The mission of the Flatiron Institute is to advance scientific research through computational methods, including data analysis, theory, modeling and simulation.

Simons Foundation

Featured News

Stylized image of bacteria swimming though an obstacle-filled liquid

Center for Computational Biology New Model Predicts How Bacteria Navigate Obstacles to Spread By Jane Beaufore

A Flatiron Institute scientist has developed the first analytical model for predicting how bacteria spread in environments filled with obstacles. This model will help inform strategies for curbing bacterial infections or for designing better drug delivery devices.

Center for Computational Mathematics CCM Group Leader Marsha Berger Named 2025 John von Neumann Prize Lecturer by Society of Industrial and Applied Mathematics

Flatiron Institute New Datasets Will Train AI Models to Think Like Scientists

Our Centers

Center for Computational Astrophysics

Center for Computational Biology

Center for Computational Mathematics

Center for Computational Neuroscience

Center for Computational Quantum Physics

Scientific Computing Core

It develops, deploys and maintains computational infrastructure — from supercomputers to desktop PCs — dedicated solely to the use of Flatiron researchers.

Initiatives

Initiative for Computational Catalysis

The Simons Foundation Initiative for Computational Catalysis is a new effort within the Flatiron Institute dedicated to the development and application of computational techniques enabling the rational design of more efficient and more affordable catalysts.

Foundation Models of Science

Our goal is to accelerate the development of versatile foundation models tailored for numerical datasets and scientific machine learning tasks. The challenge we are undertaking is to build AI models which leverage information from heterogeneous datasets and across different scientific fields, which, contrary to domains like natural language processing, do not share a unifying representation.

Collaborative Work

Machine Learning at the Flatiron Institute

Machine learning has become an indispensable tool for computational science, and it is an active and growing area of research throughout the Flatiron Institute.

Structural and Molecular Biophysics

Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited.

Learning the Universe

This collaboration, directed by Greg Bryan of Columbia University, aims to understand and determine the evolution and initial conditions of our universe, using observations via a Bayesian forward modeling approach.

CCA
| Columbia University
| Lawrence Berkeley National Lab
| Harvard University
| Stockholm University
| Institute D'Astrophysique de Paris
| Université de Montreal
| Princeton University
| Carnegie Mellon University
| Max-Planck Institute for Astrophysics

Flatiron Institute Idea Scholar Program

For distinguished scientists interested in developing scientific talent in the workforce and enabling pathways to science

Scholars may engage in a variety of activities, such as working on scientific projects, starting new collaborations, mentoring junior scientists, and organizing or participating in workshops and career development events.

Learn More

A major effort of the Flatiron Institute is the development and support of high-quality, open-source software for research.

View All Software

Research Highlights

March 4, 2025

Responses of neurons in macaque V4 to object and texture images

Justin D. Lieber, T. D. Oleskiw , Laura Palmieri, E. P. Simoncelli, J. A. Movshon

Humans and monkeys can rapidly recognize objects in everyday scenes. While it is known that this ability relies on neural…

bioRxiv:2024.02.20.581273

February 1, 2025

Optimized Linear Measurements for Inverse Problems using Diffusion-Based Image Generation

Ling-Qi Zhang, Z. Kadkhodaie, E. P. Simoncelli, D. H. Brainard

We examine the problem of selecting a small set of linear measurements for reconstructing high-dimensional signals. Well-established methods for optimizing…

arXiv:2405.17456

January 22, 2025

Discriminating image representations with principal distortions

J. Feather, D. Lipshutz, S. Harvey, A. Williams, E. P. Simoncelli

Image representations (artificial or biological) are often compared in terms of their global geometric structure; however, representations with similar global…

International Conference on Learning Representations (ICLR)

News & Announcements

Center for Computational Astrophysics

March 31, 2025

Flatiron Institute Becomes New Hub for Stellar Evolution Software Suite MESA By Rachel Scanza

Thousands upon thousands of stars illuminate this breathtaking image of star cluster Liller 1, imaged with Hubble’s Wide Field Camera 3. This stellar system, located 30,000 light-years from Earth, formed stars over 11 billion years.

Center for Computational Biology

March 21, 2025

New Model Predicts How Bacteria Navigate Obstacles to Spread By Jane Beaufore

Center for Computational Astrophysics

March 18, 2025

Atacama Cosmology Telescope Publishes Final Major Data Release By Thomas Sumner

A photo of the Atacama Cosmology Telescope in the Atacama Desert in Chile.

Leadership

Leslie Greengard, M.D., Ph.D.

Director, CCM

Leslie Greengard joined the Simons Foundation in 2013 as founding director of the Simons Center for Data Analysis, now called the Center for Computational Biology. Prior to that, Greengard served as director of the Courant Institute of Mathematical Sciences at New York University.

Julianne Dalcanton, Ph.D.

Director, CCA

Julianne Dalcanton joined the Simons Foundation in September 2021 as the director of the Flatiron Institute’s Center for Computational Astrophysics (CCA). Her research specializes in the origins and evolution of galaxies.

Ian Fisk, Ph.D.

Chief Technology Officer, Simons Foundation

Ian Fisk came to the Simons Foundation in 2014 after working in the computing division at the Fermi National Accelerator Laboratory in Illinois since 2003. Fisk was the Compact Muon Solenoid (CMS) experiment’s computing coordinator at CERN from 2010 to 2013, overseeing operations and improvements…

Antoine Georges, Ph.D.

Director, CCQ

Antoine Georges is a professor of physics at the Collège de France, where he holds the chair in condensed matter physics. He also has joint appointments with École Polytechnique and the University of Geneva. He received his Ph.D. from the École Normale Supérieure in 1988.…

Andrew Millis, Ph.D.

Co-Director, CCQ

Andrew Millis is co-director of the Center for Computational Quantum Physics at the Flatiron Institute and professor of physics at Columbia University. He currently serves as Managing Director of the Flatiron Institute.

Michael Shelley, Ph.D.

Director, CCB

Michael Shelley joined the Simons Foundation in 2016 to work on the modeling and simulation of complex systems arising in physics and biology.

Eero P. Simoncelli, Ph.D.

Director, CCN

Eero P. Simoncelli is the inaugural director of the Center for Computational Neuroscience. Eero P. Simoncelli’s research interests span a wide range of topics in the representation and analysis of visual images and sounds in both machine and biological vision systems.