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X-ORIGINAL-URL:https://www.simonsfoundation.org
X-WR-CALDESC:Events for Simons Foundation
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DTSTART:20160313T070000
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DTSTART;TZID=America/New_York:20160309T170000
DTEND;TZID=America/New_York:20160309T180000
DTSTAMP:20260406T083533
CREATED:20160210T050000Z
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UID:341-1457542800-1457546400@www.simonsfoundation.org
SUMMARY:The Formation of Structure in the Cosmos
DESCRIPTION:Studies of the universe across multiple wavelengths and over billions of years of cosmic evolution have revealed a stunning cosmological history. By the present day\, the relatively simple structures existing in the early universe have transformed into vast networks of galaxies and black holes. How and why does this happen? What can we learn by studying these transformations? \nIn this lecture\, Juna Kollmeier will take you on a cosmic journey\, starting with the infant universe and explain the current thinking about how “structure” emerges from this humble start. She will show how giant filaments of galaxies form from extremely smooth initial conditions in the current cosmological model. She will go over structures like the Milky Way and the most massive black holes in the universe and show how these are related to one another in fundamental ways. Dr. Kollmeier will highlight not only the beauty of these structures and superstructures\, as revealed by powerful telescopes\, but also the deep insights about the nature of the universe that we have learned by observing them and carefully characterizing them. \nDr. Kollmeier received a B.S. in physics from the California Institute of Technology in 2000. She was a Fulbright Scholar at the Max Planck Institute for Astrophysics before obtaining a Ph.D. at Ohio State University in 2006. She was a Carnegie-Princeton and Hubble Fellow at the Carnegie Observatories and Princeton University until 2008\, when she became a member of the permanent faculty of the Carnegie Observatories. She was the first theoretician hired to the observatories\, where she started the program in theoretical astrophysics. Her work lies at the intersection of computational\, theoretical and observational astrophysics.
URL:https://www.simonsfoundation.org/event/the-formation-of-structure-in-the-cosmos/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Astronomy, Cosmology and Particle Physics
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DTSTART;TZID=America/New_York:20160316T170000
DTEND;TZID=America/New_York:20160316T181500
DTSTAMP:20260406T083533
CREATED:20151218T050000Z
LAST-MODIFIED:20211208T181655Z
UID:327-1458147600-1458152100@www.simonsfoundation.org
SUMMARY:The Fourth Dimension of Transcriptional Networks: TIME
DESCRIPTION:Transcriptional networks operate dynamically in vivo\, but capturing and modeling these dynamics is an experimental and computational challenge. This presentation focuses on time — building predictive network models based on time-series transcriptome data\, and perturbing transcription networks in time. The outcome is a dynamic hit-and-run transcription model with relevance across eukaryotes. \nIn this lecture\, Dr. Gloria Coruzzi will probe dynamic transcription networks\, computationally and experimentally. Using a machine-learning approach called Dynamic Factor Graph\, fine-scale time-series transcriptome data is used to infer network models that were validated both in silico using left-out data\, and experimentally. To explore the molecular basis for underlying dynamic transcription\, a cell-based assay was developed to follow the mode of action of a transcription factor (TF) within one minute of nuclear entry. This uncovered genome-wide support for a hit-and-run mechanism of transcription\, in which de novo transcription initiated by a transient TF “hit” persists after the TF has “run.” \nDr. Coruzzi specializes in plant systems biology. As Carroll & Milton Petrie Professor of Biology at NYU’s Center for Genomics and Systems Biology\, her work on gene regulatory networks controlling nitrogen use in the model plant Arabidopsis is funded by NIH\, NSF and DOE. She is a Fellow of the American Association for Advancement of Science\, the American Society of Plant Biology\, and serves on the Arabidopsis Informatics Consortium and an Advisory Board to the Joint Genome Institute (JGI).
URL:https://www.simonsfoundation.org/event/the-fourth-dimension-of-transcriptional-networks-time/
CATEGORIES:Interdisciplinary
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20160322T170000
DTEND;TZID=America/New_York:20160322T181500
DTSTAMP:20260406T083533
CREATED:20170206T050000Z
LAST-MODIFIED:20211208T181705Z
UID:384-1458666000-1458670500@www.simonsfoundation.org
SUMMARY:What Can Genetics Tell Us About Autism Spectrum Disorder?
DESCRIPTION:It has been known that autism spectrum disorder is primarily caused by genetic factors for several decades. The past 10 years have seen great progress in finding some of the genes responsible and in building a map of what other types of genetic variants may contribute. These findings have been used both to provide insight into the biology of autism and\, in the clinic\, to identify individuals with specific genetic variants. This talk will outline the current state of genetics research in autism\, highlight some of the key findings that remain to be discovered\, and consider how these findings could ultimately benefit individuals with autism and their families. \nStephan Sanders trained as a pediatric physician in the United Kingdom before pursuing a research career in genomics and bioinformatics. His work has helped characterize the role of de novo mutations in the etiology of autism and identified multiple autism risk loci\, including duplications of the 7q11.23 Williams syndrome region (Sanders et al. Neuron 2011) and mutations in the sodium channel gene SCN2A (Sanders et al. Nature 2012). His work on the integration of copy number variation and exome data across multiple autism cohorts recently identified 71 autism risk loci (Sanders et al. Neuron 2015). In addition\, he worked as part of a group that integrated spatiotemporal gene expression data from the human brain with these autism-associated genes (Willsey et al. Cell 2013). This approach has implicated deep-layer glutamatergic neurons in the frontal cortex during mid-fetal development in the causation of autism. His lab has three main research aims: 1) Understanding the genetic basis of childhood neurodevelopmental conditions\, in particular autism; 2) Understanding how these genetic factors lead to the conditions; and 3) Understanding the mechanism that leads to the male bias in autism diagnosis\, in particular through identifying the biological basis of the female protective effect.
URL:https://www.simonsfoundation.org/event/what-can-genetics-tell-us-about-autism-spectrum-disorder/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
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BEGIN:VEVENT
DTSTART;TZID=America/New_York:20160330T170000
DTEND;TZID=America/New_York:20160330T181500
DTSTAMP:20260406T083533
CREATED:20160129T050000Z
LAST-MODIFIED:20211208T181503Z
UID:338-1459357200-1459361700@www.simonsfoundation.org
SUMMARY:Development Begins Before Birth: Prenatal Research Relevant to Autism
DESCRIPTION:The burgeoning research field known as the fetal origins of adult disease (FOAD) or the developmental origins of health and disease (DOHAD) demonstrates that maternal distress during pregnancy affects fetal and infant brain–behavior development. This is a ‘third pathway’ for the familial inheritance of psychiatric illness beyond shared genes and the quality of parental care\, and one that\, if fully understood\, could lead to early prevention of developmental risk. \nIn this lecture\, Dr. Catherine Monk will describe her lab’s FOAD studies that focus on women in the perinatal period and fetal and infant neurobehavioral development\, including direct studies of the fetus\, newborn brain imaging and placental methylation. \nApplying the FOAD model to autism research introduces the possibility of identifying perinatal markers for the disorder and may help advance the animal and epidemiological findings showing that prenatal maternal immune activation — often a correlate of distress — is associated with risk for the illness. \nDr. Monk holds a joint appointment as an associate professor in the Departments of Psychiatry\, and Obstetrics & Gynecology at Columbia University Medical Center. Reflecting the interdisciplinary nature of her research\, she is affiliated with two divisions in psychiatry: behavioral medicine and developmental neuroscience. She is director for research at the Women’s Program\, as well as co–director of the Sackler Parent–Infant Project and of the Domestic Violence Initiative. After completing her National Institutes of Health post–doctoral fellowship in the psychobiological sciences at Columbia in 2000\, Dr. Monk joined the faculty and established the Perinatal Pathways Laboratory
URL:https://www.simonsfoundation.org/event/development-begins-before-birth-prenatal-research-relevant-to-autism/
LOCATION:Gerald D. Fischbach Auditorium\, 160 5th Avenue\, New York\, NY\, 10010\, United States
CATEGORIES:Autism: Emerging Concepts
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