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Headshot of SFARI Investigator Jason Yi.
Headshot of SFARI Investigator Jason Yi.

Awardee

Jason Yi, Ph.D.

SFARI Investigator

Affiliations
  • Assistant Professor, Washington University School of Medicine
Website
jasonyilab.org

Publications

Identification of disease-linked hyperactivating mutations in UBE3A through large-scale functional variant analysis.

Nat. Commun., November 21, 2021

Weston K.P., Gao X., Zhao J., Kim K.-S., Maloney S.E., Gotoff J., et al.

The autism-linked UBE3AT485A mutant E3 ubiquitin ligase activates the Wnt/beta-catenin pathway by inhibiting the proteasome.

J. Biol. Chem., July 27, 2017

J. Yi, Paranjape S.R., Walker M.P., Choudhury R., Wolter J.M., Fragola G., et al.

An autism-linked mutation disables phosphorylation control of UBE3A.

Cell, August 12, 2015

J. Yi, Berrios J., Newbern J.M., Snider W.D., B. Philpot, Hahn K.M., et al.

Projects

Harnessing functional variant analysis for the targeted design of inhibitors of UBE3A

Awarded 2023
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Developmental changes in a mouse model of UBE3A hyperactivation

Awarded 2017

Featuring Jason Yi

Pilot awardees 2023

SFARI 2023 Winter Pilot Awardees Announced

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Simons Foundation Autism Research Initiative (SFARI)

SFARI is the Simons Foundation’s autism research program, advancing the basic science of autism and related neurodevelopmental disorders through funding, collaboration, and open science.

Learn more
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