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    Biological Transport and Networks Integrating computation, theory and experimental data to decipher the inner workings of living processes.

    Biomolecular Design Using exotic building blocks to design novel heteropolymers that fold into well-defined 3D structures.

    Biophysical Modeling Modeling and simulating the complex systems that arise in biology and soft condensed matter physics.

    CCBScope Observatory The Flatiron Institute's in-house, state-of-the-art imaging facility for live-cell confocal microscopy.

    CCBx Uniting theorists and experimentalists to develop and test theories of biological systems.

    COMPASS Connecting researchers working on molecular sampling, simulation and design.

    Developmental Dynamics Combining experiment, theory and computing to elucidate the inner workings of embryonic development.

    Genomics Working to unravel the complexity of the genome, its regulation and its phenotypic consequences.

    Statistical Biophysics Developing a nonequilibrium physics of living systems and learning machines.

    Structural and Molecular Biophysics Developing novel mathematical approaches to decipher the molecular mechanisms involved in key biological processes.

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Flatiron Institute Computational Biology

Computational Biology: Publications

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  1. Dissipation and energy propagation across scales in an active cytoskeletal material

    PNAS, March 31, 2023

    Peter J. Foster, and Jinhye Bae, and D. Needleman

  2. Folding and modulation of the helical conformation of Glycophorin A by point mutations

    Physical Chemistry Chemical Physics, March 27, 2023

    Pei-Yin Lee, A. Sahoo, and Silvina Matysiak

  3. Docking cholesterol to integral membrane proteins with Rosetta

    PLOS Computational Biology, March 27, 2023

    Brennica Marlow, Georg Kuenze, Jens Meiler, and J. Koehler Leman

  4. Collective Motion and Pattern Formation in Phase-Synchronizing Active Fluids

    Physical Review Letters, March 24, 2023

    B. Chakrabarti, M. Shelley, and S. Fürthauer

  5. The fluidic memristor: collective phenomena in elastohydrodynamic networks

    bioRxiv, March 19, 2023

    Alejandro Martinez-Calvo, et al.

  6. Molecular basis of polyglutamine-modulated ELF3 aggregation in Arabidopsis temperature response

    bioRxiv, March 16, 2023

    J. Lindsay, Philip A. Wigge, and S. Hanson

  7. Stochastic phenotypes in RAS-dependent developmental diseases

    Current Biology, March 13, 2023

    Robert A. Marmion, et al.

  8. Dynamics of an incoherent feedforward loop drive ERK-dependent pattern formation in the early Drosophila embryo

    Development, 2023.03.09.531972, March 10, 2023

    Emily K. Ho, et al.

  9. Evolutionary history of MEK1 illuminates the nature of cancer and RASopathy mutations

    bioRxiv, March 9, 2023

    Ekaterina P. Andrianova, Robert A. Marmion, S. Shvartsman, and Igor B. Zhulin

  10. Spindle dynamics and orientation depends in forge generators configuration

    Bulletin of the American Physical Society, March 8, 2023

    Vicente J Gomez Herrera, M. Shelley, R. Farhadifar, D. Needleman, and Maya Anjur-Dietrich

  11. Anillin Related Mid1 as an Adaptive and Multimodal Contractile Ring Anchoring Protein: A Simulation Study

    bioRxiv, February 28, 2023

    Aaron R. Hall and Dimitrios Vavylonis

  12. Flow-network-controlled shape transformation of a thin membrane through differential fluid storage and surface expansion

    Physical Review E, February 28, 2023

    Yongtian Luo, et al.

  13. Blood RNA alternative splicing events as diagnostic biomarkers for infectious disease

    Cell Reports Methods, February 27, 2023

    Zijun Zhang, N. Sauerwald, and O. Troyanskaya

  14. Fusome topology and inheritance during insect gametogenesis

    PLOS Computational Biology, February 23, 2023

    Rocky Diegmiller, et al.

  15. Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis

    Science Translational Medicine, February 22, 2023

    R. Camille Brewer, et al.

  16. Connection between MHC class II binding and aggregation propensity: The antigenic peptide 10 of Paracoccidioides brasiliensis as a benchmark study

    Computational and Structural Biotechnology Journal, February 18, 2023

    Rodrigo Ochoa, Thyago R Cardim-Pires, Ricardo Sant'Anna, P. Cossio, and Debora Foguel

  17. Omicron mutations increase interdomain interactions and reduce epitope exposure in the SARS-CoV-2 spike

    iScience, February 17, 2023

    Miłosz Wieczór, P. Tang, Modesto Orozco, and P. Cossio

  18. Emergent properties of collective gene-expression patterns in multicellular systems

    Cell Reports Physical Science, February 15, 2023

    M. Smart and Anton Zilman

  19. Multiple polarity kinases inhibit phase separation of F-BAR protein Cdc15 and antagonize cytokinetic ring assembly in fission yeast

    eLife, February 7, 2023

    Rahul Bhattacharjee, et al.

  20. Patterning potential of the terminal system in the Drosophila embryo

    Korean Journal of Chemical Engineering, February 2, 2023

    Keonyong Lee, et al.

  21. Live Imaging of Nurse Cell Behavior in Late Stages of Drosophila Oogenesis

    Methods in Molecular Biology, January 31, 2023

  22. Fluorescent azobenzene-confined coiled-coil mesofibers

    Soft Matter, January 21, 2023

    Kamia Punia and D. Renfrew

  23. Dynamics of Flexible Filaments in Oscillatory Shear Flows

    Journal of Fluid Mechanics, January 19, 2023

    Francesco Bonacci, et al.

  24. Steps of actin filament branch formation by Arp2/3 complex investigated with coarse-grained molecular dynamics

    Frontiers in Cell and Developmental Biology, January 17, 2023

    Shuting Zhang and Dimitrios Vavylonis

  25. Fluid circulation driven by collectively organized metachronal waves in swimming T. aceti nematodes

    Physical Review E, December 2, 2022

    A. C. Quillen, et al.

  26. Concurrent ARFI Plaque Imaging and Wall Shear Stress Measurement in Human Carotid Artery, with Validation by Fluid Structure Interaction Model.

    IEEE International Ultrasonics Symposium, December 1, 2022

    Keerthi S. Anand, et al.

  27. Identifying genes and pathways linking astrocyte regional specificity to Alzheimer’s disease susceptibility

    bioRxiv: 2022.11.16.515390, November 17, 2022

    Ran Zhang, et al.

  28. How to Design Peptides

    Methods in Molecular Biology, November 15, 2022

    Joseph Dodd-O, et al.

  29. Incompressible active phases at an interface. Part 1. Formulation and axisymmetric odd flows

    Journal of Fluid Mechanics, November 8, 2022

    L. Jia, William T. M. Irvine, and M. Shelley

  30. The physical basis of self-organization of the mammalian oocyte spindle

    arXiv:2211.00883, November 2, 2022

    Colm P Kelleher and D. Needleman

  31. Pre-infection antiviral innate immunity contributes to sex differences in SARS-CoV-2 infection

    Cell Systems, November 1, 2022

    N. Sauerwald, et al.

  32. Multibody molecular docking on a quantum annealer

    ArXiv, arxiv.org/abs/2210.11401, October 20, 2022

    Mohit Pandey, et al.

  33. Dynamics, scaling behavior, and control of nuclear wrinkling

    arXiv: 1704.03884, October 20, 2022

    Jonathan A. Jackson, et al.

  34. Forced and spontaneous symmetry breaking in cell polarization

    Nature Computational Science, 2022

    Pearson Miller, D. Fortunato, Cyrill Muratov, L. Greengard, and S. Shvartsman

  35. Accurate de novo design of membrane-traversing macrocycles

    Cell, September 15, 2022

    G. Bhardwaj, et al.

  36. Quadrature by fundamental solutions: kernel-independent layer potential evaluation for large collections of simple objects

    Advances in Computational Mathematics, arxiv:2109.08802, 2022

    D. Stein and A. Barnett

  37. Mechanics of stabilized intercellular bridges

    Biophysical Journal, September 6, 2022

    Jaspreet Singh, J. Alsous, Krishna Garikipati, and S. Shvartsman

  38. The role of monolayer viscosity in Langmuir film hole closure dynamics

    Journal of Fluid Mechanics, September 2, 2022

    L. Jia and M. Shelley

  39. Canary in the cardiac-valve coal mine: Flow velocity and inferred shear during prosthetic valve closure –predictors of blood damage and clotting

    bioRxiv:2022.06.23.497372, July 22, 2022

    Lawrence N. Scotten and E. Kolahdouz

  40. Independently paced Ca2+ oscillations in progenitor and differentiated cells in an ex vivo epithelial organ

    Journal of Cell Science, July 19, 2022

    Ann A. Kim, et al.

  41. Evaluating the Conformations and Dynamics of Peptoid Macrocycles

    The Journal of Physical Chemistry B, July 12, 2022

    James R. B. Eastwood, et al.

  42. A sequence-based global map of regulatory activity for deciphering human genetics

    Nature Genetics, July 11, 2022

    Kathleen Chen, A. Wong, O. Troyanskaya, and Jian Zhou

  43. Weakly nonlinear analysis of pattern formation in active suspensions

    Journal of Fluid Mechanics, arXiv: 2205.04942, July 10, 2022

    Laurel Ohm and M. Shelley

  44. Self-organized flows in phase-synchronizing active fluids

    arXiv.2206.04035, June 24, 2022

    B. Chakrabarti, M. Shelley, and Sebastian Fürthauer

  45. Parallel Discrete Convolutions on Adaptive Particle Representations of Images

    IEEE Transactions on Image Processing, June 14, 2022

    Joel Jonsson, et al.

  46. A reference tissue atlas for the human kidney

    SCIENCE ADVANCES, June 8, 2022

    Jens Hansen, et al.

  47. Molecular Characterization of Membranous Nephropathy

    Journal of the American Society of Nephrology, June 1, 2022

    R. Sealfon, Laura Mariani, J. Funk, A. Wong, and O. Troyanskaya

  48. Sex-specific topological differences in germline cell lineage trees

    bioRxiv:2022.05.18.492500, 2022

    Rocky Diegmiller, J. Alsous, and S. Shvartsman

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