All Funding 

Innate Immune System Impact Request for Applications

Closed
Program Areas
Autism & Neuroscience, Autism Research Initiative (SFARI)
Type
Investigator Award

Impact

Laboratory scene with test tubes in a plastic rack, a pipette, glass vials, and a microscope on a data sheet background, all shown with a blue and yellow tint.

Immune p38-alpha MAPK activation: Convergent mechanism linking autism models

Awarded 2014
Laboratory scene with test tubes in a plastic rack, a pipette, glass vials, and a microscope on a data sheet background, all shown with a blue and yellow tint.

A probiotic therapy for autism

Awarded 2014
Laboratory scene with test tubes in a plastic rack, a pipette, glass vials, and a microscope on a data sheet background, all shown with a blue and yellow tint.

Immune signaling in the developing brain in mouse models of autism

Awarded 2014
All Funding 

  1. Application Deadline

    March 3, 2014

  2. Notification of Award

    July 1, 2014

  3. Funding Expected to Begin

    August 1, 2014

Grants awarded through this request for applications (RFA) were intended to advance our understanding of the impact of activation of the innate immune system on behavioral, circuit, synaptic and neuronal functions in order to understand the consequences of infection and immune activation on autism-related behaviors.

To this end, we sought applications for investigations of the impact of physiologically relevant activation of the innate immune system on behavioral, circuit, synaptic and neuronal functions in animal models of autism. SFARI especially encouraged applications that address either of the following two issues:

(1) Effects of activation of the maternal innate immune system on embryonic central nervous system development in genetic models of autism and controls. How do fetal genetics and maternal innate immune activation interact to affect postnatal autism-related phenotypes, and what are the mechanisms through which they interact?

(2) Effects of activation of the innate immune system in genetic autism models and adult controls. How does innate immune activation affect behavioral, circuit, synaptic and cellular function in these genetic models and in controls? What are the roles of cytokine signaling, fever, immune cell activation and other effectors on these functions?

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