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    Biological Transport and Networks Integrating computation, theory and experimental data to decipher the inner workings of living processes.

    Biomolecular Design Using exotic building blocks to design novel heteropolymers that fold into well-defined 3D structures.

    Biophysical Modeling Modeling and simulating the complex systems that arise in biology and soft condensed matter physics.

    CCBScope Observatory The Flatiron Institute's in-house, state-of-the-art imaging facility for live-cell confocal microscopy.

    CCBx Uniting theorists and experimentalists to develop and test theories of biological systems.

    COMPASS Connecting researchers working on molecular sampling, simulation and design.

    Developmental Dynamics Combining experiment, theory and computing to elucidate the inner workings of embryonic development.

    Genomics Working to unravel the complexity of the genome, its regulation and its phenotypic consequences.

    Statistical Biophysics Developing a nonequilibrium physics of living systems and learning machines.

    Structural and Molecular Biophysics Developing novel mathematical approaches to decipher the molecular mechanisms involved in key biological processes.

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Flatiron Institute Computational Biology

Computational Biology: Publications

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  1. Generative model for the first cell fate bifurcation in mammalian development

    Development, September 5, 2025

    M. Avdeeva, et al.

  2. Stochastic Process Inference Without Trajectories: A Probabilistic Approach

    ACM SIGMETRICS Performance Evaluation Review, August 27, 2025

    D. Hathcock, Mark S Squillante, and Y. Tu

  3. Stochastic Process Inference Without Trajectories: A Probabilistic Approach

    ACM SIGMETRICS Performance Evaluation Review, August 27, 2025

    D. Hathcock, Mark S Squillante, and Y. Tu

  4. Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development

    Developmental Biology, bioRxiv, August 25, 2025

    Madeleine Chalifoux, et al.

  5. Stability of co-annular active and passive confined fluids

    Physical Review Fluids, August 21, 2025

    Tanumoy Dhar, M. Shelley, and D. Saintillan

  6. In silico, in vitro and ex vivo characterization of cystic fibrosis transmembrane conductance regulator pathogenic variants localized in the fourth intracellular loop and their rescue by modulators

    British Journal of Pharmacology, August 20, 2025

    Emanuela Pesce, et al.

  7. seekrflow: Towards end-to-end automated simulation pipeline with machine-learned force fields for accelerated drug-target kinetic and thermodynamic predictions

    bioRxiv, 2025

    A. Ojha, et al.

  8. seekrflow: Towards end-to-end automated simulation pipeline with machine-learned force fields for accelerated drug-target kinetic and thermodynamic predictions

    bioRxiv, August 17, 2025

    A. Ojha, et al.

  9. Study of Protein-Protein Interactions in Septin Assembly: Multiple amphipathic helix domains cooperate in binding to the lipid membrane

    bioRxiv, 2025

    M. Mofidi, et al.

  10. Study of Protein-Protein Interactions in Septin Assembly: Multiple amphipathic helix domains cooperate in binding to the lipid membrane

    bioRxiv, August 12, 2025

    M. Mofidi, et al.

  11. Velocity optimization of self-equilibrated obstacles in a two-dimensional viscous flow

    arXiv:2508.05481, 2025

    G. Francfort, Alessandro Giacomini, and S. Weady

  12. Velocity optimization of self-equilibrated obstacles in a two-dimensional viscous flow

    arXiv:2508.05481, August 7, 2025

    G. Francfort, Alessandro Giacomini, and S. Weady

  13. Quantitative and Predictive Folding Models from Limited Single-Molecule Data Using Simulation-Based Inference

    arXiv, August 4, 2025

    Lars Dingeldein, Aaron Lyons, and P. Cossio

  14. Quantitative and Predictive Folding Models from Limited Single-Molecule Data Using Simulation-Based Inference

    arXiv, August 4, 2025

    Lars Dingeldein, Aaron Lyons, and P. Cossio

  15. Nuclear biophysics: Spatial coordination of transcriptional dynamics?

    Current Opinion in Cell Biology, August 1, 2025

    Tae Yeon Yoo, Bernardo Gouveia, and D. Needleman

  16. Methylation Data Analysis and Interpretation

    Annual Review of Biomedical Data Science, August 1, 2025

    Yuehua Zhu, et al.

  17. Active Liquid Crystal Theory Explains the Collective Organization of Microtubules in Human Mitotic Spindles

    arXiv:2507.22273, July 29, 2025

    Colm P. Kelleher, S. Maddu, Mustafa Basaran, Thomas Müller-Reichert, M. Shelley, and D. Needleman

  18. Large protein databases reveal structural complementarity and functional locality

    Nature Communications, July 25, 2025

    Paweł Szczerbiak, et al.

  19. The physical consequences of sperm gigantism

    arXiv:2507.14567, July 25, 2025

    J. Alsous, B. Chakrabarti, B. Palmer, and M. Shelley

  20. Altruistic Resource-Sharing Mechanism for Synchronization: The Energy-Speed-Accuracy Trade-off

    Physical Review Letters, July 17, 2025

    Dongliang Zhang, Yuansheng Cao, Qi Ouyang, and Y. Tu

  21. Representational drift and learning-induced stabilization in the piriform cortex

    PNAS, July 16, 2025

    Guillermo B. Morales, Miguel A. Muñoz, and Y. Tu

  22. Prediction of local convergent shifts in evolutionary rates with phyloConverge

    Bioinformatics, 2025

    Elysia Saputra, et al.

  23. Representational drift and learning-induced stabilization in the piriform cortex

    Proceedings of the National Academy of Sciences, July 16, 2025

    Guillermo B. Morales, Miguel A. Muñoz, and Y. Tu

  24. The Fruit Fly Auxodrome: a computer vision setup for longitudinal studies of Drosophila development

    Genetics, July 11, 2025

    Changyuan Wang, Denis F Faerberg, S. Shvartsman, and Robert A Marmion

  25. The open-source Masala software suite: Facilitating rapid methods development for synthetic heteropolymer design

    Methods in Enzymology, bioRxiv:2025.07.02.662756, July 10, 2025

    Tristan Zaborniak, et al.

  26. Decomposition of phenotypic heterogeneity in autism reveals underlying genetic programs

    Nature Genetics, July 9, 2025

    Aviya Litman, et al.

  27. Flat Elastic Disc Suspensions Are Indistinguishable from Solutions of Long Flexible Polymers within Planar Incompressible Flows

    Physical Review Letters, July 8, 2025

    Fabian Hillebrand, et al.

  28. Neurons exploit stochastic growth to rapidly and economically build dense dendritic arbors

    Nature Communications, 2025

    Xiaoyi Ouyang, et al.

  29. Electrohydrodynamic drift of a drop away from an insulating wall

    Physical Review Fluids, July 1, 2025

    Diptendu Sen, et al.

  30. Integrated single-cell multiome analysis reveals muscle fiber-type gene regulatory circuitry modulated by endurance exercise

    Genome Research, July 1, 2025

    Aliza B. Rubenstein, et al.

  31. A live-cell biosensor of in vivo receptor tyrosine kinase activity reveals feedback regulation of a developmental gradient

    Cell Reports, June 27, 2025

    Emily K. Ho, et al.

  32. Sequestration of ribosome biogenesis factors in HSV- 1 nuclear aggregates revealed by spatially resolved thermal profiling

    Science Advances, June 27, 2025

    Peter J. Metzger, Tavis J. Reed, and O. Troyanskaya

  33. Microtubules in Martini: Parameterizing a heterogeneous elastic-network towards a mechanically accurate microtubule

    PNAS Nexus, 2025

    A. Sahoo and S. Hanson

  34. Microtubules in Martini: Parameterizing a heterogeneous elastic-network towards a mechanically accurate microtubule

    PNAS Nexus, June 21, 2025

    A. Sahoo and S. Hanson

  35. Spatial-Temporal Pre-Training for Embryo Viability Prediction Using Time-Lapse Videos

    arXiv, June 20, 2025

    Zhiyi Shi, et al.

  36. RocketSHP: Ultra-fast Proteome-scale Prediction of Protein Dynamics

    bioRxiv, 2025

    S. Sledzieski and S. Hanson

  37. RocketSHP: Ultra-fast Proteome-scale Prediction of Protein Dynamics

    bioRxiv, June 17, 2025

    S. Sledzieski and S. Hanson

  38. ExEnDiff: An Experiment-Guided Diffusion Model for Protein Conformational Ensemble Generation

    PRX Life, 2025

    Yikai Liu, et al.

  39. ExEnDiff: An Experiment-Guided Diffusion Model for Protein Conformational Ensemble Generation

    PRX Life, June 10, 2025

    Yikai Liu, et al.

  40. Nonlinear spontaneous flow instability in active nematics

    Physical Review Letters, June 9, 2025

    I. Lavi, Ricard Alert, Jean-François Joanny, and Jaume Casademunt

  41. Amortized template matching of molecular conformations from cryoelectron microscopy images using simulation-based inference

    Proceedings of the National Academy of Sciences, 2025

    Lars Dingeldein, et al.

  42. Amortized template matching of molecular conformations from cryoelectron microscopy images using simulation-based inference

    Biophysics and Computational Biology, June 4, 2025

    Lars Dingeldein, et al.

  43. Generation of fate patterns via intercellular forces

    Physical Review Research, June 4, 2025

    H. Nunley , Xufeng Xue, Jianping Fu, and David K. Lubensky

  44. CXCR4+ mammary gland macrophageal niche promotes tumor initiating cell activity and immune suppression during tumorigenesis

    Nature Communications, May 25, 2025

    Eunmi Lee, Jason J. Hong, and N. Sauerwald

  45. Correlations, mean-field limits, and transition to the concentrated regime in motile particle suspensions

    arXiv:2505.18299, May 23, 2025

    Bryce Palmer, S. Weady, M. O'Brien, B. Burkart, and M. Shelley

  46. Inferring stochastic dynamics with growth from cross-sectional data

    arXiv:2505.13197, May 19, 2025

    Stephen Zhang, S. Maddu, Xiaojie Qiu, and V. Chardès

  47. Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication

    Research Square, 2025

    Christine Roden, et al.

  48. Investigating the membrane curvature sensing ability of the N-terminal domain of huntingtin

    Journal of Biological Chemistry, 2025

    Shelli Frey, et al.

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