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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Learning probabilistic neural representations with randomly connected circuits

    Proc Natl Acad Sci U S A., September 18, 2020

    O Maoz, G Tkačik, MS Esteki, Roozbeh Kiani, and Elad Schneidman

  2. The Mind of a Mouse

    Cell., September 17, 2020

    LF Abbott, DD Bock, EM Callaway, W Denk, C Dulac, Adrienne Fairhall, et al.

  3. Stimulus-specific hypothalamic encoding of a persistent defensive state

    Nature., September 16, 2020

    A Kennedy, PS Kunwar, LY Li, S Stagkourakis, DA Wagenaar, and David J. Anderson

  4. A comparison of neuronal population dynamics measured with calcium imaging and electrophysiology

    PLoS Comput Biol., September 15, 2020

    Z Wei, BJ Lin, TW Chen, K Daie, Karel Svoboda, and Shaul Druckmann

  5. Capturing Multiple Timescales of Adaptation to Second-Order Statistics With Generalized Linear Models: Gain Scaling and Fractional Differentiation

    Front Syst Neurosci., September 9, 2020

    KW Latimer and Adrienne Fairhall

  6. Integrative Benchmarking to Advance Neurally Mechanistic Models of Human Intelligence

    Neuron., September 8, 2020

    M Schrimpf, J Kubilius, MJ Lee, NA Ratan Murty, R Ajemian, and James DiCarlo

  7. Computational neuroscience: a frontier of the 21st century

    National Science Review, September 7, 2020

    Xiao-Jing Wang, H Hu, C Huang, H Kennedy, CT Li, N Logothetis, et al.

  8. Systematic errors in connectivity inferred from activity in strongly recurrent networks

    Nature Neuroscience, September 7, 2020

    A Das and Ila Fiete

  9. High-dimensional dynamics of generalization error in neural networks

    Neural Netw., September 5, 2020

    MS Advani, AM Saxe, and Haim Sompolinsky

  10. A connectome and analysis of the adult Drosophila central brain

    Elife., September 3, 2020

    LK Scheffer, CS Xu, M Januszewski, Z Lu, SY Takemura, KJ Hayworth, et al.

  11. Inactivation of the Medial Entorhinal Cortex Selectively Disrupts Learning of Interval Timing

    Cell Reports, September 1, 2020

    J Heys, Z Wu, A Letizia, A Mascaro, and DA Dombeck

  12. The Neuroanatomical Ultrastructure and Function of a Biological Ring Attractor

    Neuron, September 1, 2020

    DB Turner-Evans, KT Jensen, S Ali, T Paterson, A Sheridan, RP Ray, et al.

  13. Low-dimensional dynamics for working memory and time encoding

    Proc Natl Acad Sci U S A., August 28, 2020

    CJ Cueva, A Saez, E Marcos, A Genovesio, Mehrdad Jazayeri, R Romo, et al.

  14. Decision Signals in the Local Field Potentials of Early and Mid-Level Macaque Visual Cortex

    Cereb Cortex., August 27, 2020

    A Krishna, S Tanabe, and Adam Kohn

  15. Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans

    Nat Neurosci., August 17, 2020

    D Vormstein-Schneider, JD Lin, KA Pelkey, R Chittajallu, B Guo, MA Arias-Garcia, et al.

  16. Transient and Persistent Representations of Odor Value in Prefrontal Cortex

    Neuron, August 13, 2020

    PY Wang, C Boboila, M Chin, A Higashi-Howard, P Shamash, Z Wu, et al.

  17. Engineering recurrent neural networks from task-relevant manifolds and dynamics

    PLoS Comput Biol., August 12, 2020

    E Pollock and Mehrdad Jazayeri

  18. Slow Drift of Neural Activity as a Signature of Impulsivity in Macaque Visual and Prefrontal Cortex

    Neuron, August 12, 2020

    BR Cowley, AC Synder, K Acar, RC Williamson, Byron Yu, and MA Smith

  19. Structure in Neural Activity during Observed and Executed Movements Is Shared at the Neural Population Level, Not in Single Neurons

    Cell Rep., August 11, 2020

    X Jiang, H Saggar, SI Ryu, Krishna Shenoy, and JC Kao

  20. A neural circuit model for human sensorimotor timing

    Nature Communications, August 7, 2020

    Seth W. Egger, Nhat M. Le, and Mehrdad Jazayeri

  21. A data resource from concurrent intracranial stimulation and functional MRI of the human brain

    Sci Data., August 5, 2020

    WH Thompson, R Nair, H Oya, O Esteban, JM Shine, CI Petkov, et al.

  22. Principles of Corticocortical Communication: Proposed Schemes and Design Considerations

    Trends Neurosci., August 5, 2020

    Adam Kohn, AI Jasper, JD Semedo, E Gokcen, Christian Machens, and Byron Yu

  23. The inferior temporal cortex is a potential cortical precursor of orthographic processing in untrained monkeys

    Nat Commun., August 4, 2020

    R Rajalingham, K Kar, S Sanghavi, S Dehaene, and James DiCarlo

  24. Mouse Visual Cortex Is Modulated by Distance Traveled and by Theta Oscillations

    Curr Biol., August 4, 2020

    J Fournier, AB Saleem, EM Diamanti, MJ Wells, and Matteo Carandini

  25. Memory Alone Does Not Account for the Way Rats Learn a Simple Spatial Alternation Task

    J Neurosci., August 4, 2020

    DB Kastner, Anna Gillespie, Peter Dayan, and Loren Frank

  26. A temporal record of the past with a spectrum of time constants in the monkey entorhinal cortex

    Proc Natl Acad Sci U S A., August 3, 2020

    IM Bright, MLR Meister, NA Cruzado, Z Tiganj, Elizabeth A. Buffalo, and MW Howard

  27. Rapid Bayesian learning in the mammalian olfactory system

    Nat Commun, July 31, 2020

    N Hiratani and Peter Latham

  28. A low-power band of neuronal spiking activity dominated by local single units improves the performance of brain-machine interfaces

    Nat Biomed Eng., July 27, 2020

    SR Nason, AK Vaskov, MS Willsey, EJ Welle, H An, PP Vu, et al.

  29. Value and choice as separable and stable representations in orbitofrontal cortex

    Nat Commun., July 10, 2020

    DL Kimmel, GF Elsayed, John Cunningham, and Bill Newsome

  30. Functional Architecture of Motion Direction in the Mouse Superior Colliculus.

    Curr Biol., July 9, 2020

    YT Li, Z Turan, and Markus Meister

  31. Finding the Brain in the Nose

    Annual Review of Neuroscience, July 8, 2020

    David H. Brann and Sandeep Robert Datta

  32. Computation Through Neural Population Dynamics

    Annu Rev Neurosci., July 8, 2020

    S Vyas, MD Golub, David Sussillo, and Krishna Shenoy

  33. Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons

    Elife, July 6, 2020

    SJ Jerjian, Maneesh Sahani, and A Kraskov

  34. Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons.

    Proc Natl Acad Sci U S A., July 6, 2020

    B Li, TP Nguyen, C Ma, and Yang Dan

  35. A Causal Network Analysis of Neuromodulation in the Mood Processing Network

    Neuron, July 1, 2020

    S Qiao, JI Sedillo, KA Brown, B Ferrentino, and Bijan Pesaran

  36. Structure and flexibility in cortical representations of odour space

    Nature, July 1, 2020

    SL Pashkovski, G Iurilli, D Brann, D Chicharro, K Drummey, K Franks, et al.

  37. Physiological blood-brain transport is impaired with age by a shift in transcytosis

    Nature, July 1, 2020

    AC Yang, MY Stevens, MB Chen, DP Lee, D Stähli, D Gate, et al.

  38. Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain

    Curr Biol., June 29, 2020

    AS Bates, P Schlegel, RJV Roberts, N Drummond, IFM Tamimi, R Turnbull, et al.

  39. BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals.

    Cell, June 29, 2020

    L Huang, JM Kebschull, D Fürth, S Musall, MT Kaufman, Anne K. Churchland, et al.

  40. Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator

    Neuron, June 26, 2020

    OA Shemesh, C Linghu, KD Piatkevich, D Goodwin, OT Celiker, HJ Gritton, et al.

  41. Flexible recruitment of memory-based choice representations by the human medial frontal cortex

    Science, June 26, 2020

    J Minxha, Ralph Adolphs, Stefano Fusi, AN Mamelak, and U Rutishauser

  42. Input Connectivity Reveals Additional Heterogeneity of Dopaminergic Reinforcement in Drosophila

    Curr Biol., June 25, 2020

    N Otto, MW Pleijzier, IC Morgan, AJ Edmondson-Stait, KJ Heinz, I Stark, et al.

  43. Anatomy and Function of the Primate Entorhinal Cortex

    Annu Rev Vis Sci ., June 24, 2020

    AD Garcia and Elizabeth A. Buffalo

  44. Combined model-free and model-sensitive reinforcement learning in non-human primates

    PLoS Comput Biol ., June 22, 2020

    B Miranda, WMN Malalasekera, TE Behrens, Peter Dayan, and SW Kennerley

  45. Representation, abstraction, and simple-minded sophisticates

    Behav Brain Sci., June 19, 2020

    Peter Dayan

  46. Flexible coding of object motion in multiple reference frames by parietal cortex neurons

    Nat Neurosci, June 15, 2020

    R Sasaki, A Anzai, Dora Angelaki, and GC DeAngelis

  47. Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times

    Elife, June 10, 2020

    LX Cai, K Pizano, GW Gundersen, CL Hayes, WT Fleming, S Holt, et al.

  48. A Distributed Neural Code in the Dentate Gyrus and in CA1

    Neuron, June 9, 2020

    F Stefanini, L Kushnir, JC Jimenez, JH Jennings, NI Woods, GD Stuber, et al.

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