Funded Work
Our funded projects advance discovery across mathematics, the physical and life sciences, neuroscience, and autism.
Results
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Brain imaging research strongly suggests that autism spectrum disorder (ASD) involves altered function in multiple neural networks. -
Tuberous sclerosis complex (TSC) is a genetic condition caused by inactivating mutations in TSC1 or TSC2 genes, with variable penetrance and severity. -
Speech is a highly sophisticated, uniquely human behavior. -
Prediction of the future and mental simulation of experiences are key to many forms of cognition and sensory processing. -
The ability to make decisions lies at the core of cognition, but much remains unknown about its underlying neural mechanisms. -
Learning a complex motor skill like playing tennis or a music instrument requires changes in connections between many neurons in the brain. -
Behaviors are known to arise from numerous neurons communicating with each other within and across brain areas. -
Movement is the primary way animals interact with the world. -
Investigating symbol-like reasoning in the brain: Neural mechanisms of compositional action planning
Humans and other animals can rapidly solve new problems — such as imitating a dance from a single observation — by adaptively combining components from prior knowledge to generate new … -
Individuals vary widely in the types of behavioral transitions they undergo in response to adverse environmental conditions. -
Communication is a fundamental aspect of life among animals, and yet we lack a comprehensive understanding of the underlying neural mechanisms. -
Neurodevelopmental conditions, such as autism spectrum disorder (ASD) and intellectual disability, affect more than three percent of children worldwide, yet in the majority of cases, therapeutic options and …
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TRIO is among the genes most frequently impacted by damaging de novo mutations and rare variants in individuals with autism spectrum disorder (ASD), severe intellectual disability (ID), schizophrenia …
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Since the fall of 2008, Abba Krieger and colleagues (most prominently Andreas Buja) at the Wharton School of the University of Pennsylvania have served as statistical consultants to … -
The integrated stress response (ISR) has recently emerged as a main causative driver of normal aging as well as a wide spectrum of cognitive disorders of vastly different …
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Despite the increase in the prevalence of autism spectrum disorder (ASD), currently, there are no treatments that can effectively reverse ASD core features.
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Accumulating evidence indicates that autism spectrum disorder (ASD) susceptibility mutations are frequently found within genes encoding chromatin regulators that control the expression of genes across the genome.
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Among the most challenging aspects of autism is a variety of aural speech processing issues that deeply impact individuals’ language abilities.
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Seizures are an extreme outcome of excitatory-inhibitory imbalance and are the most common neurological complication in autism spectrum disorder (ASD).
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Autism spectrum disorder (ASD) is a complex brain condition with a developmental etiology rooted in corticogenesis.
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Atypical sensory experience is a core feature of autism spectrum disorder (ASD) and is strongly determinant of other ASD traits.
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In order for the brain to carry out its complex functions, gene expression must be precisely controlled at the levels of transcription and translation.
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Social attachments form the basis of human relationships at every level of social organization, from relationships between parents and children, romantic partners, to peers and group affiliation.
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Functional genomic analyses of the developing human brain have revealed highly dynamic spatiotemporal patterns of gene expression and epigenetic changes during prenatal and early postnatal development and across …
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Motor development is a central feature in the first two years of life.
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An international live-arts convening of artists, scientists, influencers and machines to develop new works for diverse audiences. -
Karen Parker’s team has used the extremes of naturally occurring variation in the social behavior of rhesus monkeys to develop a novel model of social deficits with …
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Precise synaptic connectivity and plasticity are critical for human cognition.
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Autism spectrum disorder (ASD) can arise from a multitude of genetic and environmental factors and span a wide range of features, including difficulties in social interactions, restricted interests …
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Mutations in neurexins have been identified in genetic studies and animal models as risk factors for autism spectrum disorders (ASDs).
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Brain oscillations are critical for neural computation and can serve as a biomarker of excitatory-inhibitory (E/I) balance in neural circuits.
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Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder affecting 1 in 3,500 individuals worldwide due to inactivating mutations in the NF1 gene.
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Many of the genes strongly associated with autism spectrum disorder (ASD) risk encode chromatin modifiers that regulate gene expression during neurogenesis.
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In the current project, Stewart Mostofsky and colleagues plan to use computer vision technology to examine motor imitation ability, which is known to be crucial for social-communicative … -
Humans and other animals learn many of their complex and socially-oriented behaviors by imitating more experienced individuals in their environment.
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Autism spectrum disorders (ASDs) are neurodevelopmental syndromes associated with diverse genetic alterations.
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Individuals with autism spectrum disorders (ASDs) exhibit phenotypic diversity that reflects the complex genetic architecture of this group of conditions, which is influenced by hundreds of rare variants …
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Genetic risks for autism are diverse and encompass mutations and copy number variations in hundreds of genes.
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Unpredictable and potentially dangerous aggressive behavior by youth with autism spectrum disorder (ASD) isolates them from foundational educational, social and familial activities, thereby markedly exacerbating morbidity and costs …
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Gastrointestinal (GI) distress is pervasive in autism spectrum disorders (ASDs).
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Neurexins constitute a family of presynaptic transmembrane molecules that interact with postsynaptic cell adhesion molecules, most notably neuroligins.
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The cerebral cortex contains diverse types of excitatory projection neurons and inhibitory interneurons that form specific circuits to support healthy brain function.
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New technologies for efficiently manipulating genomes have expanded autism research to mammalian models beyond the mouse.