Innate Immune System RFA

The Simons Foundation Autism Research Initiative (SFARI) seeks to improve the diagnosis and treatment of autism spectrum disorders by funding innovative research of the highest quality and relevance.

Objective of the Innate Immune System Impact Award

Grants awarded through this Request for Applications (RFA) are intended to advance our understanding of the impact of activation of the innate immune system on behavioral, circuit, synaptic and neuronal functions in order to understand the consequences of infection and immune activation on autism-related behaviors.

To this end, we seek applications for investigations of the impact of physiologically relevant activation of the innate immune system on behavioral, circuit, synaptic and neuronal functions in animal models of autism. SFARI especially encourages applications that address either of the following two issues:

(1) Effects of activation of the maternal innate immune system on embryonic central nervous system development in genetic models of autism and controls. How do fetal genetics and maternal innate immune activation interact to affect postnatal autism-related phenotypes, and what are the mechanisms through which they interact?

(2) Effects of activation of the innate immune system in genetic autism models and adult controls. How does innate immune activation affect behavioral, circuit, synaptic and cellular function in these genetic models and in controls? What are the roles of cytokine signaling, fever, immune cell activation and other effectors on these functions?

For more information about this grant opportunity, visit SFARI.org.