Aviv Regev, a computational and systems biologist, is a core member and chair of the faculty at the Broad Institute, a professor of biology at MIT and an investigator at the Howard Hughes Medical Institute. Her research centers on combining experimental and computational approaches to decipher how complex molecular circuits function in cells and between cells in tissues. Regev is the founding director of the Klarman Cell Observatory and Cell Circuits Program at the Broad, and the founding co-chair of the international initiative to build a Human Cell Atlas (HCA), whose mission is to create comprehensive reference maps of all human cells — the fundamental units of life — as a basis for both understanding human health and diagnosing, monitoring and treating disease. Regev’s lab has been a pioneer of single-cell genomics, inventing key experimental methods and computational algorithms in the field, and demonstrating how to apply it to understand cell taxonomies, histological organization, differentiation and physiological processes, and also how to infer the molecular and cellular circuits that control the function of cells and tissues in health and disease. Among her honors are the NIH Director’s Pioneer Award, the Overton Prize and the Innovator Award from the International Society for Computational Biology (ISCB), the Earl and Thressa Stadtman Young Scholar Award from the American Society for Biochemistry and Molecular Biology, and the Paul Marks Prize for Cancer Research. She is a fellow of the International Society for Computational Biology and a member of the National Academy of Sciences.