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    Biological Transport and Networks Integrating computation, theory and experimental data to decipher the inner workings of living processes.

    Biomolecular Design Using exotic building blocks to design novel heteropolymers that fold into well-defined 3D structures.

    Biophysical Modeling Modeling and simulating the complex systems that arise in biology and soft condensed matter physics.

    CCBScope Observatory The Flatiron Institute's in-house, state-of-the-art imaging facility for live-cell confocal microscopy.

    CCBx Uniting theorists and experimentalists to develop and test theories of biological systems.

    COMPASS Connecting researchers working on molecular sampling, simulation and design.

    Developmental Dynamics Combining experiment, theory and computing to elucidate the inner workings of embryonic development.

    Genomics Working to unravel the complexity of the genome, its regulation and its phenotypic consequences.

    Statistical Biophysics Developing a nonequilibrium physics of living systems and learning machines.

    Structural and Molecular Biophysics Developing novel mathematical approaches to decipher the molecular mechanisms involved in key biological processes.

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Flatiron Institute Computational Biology

Computational Biology: Publications

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  1. CRISPR-Decryptr reveals cis-regulatory elements from noncoding perturbation screens

    bioRxiv 2020.08.13.247007, August 14, 2020

    A. Rasmussen, T. Äijö, M. Gabitto, N. Carriero, N. Sanjana, J. Skok, et al.

  2. NetQuilt: Deep Multispecies Network-based Protein Function Prediction using Homology-informed Network Similarity

    bioRxiv 2020.07.30.227611;, July 31, 2020

    M. Barot, V. Gligorijevic, K. Cho, and R. Bonneau

  3. Evaluating the Simple Arrhenius Equation for the Temperature Dependence of Complex Developmental Processes

    bioRxiv: 2020.07.17.208777, July 18, 2020

    J. Crapse, N. Pappireddi, M. Gupta, S. Shvartsman, E. Wieschaus, and M. Wühr

  4. SARS-CoV-2 titers in wastewater foreshadow dynamics and clinical presentation of new COVID-19 cases

    medRxiv 2020.06.15.20117747, July 6, 2020

    F Wu, A Xiao, J Zhang, K Moniz, N Endo, F Armas, et al.

  5. High-Resolution Longitudinal Dynamics of the Cystic Fibrosis Sputum Microbiome and Metabolome through Antibiotic Therapy

    mSystems, June 23, 2020

    R. Raghuvanshi, K. Vasco, Y. Vázquez-Baeza, L. Jiang, J. Morton, D. Li, et al.

  6. Structure-Based Protein Function Prediction using Graph Convolutional Networks

    bioRxiv 786236, June 10, 2020

    V. Gligorijevic, D. Renfrew, T Kosciolek, J. Koehler Leman, D. Berenberg, T Vatanen, et al.

  7. Inference of Bacterial Small RNA Regulatory Networks and Integration with Transcription Factor-Driven Regulatory Networks

    mSystems, June 2, 2020

    M Arrieta Ortiz, C Hafemeister, B Shuster, N Baliga, and R. Bonneau

  8. Macromolecular modeling and design in Rosetta: recent methods and frameworks

    Nature Methods, June 1, 2020

    J. Koehler Leman, B Weitzner, and R. Bonneau

  9. Better together: Elements of successful scientific software development in a distributed collaborative community

    PLoS Computational Biology, May 4, 2020

    J. Koehler Leman, B Weitzner, D. Renfrew, S Lewis, R Moretti, A Watkins, et al.

  10. Visualizing ’omic feature rankings and log-ratios using Qurro

    NAR Genomics and Bioinformatics, April 28, 2020

    M. Fedarko, C. Martino, J. Morton, A. González, G. Rahman, C. Marotz, et al.

  11. Shrinkage improves estimation of microbial associations under different normalization methods

    bioRxiv 406264, April 4, 2020

    M Badri, Z Kurtz, R. Bonneau, and C. Müller

  12. Classification of the Molecular Defects Associated with Pathogenic Variants of the SLC6A8 Creatine Transporter

    Biochemistry, March 24, 2020

    M Salazar, N Zelt, R Saldivar, C Kuntz, S Chen, W Penn, et al.

  13. Characterization of antibiotic resistance and host-microbiome interactions in the human upper respiratory tract during influenza infection

    Microbiome, March 17, 2020

    L Zhang, C Forst, A Gordon, G Gussin, A Gerber, P Fernandez, et al.

  14. Designing Peptides on a Quantum Computer

    bioRxiv 752485, March 11, 2020

    V. Mulligan, H Melo, H Merritt, S Slocum, B Weitzner, A Watkins, et al.

  15. Metabolome-Informed Microbiome Analysis Refines Metadata Classifications and Reveals Unexpected Medication Transfer in Captive Cheetahs

    mSystems, March 10, 2020

    J. Gauglitz, J. Morton, A. Tripathi, S. Hansen, M. Gaffney, C. Carpenter, et al.

  16. Optimal tuning of weighted kNN- and diffusion-based methods for denoising single cell genomics data

    bioRxiv 2020.02.28.970202, March 2, 2020

    A Tjärnberg, O Mahmood, C Jackson, G Saldi, K Cho, L Christiaen, et al.

  17. A Bayesian nonparametric approach to super-resolution single-molecule localization

    bioRxiv 2020.02.15.950873, February 25, 2020

    M. Gabitto, H. Marie-Nelly, A. Pakman, A. Pataki, X. Darzacq, and M. Jordan

  18. Characterizing chromatin landscape from aggregate and single-cell genomic assays using flexible duration modeling

    Nature Communications, February 6, 2020

    M. Gabitto, A. Rasmussen, O Wapinksi, K Allaway, N. Carriero, G Fishell, et al.

  19. Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments

    eLife, January 27, 2020

    C Jackson, D Castro, G Saldi, R. Bonneau, and D Gresham

  20. A Comprehensive Map of the Monocyte-Derived Dendritic Cell Transcriptional Network Engaged upon Innate Sensing of HIV

    Cell Reports, January 21, 2020

    J Johndon, N De Veaux, A Rives, X Lahaye, S Lucas, B Perot, et al.

  21. Lattices of Hydrodynamically Interacting Flapping Swimmers

    Physical Review X, November 1, 2019

    A. U. Oza, L. Ristroph, and M. Shelley

  22. Relating Rheotaxis and Hydrodynamic Actuation using Asymmetric Gold-Platinum Phoretic Rods

    Physical Review Letters, October 25, 2019

    Q. Brosseau, F. Balboa Usabiaga, E. Lushi, Y. Wu, L. Ristroph, J. Zhang, et al.

  23. Rotating Membrane Inclusions Crystallize Through Hydrodynamic and Steric Interactions

    Physical Review Letters, October 3, 2019

    N. Oppenheimer, D. Stein, and M. Shelley

  24. The odd free surface flows of a colloidal chiral fluid

    Nature Physics, arXiv:1812.09990, September 9, 2019

    V. Soni, E.S. Bililign, S. Magkiriadou, S. Sacanna, M. Shelley, and W. Irvine

  25. Biologically Plausible Online Principal Component Analysis Without Recurrent Neural Dynamics

    arXiv:1810.06966, October 16, 2018

    V. Minden, C. Pehlevan, and D. Chklovskii

  26. Flexibility in motor timing constrains the topology and dynamics of pattern generator circuits

    Nature Communications, 2018

    C. Pehlevan, F. Ali, and B.P. Olveczky

  27. Holography, Fractals and the Weyl Anomaly

    arXiv:1802.05362, February 14, 2018

    Gerald Guralnik, Zachary Guralnik, and C. Pehlevan

  28. Temporal probabilistic modeling of bacterial compositions derived from 16S rRNA sequencing

    Bioinformatics, bioRxiv, February 1, 2018

    Tarmo Äijö, C. Müller, and R. Bonneau

  29. A clustering neural network model of insect olfaction

    BioRxiv, November 30, 2017

    C. Pehlevan, A Genkin, and D. Chklovskii

  30. NoRMCorre: An online algorithm for piecewise rigid motion correction of calcium imaging data

    Journal of Neuroscience Methods, November 1, 2017

    E. Pnevmatikakis and A. Giovannucci

  31. Blind Nonnegative Source Separation Using Biological Neural Networks

    Neural Computation, arXiv:1706.00382, October 17, 2017

    C. Pehlevan, S. Mohan, and D. Chklovskii

  32. OnACID: Online Analysis of Calcium Imaging Data in Real Time, Advances

    Advances in Neural Information Processing Systems, October 2, 2017

    A. Giovannucci, J. Friedrich, M Kaufman, A Churchland, D. Chklovskii, L Paninski, et al.

  33. A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity

    Nature Communications, September 11, 2017

    V Ruiz, T Battaglia, S Kurtz, L Bijnens, A Ou, I Engstrand, et al.

  34. Integrated Analysis of Biopsies from Inflammatory Bowel Disease Patients Identifies SAA1 as a Link Between Mucosal Microbes with TH17 and TH22 Cells

    Inflammatory Bowel Diseases, September 1, 2017

    M Tang, R Bowcutt, J Leung, M Wolff, U Gundra, D Hudesman, et al.

  35. Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models

    Proceedings of the National Academy of Sciences of the United States of America, August 14, 2017

    A Leffler, A Kuryatov, H Zebroski, S Powell, P Filipenko, A Hussein, et al.

  36. Impact of phenylalanines outside the dimer interface on phosphotriesterase stability and function

    Molecular BioSystems, August 10, 2017

    A Olsen, L Halvorsen, C Yang, R Ventura, L Yin, D. Renfrew, et al.

  37. Identification of multi-loci hubs from 4C-seq demonstrates the functional importance of simultaneous interactions

    Nucleic Acids Research, July 20, 2017

    T Jiang, R Raviram, V Snetkova, P Rocha, C Proudhon, S Badri, et al.

  38. Automated gesture tracking in head-fixed mice

    Journal of Neuroscience Methods, July 17, 2017

    A. Giovannucci, E. Pnevmatikakis, B Deverett, T Pereira, J Fondriest, M Brady, et al.

  39. Efficient Dual siRNA and Drug Delivery Using Engineered Lipoproteoplexes

    Biomacromolecules, July 7, 2017

    C Fu Liu, R Chen, J Frezzo, P Katyal, L Hill, L Hill, et al.

  40. Lung microbiome and host immune tone in subjects with idiopathic pulmonary fibrosis treated with inhaled interferon-γ

    ERJ Open Research, July 1, 2017

    J Wang, M Lesko, M Badri, B Kapoor, B Wu, Y Li, et al.

  41. The surprising secret identity of the semidefinite relaxation of K-means: manifold learning

    arXiv:1706.06028, June 19, 2017

    M. Tepper, A.M. Sengupta, and D. Chklovskii

  42. Resource-efficient perceptron has sparse synaptic weight distribution

    Signal Processing and Communications Applications Conference (SIU), 2017 25th, May 16, 2017

    C. Pehlevan and A. Sengupta

  43. The comprehensive connectome of a neural substrate for ‘ON’ motion detection in Drosophila

    eLife, April 22, 2017

    S. Takemura, A. Nern, D. Chklovskii, L.K. Scheffer, G. Rubin, and I.A. Meinertzhagen

  44. The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design

    Journal of Chemical Theory and Computation, April 21, 2017

    R Alford, A Leaver-Fay, J Jeliazkov, M O'Meara, F DiMaio, H Park, et al.

  45. Phosphotriesterase enzymes, methods and compositions related thereto

    US Patent, April 11, 2017

    J Montclare, R. Bonneau, D. Renfrew, C Yang, and C Yuvienco

  46. Why do similarity matching objectives lead to Hebbian/anti-Hebbian networks?

    arXiv:1703.07914, March 23, 2017

    C. Pehlevan, A. Sengupta, and D. Chklovskii

  47. Cerebellar granule cells acquire a widespread predictive feedback signal during motor learning

    Nature Neuroscience, March 20, 2017

    A. Giovannucci, et al.

  48. Mocap: large-scale inference of transcription factor binding sites from chromatin accessibility

    Nucleic Acids Research, March 15, 2017

    Y Bowen, N Carriero, C Silva, and R. Bonneau

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