Life Sciences lectures are open to the public and are held at the Gerald D. Fischbach Auditorium at the Simons Foundation headquarters in New York City. Tea is served prior to each lecture.
In this lecture, Dr. Charles Sawyers will discuss this important area of research using prostate cancer as an example. Recent evidence, for instance, suggests that while more potent inhibitors deliver superior clinical efficacy, they can lead to more diverse mechanisms for cancer cells to escape treatment. Prostate cancers treated with the drug enzalutamide can develop resistance through mutations in the androgen receptor, via bypass of the androgen receptor blockade by signaling through the glucocorticoid receptor, or by lineage plasticity. During lineage plasticity, androgen-dependent luminal epithelial cells undergo an identity change to more basal-like epithelial cells. The complexity underlying these adaptive responses to targeted therapy reinforces the importance of combination therapy to achieve long-term clinical benefit.
In this lecture, Dr. Arnold Kriegstein will describe recent advances in our understanding of the unique features of human cortical development.
Dr. Joseph J. Fins will address how our evolving knowledge of disorders of consciousness has created an ethical imperative for a population often misdiagnosed, neglected and segregated from society. Meeting the needs of conscious individuals often mistakenly diagnosed as permanently unconscious is an emerging civil rights issue and challenge for basic and clinical neuroscience.
We are still far from elucidating how complex assemblies of neurons — that is, brain circuits — interact to process information. In this lecture, Michael Roukes will outline the immense complexity of such pursuits and describe efforts toward developing new tools for massively multiplexed, multi-physical interrogation of brain activity.
In this lecture, Gerald Rubin will discuss efforts to develop and apply the tools that will be required for a comprehensive analysis of the anatomy and function of the fly brain at the level of individual cell types and circuits, using examples from his lab’s recent work on visual perception, as well as the mechanisms of learning and memory.