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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Structural Attributes and Principles of the Neocortical Connectome in the Marmoset Monkey

    Cereb Cortex, July 19, 2021

    P Theodoni, P Majka, DH Reser, DK Wójcik, MGP Rosa, and Xiao-Jing Wang

  2. Remembering the Past to See the Future

    Annu Rev Vis Sci, July 16, 2021

    Nicole Rust and SE Palmer

  3. Bridging neuronal correlations and dimensionality reduction

    Neuron, July 16, 2021

    A Umakantha, R Morina, BR Cowley, AC Snyder, MA Smith, and Byron Yu

  4. Cerebral small vessel disease: A glymphopathy?

    Curr Opin Neurobiol, July 15, 2021

    H Benveniste and Maiken Nedergaard

  5. Fast deep neural correspondence for tracking and identifying neurons in C. elegans using semi-synthetic training

    Elife, July 14, 2021

    X Yu, MS Creamer, F Randi, AK Sharma, Scott Linderman, and Andrew Leifer

  6. The Glymphatic System (En)during Inflammation

    Int J Mol Sci., July 13, 2021

    FL Mogensen, C Delle, and Maiken Nedergaard

  7. Dopamine axons in dorsal striatum encode contralateral visual stimuli and choices

    J Neurosci, July 12, 2021

    MM Moss, P Zatka-Haas, Matteo Carandini, and A Lak

  8. Navigating for reward

    Nat Rev Neurosci, July 9, 2021

    M Sosa and Lisa Giocomo

  9. When the ventral visual stream is not enough: A deep learning account of medial temporal lobe involvement in perception

    Neuron, July 9, 2021

    T Bonnen, Daniel Yamins, and AD Wagner

  10. Sexual arousal gates visual processing during Drosophila courtship

    Nature, July 7, 2021

    T Hindmarsh Sten, R Li, A Otopalik, and Vanessa Ruta

  11. Identification of Multiple Noise Sources Improves Estimation of Neural Responses across Stimulus Conditions

    eNeuro, July 6, 2021

    AI Weber, E Shea-Brown, and Fred Rieke

  12. Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades

    Nat Commun, July 6, 2021

    AD Ramirez and Emre Aksay

  13. Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes

    J Alzheimers Dis, July 5, 2021

    I Driscoll, Y Ma, CL Gallagher, S Asthana, BP Hermann, MA Sager, et al.

  14. Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

    J Exp Med, July 5, 2021

    TT Ho, PV Dellorusso, EV Verovskaya, ST Bakker, J Flach, LK Smith, et al.

  15. Genetic signature of human longevity in PKC and NF-κB signaling

    Aging Cell, July 1, 2021

  16. Mice in a labyrinth show rapid learning, sudden insight, and efficient exploration

    Elife, July 1, 2021

    M Rosenberg, T Zhang, Pietro Perona, and Markus Meister

  17. A fast link between face perception and memory in the temporal pole

    Science, July 1, 2021

    SM Landi, P Viswanathan, S Serene, and Winrich Freiwald

  18. MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling

    PLoS Biol, June 28, 2021

    K Lin, G Bieri, G Gontier, S Müller, LK Smith, CE Snethlage, et al.

  19. A neural circuit state change underlying skilled movements

    Cell, June 28, 2021

    MJ Wagner, J Savall, O Hernandez, G Mel, H Inan, O Rumyantsev, et al.

  20. Modularity and robustness of frontal cortical networks

    Cell, June 25, 2021

    G Chen, B Kang, J Lindsey, Shaul Druckmann, and Nuo Li

  21. Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging

    Commun Biol, June 24, 2021

    ML Tomov, A O'Neil, HS Abbasi, BA Cimini, AE Carpenter, Lee Rubin, et al.

  22. Methods for analyzing neuronal structure and activity in Caenorhabditis elegans

    Genetics, June 20, 2021

    SW Emmons, E Yemini, and Manuel Zimmer

  23. Representational geometry of perceptual decisions in the monkey parietal cortex

    Cell, June 18, 2021

    G Okazawa, CE Hatch, A Mancoo, Christian Machens, and Roozbeh Kiani

  24. Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface

    Nat Commun., June 17, 2021

    EM Trautmann, DJ O'Shea, X Sun, JH Marshel, A Crow, B Hsueh, et al.

  25. Geometry of abstract learned knowledge in the hippocampus

    Nature, June 16, 2021

    EH Nieh, M Schottdorf, NW Freeman, RJ Low, S Lewallen, SA Koay, et al.

  26. Visual intracortical and transthalamic pathways carry distinct information to cortical areas

    Neuron, June 16, 2021

    A Blot, MM Roth, I Gasler, M Javadzadeh, F Imhof, and Sonja Hofer

  27. Sensorimotor strategies and neuronal representations for shape discrimination

    Neuron, June 15, 2021

    CC Rodgers, R Nogueira, BC Pil, EM Greeman, JM Park, YK Hong, et al.

  28. Neuronal variability reflects probabilistic inference tuned to natural image statistics

    Nat Commun., June 15, 2021

    D Festa, A Aschner, A Davila, Adam Kohn, and R Coen-Cagli

  29. Nonlinear Decoding of Natural Images From Large-Scale Primate Retinal Ganglion Recordings

    Neural Comput, June 11, 2021

    YJ Kim, N Brackbill, E Batty, J Lee, C Mitelut, W Tong, et al.

  30. Oleic Acid Protects Caenorhabditis Mothers From Mating-Induced Death and the Cost of Reproduction

    Front Cell Dev Biol, June 11, 2021

    LS Choi, C Shi, S Sohrabi, and Coleen T. Murphy

  31. Internal state: dynamic, interconnected communication loops distributed across body, brain, and time

    Integr Comp Biol, June 11, 2021

    JK Kanwal, E Coddington, R Frazer, D Limbania, G Turner, KJ Davila, et al.

  32. Unsupervised changes in core object recognition behavior are predicted by neural plasticity in inferior temporal cortex

    Elife, June 11, 2021

    X Jia, H Hong, and James DiCarlo

  33. Representational drift in primary olfactory cortex

    Nature, June 9, 2021

    CE Schoonover, SN Ohashi, Richard Axel, and AJP Fink

  34. A Suite of Neurophotonic Tools to Underpin the Contribution of Internal Brain States in fMRI

    Curr Opin Biomed Eng, June 8, 2021

    P Mächler, T Broggini, C Mateo, M Thunemann, N Fomin-Thunemann, PR Doran, et al.

  35. Inferring spikes from calcium imaging in dopamine neurons

    PLoS One, June 4, 2021

    W Fleming, S Jewell, B Engelhard, DM Witten, and Ilana Witten

  36. Collicular circuits for flexible sensorimotor routing

    Nat Neurosci, June 3, 2021

    Chunyu Ann Duan, AT Piet, CD Kopec, A Akrami, AJ Riordan, JC Erlich, et al.

  37. Mesoscale cortical dynamics reflect the interaction of sensory evidence and temporal expectation during perceptual decision-making

    Neuron, June 2, 2021

    I Orsolic, M Rio, Thomas Mrsic-Flogel, and P Znamenskiy

  38. Chronic, cortex-wide imaging of specific cell populations during behavior

    Nat Protoc, June 2, 2021

    J Couto, S Musall, XR Sun, A Khanal, S Gluf, S Saxena, et al.

  39. Improving scalability in systems neuroscience

    Neuron, June 2, 2021

    ZS Chen and Bijan Pesaran

  40. A Compendium of Age-Related PheWAS and GWAS Traits for Human Genetic Association Studies, Their Networks and Genetic Correlations

    Front Genet, June 1, 2021

    SS Kim, AD Hudgins, B Gonzalez, S Milman, N Barzilai, J Vijg, et al.

  41. Thalamic control of cortical dynamics in a model of flexible motor sequencing

    Cell Rep, June 1, 2021

    L Logiaco, Larry Abbott, and S Escola

  42. Identification of multiple noise sources improves estimation of neural responses across stimulus conditions

    eNeuro, June 1, 2021

    AI Weber, E Shea-Brown, and Fred Rieke

  43. Place-cell capacity and volatility with grid-like inputs

    Elife, May 24, 2021

    MY Yim, LA Sadun, Ila Fiete, and T Taillefumier

  44. Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease

    Front Endocrinol (Lausanne), May 20, 2021

    JM Gaitán, HY Moon, M Stremlau, Dena Dubal, DB Cook, OC Okonkwo, et al.

  45. Standardized and reproducible measurement of decision-making in mice

    Elife, May 20, 2021

    International Brain Laboratory, V Aguillon-Rodriguez, Dora Angelaki, H Bayer, N Bonacchi, M Carandini, et al.

  46. Accelerating diagnosis of Parkinson's disease through risk prediction

    BMC Neurol, May 18, 2021

    W Yuan, B Beaulieu-Jones, R Krolewski, N Palmer, C Veyrat-Follet, F Frau, et al.

  47. Accelerating diagnosis of Parkinson's disease through risk prediction

    BMC Neurol, May 18, 2021

    W Yuan, B Beaulieu-Jones, R Krolewski, N Palmer, C Veyrat-Follet, F Frau, et al.

  48. High-performance brain-to-text communication via handwriting

    Nature, May 10, 2021

    FR Willett, TD Avansino, LR Hochberg, JM Henderson, and Krishna Shenoy

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