Jones is an assistant professor of immunology in medicine at Weill Cornell Medical College in New York City. He delivered the basic sciences plenary lecture at the 2018 International AIDS Conference. His research focuses on understanding how to maximally harness innate and adaptive cellular immune responses to contribute to the elimination of the HIV reservoirs that persist in individuals on long-term therapy, and thus to inform efforts to cure infection. Work in the Jones laboratory spans from in vitro experiments using a bank of clinical HIV samples, to humanized mice as pre-clinical models of HIV infection, through to clinical trials. A significant component of this work is conducted in the context of the NIH-funded Martin Delaney ‘BELIEVE’ collaboratory, for which Jones is a principal investigator. Jones also holds NIH funding to study novel biomaterials-based approaches to enhance immunotherapy and to develop novel mouse models in which to study HIV infection of the central nervous system.