Plasticity and the Aging Brain
The Simons Collaboration on Plasticity and the Aging Brain aims to discover mechanisms of resilience and maintenance in the aging brain and to establish a baseline for age-related changes in plasticity across many model systems, in order to identify potential interventions to minimize cognitive decline and extend healthy lifespan.
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Research Highlights
Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes
F Rapino, T Natoli, F Limone, E O'Connor, J Blank, M Tegtmeyer, W Chen, E Norabuena, J Narula, D Hazelbaker, G Angelini, L Barrett, A O'Neil, UK Beattie, JM Thanos, H de Rivera, SD Sheridan, RH Perlis, S. McCarroll, B. Stevens, A Subramanian, R Nehme, L. Rubin
Stem Cell Reports X chromosome factor Kdm6a enhances cognition independent of its demethylase function in the aging XY male brain
CK Shaw, S Abdulai-Saiku, F Marino, D Wang, EJ Davis, B Panning, D. Dubal
J Gerontol A Biol Sci Med Sci Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency mode
K Mehalko, M Kim, S Paye, K Koh, RJ Lu, B. Benayoun
Transl Med Aging