The mission of the Flatiron Institute is to advance scientific research through computational methods, including data analysis, theory, modeling and simulation.
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Launched in 2016, The Flatiron Institute has since grown into a bustling hub for computational science, with hundreds of researchers working on problems in astrophysics, biology, mathematics, neuroscience and quantum physics.
Our Centers
Center for Computational Biology
Center for Computational Mathematics
Center for Computational Neuroscience
Center for Computational Quantum Physics
Scientific Computing Core
It develops, deploys and maintains computational infrastructure — from supercomputers to desktop PCs — dedicated solely to the use of Flatiron researchers.
Collaborative Work

Machine learning has become an indispensable tool for computational science, and it is an active and growing area of research throughout the Flatiron Institute.
- CCM
- CCN
- CCA
- CCB
- CCQ

Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited.
- CCB
- CCM

This collaboration, directed by Greg Bryan of Columbia University, aims to understand and determine the evolution and initial conditions of our universe, using observations via a Bayesian forward modeling approach.
- CCA
- | Columbia University
- | Lawrence Berkeley National Lab
- | Harvard University
- | Stockholm University
- | Institute D'Astrophysique de Paris
- | Université de Montreal
- | Princeton University
- | Carnegie Mellon University
- | Max-Planck Institute for Astrophysics
Flatiron Institute Inclusion, Diversity,
Equity & Advocacy (IDEA) Scholar Program
For distinguished scientists with a particular interest in diversity and inclusion
Scholars may engage in a variety of activities, such as working on scientific projects, starting new collaborations, mentoring junior scientists, and organizing or participating in workshops and career development events.
Software
A major effort of the Flatiron Institute is the development and support of high-quality, open-source software for research.
Research Highlights
Conformational heterogeneity and probability distributions from single-particle cryo-electron microscopy
Single-particle cryo-electron microscopy (cryo-EM) is a technique that takes projection images of biomolecules frozen at cryogenic temperatures. A major advantage…
Current Opinion in Structural BiologyImplicit Adaptive Mesh Refinement for Dispersive Tsunami Propagation
We present an algorithm to solve the dispersive depth-averaged Serre-Green-Naghdi (SGN) equations using patch-based adaptive mesh refinement. These equations require…
arXiv:2307.05816Low-rank Green’s function representations applied to dynamical mean-field theory
Several recent works have introduced highly compact representations of single-particle Green’s functions in the imaginary time and Matsubara frequency domains,…
Physical Review BNews & Announcements
September 28, 2023

September 14, 2023

September 05, 2023
