Plasticity and the Aging Brain
The Simons Collaboration on Plasticity and the Aging Brain (SCPAB) aims to discover mechanisms of resilience and functional maintenance in the aging brain, and to establish a baseline for plasticity-related changes with age across many model systems. The SCPAB’s focus on the basic biology of cognitive aging is foundational to future translational approaches aimed at minimizing cognitive decline and extending healthy lifespan.
Events & Lectures
View All-
SCPAB SFARI Clinical and Basic Researcher Speed Networking at INSAR 2025
The Simons Foundation Autism Research Initiative (SFARI) is hosting an event focused on bringing together basic science and clinical researchers for speed networking.
Read More
Sign up for SCPAB updates
Research Highlights
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes
F Rapino, T Natoli, F Limone, E O'Connor, J Blank, M Tegtmeyer, W Chen, E Norabuena, J Narula, D Hazelbaker, G Angelini, L Barrett, A O'Neil, UK Beattie, JM Thanos, H de Rivera, SD Sheridan, RH Perlis, S. McCarroll, B. Stevens, A Subramanian, R Nehme, L. Rubin
Stem Cell Reports X chromosome factor Kdm6a enhances cognition independent of its demethylase function in the aging XY male brain
CK Shaw, S Abdulai-Saiku, F Marino, D Wang, EJ Davis, B Panning, D. Dubal
J Gerontol A Biol Sci Med Sci Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency mode
K Mehalko, M Kim, S Paye, K Koh, RJ Lu, B. Benayoun
Transl Med Aging