The mission of the Flatiron Institute is to advance scientific research through computational methods, including data analysis, theory, modeling and simulation.
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By studying the changing geometry of cell nuclei in fruit flies, scientists have gained a better understanding of the dynamics that shape the part of our cells that carries our DNA.
Our Centers
Center for Computational Biology
Center for Computational Mathematics
Center for Computational Neuroscience
Center for Computational Quantum Physics
Scientific Computing Core
It develops, deploys and maintains computational infrastructure — from supercomputers to desktop PCs — dedicated solely to the use of Flatiron researchers.
Collaborative Work

Machine learning has become an indispensable tool for computational science, and it is an active and growing area of research throughout the Flatiron Institute.
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Underlying all biological processes are molecules and their interactions with each other. However, our ability to understand how these molecules function over biologically relevant scales remains very limited.
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This collaboration, directed by Greg Bryan of Columbia University, aims to understand and determine the evolution and initial conditions of our universe, using observations via a Bayesian forward modeling approach.
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- | Columbia University
- | Lawrence Berkeley National Lab
- | Harvard University
- | Stockholm University
- | Institute D'Astrophysique de Paris
- | Université de Montreal
- | Princeton University
- | Carnegie Mellon University
- | Max-Planck Institute for Astrophysics
Flatiron Institute Inclusion, Diversity,
Equity & Advocacy (IDEA) Scholar Program
For distinguished scientists with a particular interest in diversity and inclusion
Scholars may engage in a variety of activities, such as working on scientific projects, starting new collaborations, mentoring junior scientists, and organizing or participating in workshops and career development events.
Software
A major effort of the Flatiron Institute is the development and support of high-quality, open-source software for research.
Research Highlights
Phase plane dynamics of ERK phosphorylation
The extracellular signal–regulated kinase (ERK) controls multiple critical processes in the cell and is deregulated in human cancers, congenital abnormalities,…
Journal of Biological ChemistryAtlas of primary cell-type-specific sequence models of gene expression and variant effects
Human biology is rooted in highly specialized cell types programmed by a common genome, 98% of which is outside of…
Cell Reports MethodsA unified model for the co-evolution of galaxies and their circumgalactic medium: the relative roles of turbulence and atomic cooling physics
The circumgalactic medium (CGM) plays a pivotal role in regulating gas flows around galaxies and thus shapes their evolution. However,…
arXiv:2211.09755News & Announcements
November 29, 2023

November 03, 2023
