berkeley\nBrant Robertson\, University of Arizona\nEvan Scannapieco\, Arizona State University\nJoop Schaye\, Leiden Observatory\nSijing Shen\, UC Santa Cruz\nChuck Steidel\, Cal Tech\nGreg Stinson\, Max-Planck-Institut für Astronomie\nTodd Thompson\, Ohio State\nFreeke van de Voort\, UC Berkeley\nDavid Weinberg\, Ohio State
URL:https://www.simonsfoundation.org/event/galactic-superwinds-beyond-phenomenology-march-23-29-2014/
LOCATION:NY
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20140312T153000
DTEND;TZID=America/New_York:20140312T180000
DTSTAMP:20260413T081442
CREATED:20140612T040000Z
LAST-MODIFIED:20211207T163628Z
UID:229-1394638200-1394647200@www.simonsfoundation.org
SUMMARY:Learning With a Nontrivial Teacher
DESCRIPTION:In this lecture\, Vladimir Vapnik will discuss how the LUPI learning model can take the form of comments\, descriptions\, metaphoric reasoning and other teaching tactics. He will describe the goal of the model — to develop good decision rules even when only a small number of examples is provided. \nVladimir Vapnik\, Ph.D. works in the machine learning department at NEC Laboratories America\, Inc. and is professor of computer science at Columbia University. He has made major contributions to computer science and machine learning\, including a general theory for minimizing the expected risk of losses using empirical data\, and the widely used Support Vector Machine approach to classification. Among his many honors are the 2003 Humboldt Research Award\, the 2005 Gabor Award\, the 2010 Neural Networks Pioneer Award\, the 2012 IEEE Frank Rosenblatt Award and the 2012 Benjamin Franklin Medal in Computer and Cognitive Science from the Franklin Institute. He was elected to the National Academy of Engineering in 2006 for “insights into the fundamental complexities of learning and for inventing practical and widely applied machine-learning algorithms.” \nIf this lecture is videotaped\, it will be posted here after production.
URL:https://www.simonsfoundation.org/event/learning-with-a-nontrivial-teacher/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Frontiers of Data Science
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DTSTART;TZID=America/New_York:20140312T000000
DTEND;TZID=America/New_York:20140312T000000
DTSTAMP:20260413T081442
CREATED:20140107T050000Z
LAST-MODIFIED:20211207T163617Z
UID:1998-1394582400-1394582400@www.simonsfoundation.org
SUMMARY:March 12\, 2014: Learning With a Nontrivial Teacher
DESCRIPTION:March 12\, 2014\, 3:30-6:00 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Vladimir Vapnik will discuss how the LUPI learning model can take the form of comments\, descriptions\, metaphoric reasoning and other teaching tactics. He will describe the goal of the model — to develop good decision rules even when only a small number of examples is provided. \nVladimir Vapnik\, Ph.D. works in the machine learning department at NEC Laboratories America\, Inc. and is professor of computer science at Columbia University. He has made major contributions to computer science and machine learning\, including a general theory for minimizing the expected risk of losses using empirical data\, and the widely used Support Vector Machine approach to classification. Among his many honors are the 2003 Humboldt Research Award\, the 2005 Gabor Award\, the 2010 Neural Networks Pioneer Award\, the 2012 IEEE Frank Rosenblatt Award and the 2012 Benjamin Franklin Medal in Computer and Cognitive Science from the Franklin Institute. He was elected to the National Academy of Engineering in 2006 for “insights into the fundamental complexities of learning and for inventing practical and widely applied machine-learning algorithms.” \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production.
URL:https://www.simonsfoundation.org/event/march-12-2014-learning-with-a-nontrivial-teacher/
LOCATION:NY
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DTSTART;TZID=America/New_York:20140309T000000
DTEND;TZID=America/New_York:20140315T000000
DTSTAMP:20260413T081442
CREATED:20150908T040000Z
LAST-MODIFIED:20250813T163805Z
UID:4079-1394323200-1394841600@www.simonsfoundation.org
SUMMARY:Discrete Analysis: Beyond the Boolean Cube (2014)
DESCRIPTION:March 9 – 15\, 2014 \nOrganizers:\nElchanan Mossel\, UC Berkeley\nRyan O’Donnell\, Carnegie Mellon University\nKrzysztof Oleszkiewicz\, University of Warsaw \nThe Simons Symposium on Discrete Analysis: Beyond the Boolean Cube was the second symposium organized on this topic. The first was held in 2012 and was called Analysis of Boolean Functions. This most recent meeting focused on the interplay between the discrete cube setting and its non-commutative\, non-independent\, continuous\, and number-theoretic counterparts. Key topics included Fourier analysis on groups\, discrete analysis in additive groups and fields\, invariance principles\, discrete partitions of Gaussian and spherical spaces\, Gaussian isoperimetric problems\, connections between boundedness of Gaussian and Rademacher processes\, explicit optimal rounding of semidefinite programs\, and connections to Markov chains. \nMaterials:\nPresentation Slides\n\n \nBoaz Barak\,\nMicrosoft Research\nSome questions\, results\, and musings on Sums of Squares\, Unique Games Conjecture\, Hypercontractive norms\, Sparse vectors\, and other issues. \nWitold Bednorz\,\nUniversity of Warsaw\n(joint work with Rafal Latala)\nBeyond Bernoulli Theorem \nSubhash Khot\,\nNew York University\n(Joint work with Madhur Tulsiani and Pratik Worah)\nA Characterization of Strong Approximation Resistance \nAlexandra Kolla\,\nUniversity of Illinois Urbana-Champaign\nMaximal Inequalities Beyond the Boolean Cube \nRaghu Meka\,\nMicrosoft Research\nA PTAS for Computing the Supremum of Gaussian Processes \nYuval Peres\,\nMicrosoft Research\n(Joint work with Yael Dekel at The Hebrew University and Ori Gurel-Gurevich at University of British Columbia)\nFinding Hidden Cliques in Linear Time with High Probability \nLi-Yang Tan\,\nColumbia University\n(Joint work with Rocco Servedio)\nA Polynomial Lower Bound for Monotonicity Testing of Boolean Functions\n\nSymposium Agenda\n\nDownload PDF \nDiscrete Analysis: Beyond the Boolean Cube\nMarch 9 – 15\, 2014 \n\n\n\n\n	\n\n \n\n\nMonday\n\n\n9:00 – 9:30 AM\nAvi Wigderson\nCan Every Sequential Computation be Efficiently Parallelized?\n\n\n9:30 – 10:00 AM\nRafal Latala\nSuprema of Bernoulli Processes\n\n\n10:00 – 10:30 AM\nWitold Bednorz\nBeyond the Bernoulli Theorem\n\n\n11:00 – 11:30 AM\nYuval Filmus\nStability Results Beyond the Boolean Cube and the EKR Theorem\n\n\n11:30 AM – 12:00 PM\nRaghu Meka\nA PTAS for Computing the Supremum of Gaussian Processes\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 7:00 PM\nLonger Talk\n\n\n\n \n\n\nTuesday\n\n\n9:00 – 9:30 AM\nTom Sanders\nThe Green-Bourgain Sumset Problem\n\n\n9:30 – 10:00 AM\nThomas Vidick\nNon-commutative Extensions of Grothendieck’s Inequality\n\n\n10:00 – 10:30 AM\nOded Regev\nExtensions of Spencer’s Discrepancy Theorem\n\n\n11:00 – 11:30 AM\nLi-Yang Tan\nA Polynomial Lower Bound for Monotonicity Testing of Boolean Functions\n\n\n11:30 AM – 12:00 PM\nEhud Friedgut\nExtremal Problems in Symmetric Group via Fourier Analysis\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 7:00 PM\nLonger Talk\nChosen by Participants\n\n\n \n\n\nWednesday\n\n\n9:00 – 9:30 AM\nSubhash Khot\nA Characterization of Approximation Resistance\n\n\n9:30 – 10:00 AM\nBoaz Barak\nSums of Squares\, Optimizing Over Sparse Vectors\, and Hypercontractive Norms\n\n\n10:30 – 11:00 AM\nJulia Wolf\nBeyond the Gowers Norms\n\n\n11:00 – 11:30 AM\nStanislaw Szarek\nMeasures on\, and Generic Properties for N Qubits\n\n\n11:30 AM – 12:00 PM\nChristophe Garban\nQuestions around the Mixing Time of the Critical Ising Model and the Majority in Stablest Theorem\n\n\n2:00 – 3:00 PM\nOpen Problem Session\n\n\n\n \n\n\nThursday\n\n\n10:00 – 10:30 AM\nSergey Bobkov\nConcentration on the Cube for Permutationally Invariant Sets\n\n\n11:00 – 11:30 AM\nAlmut Burchard\nTwo-point Symmetrization and some Applications to Path Integrals\n\n\n11:30 AM – 12:00 PM\nAlexandra Kolla\nDiscrete Maximal Inequalities Beyond the Boolean cube and Bounds on Orthogonal Polynomials\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 6:00 PM\nJoe Neeman\nThe Majority is Stablest Theorem on Non-product Spaces\n\n\n6:00 – 6:30 PM\nYuval Peres\n1. The Majority is Least Stable Conjecturei2. Concentration of Lipschitz Functions of Negatively Associated Variables\n\n\n \n\n\nFriday\n\n\n9:00 – 10:00 AM\nLonger Talk\nChosen by Participants\n\n\n10:30 – 11:30 AM\nLonger Talk\nChosen by Participants\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 7:00 PM\nProgress Report\n\n\n\n\n \nSite: http://analysisofbooleanfunctions.org \nParticipants: \nBoaz Barak\, Microsoft Research New England\nWitold Bednorz\, University of Warsaw\nSergey Bobkov\, University of Minnesota\nAlmut Burchard\, University of Toronto\nYuval Filmus\, University of Toronto\nEhud Friedgut\, The Einstein Institute of Mathematics\nChristophe Garban\, ENS Lyon\, UMPA\nSubhash Khot\, New York University\nAlexandra Kolla\, University of Illinois at Urbana-Champaign\nRafal Latala\, University of Warsaw\nRaghu Meka\, IAS\nElchanan Mossel\, UC Berkeley\nJoe Neeman\, UC Berkeley\nRyan O’Donnell\, Carnegie Mellon University\nKrzysztof Oleszkiewicz\, University of Warsaw\nYuval Peres\, Microsoft Research\nOded Regev\, New York University\nTom Sanders\, Oxford University\nStanislaw Szarek\, Case Western Reserve University\nLi-Yang Tan\, Columbia University\nYuri Tschinkel\, Simons Foundation\nThomas Vidick\, MIT\nAvi Wigderson\, IAS\nJulia Wolf\, École Polytechnique
URL:https://www.simonsfoundation.org/event/discrete-analysis-beyond-the-boolean-cube-march-9-15-2014/
LOCATION:NY
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