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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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Results

  1. Locomotion-induced gain of visual responses cannot explain visuomotor mismatch responses in layer 2/3 of primary visual cortex

    Cell Rep, March 28, 2023

    A Vasilevskaya, FC Widmer, GB Keller, and Rebecca Jordan

  2. Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena

    Cell Rep, March 24, 2023

    A Nanda, GW Johnson, Y Mu, Misha Ahrens, C Chang, DJ Englot, et al.

  3. Thalamus drives vocal onsets in the zebra finch courtship song

    Nature, March 23, 2023

    FW Moll, D Kranz, A Corredera Asensio, M Elmaleh, LA Ackert-Smith, and Michael A. Long

  4. Catalyzing next-generation Artificial Intelligence through NeuroAI

    Nat Commun, March 23, 2023

    Anthony Zador, S Escola, B Richards, B Ölveczky, Y Bengio, K Boahen, et al.

  5. Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons

    J Neurosci, March 17, 2023

    JH Meng, B Schuman, B Ruby, and Xiao-Jing Wang

  6. An optical design enabling lightweight and large field-of-view head-mounted microscopes

    Nat Methods, March 17, 2023

    JR Scherrer, GF Lynch, JJ Zhang, and Michale Fee

  7. Neural learning rules for generating flexible predictions and computing the successor representation

    Elife, March 16, 2023

    C Fang, D Aronov, Larry Abbott, and EL Mackevicius

  8. Fast and sensitive GCaMP calcium indicators for imaging neural populations

    Nature, March 16, 2023

    Y Zhang, M Rózsa, Y Liang, D Bushey, Z Wei, J Zheng, et al.

  9. Fastest-ever calcium sensors broaden the potential of neuronal imaging

    Nature, March 15, 2023

    MB Ryan, Anne K. Churchland, Y Gong, and C Baker

  10. Neural circuits underlying habituation of visually evoked escape behaviors in larval zebrafish

    Elife, March 14, 2023

    H Fotowat and Florian Engert

  11. The neural architecture of theory-based reinforcement learning

    Neuron, March 10, 2023

    MS Tomov, PA Tsividis, T Pouncy, Joshua Tenenbaum, and SJ Gershman

  12. A complete biomechanical model of Hydra contractile behaviors, from neural drive to muscle to movement.

    Proc Natl Acad Sci USA, March 10, 2023

    H Wang, J Swore, S Sharma, JR Szymanski, R Yuste, TL Daniel, et al.

  13. Evolution of neural activity in circuits bridging sensory and abstract knowledge

    Elife, March 7, 2023

    F Mastrogiuseppe, N Hiratani, and Peter Latham

  14. A response to claims of emergent intelligence and sentience in a dish

    Neuron, March 2, 2023

    F Balci, S Ben Hamed, T Boraud, S Bouret, T Brochier, C Brun, et al.

  15. A modular architecture for organizing, processing and sharing neurophysiology data

    Nat Methods, March 2, 2023

    International Brain Laboratory, N Bonacchi, GA Chapuis, Anne K. Churchland, EEJ DeWitt, M Faulkner, et al.

  16. Contrast and Luminance Gain Control in the Macaque's Lateral Geniculate Nucleus

    eNeuro, March 1, 2023

    RT Raghavan, JG Kelly, JM Hasse, PG Levy, MJ Hawken, and J. Anthony Movshon

  17. Neural Plasticity in Sensorimotor Brain-Machine Interfaces

    Annu Rev Biomed Eng, February 28, 2023

    MC Dadarlat, RA Canfield, and Amy Orsborn

  18. A searchable image resource of Drosophila GAL4-driver expression patterns with single neuron resolution

    Elife, February 23, 2023

    GW Meissner, A Nern, Z Dorman, GM DePasquale, K Forster, T Gibney, et al.

  19. Abstract representations emerge naturally in neural networks trained to perform multiple tasks

    Nat Commun, February 23, 2023

    WJ Johnston and Stefano Fusi

  20. Encoding of dynamic facial information in the middle dorsal face area

    Proc Natl Acad Sci U S A., February 21, 2023

    Z Yang and Winrich Freiwald

  21. Macroscopic dynamics of neural networks with heterogeneous spiking thresholds

    Phys Rev E, February 16, 2023

    R Gast, Sara Solla, and A Kennedy

  22. Hypothalamic neurons that mirror aggression

    Cell, February 16, 2023

    T Yang, DW Bayless, Y Wei, D Landayan, IM Marcelo, Y Wang, et al.

  23. Mice and primates use distinct strategies for visual segmentation

    Elife, February 15, 2023

    FJ Luongo, L Liu, CLA Ho, JK Hesse, JB Wekselblatt, F Lanfranchi, et al.

  24. Metacognitive computations for information search: Confidence in control

    Psychol Rev, February 9, 2023

    L Schulz, SM Fleming, and Peter Dayan

  25. Hypothalamic neurons that mirror aggression

    Cell, February 7, 2023

    T Yang, DW Bayless, Y Wei, D Landayan, IM Marcelo, Y Wang, et al.

  26. IAN: Iterated Adaptive Neighborhoods for Manifold Learning and Dimensionality Estimation

    Neural Comput, February 2, 2023

    L Dyballa and Steven Zucker

  27. Sensitivity to naturalistic texture relies primarily on high spatial frequencies

    J Vis, February 1, 2023

    JD Lieber, GM Lee, NJ Majaj, and J. Anthony Movshon

  28. Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila

    Elife, January 24, 2023

    D Yamada, D Bushey, F Li, KL Hibbard, M Sammons, J Funke, et al.

  29. Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making

    Nat Neurosci, January 23, 2023

    S Musall, XR Sun, H Mohan, X An, S Gluf, SJ Li, et al.

  30. Optimal Quadratic Binding for Relational Reasoning in Vector Symbolic Neural Architectures

    Neural Comput, January 20, 2023

    N Hiratani and Haim Sompolinsky

  31. Spontaneous behaviour is structured by reinforcement without explicit reward

    Nature, January 18, 2023

    JE Markowitz, WF Gillis, M Jay, J Wood, RW Harris, R Cieszkowski, et al.

  32. A neural substrate of sex-dependent modulation of motivation

    Nat Neurosci, January 16, 2023

    J Cox, AR Minerva, WT Fleming, CA Zimmerman, C Hayes, S Zorowitz, et al.

  33. Parametric control of flexible timing through low-dimensional neural manifolds

    Neuron, January 14, 2023

    M Beiran, N Meirhaeghe, H Sohn, Mehrdad Jazayeri, and S Ostojic

  34. All-optical physiology resolves a synaptic basis for behavioral timescale plasticity

    Cell, January 13, 2023

    LZ Fan, DK Kim, JH Jennings, H Tian, PY Wang, C Ramakrishnan, et al.

  35. Residual dynamics resolves recurrent contributions to neural computation

    Nat Neurosci, January 12, 2023

    AR Galgali, Maneesh Sahani, and Valerio Mante

  36. Choice selective inhibition drives stability and competition in decision circuits

    Nat Commun, January 10, 2023

    JP Roach, Anne K. Churchland, and Tatiana Engel

  37. Behavioral origin of sound-evoked activity in mouse visual cortex

    Nat Neurosci, January 9, 2023

    C Bimbard, TPH Sit, A Lebedeva, CB Reddy, and Matteo Carandini

  38. A General Framework for Inferring Bayesian Ideal Observer Models from Psychophysical Data

    eNeuro, January 9, 2023

    TS Manning, BN Naecker, IR McLean, B Rokers, Jonathan Pillow, and EA Cooper

  39. Parametric control of flexible timing through low-dimensional neural manifolds

    Neuron, January 9, 2023

    M Beiran, N Meirhaeghe, H Sohn, Mehrdad Jazayeri, and S Ostojic

  40. The geometry of cortical representations of touch in rodents

    Nat Neurosci, January 9, 2023

    R Nogueira, CC Rodgers, RM Bruno, and Stefano Fusi

  41. Formalising social representation to explain psychiatric symptoms

    Trends Cogn Sci, January 7, 2023

    JM Barnby, Peter Dayan, and V Bell

  42. One dimensional approximations of neuronal dynamics reveal computational strategy

    PLoS Comput Biol, January 6, 2023

    C Brennan, A Aggarwal, R Pei, David Sussillo, and A Proekt

  43. The centrality of population-level factors to network computation is demonstrated by a versatile approach for training spiking networks

    Neuron, January 5, 2023

    B DePasquale, David Sussillo, Larry Abbott, and Mark M. Churchland

  44. An approximate line attractor in the hypothalamus encodes an aggressive state

    Cell, January 5, 2023

    A Nair, T Karigo, B Yang, Surya Ganguli, Mark Schnitzer, Scott Linderman, et al.

  45. The centrality of population-level factors to network computation is demonstrated by a versatile approach for training spiking networks

    Neuron, December 30, 2022

    JDS Reggiani, Q Jiang, M Barbini, A Lutas, Liang Liang, J Fernando, et al.

  46. Dimensionality reduction of calcium-imaged neuronal population activity

    Nature Computational Science, December 29, 2022

    TH Koh, WE Bishop, T Kawashima, BB Jeon, R Srinivasan, Y Mu, et al.

  47. The role of the lateral orbitofrontal cortex in creating cognitive maps

    Nat Neurosci, December 22, 2022

    KM Costa, R Scholz, K Lloyd, P Moreno-Castilla, MPH Gardner, Peter Dayan, et al.

  48. A brainstem integrator for self-location memory and positional homeostasis in zebrafish

    Cell, December 22, 2022

    E Yang, MF Zwart, B James, M Rubinov, Z Wei, S Narayan, et al.

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