Lawrence R. Frank received his Ph.D. in physics from the Massachusetts Institute of Technology. He is founder and director of the University of California, San Diego Center for Scientific Computation in Imaging (CSCI). His primary focus has been on the development of novel methods of magnetic resonance imaging (MRI) used in conjunction with computational methods. Used together, these methods address research questions in a variety of topics, such as cardiac biomechanics, evolutionary biology and characterization of neural architecture. The work at CSCI has recently expanded to the development of theoretical frameworks and computational methods for the analysis of spatial-temporal data in imaging for applications, from dynamic imaging of brain activity with functional MRI to severe weather meteorology.