The mission of the Flatiron Institute is to advance scientific research through computational methods, including data analysis, theory, modeling and simulation.

Simons Foundation

Featured News

Center for Computational Biology Unveiling the Forces Behind Millions of Years of Cell Division By Susan Reslewic Keatley

In new research, scientists take a biophysical approach to deciphering the cell’s mysteries.

Center for Computational Astrophysics Black Holes Flicker When They Eat, Revealing Their Size

Center for Computational Neuroscience Building Computer Models That See Everything

Our Centers

Center for Computational Astrophysics

Center for Computational Biology

Center for Computational Mathematics

Center for Computational Neuroscience

Center for Computational Quantum Physics

Scientific Computing Core

It develops, deploys and maintains computational infrastructure — from supercomputers to desktop PCs — dedicated solely to the use of Flatiron researchers.

Flatiron Institute Inclusion, Diversity,
Equity & Advocacy (IDEA) Scholar Program

For distinguished scientists with a particular interest in diversity and inclusion

Scholars may engage in a variety of activities, such as working on scientific projects, starting new collaborations, mentoring junior scientists, and organizing or participating in workshops and career development events.

Learn More

A major effort of the Flatiron Institute is the development and support of high-quality, open-source software for research.

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Research Highlights

August 3, 2021

Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors

Laura Gallego-Yerga, Rodrigo Ochoa, Isaías Lans, Carlos Peña-Varas, Melissa Alegría-Arcos, P. Cossio, David Ramírez, Rafael Peláez

Tubulin is a well-validated target for herbicides, fungicides, anti-parasitic, and anti-tumor drugs. Many of the non-cancer tubulin drugs bind to…

Computational and Structural Biotechnology Journal

August 2, 2021

Decoding disease: from genomes to networks to phenotypes

A. Wong, R. Sealfon, Chandra L. Theesfeld, O. Troyanskaya

Interpreting the effects of genetic variants is key to understanding individual susceptibility to disease and designing personalized therapeutic approaches. Modern…

arxiv:

2021

Opposing effects of selectivity and invariance in peripheral vision

Corey M. Ziemba, E. P. Simoncelli

Sensory processing necessitates discarding some information in service of preserving and reformatting more behaviorally relevant information. Sensory neurons seem to…

Nature Communications

News & Announcements

Simons Society of Fellows Q&As

August 30, 2021

Building Computer Models That See Everything By Marcus Banks

Center for Computational Astrophysics

August 17, 2021

Cracking a Mystery of Massive Black Holes and Quasars with Supercomputer Simulations

Center for Computational Astrophysics

August 16, 2021

Nearby Star-Forming Region Yields Clues to the Formation of Our Solar System

Leadership

Leslie Greengard, M.D., Ph.D.

Director, CCM

Leslie Greengard joined the Simons Foundation in 2013 as founding director of the Simons Center for Data Analysis, now called the Center for Computational Biology. Prior to that, Greengard served as director of the Courant Institute of Mathematical Sciences at New York University.

Nick Carriero, Ph.D.

Co-Director, SCC

Nick Carriero came to the Simons Foundation in 2014 from Yale University, where he was a senior research scientist in computer science and co-director of the W.M. Keck Biotechnology Resource Laboratory’s high-performance computing resource.

Julianne Dalcanton, Ph.D.

Director, CCA

Julianne Dalcanton joined the Simons Foundation in September 2021 as the director of the Flatiron Institute’s Center for Computational Astrophysics (CCA). Her research specializes in the origins and evolution of galaxies.

Ian Fisk, Ph.D.

Co-Director, SCC

Ian Fisk came to the Simons Foundation in 2014 after working in the computing division at the Fermi National Accelerator Laboratory in Illinois since 2003. Fisk was the Compact Muon Solenoid (CMS) experiment’s computing coordinator at CERN from 2010 to 2013, overseeing operations and improvements…

Antoine Georges, Ph.D.

Director, CCQ

Antoine Georges is a professor of physics at the Collège de France, where he holds the chair in condensed matter physics. He also has joint appointments with École Polytechnique and the University of Geneva. He received his Ph.D. from the École Normale Supérieure in 1988.…

Andrew Millis, Ph.D.

Co-Director, CCQ

Andrew Millis is co-director of the Center for Computational Quantum Physics and associate director for Physics at the Simons Foundation. He has done fundamental research on heavy fermion compounds, quantum phase transitions, ‘colossal’ magnetoresistance materials and high transition-temperature superconductivity.

Michael Shelley, Ph.D.

Director, CCB

Michael Shelley joined the Simons Foundation in 2016 to work on the modeling and simulation of complex systems arising in physics and biology.

Eero P. Simoncelli, Ph.D.

Director, CCN

Eero P. Simoncelli is the inaugural director of the Center for Computational Neuroscience. Eero P. Simoncelli’s research interests span a wide range of topics in the representation and analysis of visual images and sounds in both machine and biological vision systems.