The mission of the Flatiron Institute is to advance scientific research through computational methods, including data analysis, theory, modeling and simulation.

Simons Foundation

Featured News

Center for Computational Biology Experiments and Mathematical Model Uncover the Mechanisms Behind Wrinkles in Cell Nuclei By Mara Johnson-Groh

By studying the changing geometry of cell nuclei in fruit flies, scientists have gained a better understanding of the dynamics that shape the part of our cells that carries our DNA.

Center for Computational Neuroscience How Do Our Brains Classify Similar Objects? New Theory Works Out the Details

Center for Computational Mathematics Learning Better: Improving the Efficiency of Deep Learning Models

Our Centers

Center for Computational Astrophysics

Center for Computational Biology

Center for Computational Mathematics

Center for Computational Neuroscience

Center for Computational Quantum Physics

Scientific Computing Core

It develops, deploys and maintains computational infrastructure — from supercomputers to desktop PCs — dedicated solely to the use of Flatiron researchers.

Collaborative Work

Machine Learning at the Flatiron Institute

Machine learning has become an indispensable tool for computational science, and it is an active and growing area of research throughout the Flatiron Institute.

Structural and Molecular Biophysics

Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited.

Learning the Universe

This collaboration, directed by Greg Bryan of Columbia University, aims to understand and determine the evolution and initial conditions of our universe, using observations via a Bayesian forward modeling approach.

CCA
| Columbia University
| Lawrence Berkeley National Lab
| Harvard University
| Stockholm University
| Institute D'Astrophysique de Paris
| Université de Montreal
| Princeton University
| Carnegie Mellon University
| Max-Planck Institute for Astrophysics

Flatiron Institute Inclusion, Diversity,
Equity & Advocacy (IDEA) Scholar Program

For distinguished scientists with a particular interest in diversity and inclusion

Scholars may engage in a variety of activities, such as working on scientific projects, starting new collaborations, mentoring junior scientists, and organizing or participating in workshops and career development events.

Learn More

A major effort of the Flatiron Institute is the development and support of high-quality, open-source software for research.

View All Software

Research Highlights

November 1, 2023

Phase plane dynamics of ERK phosphorylation

S. Shvartsman, Sarah McFann, Martin Wühr , Boris Y. Rubinstein

The extracellular signal–regulated kinase (ERK) controls multiple critical processes in the cell and is deregulated in human cancers, congenital abnormalities,…

Journal of Biological Chemistry

September 25, 2023

Atlas of primary cell-type-specific sequence models of gene expression and variant effects

Ksenia Sokolova , Chandra L. Theesfeld, A. Wong, O. Troyanskaya, et al.

Human biology is rooted in highly specialized cell types programmed by a common genome, 98% of which is outside of…

Cell Reports Methods

2023

A unified model for the co-evolution of galaxies and their circumgalactic medium: the relative roles of turbulence and atomic cooling physics

Viraj Pandya, D. Fielding, Greg L. Bryan, Christopher Carr, R. Somerville, Jonathan Stern, Claude-Andre Faucher-Giguere, Zachary Hafen, D. Angles-Alcazar, J. Forbes

The circumgalactic medium (CGM) plays a pivotal role in regulating gas flows around galaxies and thus shapes their evolution. However,…

arXiv:2211.09755

News & Announcements

Center for Computational Astrophysics

November 29, 2023

New Astrophysics Model Sheds Light on Additional Source of Long Gamma-Ray Bursts

Center for Computational Biology

November 03, 2023

Experiments and Mathematical Model Uncover the Mechanisms Behind Wrinkles in Cell Nuclei By Mara Johnson-Groh

Flatiron Institute

November 01, 2023

Applications Open for 2024 – 2025 Flatiron Institute Inclusion, Diversity, Equity, Advocacy (IDEA) Scholar Program

Leadership

Leslie Greengard, M.D., Ph.D.

Director, CCM

Leslie Greengard joined the Simons Foundation in 2013 as founding director of the Simons Center for Data Analysis, now called the Center for Computational Biology. Prior to that, Greengard served as director of the Courant Institute of Mathematical Sciences at New York University.

Nick Carriero, Ph.D.

Co-Director, SCC

Nick Carriero came to the Simons Foundation in 2014 from Yale University, where he was a senior research scientist in computer science and co-director of the W.M. Keck Biotechnology Resource Laboratory’s high-performance computing resource.

Julianne Dalcanton, Ph.D.

Director, CCA

Julianne Dalcanton joined the Simons Foundation in September 2021 as the director of the Flatiron Institute’s Center for Computational Astrophysics (CCA). Her research specializes in the origins and evolution of galaxies.

Ian Fisk, Ph.D.

Co-Director, SCC

Ian Fisk came to the Simons Foundation in 2014 after working in the computing division at the Fermi National Accelerator Laboratory in Illinois since 2003. Fisk was the Compact Muon Solenoid (CMS) experiment’s computing coordinator at CERN from 2010 to 2013, overseeing operations and improvements…

Antoine Georges, Ph.D.

Director, CCQ

Antoine Georges is a professor of physics at the Collège de France, where he holds the chair in condensed matter physics. He also has joint appointments with École Polytechnique and the University of Geneva. He received his Ph.D. from the École Normale Supérieure in 1988.…

Andrew Millis, Ph.D.

Co-Director, CCQ

Andrew Millis is co-director of the Center for Computational Quantum Physics at the Flatiron Institute and professor of physics at Columbia University. He currently serves as Managing Director of the Flatiron Institute.

Michael Shelley, Ph.D.

Director, CCB

Michael Shelley joined the Simons Foundation in 2016 to work on the modeling and simulation of complex systems arising in physics and biology.

Eero P. Simoncelli, Ph.D.

Director, CCN

Eero P. Simoncelli is the inaugural director of the Center for Computational Neuroscience. Eero P. Simoncelli’s research interests span a wide range of topics in the representation and analysis of visual images and sounds in both machine and biological vision systems.