BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Simons Foundation - ECPv6.6.3//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Simons Foundation X-ORIGINAL-URL:https://www.simonsfoundation.org X-WR-CALDESC:Events for Simons Foundation REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/New_York BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20140309T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20141102T060000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/New_York:20140528T000000 DTEND;TZID=America/New_York:20140528T000000 DTSTAMP:20260413T093433 CREATED:20140224T050000Z LAST-MODIFIED:20211207T163224Z UID:2034-1401235200-1401235200@www.simonsfoundation.org SUMMARY:May 28\, 2014: Keeping Your Brain in Balance: Do Defects in Neuronal Homeostasis Contribute to Autism Spectrum Disorders? DESCRIPTION:May 28\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Gina Turrigiano will describe the plasticity mechanisms that allow our brains to ‘tune themselves up’ and remain both plastic and stable. These mechanisms include a family of ‘homeostatic’ plasticity mechanisms that allow neurons to adjust their excitability to maintain constant firing rates in the face of outside perturbations. Recently\, Turrigiano has investigated the role of homeostatic plasticity in the experience-dependent development of the visual cortex\, especially how homeostatic mechanisms interact with classical forms of synaptic plasticity to allow experience-dependent circuit refinement. A major goal of Turrigiano’s lab is to determine the molecular and biophysical mechanisms of homeostatic plasticity and use this knowledge to perturb these mechanisms in intact cortex. These studies are generating insights into the normal function of cortical microcircuits and into how the failure of homeostatic plasticity mechanisms might contribute to developmental defects in brain wiring that contribute to autism spectrum disorders. \nGina Turrigiano received her her Ph.D. from the University of California\, San Diego. She trained as a postdoc with Eve Marder at Brandeis University before joining the Brandeis faculty in 1994. She is now a full professor in the department of biology\, the Volen Center for Complex Systems and the Center for Behavioral Genomics at Brandeis. \nTurrigiano has received numerous awards for her research\, including a National Institutes of Health (NIH) career development award\, a Sloan Foundation fellowship\, a MacArthur Foundation fellowship\, McKnight Foundation Technological Innovation and Neurobiology of Disease awards\, an NIH director’s pioneer award\, the HFSP Nakasone Award\, election to the American Academy of Arts and Sciences and election to the National Academy of Sciences. Her scientific interests include mechanisms of synaptic and intrinsic plasticity and the experience-dependent refinement of neocortical microcircuitry. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/may-28-2014-keeping-your-brain-in-balance-do-defects-in-neuronal-homeostasis-contribute-to-autism-spectrum-disorders/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205949/Turrigiano1-pic-copy.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140521T154500 DTEND;TZID=America/New_York:20140521T181500 DTSTAMP:20260413T093433 CREATED:20140612T040000Z LAST-MODIFIED:20211207T163214Z UID:227-1400687100-1400696100@www.simonsfoundation.org SUMMARY:Probabilistic Topic Models of Text and Users DESCRIPTION:In this talk\, David Blei will review the basics of topic modeling and describe his recent research on collaborative topic models—models that simultaneously analyze documents and the corresponding reader behavior. Blei will explain how using collaborative topic models to discover patterns in how people read can help point readers to relevant new documents. Finally\, he will discuss the broader field of probabilistic modeling\, which gives data scientists both a rich language for expressing statistical assumptions and scalable algorithms for using those assumptions to uncover hidden patterns in massive data. \nDavid Blei is associate professor of computer science at Princeton University. Blei’s research focuses on developing methods for finding patterns in large datasets. He has received awards including a Sloan Fellowship (2010)\, the Office of Naval Research Young Investigator Award (2011)\, the Presidential Early Career Award for Scientists and Engineers (2011)\, the Blavatnik Faculty Award (2013) and the ACM-Infosys Foundation Award (2013). Blei earned his Ph.D. in computer science from the University of California\, Berkeley. URL:https://www.simonsfoundation.org/event/probabilistic-topic-models-of-text-and-users/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Frontiers of Data Science ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180722/blei-hi-res-426x6401.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140521T000000 DTEND;TZID=America/New_York:20140521T000000 DTSTAMP:20260413T093433 CREATED:20140411T040000Z LAST-MODIFIED:20211207T163205Z UID:2079-1400630400-1400630400@www.simonsfoundation.org SUMMARY:May 21\, 2014: Probabilistic Topic Models of Text and Users DESCRIPTION:May 21\, 2014\, 3:45-6:00 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this talk\, David Blei will review the basics of topic modeling and describe his recent research on collaborative topic models—models that simultaneously analyze documents and the corresponding reader behavior. Blei will explain how using collaborative topic models to discover patterns in how people read can help point readers to relevant new documents. Finally\, he will discuss the broader field of probabilistic modeling\, which gives data scientists both a rich language for expressing statistical assumptions and scalable algorithms for using those assumptions to uncover hidden patterns in massive data. \nDavid Blei is associate professor of computer science at Princeton University. Blei’s research focuses on developing methods for finding patterns in large datasets. He has received awards including a Sloan Fellowship (2010)\, the Office of Naval Research Young Investigator Award (2011)\, the Presidential Early Career Award for Scientists and Engineers (2011)\, the Blavatnik Faculty Award (2013) and the ACM-Infosys Foundation Award (2013). Blei earned his Ph.D. in computer science from the University of California\, Berkeley. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/may-21-2014-probabilistic-topic-models-of-text-and-users/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11210056/blei-hi-res.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140507T170000 DTEND;TZID=America/New_York:20140507T180000 DTSTAMP:20260413T093433 CREATED:20170428T040000Z LAST-MODIFIED:20211207T163420Z UID:454-1399482000-1399485600@www.simonsfoundation.org SUMMARY:Big Data Analytics and a Path to Enhancing Our Understanding of Human Disease DESCRIPTION:Dr. Schadt provides an overview of how his team organizes very large scale data across many different types\, and then integrates these data using sophisticated mathematical algorithms to construct predictive network models of disease. This approach well complements the type of natural artificial intelligence/machine learning approaches that have become nearly standard in the life and biomedical sciences for building classifiers for a whole range of problems (disease classification\, subtype classification\, drug response classification\, and so on). By building a causal network model that spans multiple scales (from the molecular to the cellular\, to the tissue/organ\, to the organism and community) we can understand the flow of information and how best to modulate that flow to improve human wellbeing\, whether better diagnosing and treating disease or improving overall health. Examples of building these predictive network models across a range of diseases are given\, covering areas such as Alzheimer’s disease\, inflammatory bowel disease\, and diabetes. \nDr. Schadt also discusses the application of this type of modeling in the cancer arena where interpreting any given cancer case in the context of the digital universe of information relating to the cancer of interest is carried out using predictive network models to inform on personalized treatment options for a given patient\, including personalized vaccines or novel drug combinations. \nView/Download Slides (PDF)\nAbout the Speaker \nDr. Schadt is Chair of the Department of Genetics and Genomic Sciences\, Director of the Icahn Institute for Genomics and Multiscale Biology\, and Jean C. & James W. Crystal Professor of Genomics at the Icahn School of Medicine at Mount Sinai. Dr. Schadt’s lab and broader efforts at the Icahn Institute focus on the integration of diverse\, very large scale data to build predictive models of disease that can aid in providing more accurate diagnoses of disease and how best to treat it. \nDr. Schadt is an expert on the generation and integration of very large-scale sequence variation\, molecular profiling and clinical data in disease populations for constructing molecular networks that define disease states and link molecular biology to physiology. He is known for calling for a shift in molecular biology toward a network-oriented view of living systems to complement the reductionist\, single-gene approaches that currently dominate biology in order to more accurately model the complexity of biological systems. Dr. Schadt’s research has provided novel insights into what is needed to master diverse\, large-scale data collected on normal and disease populations in order to elucidate the complexity of disease and make more informed decisions in the drug discovery arena. He has published more than 200 peer-reviewed papers in leading scientific journals\, and contributed to a number of discoveries relating to the genetic basis of common human diseases such as diabetes\, obesity\, and Alzheimer’s disease. \nDr. Schadt is also a founding member of Sage Bionetworks\, an open-access genomics initiative designed to build and support databases and an accessible platform for creating innovative dynamic disease models. Prior to joining Mount Sinai in 2011\, he was Chief Scientific Officer at Pacific Biosciences\, the next-generation sequencing technology provider. Previously\, Dr. Schadt was Executive Scientific Director of Genetics at Rosetta Inpharmatics\, a subsidiary of Merck & Co.\, Inc. in Seattle\, and before Rosetta\, Dr. Schadt was a Senior Research Scientist at Roche Bioscience. He received his B.A. in applied mathematics and computer science from California Polytechnic State University\, his M.A. in pure mathematics from University of California\, Davis\, and his Ph.D. in bio-mathematics from University of California\, Los Angeles (requiring Ph.D. candidacy in molecular biology and mathematics). URL:https://www.simonsfoundation.org/event/big-data-analytics-and-a-path-to-enhancing-our-understanding-of-human-disease/ LOCATION:NY CATEGORIES:Simons Science Series ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181145/Eric_Schadt.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140430T154500 DTEND;TZID=America/New_York:20140430T180000 DTSTAMP:20260413T093433 CREATED:20140617T040000Z LAST-MODIFIED:20211207T163407Z UID:243-1398872700-1398880800@www.simonsfoundation.org SUMMARY:Where is Fundamental Physics Heading? DESCRIPTION:In recent decades\, physicists and astronomers have discovered two beautiful standard models\, one for the quantum world of extremely short distances and one for the universe as a whole. Both models have had spectacular success\, but there are also strong arguments for new physics beyond these models. \nIn this lecture\, Nathan Seiberg will review these models\, their successes and their shortfalls. He will describe how experiments in the near future could point to new physics to suggest a profound conceptual revolution in our understanding of the world. \nSeiberg received his Ph.D. in 1982 from the Weizmann Institute of Science in Israel\, where he worked from 1985 to 1991 as senior scientist\, associate professor and professor. From 1989 to 1997\, he was a professor at Rutgers University in New Jersey. He joined the faculty at the Institute for Advanced Study in New Jersey in 1997. \nSeiberg has received many awards and honors\, including a MacArthur Fellowship\, the Oskar Klein Medal\, the Dannie Heineman Prize for Mathematical Physics of the American Physical Society and the American Institute of Physics\, and the Fundamental Physics Prize. He is a member of both the American Academy of Arts and Sciences and the National Academy of Sciences. \n  URL:https://www.simonsfoundation.org/event/where-is-fundamental-physics-heading/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180737/Seiberg-Nathan_20121.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140430T000000 DTEND;TZID=America/New_York:20140430T000000 DTSTAMP:20260413T093433 CREATED:20140307T050000Z LAST-MODIFIED:20211207T163354Z UID:2056-1398816000-1398816000@www.simonsfoundation.org SUMMARY:April 30\, 2014: Where is Fundamental Physics Heading? DESCRIPTION:April 30\, 2014\, 3:45-6:00 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn recent decades\, physicists and astronomers have discovered two beautiful standard models\, one for the quantum world of extremely short distances and one for the universe as a whole. Both models have had spectacular success\, but there are also strong arguments for new physics beyond these models. \nIn this lecture\, Nathan Seiberg will review these models\, their successes and their shortfalls.  He will describe how experiments in the near future could point to new physics to suggest a profound conceptual revolution in our understanding of the world. \nSeiberg received his Ph.D. in 1982 from the Weizmann Institute of Science in Israel\, where he worked from 1985 to 1991 as senior scientist\, associate professor and professor.  From 1989 to 1997\, he was a professor at Rutgers University in New Jersey. He joined the faculty at the Institute for Advanced Study in New Jersey in 1997. \nSeiberg has received many awards and honors\, including a MacArthur Fellowship\, the Oskar Klein Medal\, the Dannie Heineman Prize for Mathematical Physics of the American Physical Society and the American Institute of Physics\, and the Fundamental Physics Prize. He is a member of both the American Academy of Arts and Sciences and the National Academy of Sciences. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/april-30-2014-where-is-fundamental-physics-heading/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11210023/Seiberg-Nathan_2012.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140423T163000 DTEND;TZID=America/New_York:20140423T183000 DTSTAMP:20260413T093433 CREATED:20140508T040000Z LAST-MODIFIED:20211207T163345Z UID:206-1398270600-1398277800@www.simonsfoundation.org SUMMARY:New Insights and Approaches for Studying Rett Syndrome\, an Autism-Associated Disorder DESCRIPTION:In this lecture\, Gail Mandel will provide a general introduction to Rett syndrome (RTT)\, a neurodevelopmental disease of girls that results from defects in the gene encoding of the transcription factor methyl-CpG-binding protein 2 (MeCP2). She will provide evidence that the pathology is complex\, involving defects in both neurons and astrocytes in conventional RTT mouse models. She will discuss emerging ideas about the normal function of the MeCP2 protein and her recent findings that point to a role for MeCP2 in 3-D chromatin architecture. Finally\, she will discuss whether Rett syndrome could be amenable to gene replacement strategies. \nGail Mandel holds a Ph.D. in immunology from the University of California\, Los Angeles (UCLA) and did postdoctoral work in biochemistry and molecular biology at UCLA; the University of California\, San Diego; and Harvard Medical School. She began her career at Tufts Medical School in Boston\, where she was one of the first investigators to clone and express mammalian voltage-dependent ion channels. In the department of neurobiology and behavior at Stony Brook University\, she identified the protein REST\, which is responsible for regulation of sodium channel expression and the acquisition of cellular excitability. These discoveries have helped unlock the mechanisms through which embryonic cell types differentiate specifically into neurons. Currently\, Mandel is a senior scientist in the Vollum Institute at Oregon Health & Science University. She is an Investigator of the Howard Hughes Medical Institute and a member of the American Academy of Sciences and National Academy of Sciences. \n  URL:https://www.simonsfoundation.org/event/new-insights-and-approaches-for-studying-rett-syndrome-an-autism-associated-disorder/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Autism: Emerging Concepts ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180700/mandel1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140423T000000 DTEND;TZID=America/New_York:20140423T000000 DTSTAMP:20260413T093433 CREATED:20140224T050000Z LAST-MODIFIED:20211207T163333Z UID:2032-1398211200-1398211200@www.simonsfoundation.org SUMMARY:April 23\, 2014: New Insights and Approaches for Studying Rett Syndrome\, an Autism-Associated Disorder DESCRIPTION:April 23\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Gail Mandel will provide a general introduction to Rett syndrome (RTT)\, a neurodevelopmental disease of girls that results from defects in the gene encoding of the transcription factor methyl-CpG-binding protein 2 (MeCP2). She will provide evidence that the pathology is complex\, involving defects in both neurons and astrocytes in conventional RTT mouse models. She will discuss emerging ideas about the normal function of the MeCP2 protein and her recent findings that point to a role for MeCP2 in 3-D chromatin architecture. Finally\, she will discuss whether Rett syndrome could be amenable to gene replacement strategies. \nGail Mandel holds a Ph.D. in immunology from the University of California\, Los Angeles (UCLA) and did postdoctoral work in biochemistry and molecular biology at UCLA; the University of California\, San Diego; and Harvard Medical School. She began her career at Tufts Medical School in Boston\, where she was one of the first investigators to clone and express mammalian voltage-dependent ion channels. In the department of neurobiology and behavior at Stony Brook University\, she identified the protein REST\, which is responsible for regulation of sodium channel expression and the acquisition of cellular excitability. These discoveries have helped unlock the mechanisms through which embryonic cell types differentiate specifically into neurons. Currently\, Mandel is a senior scientist in the Vollum Institute at Oregon Health & Science University. She is an Investigator of the Howard Hughes Medical Institute and a member of the American Academy of Sciences and National Academy of Sciences. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/april-23-2014-new-insights-and-approaches-for-studying-rett-syndrome-an-autism-associated-disorder/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205946/mandel.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140415T163000 DTEND;TZID=America/New_York:20140415T183000 DTSTAMP:20260413T093433 CREATED:20140617T040000Z LAST-MODIFIED:20211207T163308Z UID:245-1397579400-1397586600@www.simonsfoundation.org SUMMARY:Von Neumann Machines and Molecular Darwinism DESCRIPTION:In this lecture\, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines)\, especially those with the capacity to self-reproduce\, and molecular Darwinian systems that maintain heritable ‘bits’ of information\, which are refined through evolution. Such molecular machines have been constructed in the laboratory and are able to reproduce themselves indefinitely. \nJoyce is professor of chemistry and molecular biology\, and an investigator at the Skaggs Institute for Chemical Biology at the Scripps Research Institute in La Jolla\, California. \nJoyce’s research involves the test-tube evolution of nucleic acids and the application of these methods to the development of novel RNA and DNA enzymes. He also has a longstanding interest in the origins of life and the role of RNA in the early history of life on Earth. His laboratory recently described the first example\, outside of biology\, of a self-replicating molecule that is capable of undergoing Darwinian evolution. This so-called ‘immortal molecule’ has been the subject of extensive news coverage\, including by The New York Times\, Scientific American\, CNN and the BBC. \nJoyce received his M.D. and Ph.D. from the University of California\, San Diego in 1984. URL:https://www.simonsfoundation.org/event/von-neumann-machines-and-molecular-darwinism/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Origins of Life ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180739/joyce1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140415T000000 DTEND;TZID=America/New_York:20140415T000000 DTSTAMP:20260413T093433 CREATED:20140610T040000Z LAST-MODIFIED:20211207T163523Z UID:2128-1397520000-1397520000@www.simonsfoundation.org SUMMARY:April 15\, 2014: Von Neumann Machines and Molecular Darwinism DESCRIPTION:April 15\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines)\, especially those with the capacity to self-reproduce\, and molecular Darwinian systems that maintain heritable ‘bits’ of information\, which are refined through evolution. Such molecular machines have been constructed in the laboratory and are able to reproduce themselves indefinitely. \nJoyce is professor of chemistry and molecular biology\, and an investigator at the Skaggs Institute for Chemical Biology at the Scripps Research Institute in La Jolla\, California. \nJoyce’s research involves the test-tube evolution of nucleic acids and the application of these methods to the development of novel RNA and DNA enzymes. He also has a longstanding interest in the origins of life and the role of RNA in the early history of life on Earth. His laboratory recently described the first example\, outside of biology\, of a self-replicating molecule that is capable of undergoing Darwinian evolution. This so-called ‘immortal molecule’ has been the subject of extensive news coverage\, including by The New York Times\, Scientific American\, CNN and the BBC. \nJoyce received his M.D. and Ph.D. from the University of California\, San Diego in 1984. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/april-15-2014-von-neumann-machines-and-molecular-darwinism-2/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11210206/joyce.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140415T000000 DTEND;TZID=America/New_York:20140415T000000 DTSTAMP:20260413T093433 CREATED:20140207T050000Z LAST-MODIFIED:20211207T163513Z UID:2001-1397520000-1397520000@www.simonsfoundation.org SUMMARY:April 15\, 2014: Von Neumann Machines and Molecular Darwinism DESCRIPTION:April 15\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY\nIn this lecture\, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines)\, especially those with the capacity to self-reproduce\, and molecular Darwinian systems that maintain heritable ‘bits’ of information\, which are refined through evolution. Such molecular machines have been constructed in the laboratory and are able to reproduce themselves indefinitely. \nJoyce is professor of chemistry and molecular biology\, and an investigator at the Skaggs Institute for Chemical Biology at the Scripps Research Institute in La Jolla\, California. \nJoyce’s research involves the test-tube evolution of nucleic acids and the application of these methods to the development of novel RNA and DNA enzymes. He also has a longstanding interest in the origins of life and the role of RNA in the early history of life on Earth. His laboratory recently described the first example\, outside of biology\, of a self-replicating molecule that is capable of undergoing Darwinian evolution. This so-called ‘immortal molecule’ has been the subject of extensive news coverage\, including by The New York Times\, Scientific American\, CNN and the BBC. \nJoyce received his M.D. and Ph.D. from the University of California\, San Diego in 1984. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/april-15-2014-von-neumann-machines-and-molecular-darwinism/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205904/Gerry-joyce.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140411T000000 DTEND;TZID=America/New_York:20140411T000000 DTSTAMP:20260413T093433 CREATED:20140331T040000Z LAST-MODIFIED:20211207T163501Z UID:2068-1397174400-1397174400@www.simonsfoundation.org SUMMARY:April 11\, 2014: Conference on Theory & Biology DESCRIPTION: URL:https://www.simonsfoundation.org/event/april-11-2014-conference-on-theory-biology/ LOCATION:NY END:VEVENT BEGIN:VEVENT DTSTART;VALUE=DATE:20140411 DTEND;VALUE=DATE:20140412 DTSTAMP:20260413T093433 CREATED:20170811T205831Z LAST-MODIFIED:20190416T175336Z UID:15096-1397174400-1397260799@www.simonsfoundation.org SUMMARY:2014 Conference on Theory & Biology DESCRIPTION: URL:https://www.simonsfoundation.org/event/2014-conference-on-theory-biology/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Ave\, New York\, NY\, 10010\, United States END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140409T170000 DTEND;TZID=America/New_York:20140409T180000 DTSTAMP:20260413T093433 CREATED:20170428T040000Z LAST-MODIFIED:20211207T163452Z UID:452-1397062800-1397066400@www.simonsfoundation.org SUMMARY:Transcriptional and Epigenetic Mechanisms of Depression DESCRIPTION:Eric J. Nestler\, M.D.\, Ph.D.\nNash Family Professor and Chairman\, Department of Neuroscience\nDirector\, Friedman Brain Institute\nIcahn School of Medicine at Mount Sinai\nDepression is a common\, chronic\, and debilitating disease. Although many patients benefit from antidepressant medications or other therapies\, only about half show complete remission. Factors that precipitate depression\, such as stress\, are incompletely understood. \nWe have used chronic social defeat stress as an animal model of depression. Prolonged exposure to an aggressor induces lasting changes in behavior such as social avoidance and anhedonia-like symptoms\, which are reversed by chronic (but not acute) treatment with available antidepressants. Roughly one-third of mice subjected to social defeat stress do not exhibit these deleterious behaviors and appear “resilient.” We are exploring the molecular basis of defeat-induced behavioral pathology\, antidepressant action\, and resilience by analyzing genome-wide changes in gene expression and chromatin modifications in several limbic brain regions. One area of focus is the nucleus accumbens\, a key brain reward region implicated in aspects of depression. \nWe have identified sets of genes that remain altered one month after defeat stress. Many of these changes are reversed by chronic antidepressant treatment. Interestingly\, a large subset of these genes\, whose abnormalities are corrected by antidepressants\, appear normal in resilient mice. These findings suggest that antidepressants work in part by inducing changes in gene and chromatin regulation in nucleus accumbens that occur naturally in more resilient individuals. Current studies are underway to investigate the genes and molecular pathways involved in these various responses. Specific genes that control susceptibility\, resilience\, and antidepressant responses will be discussed. \nTogether\, this work provides novel insight into the molecular mechanisms by which chronic stress produces lasting changes in specific brain areas\, and associated changes in the functioning of neural circuits\, to cause depression-like symptoms. The findings also suggest novel leads for the development of new antidepressant treatments. \nAbout the Speaker \n\n\nDr. Nestler is the Nash Family Professor of Neuroscience at the Mount Sinai School of Medicine in New York\, where he serves as Chair of the Department of Neuroscience and Director of the Friedman Brain Institute. He received his B.A.\, Ph.D.\, and M.D. degrees\, and psychiatry residency training\, from Yale University. He served on the Yale faculty from 1987-2000\, where he was the Elizabeth Mears and House Jameson Professor of Psychiatry and Neurobiology\, and Director of the Division of Molecular Psychiatry. He moved to Dallas in 2000 where he served as the Lou and Ellen McGinley Distinguished Professor and Chair of the Department of Psychiatry at The University of Texas Southwestern Medical Center until moving to New York in 2008. Dr. Nestler is a member of the Institute of Medicine and a Fellow of the American Academy of Arts and Sciences. The goal of Dr. Nestler’s research is to better understand the molecular mechanisms of addiction and depression based on work in animal models\, and to use this information to develop improved treatments of these disorders. \n“Transcriptional and Epigenetic Mechanisms of Depression” lecture slides (pdf) \n“Hidden Switches in the Mind” (pdf) \n“Epigenetic Mechanisms of Depression and Antidepressant Action” (pdf) URL:https://www.simonsfoundation.org/event/transcriptional-and-epigenetic-mechanisms-of-depression/ LOCATION:NY CATEGORIES:Simons Science Series ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181144/Nestler-MSSM_709_thumb.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140326T163000 DTEND;TZID=America/New_York:20140326T183000 DTSTAMP:20260413T093433 CREATED:20140508T040000Z LAST-MODIFIED:20211207T163441Z UID:204-1395851400-1395858600@www.simonsfoundation.org SUMMARY:An Attempt at Redefining Autism for the Biological Sciences: Implications and Translational Opportunities DESCRIPTION:In this presentation\, Ami Klin will present infant and toddler data on two behavioral assays measuring highly conserved and developmentally early emerging social adaptive behaviors. His findings suggest that these measures are more proximal to gene expression\, better capture unfolding social adaptive developmental mechanisms and are more presymptomatic and more highly quantitative than prior work. The findings have the potential to bridge genetic determinants and symptomatic outcomes\, create a common framework for gene-brain-behavior research and constrain future models of pathogenesis. \nThese concepts also have translational value in addressing autism as a public health challenge via efforts to develop community-viable systems to reduce age of diagnosis and improve access to early care in the general population. Klin’s programmatic goal at the Marcus Autism Center research enterprise is to capitalize on new science in order to address still-intractable health care challenges. \nAmi Klin\, Ph.D.\, is Georgia Research Alliance Eminent Scholar Professor and director of the division of autism and developmental disabilities at Emory University School of Medicine\, and chief of the Marcus Autism Center\, Children’s Healthcare of Atlanta. He earned his Ph.D. from the University of London and completed clinical and research work at Yale University’s Child Study Center. Until 2010\, he directed the autism program at the Yale Child Study Center\, Yale University School of Medicine\, and was Harris Professor of Child Psychology and Psychiatry there. \nKlin’s primary research focuses on the social mind and brain\, and on the developmental aspects of autism from infancy through adulthood. He is the author of over 180 publications in the field of autism and related conditions and the co-editor of Asperger Syndrome\, Autism Spectrum Disorders in Infants and Toddlers\, the third edition of the Handbook of Autism and Pervasive Developmental Disorders and several special issues of professional journals focused on autism spectrum disorders. URL:https://www.simonsfoundation.org/event/an-attempt-at-redefining-autism-for-the-biological-sciences-implications-and-translational-opportunities/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Autism: Emerging Concepts ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180658/Klin1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140326T000000 DTEND;TZID=America/New_York:20140326T000000 DTSTAMP:20260413T093433 CREATED:20140224T050000Z LAST-MODIFIED:20211207T163432Z UID:2030-1395792000-1395792000@www.simonsfoundation.org SUMMARY:March 26\, 2014: An Attempt at Redefining Autism for the Biological Sciences: Implications and Translational Opportunities DESCRIPTION:March 26\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this presentation\, Ami Klin will present infant and toddler data on two behavioral assays measuring highly conserved and developmentally early emerging social adaptive behaviors. His findings suggest that these measures are more proximal to gene expression\, better capture unfolding social adaptive developmental mechanisms and are more presymptomatic and more highly quantitative than prior work. The findings have the potential to bridge genetic determinants and symptomatic outcomes\, create a common framework for gene-brain-behavior research and constrain future models of pathogenesis. \nThese concepts also have translational value in addressing autism as a public health challenge via efforts to develop community-viable systems to reduce age of diagnosis and improve access to early care in the general population. Klin’s programmatic goal at the Marcus Autism Center research enterprise is to capitalize on new science in order to address still-intractable health care challenges. \nAmi Klin\, Ph.D.\, is Georgia Research Alliance Eminent Scholar Professor and director of the division of autism and developmental disabilities at Emory University School of Medicine\, and chief of the Marcus Autism Center\, Children’s Healthcare of Atlanta. He earned his Ph.D. from the University of London and completed clinical and research work at Yale University’s Child Study Center. Until 2010\, he directed the autism program at the Yale Child Study Center\, Yale University School of Medicine\, and was Harris Professor of Child Psychology and Psychiatry there. \nKlin’s primary research focuses on the social mind and brain\, and on the developmental aspects of autism from infancy through adulthood. He is the author of over 180 publications in the field of autism and related conditions and the co-editor of Asperger Syndrome\, Autism Spectrum Disorders in Infants and Toddlers\, the third edition of the Handbook of Autism and Pervasive Developmental Disorders and several special issues of professional journals focused on autism spectrum disorders. \nTo attend this event\, sign up here. URL:https://www.simonsfoundation.org/event/march-26-2014-an-attempt-at-redefining-autism-for-the-biological-sciences-implications-and-translational-opportunities/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205943/Klin.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140323T000000 DTEND;TZID=America/New_York:20140329T000000 DTSTAMP:20260413T093433 CREATED:20150908T040000Z LAST-MODIFIED:20250813T163845Z UID:4080-1395532800-1396051200@www.simonsfoundation.org SUMMARY:Galactic Superwinds: Beyond Phenomenology (2014) DESCRIPTION:March 23 – 29\, 2014 \nOrganizers:\nAndrew Benson\, Carnegie Observatories\nJuna Kollmeier\, Carnegie Observatories \nThe goal of this symposium was to bring together leading experts in the theory and observation of galactic superwinds — outflows of mass\, momentum and energy from galaxies thought to be driven by radiation and winds from stars\, and by supernova explosions. The major topic of discussion was the physics of cold gas flows ejected at high velocity into a low density\, hot circumgalactic medium\, specifically what physics (magnetic fields\, thermal conduction\, etc.) must be incorporated to accurately model the evolution of these clouds\, and whether these physical processes\, with characteristic length scales on the order of 1 parsec\, can be resolved in cosmological simulations at any point in the foreseeable future. An alternative to fully resolving cloud physics was suggested. In this approach\, a detailed sub-grid model of cloud evolution would be solved for each gas particle in the wind\, computing mass\, energy and momentum mixing rates with the surroundings. These rates would then be applied to the macroscopic gas distribution in the simulation. \nThe symposium also addressed the question of how best to compare theory and observation. Quantities that theorists would like to know can be derived from observations only through the addition of many extra assumptions\, all adding uncertainty to the measurements. For example\, a basic quantity of interest is the mass flux in the wind. Inferring this from observations requires assumptions about the isotropy of the wind\, the radius from which it is launched\, etc.\, leading to uncertainties of 1 to 2 orders of magnitude. A major discussion point arising from this issue was\, where should theory and observations meet? Should observers attempt to estimate mass fluxes using all of the assumptions described above\, or should theorists attempt to model the ionization structure of the outflows in their simulations and extract line profiles from their models that can be compared directly with the observables? Each approach requires assumptions\, and it is unclear which approach (or perhaps some middle ground) is optimal. Therefore\, attempting both approaches and comparing results would be advisable. \n  \nMaterials: \nPublications\n\n  \n Publications and preprints resulting from the Simons Symposium on Galactic Superwinds: \n\nThe Systematic Properties of the Warm Phase of Starburst-Driven Galactic Winds; T. Heckman\, R. Alexandroff\, S. Borthakur; in preparation.\nIndirect Evidence for Escaping Lyman Continuum Photons in Local Lyman Break Galaxy Analogs; R. Alexandroff\, T. Heckman\, et al.; submitted to ApJ (2015): http://adsabs.harvard.edu/abs/2015AAS…22525109A.\nConnection Between the Circumgalactic Medium and the Atomic Hydrogen Disk in Galaxies; S. Borthakur\, T. Heckman\, et al.; submitted to ApJ (2015): http://adsabs.harvard.edu/abs/2015AAS…22542701B.\nThe Launching of Cold Clouds by Galaxy Outflows I: Hydrodynamic Interactions with Radiative Cooling; E. Scannapieco & M. Brüggen; (2015): http://arxiv.org/pdf/1503.06800v1.pdf.\nGalaxy Outflows Without Supernovae; S. Sur\, E. Scannapieco\, E. C. Ostriker; in preparation.\nEntrainment in Trouble: Cool Cloud Acceleration and Destruction in Hot Supernova-Driven Galactic Winds; D. Zhang\, T. A. Thompson\, N. Murray\, E. Quataert; to be submitted to MNRAS (2015).\nMagnetized gas clouds can survive acceleration by a hot wind; M. McCourt\, R. O’Leary\, A-M. Madigan\, E. Quataert; MNRAS Letters (2015) 449 (1)\, 2–7: http://dx.doi.org/10.1093/mnras/stv355.\nSub-Eddington Star-Forming Regions Are Super-Eddington: Momentum Driven Outflows from Supersonic Turbulence; A. Thompson & M. R. Krumholz; submitted to MNRAS (2014): http://arxiv.org/abs/1411.1769.\nThe Lyα Line Profiles of Ultraluminous Infrared Galaxies: Fast Winds and Lyman Continuum Leakage; C. L. Martin\, M. Dijkstra\, A. Henry\, K. T. Soto\, C. W. Danforth\, J. Wong; submitted to ApJ (2015): http://arxiv.org/abs/1501.05946.\nBaryon Cycling in the Low-Redshift Circumgalactic Medium: A Comparison of Simulations to the COS-Halos Survey; A. B. Ford\, J. K. Werk\, R. Davé\, J. Tumlinson\, R. Bordoloi\, N. Katz\, J. A. Kollmeier\, B. D. Oppenheimer\, M. S. Peeples\, J. X. Prochaska\, D. H. Weinberg; submitted to MNRAS (2015): http://arxiv.org/abs/1503.02084.\nThe EAGLE project: simulating the evolution and assembly of galaxies and their environments; J. Schaye\, R. A. Crain\, R. G. Bower\, M. Furlong\, M. Schaller\, T. Theuns\, C. D. Vecchia\, C. S. Frenk\, I. G. McCarthy\, J. C. Helly\, A. Jenkins\, Y. M. Rosas-Guevara\, S. D. M. White\, M. Baes\, C. M. Booth\, P. Camps\, J. F. Navarro\, Y. Qu\, A. Rahmati\, T. Sawala\, P. A. Thomas\, J. Trayford; MNRAS (2015) 446 (1)\, 521–554: http://dx.doi.org/10.1093/mnras/stu2058.\nThe EAGLE simulations of galaxy formation: calibration of subgrid physics and model variations; R. A. Crain\, J. Schaye\, R. G. Bower\, M. Furlong\, M. Schaller\, T. Theuns\, C. D. Vecchia\, C. S. Frenk\, I. G. McCarthy\, J. C. Helly\, A. Jenkins\, Y. M. Rosas-Guevara\, S. D. M. White\, J. W. Trayford; submitted to MNRAS (2015): http://arxiv.org/abs/1501.01311.\nEvolution of galaxy stellar masses and star formation rates in the EAGLE simulations; M. Furlong\, R. G. Bower\, T. Theuns\, J. Schaye\, R. A. Crain\, M. Schaller\, C. D. Vecchia\, C. S. Frenk\, I. G. McCarthy\, J. Helly\, A. Jenkins\, Y. M. Rosas-Guevara\, submitted to MNRAS (2014): http://arxiv.org/abs/1410.3485.\nOn the interplay between star formation and feedback in galaxy formation simulations; O. Agertz & A. V. Kravtsov; submitted to and in press at ApJ (2015): http://arxiv.org/abs/1404.2613.\nStellar feedback driven winds and galaxy morphology; O. Agertz & A. Kravtsov; to be submitted.\nThe distribution of neutral hydrogen around high-redshift galaxies and quasars in the EAGLE simulation; Rahmati\, J. Schaye\, R. G. Bower\, R. A. Crain\, M. Furlong\, M. Schaller\, T. Theuns; submitted to MNRAS (2015): http://arxiv.org/abs/1503.05553.\nGalaxies that shine: radiation-hydrodynamical simulations of disk galaxies; Rosdahl\, J. Schaye\, R. Teyssier\, O. Agertz; submitted to MNRAS (2015): http://arxiv.org/abs/1501.04632.\nDetection of hot\, metal-enriched outflowing gas around z ≈ 2.3 star-forming galaxies in the Keck Baryonic Structure Survey; L. Turner\, J. Schaye\, C. C. Steidel\, G. C. Rudie\, A. L. Strom; submitted to MNRAS (2014): http://arxiv.org/abs/1410.8214.\n\n\nPresentation Slides\n\n Rob Crain\, Leiden Observatory\n Download Slides \n Romeel Davé\, Arizona State University\n Download Slides \n Nick Gnedin\, University of Chicago/Fermilab\n Download Slides \n Mark Krumholz\, UC Santa Cruz\n Download Slides \n Eliot Quataert\, UC Berkeley\n Download Slides \n Joop Schaye\, Leiden Observatory\n Download Slides \n David Weinberg\, Ohio State\n Download Slides\n\n$(‘#presentation-slides’).toggle(0);\nSession Slides\n\nRichard Bower\, University of Durham\nOutflow Questions \nRob Crain\, Leiden Observatory\nPre-SNe Stellar Winds\, Intermediate Age Populations\, Momentum Driving Relevance on Scales Beyond GMCs\, 1051 erg/SN\, Short AGN Duty Cycles\, Accuracy of Models (SAM/hydro)\, Dwarf Galaxy Simulation Parameters v. Observational Constraints \nRomeel Davé\, Arizona State University\nWind Propagation & Mixing \nNick Gnedin\, University of Chicago/Fermilab\nHow We Should Think About Star Formation \nNeal Katz\, University of Massachusetts\nPhenomenologically Obtained Winds (POW) \nDusan Keres\, University of San Diego\nChallenges in (Numerical) Galactic Wind Modeling \nMark Krumholz\, UC Santa Cruz\nGalactic Winds: The “Last pc” Problem \nCrystal Martin\, UC Santa Barbara\nWhat Is the Mass Flux in Galactic Winds? \nEliot Quataert\, UC Berkeley\nGalactic Winds (impact of star formation vs. AGNs\, role of cosmic rays\, level of detail needed/feasible for predictive galaxy formation models) \nBrant Robertson\, University of Arizona\nPhysical Coupling of Winds to the Turbulent Interstellar Medium \nEvan Scannapieco\, Arizona State University\nWhat are the Turbulent Velocity and Scale Height in Starbursting Galaxies? \nJoop Schaye\, Leiden Observatory\nKey Challenges in Wind Modeling \nSijing Shen\, UC Santa Cruz\nChallenges in Galactic Wind Modeling \nChuck Steidel\, Cal Tech\nNon-Exhaustive List of Questions \nGreg Stinson\, Max-Planck-Institut für Astronomie\nHow Do Outflows Work? \nTodd Thompson\, Ohio State\nTheoretical & Observational Challenges \nFreeke van de Voort\, UC Berkeley\nAspects in Need of Simulation and Study \nDavid Weinberg\, Ohio State\nPrimary Questions of Galaxy Formation / What Happens to Gas After it is Ejected? / Other Key Isssues \n\nSymposium Agenda\n\nDownload PDF \nGalactic Superwinds: Beyond Phenomenology\nMarch 23 – 29\, 2014 \n\n\n\n\n \n\nMONDAY: ISM\n\n\n9:00 – 10:30 AM\nStar Formation\nModerators: Gnedin & Krumholz\n\n\n11:00 AM – 12:30 PM\nTurbulence\nModerators: Robertson & Scannapieco\n\n\n4:00 – 5:30 PM\nStellar Populations / Stellar Winds / Supernovae\nModerators: Crain & Schaye\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n8:30 – 10:00 PM\nNumerics @ Night\nModerator: Krumholz\n\n\n \n\n\nTUESDAY: Energy Input\n\n\n9:00 – 10:30 AM\nAGN/Preventative Feedback\nModerators: Quataert & Katz\n\n\n11:00 AM – 12:30 PM\nKnown Unknowns(Magnetics Fields\, Cosmic Rays\, etc.)\nModerators: Stinson\, Keres & Schaye\n\n\n4:00 – 5:30 PM\nCoupling to ISM\nModerators: Thompson & Krumholz\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n8:30 – 10:00 PM\nNumerics @ Night\nModerator: Katz\n\n\n \n\n\nWEDNESDAY: Wind Structure\n\n\n9:00 – 10:30 AM\nMass\, Energy\, Momentum & Metal Fluxes\nModerators: Davé & Martin\n\n\n11:00 AM – 12:30 PM\nMultiphase Wind Structure\nModerators: Keres & Steidel\n\n\n2:30 – 4:00 PM\nCoupling to the CGM\nModerators: Shen & Heckman\n\n\n \n\n\nTHURSDAY: Diagnostics\nÜber Moderators: Steidel\, Heckman\, Martin\n\n\n9:00 – 10:30 AM\nISM\nModerator: Murray\n\n\n11:00 AM – 12:30 PM\nGalactic\nModerator: van de Voort\n\n\n4:00 – 5:30 PM\nCGM\nModerator: Weinberg\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n8:30 – 10:00 PM\nNumerics @ Night\nModerator: Shen & Keres\n\n\n \n\n\nFRIDAY: Synthesis\n\n\n9:00 – 10:30 AM\nObservational\nModerators: Steidel\, Heckman & Martin\n\n\n11:00 AM – 12:30 PM\nTheoretical/Numerical\nModerators: Bower\, Kravtsov & Murray\n\n\n4:00 – 5:30 PM\nRoadmap\nModerators: Benson\, Kollmeier\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n\n \nParticipants: \nAndrew Benson\, Carnegie Observatories\nRichard Bower\, University of Durham\nRob Crain\, Leiden Observatory\nRomeel Dave\, Arizona State University\nNick Gnedin\, University of Chicago/Fermilab\nTim Heckman\, Johns Hopkins University\nNeal Katz\, University of Massachusetts\nDusan Keres\, University of San Diego\nJuna Kollmeier\, Carnegie Observatories\nAndrey Kravtsov\, University of Chicago\nMark Krumholz\, UC Santa Cruz\nCrystal Martin\, UC Santa Barbara\nNorman Murray\, Canadian Institute of Theoretical Astrophysics\nEliot Quataert\, UC Berkeley\nBrant Robertson\, University of Arizona\nEvan Scannapieco\, Arizona State University\nJoop Schaye\, Leiden Observatory\nSijing Shen\, UC Santa Cruz\nChuck Steidel\, Cal Tech\nGreg Stinson\, Max-Planck-Institut für Astronomie\nTodd Thompson\, Ohio State\nFreeke van de Voort\, UC Berkeley\nDavid Weinberg\, Ohio State URL:https://www.simonsfoundation.org/event/galactic-superwinds-beyond-phenomenology-march-23-29-2014/ LOCATION:NY END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140312T153000 DTEND;TZID=America/New_York:20140312T180000 DTSTAMP:20260413T093433 CREATED:20140612T040000Z LAST-MODIFIED:20211207T163628Z UID:229-1394638200-1394647200@www.simonsfoundation.org SUMMARY:Learning With a Nontrivial Teacher DESCRIPTION:In this lecture\, Vladimir Vapnik will discuss how the LUPI learning model can take the form of comments\, descriptions\, metaphoric reasoning and other teaching tactics. He will describe the goal of the model — to develop good decision rules even when only a small number of examples is provided. \nVladimir Vapnik\, Ph.D. works in the machine learning department at NEC Laboratories America\, Inc. and is professor of computer science at Columbia University. He has made major contributions to computer science and machine learning\, including a general theory for minimizing the expected risk of losses using empirical data\, and the widely used Support Vector Machine approach to classification. Among his many honors are the 2003 Humboldt Research Award\, the 2005 Gabor Award\, the 2010 Neural Networks Pioneer Award\, the 2012 IEEE Frank Rosenblatt Award and the 2012 Benjamin Franklin Medal in Computer and Cognitive Science from the Franklin Institute. He was elected to the National Academy of Engineering in 2006 for “insights into the fundamental complexities of learning and for inventing practical and widely applied machine-learning algorithms.” \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/learning-with-a-nontrivial-teacher/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Frontiers of Data Science ATTACH;FMTTYPE=image/png:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180724/vald11.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140312T000000 DTEND;TZID=America/New_York:20140312T000000 DTSTAMP:20260413T093433 CREATED:20140107T050000Z LAST-MODIFIED:20211207T163617Z UID:1998-1394582400-1394582400@www.simonsfoundation.org SUMMARY:March 12\, 2014: Learning With a Nontrivial Teacher DESCRIPTION:March 12\, 2014\, 3:30-6:00 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Vladimir Vapnik will discuss how the LUPI learning model can take the form of comments\, descriptions\, metaphoric reasoning and other teaching tactics. He will describe the goal of the model — to develop good decision rules even when only a small number of examples is provided. \nVladimir Vapnik\, Ph.D. works in the machine learning department at NEC Laboratories America\, Inc. and is professor of computer science at Columbia University. He has made major contributions to computer science and machine learning\, including a general theory for minimizing the expected risk of losses using empirical data\, and the widely used Support Vector Machine approach to classification. Among his many honors are the 2003 Humboldt Research Award\, the 2005 Gabor Award\, the 2010 Neural Networks Pioneer Award\, the 2012 IEEE Frank Rosenblatt Award and the 2012 Benjamin Franklin Medal in Computer and Cognitive Science from the Franklin Institute. He was elected to the National Academy of Engineering in 2006 for “insights into the fundamental complexities of learning and for inventing practical and widely applied machine-learning algorithms.” \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/march-12-2014-learning-with-a-nontrivial-teacher/ LOCATION:NY ATTACH;FMTTYPE=image/png:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205900/vald1.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140309T000000 DTEND;TZID=America/New_York:20140315T000000 DTSTAMP:20260413T093433 CREATED:20150908T040000Z LAST-MODIFIED:20250813T163805Z UID:4079-1394323200-1394841600@www.simonsfoundation.org SUMMARY:Discrete Analysis: Beyond the Boolean Cube (2014) DESCRIPTION:March 9 – 15\, 2014 \nOrganizers:\nElchanan Mossel\, UC Berkeley\nRyan O’Donnell\, Carnegie Mellon University\nKrzysztof Oleszkiewicz\, University of Warsaw \nThe Simons Symposium on Discrete Analysis: Beyond the Boolean Cube was the second symposium organized on this topic. The first was held in 2012 and was called Analysis of Boolean Functions. This most recent meeting focused on the interplay between the discrete cube setting and its non-commutative\, non-independent\, continuous\, and number-theoretic counterparts. Key topics included Fourier analysis on groups\, discrete analysis in additive groups and fields\, invariance principles\, discrete partitions of Gaussian and spherical spaces\, Gaussian isoperimetric problems\, connections between boundedness of Gaussian and Rademacher processes\, explicit optimal rounding of semidefinite programs\, and connections to Markov chains. \nMaterials:\nPresentation Slides\n\n \nBoaz Barak\,\nMicrosoft Research\nSome questions\, results\, and musings on Sums of Squares\, Unique Games Conjecture\, Hypercontractive norms\, Sparse vectors\, and other issues. \nWitold Bednorz\,\nUniversity of Warsaw\n(joint work with Rafal Latala)\nBeyond Bernoulli Theorem \nSubhash Khot\,\nNew York University\n(Joint work with Madhur Tulsiani and Pratik Worah)\nA Characterization of Strong Approximation Resistance \nAlexandra Kolla\,\nUniversity of Illinois Urbana-Champaign\nMaximal Inequalities Beyond the Boolean Cube \nRaghu Meka\,\nMicrosoft Research\nA PTAS for Computing the Supremum of Gaussian Processes \nYuval Peres\,\nMicrosoft Research\n(Joint work with Yael Dekel at The Hebrew University and Ori Gurel-Gurevich at University of British Columbia)\nFinding Hidden Cliques in Linear Time with High Probability \nLi-Yang Tan\,\nColumbia University\n(Joint work with Rocco Servedio)\nA Polynomial Lower Bound for Monotonicity Testing of Boolean Functions\n\nSymposium Agenda\n\nDownload PDF \nDiscrete Analysis: Beyond the Boolean Cube\nMarch 9 – 15\, 2014 \n\n\n\n\n \n\n \n\n\nMonday\n\n\n9:00 – 9:30 AM\nAvi Wigderson\nCan Every Sequential Computation be Efficiently Parallelized?\n\n\n9:30 – 10:00 AM\nRafal Latala\nSuprema of Bernoulli Processes\n\n\n10:00 – 10:30 AM\nWitold Bednorz\nBeyond the Bernoulli Theorem\n\n\n11:00 – 11:30 AM\nYuval Filmus\nStability Results Beyond the Boolean Cube and the EKR Theorem\n\n\n11:30 AM – 12:00 PM\nRaghu Meka\nA PTAS for Computing the Supremum of Gaussian Processes\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 7:00 PM\nLonger Talk\n\n\n\n \n\n\nTuesday\n\n\n9:00 – 9:30 AM\nTom Sanders\nThe Green-Bourgain Sumset Problem\n\n\n9:30 – 10:00 AM\nThomas Vidick\nNon-commutative Extensions of Grothendieck’s Inequality\n\n\n10:00 – 10:30 AM\nOded Regev\nExtensions of Spencer’s Discrepancy Theorem\n\n\n11:00 – 11:30 AM\nLi-Yang Tan\nA Polynomial Lower Bound for Monotonicity Testing of Boolean Functions\n\n\n11:30 AM – 12:00 PM\nEhud Friedgut\nExtremal Problems in Symmetric Group via Fourier Analysis\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 7:00 PM\nLonger Talk\nChosen by Participants\n\n\n \n\n\nWednesday\n\n\n9:00 – 9:30 AM\nSubhash Khot\nA Characterization of Approximation Resistance\n\n\n9:30 – 10:00 AM\nBoaz Barak\nSums of Squares\, Optimizing Over Sparse Vectors\, and Hypercontractive Norms\n\n\n10:30 – 11:00 AM\nJulia Wolf\nBeyond the Gowers Norms\n\n\n11:00 – 11:30 AM\nStanislaw Szarek\nMeasures on\, and Generic Properties for N Qubits\n\n\n11:30 AM – 12:00 PM\nChristophe Garban\nQuestions around the Mixing Time of the Critical Ising Model and the Majority in Stablest Theorem\n\n\n2:00 – 3:00 PM\nOpen Problem Session\n\n\n\n \n\n\nThursday\n\n\n10:00 – 10:30 AM\nSergey Bobkov\nConcentration on the Cube for Permutationally Invariant Sets\n\n\n11:00 – 11:30 AM\nAlmut Burchard\nTwo-point Symmetrization and some Applications to Path Integrals\n\n\n11:30 AM – 12:00 PM\nAlexandra Kolla\nDiscrete Maximal Inequalities Beyond the Boolean cube and Bounds on Orthogonal Polynomials\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 6:00 PM\nJoe Neeman\nThe Majority is Stablest Theorem on Non-product Spaces\n\n\n6:00 – 6:30 PM\nYuval Peres\n1. The Majority is Least Stable Conjecturei2. Concentration of Lipschitz Functions of Negatively Associated Variables\n\n\n \n\n\nFriday\n\n\n9:00 – 10:00 AM\nLonger Talk\nChosen by Participants\n\n\n10:30 – 11:30 AM\nLonger Talk\nChosen by Participants\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 7:00 PM\nProgress Report\n\n\n\n\n \nSite: http://analysisofbooleanfunctions.org \nParticipants: \nBoaz Barak\, Microsoft Research New England\nWitold Bednorz\, University of Warsaw\nSergey Bobkov\, University of Minnesota\nAlmut Burchard\, University of Toronto\nYuval Filmus\, University of Toronto\nEhud Friedgut\, The Einstein Institute of Mathematics\nChristophe Garban\, ENS Lyon\, UMPA\nSubhash Khot\, New York University\nAlexandra Kolla\, University of Illinois at Urbana-Champaign\nRafal Latala\, University of Warsaw\nRaghu Meka\, IAS\nElchanan Mossel\, UC Berkeley\nJoe Neeman\, UC Berkeley\nRyan O’Donnell\, Carnegie Mellon University\nKrzysztof Oleszkiewicz\, University of Warsaw\nYuval Peres\, Microsoft Research\nOded Regev\, New York University\nTom Sanders\, Oxford University\nStanislaw Szarek\, Case Western Reserve University\nLi-Yang Tan\, Columbia University\nYuri Tschinkel\, Simons Foundation\nThomas Vidick\, MIT\nAvi Wigderson\, IAS\nJulia Wolf\, École Polytechnique URL:https://www.simonsfoundation.org/event/discrete-analysis-beyond-the-boolean-cube-march-9-15-2014/ LOCATION:NY END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140307T123000 DTEND;TZID=America/New_York:20140307T173000 DTSTAMP:20260413T093433 CREATED:20140612T040000Z LAST-MODIFIED:20211207T163606Z UID:219-1394195400-1394213400@www.simonsfoundation.org SUMMARY:Perspectives on Big Data in Biology DESCRIPTION:This Biotech Symposium will focus on perspectives on big data in biology from leading practitioners in the field. Past Biotech Symposia topics have included single nucleotide polymorphism detection\, diffusion magnetic resonance imaging\, structural variant detections and resting state fMRI.  Future symposia will focus on related bioinformatics and neuroimaging topics. \nSpeakers: \n \nNicholas Carriero\, Ph.D.\nYale University\nScaling Up Bioinformatics Pipelines \nDavid Lipman\, M.D.\nNational Center for Biotechnology Information\, National Institutes of Health\nWhat Is the Big Data Problem in Biology? \n \nDavid Haussler\, Ph.D.\nUniversity of California\, Santa Cruz\nLarge-Scale Cancer Genomics \n \nCharles Sawyers\, M.D.\nMemorial Sloan-Kettering Cancer Center\nGlobal Alliance for Genomics and Health \n  URL:https://www.simonsfoundation.org/event/perspectives-on-big-data-in-biology/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Biotech Symposia ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180714/Perspectives-on-dig-data1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140307T000000 DTEND;TZID=America/New_York:20140307T000000 DTSTAMP:20260413T093433 CREATED:20140206T050000Z LAST-MODIFIED:20211207T163556Z UID:2023-1394150400-1394150400@www.simonsfoundation.org SUMMARY:March 7\, 2014: Perspectives on Big Data in Biology DESCRIPTION:March 7\, 2014\, 12:30-5:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nThis Biotech Symposium focused on perspectives on big data in biology from leading practitioners in the field. Other Biotech Symposia topics have included single nucleotide polymorphism detection\, diffusion magnetic resonance imaging\, structural variant detections and resting state fMRI. Future symposia will focus on related bioinformatics and neuroimaging topics. \n  \n  \n  \nSpeakers: \nDavid Lipman\, M.D. (First video below\, begins at 00:03:30)\nNational Center for Biotechnology Information\, National Institutes of Health\nWhat Is the Big Data Problem in Biology? \nNicholas Carriero\, Ph.D. (First video below\, begins at 01:05:20)\nYale University\nScaling Up Bioinformatics Pipelines \nDavid Haussler\, Ph.D. (Second video below)\nUniversity of California\, Santa Cruz\nLarge-Scale Cancer Genomics \nCharles Sawyers\, M.D. (Third video below)\nMemorial Sloan-Kettering Cancer Center\nGlobal Alliance for Genomics and Health \n  \n  URL:https://www.simonsfoundation.org/event/march-7-2014-perspectives-on-big-data-in-biology/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205933/Perspectives-on-dig-data.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140305T170000 DTEND;TZID=America/New_York:20140305T180000 DTSTAMP:20260413T093433 CREATED:20170428T040000Z LAST-MODIFIED:20211207T163545Z UID:450-1394038800-1394042400@www.simonsfoundation.org SUMMARY:Genes That Regulate Sleep and Circadian Rhythms in Drosophila DESCRIPTION:Circadian (~24 hour) clocks are endogenous mechanisms that time the recurring\, daily activities observed in most organisms. These clocks are genetically regulated\, and generate biochemical oscillations within individual cells composing most tissues. Our work began in Drosophila melanogaster\, where we identified a small group of genes that are principal components of an intracellular circadian clock. Mutations in any of these genes can lengthen or shorten the period of behavioral and other circadian rhythms or can abolish the rhythms altogether. The abundance of proteins encoded by several of these genes changes rhythmically with a circadian period. Mutations affecting any of these genes have corresponding effects on behavioral rhythms as well as the molecular rhythms of hundreds of clock-regulated genes that are expressed in most organ systems. Orthologous genes regulate mammalian\, including human\, circadian rhythms\, so that today our lab studies the action of these genes and proteins in a variety of biological models. We are also currently studying prominent rhythmic behaviors that are controlled by circadian clock with a particular focus on sleep. Recently our laboratory has searched for and identified genes that affect the homeostatic regulation of sleep in Drosophila. This research has uncovered specific neurons whose activity promotes sleep. \nAbout the Speaker \nDr. Young received his undergraduate degree in biology in 1971 and his Ph.D. in genetics in 1975\, both from The University of Texas\, Austin. Following postdoctoral work in biochemistry at the Stanford University School of Medicine\, he was appointed assistant professor at Rockefeller in 1978 as part of The Rockefeller University Fellows Program. He was named associate professor in 1984 and professor in 1988\, and from 1987 to 1996 he was an investigator of the Howard Hughes Medical Institute. From 1991 to 2001 Young headed the Rockefeller unit of the National Science Foundation’s Science and Technology Center for Biological Timing. Young was named the university’s Vice President for Academic Affairs and Richard and Jeanne Fisher Professor in 2004. \nDr. Young is a member of the National Academy of Sciences and a Fellow of the American Academy of Microbiology. He is a recipient of the 2013 Shaw Prize in Life Science and Medicine\, the 2013 Wiley Prize in Biomedical Science\, the 2012 Canada Gairdner International Award\, the 2012 Massry Prize\, the 2011 Louisa Gross Horwitz Prize for Biology or Biochemistry and the 2009 Neuroscience Prize of the Peter and Patricia Gruber Foundation. \nIntro Article (pdf)\nLecture Slides (pdf)\nPER-CFP/TIM-YFP video (QuickTime)\nPER-CFP/TIM-YFP/FRET video (QuickTime) URL:https://www.simonsfoundation.org/event/genes-that-regulate-sleep-and-circadian-rhythms-in-drosophila/ LOCATION:NY CATEGORIES:Simons Science Series ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181142/Michael-Young-Headshot-thumb.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140226T163000 DTEND;TZID=America/New_York:20140226T183000 DTSTAMP:20260413T093433 CREATED:20140508T040000Z LAST-MODIFIED:20211207T163533Z UID:202-1393432200-1393439400@www.simonsfoundation.org SUMMARY:Neuroimaging Contributions to the Understanding of Brain Development in Autism DESCRIPTION:In this lecture\, David G. Amaral will present neuroimaging data acquired through the University of California\, Davis MIND Institute’s Autism Phenome Project. Young children (aged 2 to 3 and a half years old) are recruited into this longitudinal project and MRI scans are acquired annually. Results will be presented supporting the concept that there are different types of altered brain development in different children with autism. Amaral will also discuss neuroimaging studies of infant siblings of children with autism that provide evidence for abnormal brain growth that may contribute to early biomarkers of autism. \nDavid G. Amaral joined the University of California\, Davis in 1995 as a professor in the department of psychiatry and behavioral sciences and the Center for Neuroscience. He is a staff scientist in the Brain\, Mind and Behavior Unit at the California National Primate Research Center. Amaral was named the Beneto Foundation Chair and research director of the MIND Institute in 1998. He received a joint Ph.D. in psychology and neurobiology from the University of Rochester. \nAmaral’s research focuses on the neurobiology of social behavior and the development and neuroanatomical organization and plasticity of the primate and human amygdala and hippocampal formation. Increasingly\, his research has been dedicated to understanding the biological basis of autism. As research director of the MIND Institute\, Amaral coordinates a comprehensive and multidisciplinary analysis of children with autism\, called the Autism Phenome Project\, to define biomedical characteristics of different types of autism. \nMost recently\, Amaral became director of Autism BrainNet\, a collaborative effort sponsored by the Simons Foundation and Autism Speaks\, to solicit postmortem brain tissue to facilitate autism research. \n  URL:https://www.simonsfoundation.org/event/neuroimaging-contributions-to-the-understanding-of-brain-development-in-autism/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Autism: Emerging Concepts ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180657/20130905_amaral_david_087-copy-640x4251.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140226T000000 DTEND;TZID=America/New_York:20140226T000000 DTSTAMP:20260413T093433 CREATED:20140225T050000Z LAST-MODIFIED:20211207T160450Z UID:2018-1393372800-1393372800@www.simonsfoundation.org SUMMARY:February 26\, 2014: Neuroimaging Contributions to the Understanding of Brain Development in Autism DESCRIPTION:February 26\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, David G. Amaral will present neuroimaging data acquired through the University of California\, Davis MIND Institute’s Autism Phenome Project. Young children (aged 2 to 3 and a half years old) are recruited into this longitudinal project and MRI scans are acquired annually. Results will be presented supporting the concept that there are different types of altered brain development in different children with autism. Amaral will also discuss neuroimaging studies of infant siblings of children with autism that provide evidence for abnormal brain growth that may contribute to early biomarkers of autism. \nDavid G. Amaral joined the University of California\, Davis in 1995 as a professor in the department of psychiatry and behavioral sciences and the Center for Neuroscience. He is a staff scientist in the Brain\, Mind and Behavior Unit at the California National Primate Research Center. Amaral was named the Beneto Foundation Chair and research director of the MIND Institute in 1998. He received a joint Ph.D. in psychology and neurobiology from the University of Rochester. \nAmaral’s research focuses on the neurobiology of social behavior and the development and neuroanatomical organization and plasticity of the primate and human amygdala and hippocampal formation. Increasingly\, his research has been dedicated to understanding the biological basis of autism. As research director of the MIND Institute\, Amaral coordinates a comprehensive and multidisciplinary analysis of children with autism\, called the Autism Phenome Project\, to define biomedical characteristics of different types of autism. \nMost recently\, Amaral became director of Autism BrainNet\, a collaborative effort sponsored by the Simons Foundation and Autism Speaks\, to solicit postmortem brain tissue to facilitate autism research. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/february-26-2014-neuroimaging-contributions-to-the-understanding-of-brain-development-in-autism/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205927/20130905_amaral_david_087-copy.jpg END:VEVENT BEGIN:VEVENT DTSTART;VALUE=DATE:20140223 DTEND;VALUE=DATE:20140302 DTSTAMP:20260413T093433 CREATED:20171031T204436Z LAST-MODIFIED:20250813T163649Z UID:29397-1393113600-1393718399@www.simonsfoundation.org SUMMARY:Quantum Physics Beyond Simple Systems (2014) DESCRIPTION:Organizers:\nBoris Altshuler\, Columbia University\nVladimir Falko\, Lancaster University\nCharles Marcus\, Neils Bohr Institute\n  \nThe Simons Symposium on Quantum Physics Beyond Simple Systems was the second symposium organized on this topic\, the first having been held in 2012. It offered another opportunity for researchers to discuss the fast-evolving themes of modern quantum complex systems. These themes include superconducting and semiconductors quibits; topological insulators and superconductors\, Majora fermions; graphene and heterostructures of 2D atomic crystals; polaritons and quantum optics. The first three themes were the focus of the 2012 Symposium and in the intervening two years proved that they offer a fertile field for further progress. \nMaterials: \nSymposium Agenda\n\n \nDownload PDF\n\nQuantum Physics Beyond Simple Systems\nFebruary 23 – March 1\, 2014\n \n\n\n\n\n \n\n \n\n\n Monday \n\n\n10:00 – 10:50 AM\nKitaev\nTopological Classification of Three-Dimensional Superconductors with Interactions Beyond Mean Field\n\n\n11:20 AM – 12:10 PM\nYao\nValley and Spin Physics in 2D Transition Metal Dichalcogenides\n\n\n12:10 – 1:00 PM\nAkhmerov\n \n\n\n 5:00 – 5:50 PM\nJarillo-Herrero\n \n\n\n 5:50 – 6:40 PM\nMele\n \n\n\n 8:00 – 11:00 PM\nOpen Discussion\n\n\n \n\n\n Tuesday \n\n\n10:00 – 10:50 AM\nYacoby\nInduced Superconductivity in the Quantum Spin Hall Edge\n\n\n11:20 AM – 12:10 PM\nGeim\n \n\n\n12:10 – 1:00 PM\nFalko\nhBN-Caged Graphene\n\n\n 5:00 – 5:50 PM\nLoss\n \n\n\n 5:50 – 6:40 PM\nMarcus\n \n\n\n 8:00 – 11:00 PM\nOpen Discussion\n\n\n \n\n\n Wednesday \n\n\n10:00 – 10:50 AM\nBloch\nPolariton Condensates in Microstructures\n\n\n11:20 AM – 12:10 PM\nMorpurgo\nEven-Denominator Fractional Quantum Hall Effect in Bilayer Graphene / Strain Induced Universality of Transport Through Graphene-on-Substrate\n\n\n12:10 – 1:00 PM\nGuinea\n \n\n\n 2:30 – 3:20 PM\nStern\nEngineered Non-Abelian Anyons Beyond Majorana Fermions \n\n\n 3:20 – 4:00 PM\nDiscussion\n\n\n \n\n\n Thursday \n\n\n10:00 – 10:50 AM\nImamoglu\nInterfacing Single Photons and Condensed-Matter Systems\n\n\n11:20 AM – 12:10 PM\nFlensberg\n \n\n\n12:10 – 1:00 PM\nAltshuler\nAnderson Localization at the 1D Edge of a 2D Topological Insulator\n\n\n 5:00 – 5:50 PM\nGlazman\nEffect of Charge Disorder on the Conduction of a Helical Edge\n\n\n 5:50 – 6:40 PM\nAleiner\n \n\n\n 8:00 – 11:00 PM\nOpen Discussion\n\n\n \n\n\n Friday \n\n\n10:00 – 10:50 AM\nDas Sarma\n \n\n\n11:20 AM – 12:10 PM\nGershenson\n \n\n\n12:10 – 1:00 PM\nIoffe\n \n\n\n 5:00 – 6:40 PM\nOrganized Discussion on Challenges & Trends\n\n\n 8:00 – 11:00 PM\nOpen Discussion\n\n\n\nPresentation Slides\n\n  \n Boris Altshuler:\n Anderson Localization at the 1D Edge of a 2D Topological Insulator \n Jacqueline Bloch:\n Polariton Condensates in Microstructures \n Vladimir Falko:\n hBN-Caged Graphene \n Leonid Glazman:\n Effect of Charge Disorder on the Conduction of a Helical Edge \n Atac Imamoglu:\n Interfacing Single Photons and Condensed-Matter Systems \n Alexei Kitaev:\n Topological Classification of Three-Dimensional Superconductors with Interactions Beyond Mean Field \n Alberto Morpurgo:\n Even-Denominator Fractional Quantum Hall Effect in Bilayer Graphene / Strain Induced Universality of Transport Through Graphene-on-Substrate \n Adiel Stern:\n Engineered Non-Abelian Anyons Beyond Majorana Fermions \n Amir Yacoby:\n Induced Superconductivity in the Quantum Spin Hall Edge \n Wang Yao:\n Valley and Spin Physics in 2D Transition Metal Dichalcogenides \n\n\nParticipants:\nAnton Akhmerov\, Delft Technical University\nIgor Aleiner\, Columbia University\nBoris Altshuler\, Columbia University\nJacqueline Bloch\, Centre National de la Recherche Scientifique\nVladimir Falko\, Lancaster University\nKarsten Flensberg\, Niels Bohr Institute\nSarma Das\, Sankar University of Maryland\nSir Geim\, Andre University of Manchester\nMikhail Gershenson\, Rutgers University\nLeonid Glazman\, Yale University\nPaco Guinea\, Instituto de Ciencia de Materiales de Madrid\nAtac Imamoglu\, ETH Zürich\nLev Ioffe\, Rutgers University\nPablo Jarillo-Herrero\, MIT\nAlexei Kitaev\, Cal Tech\nDaniel Loss\, University of Basel\nCharles Marcus\, Niels Bohr Institute\nEugene Mele\, University of Pennsylvania\nAlberto Morpurgo\, Université de Genève\nAdiel Stern\, Weizmann Institute\nAmir Yacoby\, Harvard University\nWang Yao\, University of Hong Kong URL:https://www.simonsfoundation.org/event/quantum-physics-beyond-simple-systems-february-23-march-1-2014/ LOCATION:St. Regis Bahia Beach Resort\, State Road 187 kilometer 4.2\, Río Grande\, 00745\, Puerto Rico END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140219T170000 DTEND;TZID=America/New_York:20140219T180000 DTSTAMP:20260413T093433 CREATED:20170428T040000Z LAST-MODIFIED:20211207T160254Z UID:448-1392829200-1392832800@www.simonsfoundation.org SUMMARY:Robust Integral Equation Methods for Forward and Inverse Scattering DESCRIPTION:Integral equation methods play an important role in the numerical simulation of electromagnetic scattering. They are easy to employ in complex geometry and impose the desired radiation conditions at infinity without the need for artificial numerical boundaries. Two of the obstacles faced by current forward simulation tools are “low-frequency breakdown” and the lack of easy to use high order quadrature rules for complicated surfaces. In this talk\, I will review the relevant background material\, discuss a new mathematical formalism for scattering from perfect conductors and briefly describe a new quadrature technique that yields easily implementable high order rules for singular and weakly singular integrals. The scheme\, denoted QBX (quadrature by expansion) is compatible with fast hierarchical algorithms such as the fast multipole method. I will also present some preliminary results on inverse obstacle scattering. This is joint work with A. Barnett\, C. Borges\, C. L. Epstein\, M. Ferrando\, Z. Gimbutas\, A. Kloeckner\, M. O’Neil\, and F. Vico. URL:https://www.simonsfoundation.org/event/robust-integral-equation-methods-for-forward-and-inverse-scattering/ LOCATION:NY CATEGORIES:Simons Science Series ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181140/greengard_thumb.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140212T163000 DTEND;TZID=America/New_York:20140212T183000 DTSTAMP:20260413T093433 CREATED:20140617T040000Z LAST-MODIFIED:20211207T160501Z UID:247-1392222600-1392229800@www.simonsfoundation.org SUMMARY:Other Earths and the Origins of Life DESCRIPTION:In this lecture\, Dimitar Sasselov will review recent discoveries of exoplanets — planets outside of our solar system — and new estimates of how common potentially habitable worlds appear to be. He will describe new\, comprehensive efforts to hone the search for signatures of life on exoplanets. Central to the success of that search is a deeper understanding of the nature of life and its origins. Sasselov will review recent progress from laboratory studies that connects astronomical exploration and the question of life’s origins. \nSasselov studies stars and planets at Harvard University\, where he is professor of astronomy. His research explores modes of interaction between light and matter. He and his team discovered several planets orbiting stars outside our solar system with novel techniques\, which he hopes to use to find planets like Earth. \nSasselov is founding director of the Harvard Origins of Life Initiative\, a cross-disciplinary research effort bridging the physical and life sciences. He was a senior science advisor for the Radcliffe Institute for Advanced Study at Harvard and a member of the Global Agenda Council on Space Security at the World Economic Forum. \n  URL:https://www.simonsfoundation.org/event/other-earths-and-the-origins-of-life/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Origins of Life ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180741/dimitar1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140212T000000 DTEND;TZID=America/New_York:20140212T000000 DTSTAMP:20260413T093433 CREATED:20140212T050000Z LAST-MODIFIED:20211207T160242Z UID:2066-1392163200-1392163200@www.simonsfoundation.org SUMMARY:February 12\, 2014: Other Earths and the Origins of Life DESCRIPTION:February 12\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Dimitar Sasselov will review recent discoveries of exoplanets — planets outside of our solar system — and new estimates of how common potentially habitable worlds appear to be. He will describe new\, comprehensive efforts to hone the search for signatures of life on exoplanets. Central to the success of that search is a deeper understanding of the nature of life and its origins. Sasselov will review recent progress from laboratory studies that connects astronomical exploration and the question of life’s origins. \nSasselov studies stars and planets at Harvard University\, where he is professor of astronomy. His research explores modes of interaction between light and matter. He and his team discovered several planets orbiting stars outside our solar system with novel techniques\, which he hopes to use to find planets like Earth. \nSasselov is founding director of the Harvard Origins of Life Initiative\, a cross-disciplinary research effort bridging the physical and life sciences. He was a senior science advisor for the Radcliffe Institute for Advanced Study at Harvard and a member of the Global Agenda Council on Space Security at the World Economic Forum. \n  \n  URL:https://www.simonsfoundation.org/event/february-12-2014-other-earths-and-the-origins-of-life-2/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11210037/sasselov.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140212T000000 DTEND;TZID=America/New_York:20140212T000000 DTSTAMP:20260413T093433 CREATED:20140114T050000Z LAST-MODIFIED:20211207T160231Z UID:2016-1392163200-1392163200@www.simonsfoundation.org SUMMARY:February 12\, 2014: Other Earths and the Origins of Life DESCRIPTION:February 12\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Dimitar Sasselov will review recent discoveries of exoplanets — planets outside of our solar system — and new estimates of how common potentially habitable worlds appear to be. He will describe new\, comprehensive efforts to hone the search for signatures of life on exoplanets. Central to the success of that search is a deeper understanding of the nature of life and its origins. Sasselov will review recent progress from laboratory studies that connects astronomical exploration and the question of life’s origins. \nSasselov studies stars and planets at Harvard University\, where he is professor of astronomy. His research explores modes of interaction between light and matter. He and his team discovered several planets orbiting stars outside our solar system with novel techniques\, which he hopes to use to find planets like Earth. \nSasselov is founding director of the Harvard Origins of Life Initiative\, a cross-disciplinary research effort bridging the physical and life sciences. He was a senior science advisor for the Radcliffe Institute for Advanced Study at Harvard and a member of the Global Agenda Council on Space Security at the World Economic Forum. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/february-12-2014-other-earths-and-the-origins-of-life/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205923/dimitar.jpg END:VEVENT END:VCALENDAR