The mission of the Flatiron Institute is to advance scientific research through computational methods, including data analysis, theory, modeling and simulation.

Simons Foundation

Featured News

Center for Computational Astrophysics New Application of Artificial Intelligence Just Removed One of the Biggest Roadblocks in Astrophysics By Thomas Sumner

Using neural networks, Flatiron Institute research fellow Yin Li and his colleagues simulated vast, complex universes in a fraction of the time it takes with conventional methods.

Center for Computational Biology Mystery Solved About the Machines That Move Your Genes

Center for Computational Quantum Physics Machine Learning Cracks Quantum Chemistry Conundrum

Our Centers

Center for Computational Astrophysics

Center for Computational Biology

Center for Computational Mathematics

Center for Computational Neuroscience

Center for Computational Quantum Physics

Scientific Computing Core

It develops, deploys and maintains computational infrastructure — from supercomputers to desktop PCs — dedicated solely to the use of Flatiron researchers.

Flatiron Institute Inclusion, Diversity,
Equity & Advocacy (IDEA) Scholar Program

For distinguished scientists with a particular interest in diversity and inclusion

Scholars may engage in a variety of activities, such as working on scientific projects, starting new collaborations, mentoring junior scientists, and organizing or participating in workshops and career development events.

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A major effort of the Flatiron Institute is the development and support of high-quality, open-source software for research.

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Research Highlights

May 1, 2021

A stable and accurate scheme for solving the Stefan problem coupled with natural convection using the Immersed Boundary Smooth Extension method

J. Huang, M. Shelley, D. Stein

The dissolution of solids has created spectacular geomorphologies ranging from centimeter-scale cave scallops to the kilometer-scale “stone forests” of China…

Journal of Computational Physics

April 28, 2021

SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma

J. Choe, P. Watchmaker, M. Simic , ..., O. Troyanskaya, et al.

Two major hurdles in chimeric antigen receptor (CAR) T cell therapy for solid tumors are ensuring specificity to tumor cells…

Science Translational Medicine

April 26, 2021

MHCEpitopeEnergy, a Flexible Rosetta-Based Biotherapeutic Deimmunization Platform

B. Yachnin, V. Mulligan, S. Khare, C. Bailey-Kellogg

As non-“self” macromolecules, biotherapeutics can trigger an immune response that can reduce drug efficacy, require patients to be taken off…

Journal of Chemical Information and Modeling

News & Announcements

Center for Computational Astrophysics

May 14, 2021

Shrinking Planets Could Explain Mystery of Universe’s Missing Worlds By Thomas Sumner

This artist's animation flies through the Kepler-20 star system, where NASA's Kepler mission discovered the first Earth-size planets around a star beyond our own. The system is jam-packed with five planets, all circling within a distance roughly equivalent to Mercury's orbit in our solar system.

The two Earth-size planets, which are presumably rocky, are Kepler-20e and Kepler-20f, and the three larger gas planets are Kepler-20b, Kepler-20c and Kepler-20d. The arrangement of the planets from the closest to its star to the farthest is: b, e, c, f and d, with the ordering of the letters reflecting the time at which the planets were initially discovered.

This animation begins by showing the farthest planet from the star, Kepler-20d, then flies over to Kepler-20f and moves on successively to closer and closer planets. It then pans out to show all five planets in the miniature solar system.

The Kepler-20 system is unusual in that the sizes of the planets alternate, with the closest in being large, followed by a small planet, and then continuing on with the planets switching back and forth in size. Astronomers are intrigued by this configuration because it completely differs from that of our solar system, where there is a clear separation between the four small, rocky inner planets, and the four giant, gaseous outer planets.

NASA's Ames Research Center in Moffett Field, Calif., manages Kepler's ground system development, mission operations and science data analysis. JPL managed the Kepler mission's development.

For more information about the Kepler mission and to view the digital press kit, visit http://www.nasa.gov/kepler.

Center for Computational Astrophysics

May 04, 2021

New Application of Artificial Intelligence Just Removed One of the Biggest Roadblocks in Astrophysics By Thomas Sumner

Center for Computational Quantum Physics

March 23, 2021

Quantum Showdown: Competing Methods of Solving Quantum Systems Put to the Test By Thomas Sumner

Leadership

David Spergel, Ph.D.

Director, CCA

David Spergel joined the foundation in 2016 to lead its Center for Computational Astrophysics. He is an astrophysicist with research interests ranging from the search for planets around nearby stars to the shape of the universe.

Michael Shelley, Ph.D.

Director, CCB

Michael Shelley joined the Simons Foundation in 2016 to work on the modeling and simulation of complex systems arising in physics and biology.

Leslie Greengard, M.D., Ph.D.

Director, CCM

Leslie Greengard joined the Simons Foundation in 2013 as founding director of the Simons Center for Data Analysis, now called the Center for Computational Biology. Prior to that, Greengard served as director of the Courant Institute of Mathematical Sciences at New York University.

Eero P. Simoncelli, Ph.D.

Director, CCN

Eero P. Simoncelli’s research interests span a wide range of topics in the representation and analysis of visual images and sounds in both machine and biological vision systems.

Antoine Georges, Ph.D.

Director, CCQ

Antoine Georges is a professor of physics at the Collège de France, where he holds the chair in condensed matter physics. He also has joint appointments with École Polytechnique and the University of Geneva. He received his Ph.D. from the École Normale Supérieure in 1988.…

Andrew Millis, Ph.D.

Co-Director, CCQ

Andrew Millis is co-director of the Center for Computational Quantum Physics and associate director for Physics at the Simons Foundation. He has done fundamental research on heavy fermion compounds, quantum phase transitions, ‘colossal’ magnetoresistance materials and high transition-temperature superconductivity.

Nick Carriero, Ph.D.

Co-Director, SCC

Nick Carriero came to the Simons Foundation in 2014 from Yale University, where he was a senior research scientist in computer science and co-director of the W.M. Keck Biotechnology Resource Laboratory’s high-performance computing resource.

Ian Fisk, Ph.D.

Co-Director, SCC

Ian Fisk came to the Simons Foundation in 2014 after working in the computing division at the Fermi National Accelerator Laboratory in Illinois since 2003. Fisk was the Compact Muon Solenoid (CMS) experiment’s computing coordinator at CERN from 2010 to 2013, overseeing operations and improvements…