BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Simons Foundation - ECPv6.6.3//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Simons Foundation X-ORIGINAL-URL:https://www.simonsfoundation.org X-WR-CALDESC:Events for Simons Foundation REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/New_York BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20130310T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20131103T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20140309T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20141102T060000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/New_York:20140415T000000 DTEND;TZID=America/New_York:20140415T000000 DTSTAMP:20260413T110429 CREATED:20140207T050000Z LAST-MODIFIED:20211207T163513Z UID:2001-1397520000-1397520000@www.simonsfoundation.org SUMMARY:April 15\, 2014: Von Neumann Machines and Molecular Darwinism DESCRIPTION:April 15\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY\nIn this lecture\, Gerald Joyce focuses on the perpetuation of genetic information as a defining characteristic of life. He draws a connection between digital computers (von Neumann machines)\, especially those with the capacity to self-reproduce\, and molecular Darwinian systems that maintain heritable ‘bits’ of information\, which are refined through evolution. Such molecular machines have been constructed in the laboratory and are able to reproduce themselves indefinitely. \nJoyce is professor of chemistry and molecular biology\, and an investigator at the Skaggs Institute for Chemical Biology at the Scripps Research Institute in La Jolla\, California. \nJoyce’s research involves the test-tube evolution of nucleic acids and the application of these methods to the development of novel RNA and DNA enzymes. He also has a longstanding interest in the origins of life and the role of RNA in the early history of life on Earth. His laboratory recently described the first example\, outside of biology\, of a self-replicating molecule that is capable of undergoing Darwinian evolution. This so-called ‘immortal molecule’ has been the subject of extensive news coverage\, including by The New York Times\, Scientific American\, CNN and the BBC. \nJoyce received his M.D. and Ph.D. from the University of California\, San Diego in 1984. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/april-15-2014-von-neumann-machines-and-molecular-darwinism/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205904/Gerry-joyce.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140411T000000 DTEND;TZID=America/New_York:20140411T000000 DTSTAMP:20260413T110429 CREATED:20140331T040000Z LAST-MODIFIED:20211207T163501Z UID:2068-1397174400-1397174400@www.simonsfoundation.org SUMMARY:April 11\, 2014: Conference on Theory & Biology DESCRIPTION: URL:https://www.simonsfoundation.org/event/april-11-2014-conference-on-theory-biology/ LOCATION:NY END:VEVENT BEGIN:VEVENT DTSTART;VALUE=DATE:20140411 DTEND;VALUE=DATE:20140412 DTSTAMP:20260413T110429 CREATED:20170811T205831Z LAST-MODIFIED:20190416T175336Z UID:15096-1397174400-1397260799@www.simonsfoundation.org SUMMARY:2014 Conference on Theory & Biology DESCRIPTION: URL:https://www.simonsfoundation.org/event/2014-conference-on-theory-biology/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Ave\, New York\, NY\, 10010\, United States END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140409T170000 DTEND;TZID=America/New_York:20140409T180000 DTSTAMP:20260413T110429 CREATED:20170428T040000Z LAST-MODIFIED:20211207T163452Z UID:452-1397062800-1397066400@www.simonsfoundation.org SUMMARY:Transcriptional and Epigenetic Mechanisms of Depression DESCRIPTION:Eric J. Nestler\, M.D.\, Ph.D.\nNash Family Professor and Chairman\, Department of Neuroscience\nDirector\, Friedman Brain Institute\nIcahn School of Medicine at Mount Sinai\nDepression is a common\, chronic\, and debilitating disease. Although many patients benefit from antidepressant medications or other therapies\, only about half show complete remission. Factors that precipitate depression\, such as stress\, are incompletely understood. \nWe have used chronic social defeat stress as an animal model of depression. Prolonged exposure to an aggressor induces lasting changes in behavior such as social avoidance and anhedonia-like symptoms\, which are reversed by chronic (but not acute) treatment with available antidepressants. Roughly one-third of mice subjected to social defeat stress do not exhibit these deleterious behaviors and appear “resilient.” We are exploring the molecular basis of defeat-induced behavioral pathology\, antidepressant action\, and resilience by analyzing genome-wide changes in gene expression and chromatin modifications in several limbic brain regions. One area of focus is the nucleus accumbens\, a key brain reward region implicated in aspects of depression. \nWe have identified sets of genes that remain altered one month after defeat stress. Many of these changes are reversed by chronic antidepressant treatment. Interestingly\, a large subset of these genes\, whose abnormalities are corrected by antidepressants\, appear normal in resilient mice. These findings suggest that antidepressants work in part by inducing changes in gene and chromatin regulation in nucleus accumbens that occur naturally in more resilient individuals. Current studies are underway to investigate the genes and molecular pathways involved in these various responses. Specific genes that control susceptibility\, resilience\, and antidepressant responses will be discussed. \nTogether\, this work provides novel insight into the molecular mechanisms by which chronic stress produces lasting changes in specific brain areas\, and associated changes in the functioning of neural circuits\, to cause depression-like symptoms. The findings also suggest novel leads for the development of new antidepressant treatments. \nAbout the Speaker \n\n\nDr. Nestler is the Nash Family Professor of Neuroscience at the Mount Sinai School of Medicine in New York\, where he serves as Chair of the Department of Neuroscience and Director of the Friedman Brain Institute. He received his B.A.\, Ph.D.\, and M.D. degrees\, and psychiatry residency training\, from Yale University. He served on the Yale faculty from 1987-2000\, where he was the Elizabeth Mears and House Jameson Professor of Psychiatry and Neurobiology\, and Director of the Division of Molecular Psychiatry. He moved to Dallas in 2000 where he served as the Lou and Ellen McGinley Distinguished Professor and Chair of the Department of Psychiatry at The University of Texas Southwestern Medical Center until moving to New York in 2008. Dr. Nestler is a member of the Institute of Medicine and a Fellow of the American Academy of Arts and Sciences. The goal of Dr. Nestler’s research is to better understand the molecular mechanisms of addiction and depression based on work in animal models\, and to use this information to develop improved treatments of these disorders. \n“Transcriptional and Epigenetic Mechanisms of Depression” lecture slides (pdf) \n“Hidden Switches in the Mind” (pdf) \n“Epigenetic Mechanisms of Depression and Antidepressant Action” (pdf) URL:https://www.simonsfoundation.org/event/transcriptional-and-epigenetic-mechanisms-of-depression/ LOCATION:NY CATEGORIES:Simons Science Series ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181144/Nestler-MSSM_709_thumb.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140326T163000 DTEND;TZID=America/New_York:20140326T183000 DTSTAMP:20260413T110429 CREATED:20140508T040000Z LAST-MODIFIED:20211207T163441Z UID:204-1395851400-1395858600@www.simonsfoundation.org SUMMARY:An Attempt at Redefining Autism for the Biological Sciences: Implications and Translational Opportunities DESCRIPTION:In this presentation\, Ami Klin will present infant and toddler data on two behavioral assays measuring highly conserved and developmentally early emerging social adaptive behaviors. His findings suggest that these measures are more proximal to gene expression\, better capture unfolding social adaptive developmental mechanisms and are more presymptomatic and more highly quantitative than prior work. The findings have the potential to bridge genetic determinants and symptomatic outcomes\, create a common framework for gene-brain-behavior research and constrain future models of pathogenesis. \nThese concepts also have translational value in addressing autism as a public health challenge via efforts to develop community-viable systems to reduce age of diagnosis and improve access to early care in the general population. Klin’s programmatic goal at the Marcus Autism Center research enterprise is to capitalize on new science in order to address still-intractable health care challenges. \nAmi Klin\, Ph.D.\, is Georgia Research Alliance Eminent Scholar Professor and director of the division of autism and developmental disabilities at Emory University School of Medicine\, and chief of the Marcus Autism Center\, Children’s Healthcare of Atlanta. He earned his Ph.D. from the University of London and completed clinical and research work at Yale University’s Child Study Center. Until 2010\, he directed the autism program at the Yale Child Study Center\, Yale University School of Medicine\, and was Harris Professor of Child Psychology and Psychiatry there. \nKlin’s primary research focuses on the social mind and brain\, and on the developmental aspects of autism from infancy through adulthood. He is the author of over 180 publications in the field of autism and related conditions and the co-editor of Asperger Syndrome\, Autism Spectrum Disorders in Infants and Toddlers\, the third edition of the Handbook of Autism and Pervasive Developmental Disorders and several special issues of professional journals focused on autism spectrum disorders. URL:https://www.simonsfoundation.org/event/an-attempt-at-redefining-autism-for-the-biological-sciences-implications-and-translational-opportunities/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Autism: Emerging Concepts ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180658/Klin1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140326T000000 DTEND;TZID=America/New_York:20140326T000000 DTSTAMP:20260413T110429 CREATED:20140224T050000Z LAST-MODIFIED:20211207T163432Z UID:2030-1395792000-1395792000@www.simonsfoundation.org SUMMARY:March 26\, 2014: An Attempt at Redefining Autism for the Biological Sciences: Implications and Translational Opportunities DESCRIPTION:March 26\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this presentation\, Ami Klin will present infant and toddler data on two behavioral assays measuring highly conserved and developmentally early emerging social adaptive behaviors. His findings suggest that these measures are more proximal to gene expression\, better capture unfolding social adaptive developmental mechanisms and are more presymptomatic and more highly quantitative than prior work. The findings have the potential to bridge genetic determinants and symptomatic outcomes\, create a common framework for gene-brain-behavior research and constrain future models of pathogenesis. \nThese concepts also have translational value in addressing autism as a public health challenge via efforts to develop community-viable systems to reduce age of diagnosis and improve access to early care in the general population. Klin’s programmatic goal at the Marcus Autism Center research enterprise is to capitalize on new science in order to address still-intractable health care challenges. \nAmi Klin\, Ph.D.\, is Georgia Research Alliance Eminent Scholar Professor and director of the division of autism and developmental disabilities at Emory University School of Medicine\, and chief of the Marcus Autism Center\, Children’s Healthcare of Atlanta. He earned his Ph.D. from the University of London and completed clinical and research work at Yale University’s Child Study Center. Until 2010\, he directed the autism program at the Yale Child Study Center\, Yale University School of Medicine\, and was Harris Professor of Child Psychology and Psychiatry there. \nKlin’s primary research focuses on the social mind and brain\, and on the developmental aspects of autism from infancy through adulthood. He is the author of over 180 publications in the field of autism and related conditions and the co-editor of Asperger Syndrome\, Autism Spectrum Disorders in Infants and Toddlers\, the third edition of the Handbook of Autism and Pervasive Developmental Disorders and several special issues of professional journals focused on autism spectrum disorders. \nTo attend this event\, sign up here. URL:https://www.simonsfoundation.org/event/march-26-2014-an-attempt-at-redefining-autism-for-the-biological-sciences-implications-and-translational-opportunities/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205943/Klin.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140323T000000 DTEND;TZID=America/New_York:20140329T000000 DTSTAMP:20260413T110429 CREATED:20150908T040000Z LAST-MODIFIED:20250813T163845Z UID:4080-1395532800-1396051200@www.simonsfoundation.org SUMMARY:Galactic Superwinds: Beyond Phenomenology (2014) DESCRIPTION:March 23 – 29\, 2014 \nOrganizers:\nAndrew Benson\, Carnegie Observatories\nJuna Kollmeier\, Carnegie Observatories \nThe goal of this symposium was to bring together leading experts in the theory and observation of galactic superwinds — outflows of mass\, momentum and energy from galaxies thought to be driven by radiation and winds from stars\, and by supernova explosions. The major topic of discussion was the physics of cold gas flows ejected at high velocity into a low density\, hot circumgalactic medium\, specifically what physics (magnetic fields\, thermal conduction\, etc.) must be incorporated to accurately model the evolution of these clouds\, and whether these physical processes\, with characteristic length scales on the order of 1 parsec\, can be resolved in cosmological simulations at any point in the foreseeable future. An alternative to fully resolving cloud physics was suggested. In this approach\, a detailed sub-grid model of cloud evolution would be solved for each gas particle in the wind\, computing mass\, energy and momentum mixing rates with the surroundings. These rates would then be applied to the macroscopic gas distribution in the simulation. \nThe symposium also addressed the question of how best to compare theory and observation. Quantities that theorists would like to know can be derived from observations only through the addition of many extra assumptions\, all adding uncertainty to the measurements. For example\, a basic quantity of interest is the mass flux in the wind. Inferring this from observations requires assumptions about the isotropy of the wind\, the radius from which it is launched\, etc.\, leading to uncertainties of 1 to 2 orders of magnitude. A major discussion point arising from this issue was\, where should theory and observations meet? Should observers attempt to estimate mass fluxes using all of the assumptions described above\, or should theorists attempt to model the ionization structure of the outflows in their simulations and extract line profiles from their models that can be compared directly with the observables? Each approach requires assumptions\, and it is unclear which approach (or perhaps some middle ground) is optimal. Therefore\, attempting both approaches and comparing results would be advisable. \n  \nMaterials: \nPublications\n\n  \n Publications and preprints resulting from the Simons Symposium on Galactic Superwinds: \n\nThe Systematic Properties of the Warm Phase of Starburst-Driven Galactic Winds; T. Heckman\, R. Alexandroff\, S. Borthakur; in preparation.\nIndirect Evidence for Escaping Lyman Continuum Photons in Local Lyman Break Galaxy Analogs; R. Alexandroff\, T. Heckman\, et al.; submitted to ApJ (2015): http://adsabs.harvard.edu/abs/2015AAS…22525109A.\nConnection Between the Circumgalactic Medium and the Atomic Hydrogen Disk in Galaxies; S. Borthakur\, T. Heckman\, et al.; submitted to ApJ (2015): http://adsabs.harvard.edu/abs/2015AAS…22542701B.\nThe Launching of Cold Clouds by Galaxy Outflows I: Hydrodynamic Interactions with Radiative Cooling; E. Scannapieco & M. Brüggen; (2015): http://arxiv.org/pdf/1503.06800v1.pdf.\nGalaxy Outflows Without Supernovae; S. Sur\, E. Scannapieco\, E. C. Ostriker; in preparation.\nEntrainment in Trouble: Cool Cloud Acceleration and Destruction in Hot Supernova-Driven Galactic Winds; D. Zhang\, T. A. Thompson\, N. Murray\, E. Quataert; to be submitted to MNRAS (2015).\nMagnetized gas clouds can survive acceleration by a hot wind; M. McCourt\, R. O’Leary\, A-M. Madigan\, E. Quataert; MNRAS Letters (2015) 449 (1)\, 2–7: http://dx.doi.org/10.1093/mnras/stv355.\nSub-Eddington Star-Forming Regions Are Super-Eddington: Momentum Driven Outflows from Supersonic Turbulence; A. Thompson & M. R. Krumholz; submitted to MNRAS (2014): http://arxiv.org/abs/1411.1769.\nThe Lyα Line Profiles of Ultraluminous Infrared Galaxies: Fast Winds and Lyman Continuum Leakage; C. L. Martin\, M. Dijkstra\, A. Henry\, K. T. Soto\, C. W. Danforth\, J. Wong; submitted to ApJ (2015): http://arxiv.org/abs/1501.05946.\nBaryon Cycling in the Low-Redshift Circumgalactic Medium: A Comparison of Simulations to the COS-Halos Survey; A. B. Ford\, J. K. Werk\, R. Davé\, J. Tumlinson\, R. Bordoloi\, N. Katz\, J. A. Kollmeier\, B. D. Oppenheimer\, M. S. Peeples\, J. X. Prochaska\, D. H. Weinberg; submitted to MNRAS (2015): http://arxiv.org/abs/1503.02084.\nThe EAGLE project: simulating the evolution and assembly of galaxies and their environments; J. Schaye\, R. A. Crain\, R. G. Bower\, M. Furlong\, M. Schaller\, T. Theuns\, C. D. Vecchia\, C. S. Frenk\, I. G. McCarthy\, J. C. Helly\, A. Jenkins\, Y. M. Rosas-Guevara\, S. D. M. White\, M. Baes\, C. M. Booth\, P. Camps\, J. F. Navarro\, Y. Qu\, A. Rahmati\, T. Sawala\, P. A. Thomas\, J. Trayford; MNRAS (2015) 446 (1)\, 521–554: http://dx.doi.org/10.1093/mnras/stu2058.\nThe EAGLE simulations of galaxy formation: calibration of subgrid physics and model variations; R. A. Crain\, J. Schaye\, R. G. Bower\, M. Furlong\, M. Schaller\, T. Theuns\, C. D. Vecchia\, C. S. Frenk\, I. G. McCarthy\, J. C. Helly\, A. Jenkins\, Y. M. Rosas-Guevara\, S. D. M. White\, J. W. Trayford; submitted to MNRAS (2015): http://arxiv.org/abs/1501.01311.\nEvolution of galaxy stellar masses and star formation rates in the EAGLE simulations; M. Furlong\, R. G. Bower\, T. Theuns\, J. Schaye\, R. A. Crain\, M. Schaller\, C. D. Vecchia\, C. S. Frenk\, I. G. McCarthy\, J. Helly\, A. Jenkins\, Y. M. Rosas-Guevara\, submitted to MNRAS (2014): http://arxiv.org/abs/1410.3485.\nOn the interplay between star formation and feedback in galaxy formation simulations; O. Agertz & A. V. Kravtsov; submitted to and in press at ApJ (2015): http://arxiv.org/abs/1404.2613.\nStellar feedback driven winds and galaxy morphology; O. Agertz & A. Kravtsov; to be submitted.\nThe distribution of neutral hydrogen around high-redshift galaxies and quasars in the EAGLE simulation; Rahmati\, J. Schaye\, R. G. Bower\, R. A. Crain\, M. Furlong\, M. Schaller\, T. Theuns; submitted to MNRAS (2015): http://arxiv.org/abs/1503.05553.\nGalaxies that shine: radiation-hydrodynamical simulations of disk galaxies; Rosdahl\, J. Schaye\, R. Teyssier\, O. Agertz; submitted to MNRAS (2015): http://arxiv.org/abs/1501.04632.\nDetection of hot\, metal-enriched outflowing gas around z ≈ 2.3 star-forming galaxies in the Keck Baryonic Structure Survey; L. Turner\, J. Schaye\, C. C. Steidel\, G. C. Rudie\, A. L. Strom; submitted to MNRAS (2014): http://arxiv.org/abs/1410.8214.\n\n\nPresentation Slides\n\n Rob Crain\, Leiden Observatory\n Download Slides \n Romeel Davé\, Arizona State University\n Download Slides \n Nick Gnedin\, University of Chicago/Fermilab\n Download Slides \n Mark Krumholz\, UC Santa Cruz\n Download Slides \n Eliot Quataert\, UC Berkeley\n Download Slides \n Joop Schaye\, Leiden Observatory\n Download Slides \n David Weinberg\, Ohio State\n Download Slides\n\n$(‘#presentation-slides’).toggle(0);\nSession Slides\n\nRichard Bower\, University of Durham\nOutflow Questions \nRob Crain\, Leiden Observatory\nPre-SNe Stellar Winds\, Intermediate Age Populations\, Momentum Driving Relevance on Scales Beyond GMCs\, 1051 erg/SN\, Short AGN Duty Cycles\, Accuracy of Models (SAM/hydro)\, Dwarf Galaxy Simulation Parameters v. Observational Constraints \nRomeel Davé\, Arizona State University\nWind Propagation & Mixing \nNick Gnedin\, University of Chicago/Fermilab\nHow We Should Think About Star Formation \nNeal Katz\, University of Massachusetts\nPhenomenologically Obtained Winds (POW) \nDusan Keres\, University of San Diego\nChallenges in (Numerical) Galactic Wind Modeling \nMark Krumholz\, UC Santa Cruz\nGalactic Winds: The “Last pc” Problem \nCrystal Martin\, UC Santa Barbara\nWhat Is the Mass Flux in Galactic Winds? \nEliot Quataert\, UC Berkeley\nGalactic Winds (impact of star formation vs. AGNs\, role of cosmic rays\, level of detail needed/feasible for predictive galaxy formation models) \nBrant Robertson\, University of Arizona\nPhysical Coupling of Winds to the Turbulent Interstellar Medium \nEvan Scannapieco\, Arizona State University\nWhat are the Turbulent Velocity and Scale Height in Starbursting Galaxies? \nJoop Schaye\, Leiden Observatory\nKey Challenges in Wind Modeling \nSijing Shen\, UC Santa Cruz\nChallenges in Galactic Wind Modeling \nChuck Steidel\, Cal Tech\nNon-Exhaustive List of Questions \nGreg Stinson\, Max-Planck-Institut für Astronomie\nHow Do Outflows Work? \nTodd Thompson\, Ohio State\nTheoretical & Observational Challenges \nFreeke van de Voort\, UC Berkeley\nAspects in Need of Simulation and Study \nDavid Weinberg\, Ohio State\nPrimary Questions of Galaxy Formation / What Happens to Gas After it is Ejected? / Other Key Isssues \n\nSymposium Agenda\n\nDownload PDF \nGalactic Superwinds: Beyond Phenomenology\nMarch 23 – 29\, 2014 \n\n\n\n\n \n\nMONDAY: ISM\n\n\n9:00 – 10:30 AM\nStar Formation\nModerators: Gnedin & Krumholz\n\n\n11:00 AM – 12:30 PM\nTurbulence\nModerators: Robertson & Scannapieco\n\n\n4:00 – 5:30 PM\nStellar Populations / Stellar Winds / Supernovae\nModerators: Crain & Schaye\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n8:30 – 10:00 PM\nNumerics @ Night\nModerator: Krumholz\n\n\n \n\n\nTUESDAY: Energy Input\n\n\n9:00 – 10:30 AM\nAGN/Preventative Feedback\nModerators: Quataert & Katz\n\n\n11:00 AM – 12:30 PM\nKnown Unknowns(Magnetics Fields\, Cosmic Rays\, etc.)\nModerators: Stinson\, Keres & Schaye\n\n\n4:00 – 5:30 PM\nCoupling to ISM\nModerators: Thompson & Krumholz\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n8:30 – 10:00 PM\nNumerics @ Night\nModerator: Katz\n\n\n \n\n\nWEDNESDAY: Wind Structure\n\n\n9:00 – 10:30 AM\nMass\, Energy\, Momentum & Metal Fluxes\nModerators: Davé & Martin\n\n\n11:00 AM – 12:30 PM\nMultiphase Wind Structure\nModerators: Keres & Steidel\n\n\n2:30 – 4:00 PM\nCoupling to the CGM\nModerators: Shen & Heckman\n\n\n \n\n\nTHURSDAY: Diagnostics\nÜber Moderators: Steidel\, Heckman\, Martin\n\n\n9:00 – 10:30 AM\nISM\nModerator: Murray\n\n\n11:00 AM – 12:30 PM\nGalactic\nModerator: van de Voort\n\n\n4:00 – 5:30 PM\nCGM\nModerator: Weinberg\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n8:30 – 10:00 PM\nNumerics @ Night\nModerator: Shen & Keres\n\n\n \n\n\nFRIDAY: Synthesis\n\n\n9:00 – 10:30 AM\nObservational\nModerators: Steidel\, Heckman & Martin\n\n\n11:00 AM – 12:30 PM\nTheoretical/Numerical\nModerators: Bower\, Kravtsov & Murray\n\n\n4:00 – 5:30 PM\nRoadmap\nModerators: Benson\, Kollmeier\n\n\n5:30 – 6:30 PM\nInformal Discussion\n\n\n\n\n \nParticipants: \nAndrew Benson\, Carnegie Observatories\nRichard Bower\, University of Durham\nRob Crain\, Leiden Observatory\nRomeel Dave\, Arizona State University\nNick Gnedin\, University of Chicago/Fermilab\nTim Heckman\, Johns Hopkins University\nNeal Katz\, University of Massachusetts\nDusan Keres\, University of San Diego\nJuna Kollmeier\, Carnegie Observatories\nAndrey Kravtsov\, University of Chicago\nMark Krumholz\, UC Santa Cruz\nCrystal Martin\, UC Santa Barbara\nNorman Murray\, Canadian Institute of Theoretical Astrophysics\nEliot Quataert\, UC Berkeley\nBrant Robertson\, University of Arizona\nEvan Scannapieco\, Arizona State University\nJoop Schaye\, Leiden Observatory\nSijing Shen\, UC Santa Cruz\nChuck Steidel\, Cal Tech\nGreg Stinson\, Max-Planck-Institut für Astronomie\nTodd Thompson\, Ohio State\nFreeke van de Voort\, UC Berkeley\nDavid Weinberg\, Ohio State URL:https://www.simonsfoundation.org/event/galactic-superwinds-beyond-phenomenology-march-23-29-2014/ LOCATION:NY END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140312T153000 DTEND;TZID=America/New_York:20140312T180000 DTSTAMP:20260413T110429 CREATED:20140612T040000Z LAST-MODIFIED:20211207T163628Z UID:229-1394638200-1394647200@www.simonsfoundation.org SUMMARY:Learning With a Nontrivial Teacher DESCRIPTION:In this lecture\, Vladimir Vapnik will discuss how the LUPI learning model can take the form of comments\, descriptions\, metaphoric reasoning and other teaching tactics. He will describe the goal of the model — to develop good decision rules even when only a small number of examples is provided. \nVladimir Vapnik\, Ph.D. works in the machine learning department at NEC Laboratories America\, Inc. and is professor of computer science at Columbia University. He has made major contributions to computer science and machine learning\, including a general theory for minimizing the expected risk of losses using empirical data\, and the widely used Support Vector Machine approach to classification. Among his many honors are the 2003 Humboldt Research Award\, the 2005 Gabor Award\, the 2010 Neural Networks Pioneer Award\, the 2012 IEEE Frank Rosenblatt Award and the 2012 Benjamin Franklin Medal in Computer and Cognitive Science from the Franklin Institute. He was elected to the National Academy of Engineering in 2006 for “insights into the fundamental complexities of learning and for inventing practical and widely applied machine-learning algorithms.” \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/learning-with-a-nontrivial-teacher/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Frontiers of Data Science ATTACH;FMTTYPE=image/png:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180724/vald11.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140312T000000 DTEND;TZID=America/New_York:20140312T000000 DTSTAMP:20260413T110429 CREATED:20140107T050000Z LAST-MODIFIED:20211207T163617Z UID:1998-1394582400-1394582400@www.simonsfoundation.org SUMMARY:March 12\, 2014: Learning With a Nontrivial Teacher DESCRIPTION:March 12\, 2014\, 3:30-6:00 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Vladimir Vapnik will discuss how the LUPI learning model can take the form of comments\, descriptions\, metaphoric reasoning and other teaching tactics. He will describe the goal of the model — to develop good decision rules even when only a small number of examples is provided. \nVladimir Vapnik\, Ph.D. works in the machine learning department at NEC Laboratories America\, Inc. and is professor of computer science at Columbia University. He has made major contributions to computer science and machine learning\, including a general theory for minimizing the expected risk of losses using empirical data\, and the widely used Support Vector Machine approach to classification. Among his many honors are the 2003 Humboldt Research Award\, the 2005 Gabor Award\, the 2010 Neural Networks Pioneer Award\, the 2012 IEEE Frank Rosenblatt Award and the 2012 Benjamin Franklin Medal in Computer and Cognitive Science from the Franklin Institute. He was elected to the National Academy of Engineering in 2006 for “insights into the fundamental complexities of learning and for inventing practical and widely applied machine-learning algorithms.” \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/march-12-2014-learning-with-a-nontrivial-teacher/ LOCATION:NY ATTACH;FMTTYPE=image/png:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205900/vald1.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140309T000000 DTEND;TZID=America/New_York:20140315T000000 DTSTAMP:20260413T110429 CREATED:20150908T040000Z LAST-MODIFIED:20250813T163805Z UID:4079-1394323200-1394841600@www.simonsfoundation.org SUMMARY:Discrete Analysis: Beyond the Boolean Cube (2014) DESCRIPTION:March 9 – 15\, 2014 \nOrganizers:\nElchanan Mossel\, UC Berkeley\nRyan O’Donnell\, Carnegie Mellon University\nKrzysztof Oleszkiewicz\, University of Warsaw \nThe Simons Symposium on Discrete Analysis: Beyond the Boolean Cube was the second symposium organized on this topic. The first was held in 2012 and was called Analysis of Boolean Functions. This most recent meeting focused on the interplay between the discrete cube setting and its non-commutative\, non-independent\, continuous\, and number-theoretic counterparts. Key topics included Fourier analysis on groups\, discrete analysis in additive groups and fields\, invariance principles\, discrete partitions of Gaussian and spherical spaces\, Gaussian isoperimetric problems\, connections between boundedness of Gaussian and Rademacher processes\, explicit optimal rounding of semidefinite programs\, and connections to Markov chains. \nMaterials:\nPresentation Slides\n\n \nBoaz Barak\,\nMicrosoft Research\nSome questions\, results\, and musings on Sums of Squares\, Unique Games Conjecture\, Hypercontractive norms\, Sparse vectors\, and other issues. \nWitold Bednorz\,\nUniversity of Warsaw\n(joint work with Rafal Latala)\nBeyond Bernoulli Theorem \nSubhash Khot\,\nNew York University\n(Joint work with Madhur Tulsiani and Pratik Worah)\nA Characterization of Strong Approximation Resistance \nAlexandra Kolla\,\nUniversity of Illinois Urbana-Champaign\nMaximal Inequalities Beyond the Boolean Cube \nRaghu Meka\,\nMicrosoft Research\nA PTAS for Computing the Supremum of Gaussian Processes \nYuval Peres\,\nMicrosoft Research\n(Joint work with Yael Dekel at The Hebrew University and Ori Gurel-Gurevich at University of British Columbia)\nFinding Hidden Cliques in Linear Time with High Probability \nLi-Yang Tan\,\nColumbia University\n(Joint work with Rocco Servedio)\nA Polynomial Lower Bound for Monotonicity Testing of Boolean Functions\n\nSymposium Agenda\n\nDownload PDF \nDiscrete Analysis: Beyond the Boolean Cube\nMarch 9 – 15\, 2014 \n\n\n\n\n \n\n \n\n\nMonday\n\n\n9:00 – 9:30 AM\nAvi Wigderson\nCan Every Sequential Computation be Efficiently Parallelized?\n\n\n9:30 – 10:00 AM\nRafal Latala\nSuprema of Bernoulli Processes\n\n\n10:00 – 10:30 AM\nWitold Bednorz\nBeyond the Bernoulli Theorem\n\n\n11:00 – 11:30 AM\nYuval Filmus\nStability Results Beyond the Boolean Cube and the EKR Theorem\n\n\n11:30 AM – 12:00 PM\nRaghu Meka\nA PTAS for Computing the Supremum of Gaussian Processes\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 7:00 PM\nLonger Talk\n\n\n\n \n\n\nTuesday\n\n\n9:00 – 9:30 AM\nTom Sanders\nThe Green-Bourgain Sumset Problem\n\n\n9:30 – 10:00 AM\nThomas Vidick\nNon-commutative Extensions of Grothendieck’s Inequality\n\n\n10:00 – 10:30 AM\nOded Regev\nExtensions of Spencer’s Discrepancy Theorem\n\n\n11:00 – 11:30 AM\nLi-Yang Tan\nA Polynomial Lower Bound for Monotonicity Testing of Boolean Functions\n\n\n11:30 AM – 12:00 PM\nEhud Friedgut\nExtremal Problems in Symmetric Group via Fourier Analysis\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 7:00 PM\nLonger Talk\nChosen by Participants\n\n\n \n\n\nWednesday\n\n\n9:00 – 9:30 AM\nSubhash Khot\nA Characterization of Approximation Resistance\n\n\n9:30 – 10:00 AM\nBoaz Barak\nSums of Squares\, Optimizing Over Sparse Vectors\, and Hypercontractive Norms\n\n\n10:30 – 11:00 AM\nJulia Wolf\nBeyond the Gowers Norms\n\n\n11:00 – 11:30 AM\nStanislaw Szarek\nMeasures on\, and Generic Properties for N Qubits\n\n\n11:30 AM – 12:00 PM\nChristophe Garban\nQuestions around the Mixing Time of the Critical Ising Model and the Majority in Stablest Theorem\n\n\n2:00 – 3:00 PM\nOpen Problem Session\n\n\n\n \n\n\nThursday\n\n\n10:00 – 10:30 AM\nSergey Bobkov\nConcentration on the Cube for Permutationally Invariant Sets\n\n\n11:00 – 11:30 AM\nAlmut Burchard\nTwo-point Symmetrization and some Applications to Path Integrals\n\n\n11:30 AM – 12:00 PM\nAlexandra Kolla\nDiscrete Maximal Inequalities Beyond the Boolean cube and Bounds on Orthogonal Polynomials\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 6:00 PM\nJoe Neeman\nThe Majority is Stablest Theorem on Non-product Spaces\n\n\n6:00 – 6:30 PM\nYuval Peres\n1. The Majority is Least Stable Conjecturei2. Concentration of Lipschitz Functions of Negatively Associated Variables\n\n\n \n\n\nFriday\n\n\n9:00 – 10:00 AM\nLonger Talk\nChosen by Participants\n\n\n10:30 – 11:30 AM\nLonger Talk\nChosen by Participants\n\n\n4:30 – 5:30 PM\nOpen Problem Session\n\n\n\n5:30 – 7:00 PM\nProgress Report\n\n\n\n\n \nSite: http://analysisofbooleanfunctions.org \nParticipants: \nBoaz Barak\, Microsoft Research New England\nWitold Bednorz\, University of Warsaw\nSergey Bobkov\, University of Minnesota\nAlmut Burchard\, University of Toronto\nYuval Filmus\, University of Toronto\nEhud Friedgut\, The Einstein Institute of Mathematics\nChristophe Garban\, ENS Lyon\, UMPA\nSubhash Khot\, New York University\nAlexandra Kolla\, University of Illinois at Urbana-Champaign\nRafal Latala\, University of Warsaw\nRaghu Meka\, IAS\nElchanan Mossel\, UC Berkeley\nJoe Neeman\, UC Berkeley\nRyan O’Donnell\, Carnegie Mellon University\nKrzysztof Oleszkiewicz\, University of Warsaw\nYuval Peres\, Microsoft Research\nOded Regev\, New York University\nTom Sanders\, Oxford University\nStanislaw Szarek\, Case Western Reserve University\nLi-Yang Tan\, Columbia University\nYuri Tschinkel\, Simons Foundation\nThomas Vidick\, MIT\nAvi Wigderson\, IAS\nJulia Wolf\, École Polytechnique URL:https://www.simonsfoundation.org/event/discrete-analysis-beyond-the-boolean-cube-march-9-15-2014/ LOCATION:NY END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140307T123000 DTEND;TZID=America/New_York:20140307T173000 DTSTAMP:20260413T110429 CREATED:20140612T040000Z LAST-MODIFIED:20211207T163606Z UID:219-1394195400-1394213400@www.simonsfoundation.org SUMMARY:Perspectives on Big Data in Biology DESCRIPTION:This Biotech Symposium will focus on perspectives on big data in biology from leading practitioners in the field. Past Biotech Symposia topics have included single nucleotide polymorphism detection\, diffusion magnetic resonance imaging\, structural variant detections and resting state fMRI.  Future symposia will focus on related bioinformatics and neuroimaging topics. \nSpeakers: \n \nNicholas Carriero\, Ph.D.\nYale University\nScaling Up Bioinformatics Pipelines \nDavid Lipman\, M.D.\nNational Center for Biotechnology Information\, National Institutes of Health\nWhat Is the Big Data Problem in Biology? \n \nDavid Haussler\, Ph.D.\nUniversity of California\, Santa Cruz\nLarge-Scale Cancer Genomics \n \nCharles Sawyers\, M.D.\nMemorial Sloan-Kettering Cancer Center\nGlobal Alliance for Genomics and Health \n  URL:https://www.simonsfoundation.org/event/perspectives-on-big-data-in-biology/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Biotech Symposia ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180714/Perspectives-on-dig-data1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140307T000000 DTEND;TZID=America/New_York:20140307T000000 DTSTAMP:20260413T110429 CREATED:20140206T050000Z LAST-MODIFIED:20211207T163556Z UID:2023-1394150400-1394150400@www.simonsfoundation.org SUMMARY:March 7\, 2014: Perspectives on Big Data in Biology DESCRIPTION:March 7\, 2014\, 12:30-5:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nThis Biotech Symposium focused on perspectives on big data in biology from leading practitioners in the field. Other Biotech Symposia topics have included single nucleotide polymorphism detection\, diffusion magnetic resonance imaging\, structural variant detections and resting state fMRI. Future symposia will focus on related bioinformatics and neuroimaging topics. \n  \n  \n  \nSpeakers: \nDavid Lipman\, M.D. (First video below\, begins at 00:03:30)\nNational Center for Biotechnology Information\, National Institutes of Health\nWhat Is the Big Data Problem in Biology? \nNicholas Carriero\, Ph.D. (First video below\, begins at 01:05:20)\nYale University\nScaling Up Bioinformatics Pipelines \nDavid Haussler\, Ph.D. (Second video below)\nUniversity of California\, Santa Cruz\nLarge-Scale Cancer Genomics \nCharles Sawyers\, M.D. (Third video below)\nMemorial Sloan-Kettering Cancer Center\nGlobal Alliance for Genomics and Health \n  \n  URL:https://www.simonsfoundation.org/event/march-7-2014-perspectives-on-big-data-in-biology/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205933/Perspectives-on-dig-data.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140305T170000 DTEND;TZID=America/New_York:20140305T180000 DTSTAMP:20260413T110429 CREATED:20170428T040000Z LAST-MODIFIED:20211207T163545Z UID:450-1394038800-1394042400@www.simonsfoundation.org SUMMARY:Genes That Regulate Sleep and Circadian Rhythms in Drosophila DESCRIPTION:Circadian (~24 hour) clocks are endogenous mechanisms that time the recurring\, daily activities observed in most organisms. These clocks are genetically regulated\, and generate biochemical oscillations within individual cells composing most tissues. Our work began in Drosophila melanogaster\, where we identified a small group of genes that are principal components of an intracellular circadian clock. Mutations in any of these genes can lengthen or shorten the period of behavioral and other circadian rhythms or can abolish the rhythms altogether. The abundance of proteins encoded by several of these genes changes rhythmically with a circadian period. Mutations affecting any of these genes have corresponding effects on behavioral rhythms as well as the molecular rhythms of hundreds of clock-regulated genes that are expressed in most organ systems. Orthologous genes regulate mammalian\, including human\, circadian rhythms\, so that today our lab studies the action of these genes and proteins in a variety of biological models. We are also currently studying prominent rhythmic behaviors that are controlled by circadian clock with a particular focus on sleep. Recently our laboratory has searched for and identified genes that affect the homeostatic regulation of sleep in Drosophila. This research has uncovered specific neurons whose activity promotes sleep. \nAbout the Speaker \nDr. Young received his undergraduate degree in biology in 1971 and his Ph.D. in genetics in 1975\, both from The University of Texas\, Austin. Following postdoctoral work in biochemistry at the Stanford University School of Medicine\, he was appointed assistant professor at Rockefeller in 1978 as part of The Rockefeller University Fellows Program. He was named associate professor in 1984 and professor in 1988\, and from 1987 to 1996 he was an investigator of the Howard Hughes Medical Institute. From 1991 to 2001 Young headed the Rockefeller unit of the National Science Foundation’s Science and Technology Center for Biological Timing. Young was named the university’s Vice President for Academic Affairs and Richard and Jeanne Fisher Professor in 2004. \nDr. Young is a member of the National Academy of Sciences and a Fellow of the American Academy of Microbiology. He is a recipient of the 2013 Shaw Prize in Life Science and Medicine\, the 2013 Wiley Prize in Biomedical Science\, the 2012 Canada Gairdner International Award\, the 2012 Massry Prize\, the 2011 Louisa Gross Horwitz Prize for Biology or Biochemistry and the 2009 Neuroscience Prize of the Peter and Patricia Gruber Foundation. \nIntro Article (pdf)\nLecture Slides (pdf)\nPER-CFP/TIM-YFP video (QuickTime)\nPER-CFP/TIM-YFP/FRET video (QuickTime) URL:https://www.simonsfoundation.org/event/genes-that-regulate-sleep-and-circadian-rhythms-in-drosophila/ LOCATION:NY CATEGORIES:Simons Science Series ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181142/Michael-Young-Headshot-thumb.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140226T163000 DTEND;TZID=America/New_York:20140226T183000 DTSTAMP:20260413T110429 CREATED:20140508T040000Z LAST-MODIFIED:20211207T163533Z UID:202-1393432200-1393439400@www.simonsfoundation.org SUMMARY:Neuroimaging Contributions to the Understanding of Brain Development in Autism DESCRIPTION:In this lecture\, David G. Amaral will present neuroimaging data acquired through the University of California\, Davis MIND Institute’s Autism Phenome Project. Young children (aged 2 to 3 and a half years old) are recruited into this longitudinal project and MRI scans are acquired annually. Results will be presented supporting the concept that there are different types of altered brain development in different children with autism. Amaral will also discuss neuroimaging studies of infant siblings of children with autism that provide evidence for abnormal brain growth that may contribute to early biomarkers of autism. \nDavid G. Amaral joined the University of California\, Davis in 1995 as a professor in the department of psychiatry and behavioral sciences and the Center for Neuroscience. He is a staff scientist in the Brain\, Mind and Behavior Unit at the California National Primate Research Center. Amaral was named the Beneto Foundation Chair and research director of the MIND Institute in 1998. He received a joint Ph.D. in psychology and neurobiology from the University of Rochester. \nAmaral’s research focuses on the neurobiology of social behavior and the development and neuroanatomical organization and plasticity of the primate and human amygdala and hippocampal formation. Increasingly\, his research has been dedicated to understanding the biological basis of autism. As research director of the MIND Institute\, Amaral coordinates a comprehensive and multidisciplinary analysis of children with autism\, called the Autism Phenome Project\, to define biomedical characteristics of different types of autism. \nMost recently\, Amaral became director of Autism BrainNet\, a collaborative effort sponsored by the Simons Foundation and Autism Speaks\, to solicit postmortem brain tissue to facilitate autism research. \n  URL:https://www.simonsfoundation.org/event/neuroimaging-contributions-to-the-understanding-of-brain-development-in-autism/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Autism: Emerging Concepts ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180657/20130905_amaral_david_087-copy-640x4251.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140226T000000 DTEND;TZID=America/New_York:20140226T000000 DTSTAMP:20260413T110429 CREATED:20140225T050000Z LAST-MODIFIED:20211207T160450Z UID:2018-1393372800-1393372800@www.simonsfoundation.org SUMMARY:February 26\, 2014: Neuroimaging Contributions to the Understanding of Brain Development in Autism DESCRIPTION:February 26\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, David G. Amaral will present neuroimaging data acquired through the University of California\, Davis MIND Institute’s Autism Phenome Project. Young children (aged 2 to 3 and a half years old) are recruited into this longitudinal project and MRI scans are acquired annually. Results will be presented supporting the concept that there are different types of altered brain development in different children with autism. Amaral will also discuss neuroimaging studies of infant siblings of children with autism that provide evidence for abnormal brain growth that may contribute to early biomarkers of autism. \nDavid G. Amaral joined the University of California\, Davis in 1995 as a professor in the department of psychiatry and behavioral sciences and the Center for Neuroscience. He is a staff scientist in the Brain\, Mind and Behavior Unit at the California National Primate Research Center. Amaral was named the Beneto Foundation Chair and research director of the MIND Institute in 1998. He received a joint Ph.D. in psychology and neurobiology from the University of Rochester. \nAmaral’s research focuses on the neurobiology of social behavior and the development and neuroanatomical organization and plasticity of the primate and human amygdala and hippocampal formation. Increasingly\, his research has been dedicated to understanding the biological basis of autism. As research director of the MIND Institute\, Amaral coordinates a comprehensive and multidisciplinary analysis of children with autism\, called the Autism Phenome Project\, to define biomedical characteristics of different types of autism. \nMost recently\, Amaral became director of Autism BrainNet\, a collaborative effort sponsored by the Simons Foundation and Autism Speaks\, to solicit postmortem brain tissue to facilitate autism research. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/february-26-2014-neuroimaging-contributions-to-the-understanding-of-brain-development-in-autism/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205927/20130905_amaral_david_087-copy.jpg END:VEVENT BEGIN:VEVENT DTSTART;VALUE=DATE:20140223 DTEND;VALUE=DATE:20140302 DTSTAMP:20260413T110429 CREATED:20171031T204436Z LAST-MODIFIED:20250813T163649Z UID:29397-1393113600-1393718399@www.simonsfoundation.org SUMMARY:Quantum Physics Beyond Simple Systems (2014) DESCRIPTION:Organizers:\nBoris Altshuler\, Columbia University\nVladimir Falko\, Lancaster University\nCharles Marcus\, Neils Bohr Institute\n  \nThe Simons Symposium on Quantum Physics Beyond Simple Systems was the second symposium organized on this topic\, the first having been held in 2012. It offered another opportunity for researchers to discuss the fast-evolving themes of modern quantum complex systems. These themes include superconducting and semiconductors quibits; topological insulators and superconductors\, Majora fermions; graphene and heterostructures of 2D atomic crystals; polaritons and quantum optics. The first three themes were the focus of the 2012 Symposium and in the intervening two years proved that they offer a fertile field for further progress. \nMaterials: \nSymposium Agenda\n\n \nDownload PDF\n\nQuantum Physics Beyond Simple Systems\nFebruary 23 – March 1\, 2014\n \n\n\n\n\n \n\n \n\n\n Monday \n\n\n10:00 – 10:50 AM\nKitaev\nTopological Classification of Three-Dimensional Superconductors with Interactions Beyond Mean Field\n\n\n11:20 AM – 12:10 PM\nYao\nValley and Spin Physics in 2D Transition Metal Dichalcogenides\n\n\n12:10 – 1:00 PM\nAkhmerov\n \n\n\n 5:00 – 5:50 PM\nJarillo-Herrero\n \n\n\n 5:50 – 6:40 PM\nMele\n \n\n\n 8:00 – 11:00 PM\nOpen Discussion\n\n\n \n\n\n Tuesday \n\n\n10:00 – 10:50 AM\nYacoby\nInduced Superconductivity in the Quantum Spin Hall Edge\n\n\n11:20 AM – 12:10 PM\nGeim\n \n\n\n12:10 – 1:00 PM\nFalko\nhBN-Caged Graphene\n\n\n 5:00 – 5:50 PM\nLoss\n \n\n\n 5:50 – 6:40 PM\nMarcus\n \n\n\n 8:00 – 11:00 PM\nOpen Discussion\n\n\n \n\n\n Wednesday \n\n\n10:00 – 10:50 AM\nBloch\nPolariton Condensates in Microstructures\n\n\n11:20 AM – 12:10 PM\nMorpurgo\nEven-Denominator Fractional Quantum Hall Effect in Bilayer Graphene / Strain Induced Universality of Transport Through Graphene-on-Substrate\n\n\n12:10 – 1:00 PM\nGuinea\n \n\n\n 2:30 – 3:20 PM\nStern\nEngineered Non-Abelian Anyons Beyond Majorana Fermions \n\n\n 3:20 – 4:00 PM\nDiscussion\n\n\n \n\n\n Thursday \n\n\n10:00 – 10:50 AM\nImamoglu\nInterfacing Single Photons and Condensed-Matter Systems\n\n\n11:20 AM – 12:10 PM\nFlensberg\n \n\n\n12:10 – 1:00 PM\nAltshuler\nAnderson Localization at the 1D Edge of a 2D Topological Insulator\n\n\n 5:00 – 5:50 PM\nGlazman\nEffect of Charge Disorder on the Conduction of a Helical Edge\n\n\n 5:50 – 6:40 PM\nAleiner\n \n\n\n 8:00 – 11:00 PM\nOpen Discussion\n\n\n \n\n\n Friday \n\n\n10:00 – 10:50 AM\nDas Sarma\n \n\n\n11:20 AM – 12:10 PM\nGershenson\n \n\n\n12:10 – 1:00 PM\nIoffe\n \n\n\n 5:00 – 6:40 PM\nOrganized Discussion on Challenges & Trends\n\n\n 8:00 – 11:00 PM\nOpen Discussion\n\n\n\nPresentation Slides\n\n  \n Boris Altshuler:\n Anderson Localization at the 1D Edge of a 2D Topological Insulator \n Jacqueline Bloch:\n Polariton Condensates in Microstructures \n Vladimir Falko:\n hBN-Caged Graphene \n Leonid Glazman:\n Effect of Charge Disorder on the Conduction of a Helical Edge \n Atac Imamoglu:\n Interfacing Single Photons and Condensed-Matter Systems \n Alexei Kitaev:\n Topological Classification of Three-Dimensional Superconductors with Interactions Beyond Mean Field \n Alberto Morpurgo:\n Even-Denominator Fractional Quantum Hall Effect in Bilayer Graphene / Strain Induced Universality of Transport Through Graphene-on-Substrate \n Adiel Stern:\n Engineered Non-Abelian Anyons Beyond Majorana Fermions \n Amir Yacoby:\n Induced Superconductivity in the Quantum Spin Hall Edge \n Wang Yao:\n Valley and Spin Physics in 2D Transition Metal Dichalcogenides \n\n\nParticipants:\nAnton Akhmerov\, Delft Technical University\nIgor Aleiner\, Columbia University\nBoris Altshuler\, Columbia University\nJacqueline Bloch\, Centre National de la Recherche Scientifique\nVladimir Falko\, Lancaster University\nKarsten Flensberg\, Niels Bohr Institute\nSarma Das\, Sankar University of Maryland\nSir Geim\, Andre University of Manchester\nMikhail Gershenson\, Rutgers University\nLeonid Glazman\, Yale University\nPaco Guinea\, Instituto de Ciencia de Materiales de Madrid\nAtac Imamoglu\, ETH Zürich\nLev Ioffe\, Rutgers University\nPablo Jarillo-Herrero\, MIT\nAlexei Kitaev\, Cal Tech\nDaniel Loss\, University of Basel\nCharles Marcus\, Niels Bohr Institute\nEugene Mele\, University of Pennsylvania\nAlberto Morpurgo\, Université de Genève\nAdiel Stern\, Weizmann Institute\nAmir Yacoby\, Harvard University\nWang Yao\, University of Hong Kong URL:https://www.simonsfoundation.org/event/quantum-physics-beyond-simple-systems-february-23-march-1-2014/ LOCATION:St. Regis Bahia Beach Resort\, State Road 187 kilometer 4.2\, Río Grande\, 00745\, Puerto Rico END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140219T170000 DTEND;TZID=America/New_York:20140219T180000 DTSTAMP:20260413T110429 CREATED:20170428T040000Z LAST-MODIFIED:20211207T160254Z UID:448-1392829200-1392832800@www.simonsfoundation.org SUMMARY:Robust Integral Equation Methods for Forward and Inverse Scattering DESCRIPTION:Integral equation methods play an important role in the numerical simulation of electromagnetic scattering. They are easy to employ in complex geometry and impose the desired radiation conditions at infinity without the need for artificial numerical boundaries. Two of the obstacles faced by current forward simulation tools are “low-frequency breakdown” and the lack of easy to use high order quadrature rules for complicated surfaces. In this talk\, I will review the relevant background material\, discuss a new mathematical formalism for scattering from perfect conductors and briefly describe a new quadrature technique that yields easily implementable high order rules for singular and weakly singular integrals. The scheme\, denoted QBX (quadrature by expansion) is compatible with fast hierarchical algorithms such as the fast multipole method. I will also present some preliminary results on inverse obstacle scattering. This is joint work with A. Barnett\, C. Borges\, C. L. Epstein\, M. Ferrando\, Z. Gimbutas\, A. Kloeckner\, M. O’Neil\, and F. Vico. URL:https://www.simonsfoundation.org/event/robust-integral-equation-methods-for-forward-and-inverse-scattering/ LOCATION:NY CATEGORIES:Simons Science Series ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181140/greengard_thumb.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140212T163000 DTEND;TZID=America/New_York:20140212T183000 DTSTAMP:20260413T110429 CREATED:20140617T040000Z LAST-MODIFIED:20211207T160501Z UID:247-1392222600-1392229800@www.simonsfoundation.org SUMMARY:Other Earths and the Origins of Life DESCRIPTION:In this lecture\, Dimitar Sasselov will review recent discoveries of exoplanets — planets outside of our solar system — and new estimates of how common potentially habitable worlds appear to be. He will describe new\, comprehensive efforts to hone the search for signatures of life on exoplanets. Central to the success of that search is a deeper understanding of the nature of life and its origins. Sasselov will review recent progress from laboratory studies that connects astronomical exploration and the question of life’s origins. \nSasselov studies stars and planets at Harvard University\, where he is professor of astronomy. His research explores modes of interaction between light and matter. He and his team discovered several planets orbiting stars outside our solar system with novel techniques\, which he hopes to use to find planets like Earth. \nSasselov is founding director of the Harvard Origins of Life Initiative\, a cross-disciplinary research effort bridging the physical and life sciences. He was a senior science advisor for the Radcliffe Institute for Advanced Study at Harvard and a member of the Global Agenda Council on Space Security at the World Economic Forum. \n  URL:https://www.simonsfoundation.org/event/other-earths-and-the-origins-of-life/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Origins of Life ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180741/dimitar1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140212T000000 DTEND;TZID=America/New_York:20140212T000000 DTSTAMP:20260413T110429 CREATED:20140212T050000Z LAST-MODIFIED:20211207T160242Z UID:2066-1392163200-1392163200@www.simonsfoundation.org SUMMARY:February 12\, 2014: Other Earths and the Origins of Life DESCRIPTION:February 12\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Dimitar Sasselov will review recent discoveries of exoplanets — planets outside of our solar system — and new estimates of how common potentially habitable worlds appear to be. He will describe new\, comprehensive efforts to hone the search for signatures of life on exoplanets. Central to the success of that search is a deeper understanding of the nature of life and its origins. Sasselov will review recent progress from laboratory studies that connects astronomical exploration and the question of life’s origins. \nSasselov studies stars and planets at Harvard University\, where he is professor of astronomy. His research explores modes of interaction between light and matter. He and his team discovered several planets orbiting stars outside our solar system with novel techniques\, which he hopes to use to find planets like Earth. \nSasselov is founding director of the Harvard Origins of Life Initiative\, a cross-disciplinary research effort bridging the physical and life sciences. He was a senior science advisor for the Radcliffe Institute for Advanced Study at Harvard and a member of the Global Agenda Council on Space Security at the World Economic Forum. \n  \n  URL:https://www.simonsfoundation.org/event/february-12-2014-other-earths-and-the-origins-of-life-2/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11210037/sasselov.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140212T000000 DTEND;TZID=America/New_York:20140212T000000 DTSTAMP:20260413T110429 CREATED:20140114T050000Z LAST-MODIFIED:20211207T160231Z UID:2016-1392163200-1392163200@www.simonsfoundation.org SUMMARY:February 12\, 2014: Other Earths and the Origins of Life DESCRIPTION:February 12\, 2014\, 4:30-6:30 p.m. EST\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nIn this lecture\, Dimitar Sasselov will review recent discoveries of exoplanets — planets outside of our solar system — and new estimates of how common potentially habitable worlds appear to be. He will describe new\, comprehensive efforts to hone the search for signatures of life on exoplanets. Central to the success of that search is a deeper understanding of the nature of life and its origins. Sasselov will review recent progress from laboratory studies that connects astronomical exploration and the question of life’s origins. \nSasselov studies stars and planets at Harvard University\, where he is professor of astronomy. His research explores modes of interaction between light and matter. He and his team discovered several planets orbiting stars outside our solar system with novel techniques\, which he hopes to use to find planets like Earth. \nSasselov is founding director of the Harvard Origins of Life Initiative\, a cross-disciplinary research effort bridging the physical and life sciences. He was a senior science advisor for the Radcliffe Institute for Advanced Study at Harvard and a member of the Global Agenda Council on Space Security at the World Economic Forum. \nTo attend this event\, sign up here. \nIf this lecture is videotaped\, it will be posted here after production. URL:https://www.simonsfoundation.org/event/february-12-2014-other-earths-and-the-origins-of-life/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11205923/dimitar.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20140126T000000 DTEND;TZID=America/New_York:20140201T000000 DTSTAMP:20260413T110429 CREATED:20150908T040000Z LAST-MODIFIED:20250813T163602Z UID:4077-1390694400-1391212800@www.simonsfoundation.org SUMMARY:Families of Automorphic Forms and the Trace Formula (2014) DESCRIPTION:January 26 – February 1\, 2014 \nOrganizers:\nWerner Mueller\, University of Bonn\nSug Woo Shin\, Massachussets Institute of Technology\nNicolas Templier\, Princeton University \nThe Simons Symposium on Families of Automorphic Forms and the Trace Formula provided an opportunity for researchers to study families of automorphic representations of higher rank groups. During the symposium participants investigated the trace formula\, plancherel equidistribution and other recent techniques from harmonic analysis and representation theory with the goal to set an agenda for the field. \nMaterials: \n→ Symposium Report (PDF)\nSymposium Agenda\n\n \nDownload PDF \n\nFamilies of Automorphic Forms & the Trace Formula\nJanuary 26 – February 1\, 2014\n \n\n\n\n\n \n\n \n\n\n Monday \n\n\n 9:00 – 9:15 AM\nOpening\n\n 9:30 – 10:30 AM\nCalegari \nFamilies of automorphic forms of cohomological type \n\n\n11:00 AM – 12:00 PM\nMuller \nLimit multiplicities for principal congruence subgroups of GL(n) \n\n\n 3:00 – 3:50 PM\nHida \nGrowth of Hecke fields over a slope 0 family \n\n\n 3:50 – 4:40 PM\nTemplier \nFamilies of L-functions and their symmetry \n\n\n 5:10 – 6:00 PM\n Problem Session \n\n\n 8:00 – 8:30 PM\n Problem Session \n\n\n 8:40 – 9:30 PM\nGordon \nUsing model theory to obtain uniform bounds for orbital integrals \n\n\n \n\n\n Tuesday \n\n\n 9:00 – 9:50 AM\nGee \nConjectures of Buzzard and Gouvea\n\n\n 9:50 – 10:40 AM\n Open Discussion \n Calegari \n\n\n11:10 AM – 12:00 PM\nMiller \nL-functions and low-lying zeros \n\n\n 3:00 – 3:50 PM\nCluckers \nMotivic integration and transfer principles \n\n\n 3:50 – 4:40 PM\n Open Discussion \n Organizers \n\n\n 5:10 – 6:00 PM\nUrban \nEigenvarieties \n\n\n 8:00 – 8:30 PM\n Problem Session \n\n\n 8:40 – 9:30 PM\nSoundararajan \nUpper bounds for moments of L-functions \n\n\n \n\n\n Wednesday \n\n\n 9:00 – 9:50 AM\nHoffman \nThe trace formula and prehomogeneous vector spaces \n\n\n11:10 AM – 12:00 PM\n Open Discussion \n\n\n 3:00 – 4:00 PM\nShin \nSato-Tate conjecture for families \n\n\n 4:00 – 5:00 PM\n Open Discussion \n Gordon \n\n\n \n\n\n Thursday \n\n\n 9:00 – 9:50 AM\nSpeh \nSymmetry breaking and the Gross-Prasad conjectures for real orthogonal groups \n\n\n 9:50 – 10:40 AM\n Open Discussion \n Gee \n\n\n11:10 AM – 12:00 PM\nNadler \nAffine character sheaves \n\n\n 3:00 – 3:50 PM\n Open Discussion \n\n\n 3:50 – 4:40 PM\n Open Discussion \n Shin \n\n\n 5:10 – 6:00 PM\nKaletha \nEndoscopy for general groups \n\n\n 8:00 – 8:30 PM\n Problem Session \n\n\n 8:40 – 9:30 PM\nMarshall \nCohomology growth on U(3)\n\n\n \n\n\n Friday \n\n\n 9:00 – 9:50 AM\nKim \n\n\n 9:50 – 10:40 AM\n Open Discussion \n\n\n11:10 AM – 12:00 PM\nHolowinsky \nSubconvexity bounds for Rankin-Selberg L-functions \n\n\n 3:00 – 4:30 PM\n Agenda \n\n\n 5:10 – 6:00 PM\n Open Discussion \n\n\n 8:00 – 8:30 PM\n Problem Session \n\n\n 8:40 – 9:30 PM\n Open Discussion \n\n\n\nNotes and Handouts\n\n \nNotes on Talks at the Simons Symposium on Families of Automorphic Forms and the Trace Formula\nNotes on the talks of the speakers\, as recorded by Steven J. Miller. \nMotivic Functions\, Integrability\, and Uniform in p Bounds for Orbital Integrals\nRaf Cluckers\, Université Lille 1\nJulia Gordon\, University of British Columbia\nImmanuel Halupczok\, University of Leeds \nSlopes of Modular Forms\nToby Gee\, Imperial College London \nProblems on Growth of Hecke Fields\nHaruzo Hida\, UCLA \nProblems in the Theory of Low-Lying Zeros\nSteven J. Miller\, Williams College \nProblems for Thursday\, 3:50 pm\, Jan. 30\, 2014 Discussion Session\nSug Woo Shin\, Massachussets Institute of Technology \n\nLecture Slides\n\n \nGrowth of Hecke Fields Over a Slope 0 Family\nHaruzo Hida\, UCLA \nThe Trace Formula and Prehomogeneous Vector Spaces\nWerner Hoffmann\, Bielefeld University \nRigid Inner Forms and Endoscopy\nTasho Kaletha\, Princeton University \nResults in the Theory of Low-Lying Zeros\nSteven J. Miller\, Williams College \nClosed-Form Moments in Elliptic Curve Families and Low-Lying Zeros\nSteven J. Miller\, Williams College \nSymmetry Breaking and the Gross Prasad Conjectures for Orthogonal Groups\nBirgit Speh\, Cornell University \n\n  \nParticipants: \nFrank Calegari\, Northwestern University\nRaf Cluckers\, Université Lille 1\nToby Gee\, Imperial College London\nJulia Gordon\, University of British Columbia\nHaruzo Hida\, UCLA\nWerner Hoffmann\, Universitat Bielefeld\nRoman Holowinsky\, Ohio State University\nTasho Kaletha\, Princeton University\nJu-Lee Kim\, Massachussets institute of Technology\nSimon Marshall\, Northwestern University\nSteven J. Miller\, Williams College\nWerner Mueller\, University of Bonn\nDavid Nadler\, UC Berkeley\nSug Woo Shin\, Massachussets Institute of Technology\nKannan Soundararajan\, Stanford University\nBirgit Speh\, Cornell University\nNicolas Templier\, Princeton University\nEric Urban\, Columbia University URL:https://www.simonsfoundation.org/event/families-of-automorphic-forms-and-the-trace-formula-january-26-february-1-2014/ LOCATION:NY END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20131211T170000 DTEND;TZID=America/New_York:20131211T180000 DTSTAMP:20260413T110429 CREATED:20170428T040000Z LAST-MODIFIED:20211207T160221Z UID:446-1386781200-1386784800@www.simonsfoundation.org SUMMARY:Identities About Self Assembly DESCRIPTION:In biological systems\, there are striking examples where complicated structures (i.e.\, the bacterial ribosome) can spontaneously assemble\, driven by specific interactions between the components. But how can systems be designed to have this property? Recent technological  advances have created the opportunity for making technologically relevant systems that self assemble\, using strands of DNA or objects coated with DNA. We will use these systems as inspiration to formulate theoretical models to understand how self assembly works in these systems\, through theory\, numerical simulation and experiment — and start to speculate as to whether resulting principles might be useful for unravelling the rules of biological self-assembly. \nMichael Brenner is the Glover Professor of Applied Mathematics and Applied Physics at the Harvard School of Engineering and Applied Sciences. His research uses mathematics to examine a wide variety of problems in science and engineering\, ranging from understanding the shapes of whale flippers\, bird beaks and fungal spores\, to answering ordinary questions about daily life\, such as why a droplet of fluid splashes when it collides with a solid surface. URL:https://www.simonsfoundation.org/event/michael-brenner/ LOCATION:NY CATEGORIES:Simons Science Series ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181138/Michael-Brenner.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20131204T160000 DTEND;TZID=America/New_York:20131204T180000 DTSTAMP:20260413T110429 CREATED:20140612T040000Z LAST-MODIFIED:20211207T160526Z UID:231-1386172800-1386180000@www.simonsfoundation.org SUMMARY:On Growth and Form: Geometry\, Physics and Biology DESCRIPTION:Of the diversity of living form\, Charles Darwin said\, “It is enough to drive the sanest man mad.” A century and a half later\, how can we quantify\, understand and predict this variety? How might we control it? Motivated by biological observations on scales ranging from molecular to histological\, L. Mahadevan will explain how a combination of biological and physical experiments\, together with mathematical models and computations\, begin to unravel the physical basis for morphogenesis. He will go on to explore how these pan-disciplinary problems enrich the origins of this topic\, creating new questions in mathematics\, physics and biology. \nSpeaker \nL. Mahadevan\, Ph.D.\nHarvard University URL:https://www.simonsfoundation.org/event/on-growth-and-form-geometry-physics-and-biology/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Theory and Biology ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180726/L_mahadevan_thumb1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20131204T160000 DTEND;TZID=America/New_York:20131204T180000 DTSTAMP:20260413T110429 CREATED:20130906T040000Z LAST-MODIFIED:20170823T192453Z UID:1920-1386172800-1386180000@www.simonsfoundation.org SUMMARY:December 4\, 2013: On Growth and Form: Geometry\, Physics and Biology DESCRIPTION:December 4\, 2013 \nOf the diversity of living form\, Charles Darwin said\, “It is enough to drive the sanest man mad.” A century and a half later\, how can we quantify\, understand and predict this variety? How might we control it? Motivated by biological observations on scales ranging from molecular to histological\, L. Mahadevan will explain how a combination of biological and physical experiments\, together with mathematical models and computations\, begin to unravel the physical basis for morphogenesis. He will go on to explore how these pan-disciplinary problems enrich the origins of this topic\, creating new questions in mathematics\, physics and biology. \nSpeaker \nL. Mahadevan\, Ph.D.\nHarvard University \n  URL:https://www.simonsfoundation.org/event/december-4-2013-on-growth-and-form-geometry-physics-and-biology-2/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200230/L_mahadevan_thumb.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20131204T000000 DTEND;TZID=America/New_York:20131204T000000 DTSTAMP:20260413T110429 CREATED:20131031T040000Z LAST-MODIFIED:20170823T200340Z UID:1825-1386115200-1386115200@www.simonsfoundation.org SUMMARY:December 4\, 2013: On Growth and Form: Geometry\, Physics and Biology DESCRIPTION:December 4\, 2013 \nOf the diversity of living form\, Charles Darwin said\, “It is enough to drive the sanest man mad.” A century and a half later\, how can we quantify\, understand and predict this variety? How might we control it? Motivated by biological observations on scales ranging from molecular to histological\, L. Mahadevan will explain how a combination of biological and physical experiments\, together with mathematical models and computations\, begin to unravel the physical basis for morphogenesis. He will go on to explore how these pan-disciplinary problems enrich the origins of this topic\, creating new questions in mathematics\, physics and biology. \nSpeaker \nL. Mahadevan\, Ph.D.\nHarvard University \nLocation \nGerald D. Fischbach Auditorium\, Simons Foundation\n160 5th Avenue\nNew York\, NY 10010 \nWednesday\, December 4\, 2013 from 4:00 PM to 6:00 PM (EST) \nTo RSVP for this event\, please do so at Eventbrite. \nClick here to learn more about the Theory and Biology Lectures. URL:https://www.simonsfoundation.org/event/december-4-2013-on-growth-and-form-geometry-physics-and-biology/ LOCATION:NY ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200230/L_mahadevan_thumb.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20131120T170000 DTEND;TZID=America/New_York:20131120T180000 DTSTAMP:20260413T110429 CREATED:20170428T040000Z LAST-MODIFIED:20211207T160515Z UID:444-1384966800-1384970400@www.simonsfoundation.org SUMMARY:Black Holes\, Quantum Mechanics and Firewalls DESCRIPTION:Thought experiments have played an important role in figuring out the laws of physics. For the unification of quantum mechanics and gravity\, where the phenomena take place in extreme regimes\, they are even more crucial. Hawking’s 1976 paper “Breakdown of Predictability in Gravitational Collapse” presented one of the great thought experiments in the history of physics\, arguing that black holes destroy information in a way that requires a modification of the laws of quantum mechanics. Skeptics for years failed to\npoke holes in Hawking’s argument\, but concluded that if quantum mechanics is to be saved then our understanding of spacetime must break down in a radical way. I present some of the history of these ideas\, what has already been learned from this puzzle\, and the recent `firewall’ controversy\, which argues that Einstein’s theory breaks down radically for an observer falling into a black hole. \nReading material here and here. (pdf)\nLecture Slides (pdf) \nAbout the Speaker \nJoseph Polchinski (Joe) received his BS in Physics from the California Institute of Technology in 1975\, and his PhD in Physics from UC Berkeley in 1980. After two-year stints as a research associate at the Stanford Linear Accelerator (SLAC) and at Harvard\, he joined the faculty at the University of Texas at Austin in 1984. He moved to UC Santa Barbara in 1992\, where he is a Professor of Physics and a Permanent Member of the Kavli Institute for Theoretical Physics. \nPolchinski’s contributions to theoretical physics include a modern formulation of renormalization theory and some of the original work on the string landscape. He is best known for his discovery of D-branes\, extended structures that appear to be central to the mathematics and physics of string theory. He is also the author of a widely used two-volume text on string theory. \nPolchinski held an Alfred P. Sloan Fellowship from 1985 to 1989. He was elected a fellow of the American Physical Society in 1997\, a member of the American Academy of Arts and Sciences in 2002\, and a member of the National Academy of Sciences in 2005. He has been awarded the 2007 Dannie Heineman Prize in Mathematical Physics of the American Physical Society\, and the 2008 Dirac Medal of the International Center for Theoretical Physics\, Trieste and the 2013 and 2014 Physics Frontiers Prizes. URL:https://www.simonsfoundation.org/event/black-holes-quantum-mechanics-and-firewalls/ LOCATION:NY CATEGORIES:Simons Science Series ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10181136/polchinski.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20131115T123000 DTEND;TZID=America/New_York:20131115T173000 DTSTAMP:20260413T110429 CREATED:20140612T040000Z LAST-MODIFIED:20170818T184142Z UID:223-1384518600-1384536600@www.simonsfoundation.org SUMMARY:Structural Variant Detection DESCRIPTION:This Biotech Symposium will focus on computational methods for detecting structural variants\, which include large chromosomal insertions\, deletions\, inversions and translocations. Structural variants may cause both germline and somatic genetic diseases — such as inherited disorders and cancer — and contribute to human diversity and disease susceptibility. \nAttendees will include New York City area faculty\, postdoctoral and clinical fellows\, students and technical staff. Guests are invited to meet the speakers and mingle during the mid-afternoon break. \nEvan Eichler \n“Discovery & Genotyping Human Genome Structural Variation” \n \nSohrab Shah \n“Modeling Evolution of the Structural Genome in Cancer Cell Populations” \n \nAli Bashar \n“Update on Mt. Sinai Institute of Genomics & Multiscale Biology” URL:https://www.simonsfoundation.org/event/structural-variant-detection/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States CATEGORIES:Biotech Symposia ATTACH;FMTTYPE=image/png:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180718/bioinformatics11.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20131115T000000 DTEND;TZID=America/New_York:20131115T000000 DTSTAMP:20260413T110429 CREATED:20131030T040000Z LAST-MODIFIED:20170823T195213Z UID:1805-1384473600-1384473600@www.simonsfoundation.org SUMMARY:November 15\, 2013: Structural Variant Detection DESCRIPTION:15 November 2013\, 12:30-5:30 p.m. Eastern\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY\nThis Biotech Symposium will focus on computational methods for detecting structural variants\, which include large chromosomal insertions\, deletions\, inversions and translocations. Structural variants may cause both germline and somatic genetic diseases — such as inherited disorders and cancer — and contribute to human diversity and disease susceptibility. \nAttendees will include New York City area faculty\, postdoctoral and clinical fellows\, students and technical staff. Guests are invited to meet the speakers and mingle during the mid-afternoon break. \nEvan Eichler \n“Discovery & Genotyping Human Genome Structural Variation” \n \nSohrab Shah \n“Modeling Evolution of the Structural Genome in Cancer Cell Populations” \n \nAli Bashar \n“Update on Mt. Sinai Institute of Genomics & Multiscale Biology” \n \n  URL:https://www.simonsfoundation.org/event/november-15-2013-structural-variant-detection-2/ LOCATION:NY ATTACH;FMTTYPE=image/png:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200203/bioinformatics2.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20131115T000000 DTEND;TZID=America/New_York:20131115T000000 DTSTAMP:20260413T110429 CREATED:20131002T040000Z LAST-MODIFIED:20170823T192612Z UID:1767-1384473600-1384473600@www.simonsfoundation.org SUMMARY:November 15\, 2013: Structural Variant Detection DESCRIPTION:15 November 2013\, 12:30-5:30 p.m. Eastern\nGerald D. Fischbach Auditorium at the Simons Foundation\n160 Fifth Avenue\, New York\, NY \nThis Biotech Symposium will focus on computational methods for detecting structural variants\, which include large chromosomal insertions\, deletions\, inversions and translocations. Structural variants may cause both germline and somatic genetic diseases — such as inherited disorders and cancer — and contribute to human diversity and disease susceptibility. \nEvan Eichler \n“Discovery & Genotyping Human Genome Structural Variation” \n \nSohrab Shah \n“Modeling Evolution of the Structural Genome in Cancer Cell Populations” \n \nAli Bashar \n“Update on Mt. Sinai Institute of Genomics & Multiscale Biology” \n \n  URL:https://www.simonsfoundation.org/event/november-15-2013-structural-variant-detection/ LOCATION:NY ATTACH;FMTTYPE=image/png:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/11200117/bioinformatics.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/New_York:20131113T160000 DTEND;TZID=America/New_York:20131113T180000 DTSTAMP:20260413T110429 CREATED:20140618T040000Z LAST-MODIFIED:20211207T160551Z UID:251-1384358400-1384365600@www.simonsfoundation.org SUMMARY:The Discovery and Study of a Higgs Boson at the Large Hadron Collider DESCRIPTION:In this talk\, Joe Incandela will present an overview of the LHC physics program\, including highlights from the discovery of a Higgs boson and a summary of more recent studies that incorporate more data. He will briefly discuss expectations for future results in years to come. \nIncandela is distinguished professor of physics at the University of California\, Santa Barbara and a guest professor at CERN. He is the current spokesperson and executive head of the Compact Muon Solenoid (CMS) experiment for 2012-2013\, and in July 2012 he presented the experiment’s observation of a new particle resembling a Higgs boson. His current work focuses on the completion of data analyses on all 2011-2012 data\, as well as the consolidation of data\, repair and upgrades to the detector for future running periods. URL:https://www.simonsfoundation.org/event/the-discovery-and-study-of-a-higgs-boson-at-the-large-hadron-collider/ LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States ATTACH;FMTTYPE=image/jpeg:https://sf-web-assets-prod.s3.amazonaws.com/wp-content/uploads/2017/07/10180745/cmsIMG_6589b-447x6401.jpg END:VEVENT END:VCALENDAR