The mission of the Flatiron Institute is to advance scientific research through computational methods, including data analysis, theory, modeling and simulation.

Simons Foundation

Featured News

Center for Computational Biology Big Data and Powerful Computing Join Forces to Link DNA Sequence and Function By Susan Reslewic-Keatley, Ph.D.

Built from one of the world’s largest collections of epigenetic data, the newly developed model Sei predicts how DNA sequence variation alters gene expression, advancing our understanding of human traits, disease and evolution.

ALMA Scientists Find Pair of Black Holes Dining Together in Nearby Galaxy Merger
While studying a nearby pair of merging galaxies using the Atacama Large Millimeter/submillimeter Array (ALMA)— and international observatory co-operated by the U.S. National Science Foundation’s National Radio Astronomy Observatory (NRAO)— scientists discovered two supermassive black holes growing simultaneously near the center of the newly coalescing galaxy. These super-hungry giants are the closest together that scientists have ever observed in multiple wavelengths. What’s more, the new research reveals that binary black holes and the galaxy mergers that create them may be surprisingly commonplace in the Universe.

Center for Computational Astrophysics Doomed Pair of Supermassive Black Holes the Closest to Collision Ever Seen

Center for Computational Quantum Physics Controlling the Complexity: Tuning Quantum Materials for Science and Technology

Our Centers

Center for Computational Astrophysics

Center for Computational Biology

Center for Computational Mathematics

Center for Computational Neuroscience

Center for Computational Quantum Physics

Scientific Computing Core

It develops, deploys and maintains computational infrastructure — from supercomputers to desktop PCs — dedicated solely to the use of Flatiron researchers.

Collaborative Work

Machine Learning at the Flatiron Institute

Machine learning has become an indispensable tool for computational science, and it is an active and growing area of research throughout the Flatiron Institute.

Structural and Molecular Biophysics Collaboration

Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited.

Learning the Universe

This collaboration, directed by Greg Bryan of Columbia University, aims to understand and determine the evolution and initial conditions of our universe, using observations via a Bayesian forward modeling approach.

CCA
| Columbia University
| Lawrence Berkeley National Lab
| Harvard University
| Stockholm University
| Institute D'Astrophysique de Paris
| Université de Montreal
| Princeton University
| Carnegie Mellon University
| Max-Planck Institute for Astrophysics

Flatiron Institute Inclusion, Diversity,
Equity & Advocacy (IDEA) Scholar Program

For distinguished scientists with a particular interest in diversity and inclusion

Scholars may engage in a variety of activities, such as working on scientific projects, starting new collaborations, mentoring junior scientists, and organizing or participating in workshops and career development events.

Learn More

A major effort of the Flatiron Institute is the development and support of high-quality, open-source software for research.

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Research Highlights

December 10, 2022

Ensemble reweighting using Cryo-EM particles

P. Tang, B. Carpenter, D. Silva-Sánchez, J. Giraldo-Barreto, S. Hanson, A. Barnett, E. Thiede, P. Cossio

Cryo-electron microscopy (cryo-EM) has recently become a premier method for obtaining high-resolution structures of biological macromolecules. However, it is limited…

arXiv:2212.05320

December 1, 2022

Concurrent ARFI Plaque Imaging and Wall Shear Stress Measurement in Human Carotid Artery, with Validation by Fluid Structure Interaction Model.

Keerthi S. Anand, E. Kolahdouz, et al.

The rupture potential of an atherosclerotic plaque is dependent on both the plaque’s composition and the shear stresses it encounters…

IEEE International Ultrasonics Symposium

November 22, 2022

SARS-CoV-2 Outbreak Dynamics in an Isolated US Military Recruit Training Center With Rigorous Prevention Measures

Rhonda A. Lizewski, R. Sealfon, O. Troyanskaya, et al.

Marine recruits training at Parris Island experienced an unexpectedly high rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection,…

Epidemiology

News & Announcements

Flatiron Scientist Spotlight

January 26, 2023

Small Cell, Big Picture: Fundamental Biology Through the Lens of Simplified Models By Mara Johnson-Groh

January 24, 2023

Colin Hill and Oliver Philcox Among Winners of Buchalter Cosmology Prize

Center for Computational Biology

January 24, 2023

Big Data and Powerful Computing Join Forces to Link DNA Sequence and Function By Susan Reslewic-Keatley, Ph.D.

Leadership

Leslie Greengard, M.D., Ph.D.

Director, CCM

Leslie Greengard joined the Simons Foundation in 2013 as founding director of the Simons Center for Data Analysis, now called the Center for Computational Biology. Prior to that, Greengard served as director of the Courant Institute of Mathematical Sciences at New York University.

Nick Carriero, Ph.D.

Co-Director, SCC

Nick Carriero came to the Simons Foundation in 2014 from Yale University, where he was a senior research scientist in computer science and co-director of the W.M. Keck Biotechnology Resource Laboratory’s high-performance computing resource.

Julianne Dalcanton, Ph.D.

Director, CCA

Julianne Dalcanton joined the Simons Foundation in September 2021 as the director of the Flatiron Institute’s Center for Computational Astrophysics (CCA). Her research specializes in the origins and evolution of galaxies.

Ian Fisk, Ph.D.

Co-Director, SCC

Ian Fisk came to the Simons Foundation in 2014 after working in the computing division at the Fermi National Accelerator Laboratory in Illinois since 2003. Fisk was the Compact Muon Solenoid (CMS) experiment’s computing coordinator at CERN from 2010 to 2013, overseeing operations and improvements…

Antoine Georges, Ph.D.

Director, CCQ

Antoine Georges is a professor of physics at the Collège de France, where he holds the chair in condensed matter physics. He also has joint appointments with École Polytechnique and the University of Geneva. He received his Ph.D. from the École Normale Supérieure in 1988.…

Andrew Millis, Ph.D.

Collaboration Director

Andrew Millis is co-director of the Center for Computational Quantum Physics and associate director for Physics at the Simons Foundation. He has done fundamental research on heavy fermion compounds, quantum phase transitions, ‘colossal’ magnetoresistance materials and high transition-temperature superconductivity.

Michael Shelley, Ph.D.

Director, CCB

Michael Shelley joined the Simons Foundation in 2016 to work on the modeling and simulation of complex systems arising in physics and biology.

Eero P. Simoncelli, Ph.D.

Director, CCN

Eero P. Simoncelli is the inaugural director of the Center for Computational Neuroscience. Eero P. Simoncelli’s research interests span a wide range of topics in the representation and analysis of visual images and sounds in both machine and biological vision systems.