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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Sex and death

    Curr Top Dev Biol, May 5, 2021

    C Shi and Coleen T. Murphy

  2. Rhesus monkeys as a translational model for late-onset Alzheimer's disease

    Aging Cell, May 5, 2021

    DC Souder, IA Dreischmeier, AB Smith, S Wright, SA Martin, MAK Sagar, et al.

  3. Fluid Transport in the Brain

    Physiol Rev., May 5, 2021

    MK Rasmussen, H Mestre, and Maiken Nedergaard

  4. Pinpointing the neural signatures of single-exposure visual recognition memory

    Proc Natl Acad Sci U S A, May 4, 2021

    V Mehrpour, T Meyer, Eero P. Simoncelli, and Nicole Rust

  5. Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP-mediated feedforward loop

    J Cell Biol, May 3, 2021

    Y Lee, Y Jung, DE Jeong, W Hwang, S Ham, HH Park, et al.

  6. Age-related telomere attrition causes aberrant gene expression in sub-telomeric regions

    Aging CellTelomere attrition has been proposed as a biomarker and causal factor in aging. In addition to causing cellular senescence and apoptosis, telomere shortening has been found to affect gene expression in subtelomeric regions. Here, we analyzed the distribution of age-related differentially expressed genes from the GTEx RNA sequencing database of 54 tissue types from 979 human subjects and found significantly more upregulated than downregulated genes in subtelomeric regions as compared to the genome-wide average. Our data demonstrate spatial relationships between telomeres and gene expression in aging., May 2, 2021

    X Dong, S Sun, L Zhang, S Kim, Z Tu, C Montagna, et al.

  7. In Silico: Where Next?

    eNeuro, April 30, 2021

    Adrienne Fairhall

  8. Explaining face representation in the primate brain using different computational models

    Curr Biol., April 29, 2021

    L Chang, B Egger, T Vetter, and Doris Tsao

  9. Coupling of activity, metabolism and behaviour across the Drosophila brain

    Nature, April 28, 2021

    K Mann, S Deny, Surya Ganguli, and Thomas R. Clandinin

  10. Geometric deep learning enables 3D kinematic profiling across species and environments

    Nat Methods., April 19, 2021

    TW Dunn, JD Marshall, KS Severson, DE Aldarondo, DGC Hildebrand, SN Chettih, et al.

  11. Attractor dynamics gate cortical information flow during decision-making

    Nat Neurosci., April 19, 2021

    A Finkelstein, L Fontolan, MN Economo, Nuo Li, S Romani, and Karel Svoboda

  12. The Geometry of Information Coding in Correlated Neural Populations

    Annu Rev Neurosci, April 16, 2021

    RA da Silveira and Fred Rieke

  13. Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings

    Science, April 16, 2021

    NA Steinmetz, C Aydin, A Lebedeva, M Okun, M Pachitariu, M Bauza, et al.

  14. Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization

    Sci Rep, April 14, 2021

    H Monai, S Koketsu, Y Shinohara, T Ueki, P Kusk, NL Hauglund, et al.

  15. Mesoscale cortical dynamics reflect the interaction of sensory evidence and temporal expectation during perceptual decision-making

    Neuron, April 13, 2021

    I Orsolic, M Rio, TD Mrsic-Flogel, and P Znamenskiy

  16. Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation

    Nat Biomed Eng, April 12, 2021

    Y Yang, S Qiao, OG Sani, JI Sedillo, B Ferrentino, Bijan Pesaran, et al.

  17. Spatial memory: Place cell activity is causally related to behavior

    Curr Biol., April 12, 2021

    MH Plitt and Lisa Giocomo

  18. Neural Anatomy and Optical Microscopy (NAOMi) Simulation for evaluating calcium imaging methods

    J Neurosci Methods, April 8, 2021

    A Song, JL Gauthier, Jonathan Pillow, David W. Tank, and AS Charles

  19. A cross-species neural integration of gravity for motor optimization

    Sci Adv., April 7, 2021

    J Gaveau, S Grospretre, B Berret, Dora Angelaki, and C Papaxanthis

  20. High-fidelity estimates of spikes and subthreshold waveforms from 1-photon voltage imaging in vivo

    Cell Rep., April 6, 2021

    ME Xie, Y Adam, LZ Fan, UL Böhm, I Kinsella, D Zhou, et al.

  21. Synaptic plasticity as Bayesian inference

    Nat Neurosci., April 5, 2021

    L Aitchison, J Jegminat, JA Menendez, JP Pfister, Alexandre Pouget, and Peter Latham

  22. Improving scalability in systems neuroscience

    Neuron, April 1, 2021

    ZS Chen and Bijan Pesaran

  23. Flexible scaling and persistence of social vocal communication

    Nature, March 31, 2021

    J Chen, JE Markowitz, V Lilascharoen, S Taylor, P Sheurpukdi, JA Keller, et al.

  24. Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues

    Cell Rep., March 31, 2021

    MB Chen, AC Yang, H Yousef, D Lee, W Chen, N Schaum, et al.

  25. 3DeeCellTracker, a deep learning-based pipeline for segmenting and tracking cells in 3D time lapse images

    Elife, March 30, 2021

    C Wen, T Miura, V Voleti, K Yamaguchi, M Tsutsumi, K Yamamoto, et al.

  26. Learning is shaped by abrupt changes in neural engagement

    Nat Neurosci, March 29, 2021

    JA Hennig, EF Oby, MD Golub, LA Bahureksa, PT Sadtler, KM Quick, et al.

  27. Combining Brain Perturbation and Neuroimaging in Non-human Primates

    Neuroimage, March 29, 2021

    PC Klink, JF Aubry, VP Ferrera, AS Fox, S Froudist-Walsh, B Jarraya, et al.

  28. The connectome predicts resting-state functional connectivity across the Drosophila brain

    Curr Biol, March 23, 2021

    MH Turner, K Mann, and Thomas R. Clandinin

  29. Experience-dependent contextual codes in the hippocampus

    Nat Neurosci, March 22, 2021

    MH Plitt and Lisa Giocomo

  30. Prefrontal cortex represents heuristics that shape choice bias and its integration into future behavior

    Curr Biol, March 22, 2021

    G Mochol, Roozbeh Kiani, and R Moreno-Bote

  31. Nonequilibrium Green's Functions for Functional Connectivity in the Brain

    Phys Rev Lett, March 19, 2021

    Francesco Randi and Andrew Leifer

  32. Synaptic plasticity as Bayesian inference

    Nat Neurosci, March 11, 2021

    L Aitchison, J Jegminat, JA Menendez, JP Pfister, Alexandre Pouget, and Peter Latham

  33. Protocol for transgenerational learned pathogen avoidance behavior assays in Caenorhabditis elegans

    STAR Protoc, March 10, 2021

    RS Moore, R Kaletsky, and Coleen T. Murphy

  34. BARcode DEmixing through Non-negative Spatial Regression (BarDensr)

    PLoS Comput Biol, March 8, 2021

    S Chen, J Loper, X Chen, A Vaughan, Anthony Zador, and Liam Paninski

  35. Functional genomics of inflamm-aging and immunosenescence

    Brief Funct Genomics, March 5, 2021

    Lu RJ, EK Wang, and Bérénice Benayoun

  36. Limited Evidence for Sensory Prediction Error Responses in Visual Cortex of Macaques and Humans

    Cereb Cortex, March 4, 2021

    SS Solomon, H Tang, E Sussman, and Adam Kohn

  37. Transcriptome analysis reveals the difference between "healthy" and "common" aging and their connection with age-related diseases

    Aging Cell, March 3, 2021

    L Zeng, J Yang, S Peng, J Zhu, B Zhang, Yousin Suh, et al.

  38. Human geroprotector discovery by targeting the converging subnetworks of aging and age-related diseases

    Geroscience, February 23, 2021

    J Yang, S Peng, B Zhang, S Houten, E Schadt, J Zhu, et al.

  39. Nonlinear convergence boosts information coding in circuits with parallel outputs

    Proc Natl Acad Sci U S A, February 23, 2021

    GJ Gutierrez, Fred Rieke, and ET Shea-Brown

  40. Independent generation of sequence elements by motor cortex

    Nat Neuro, February 22, 2021

    AJ Zimnik and Mark M. Churchland

  41. Distributed chromatic processing at the interface between retina and brain in the larval zebrafish

    Curr Biol, February 19, 2021

    DA Guggiana Nilo, C Riegler, M Hübener, and Florian Engert

  42. Topography in the Bursting Dynamics of Entorhinal Neurons

    Cell Rep, February 18, 2021

    JS Bant, K Hardcastle, SA Ocko, and Lisa Giocomo

  43. Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years

    Hum Brain Mapp., February 17, 2021

    S Frangou, et al.

  44. Cell-to-cell variation in gene expression and the aging process

    Geroscience, February 17, 2021

    AR Mendenhall, GM Martin, M Kaeberlein, and Rozalyn Anderson

  45. Extracting the dynamics of behavior in sensory decision-making experiments

    Neuron, February 17, 2021

    NA Roy, JH Bak, International Brain Laboratory, A Akrami, Carlos Brody, and Jonathan Pillow

  46. Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial

    Sci Rep., February 15, 2021

    RP Sloan, M Wall, LK Yeung, T Feng, X Feng, F Provenzano, et al.

  47. Investigating the representation of uncertainty in neuronal circuits

    PLoS Comput Biol, February 12, 2021

    GP Dehaene, R Coen-Cagli, and Alexandre Pouget

  48. Implanting and Recycling Neuropixels Probes for Recordings in Freely Moving Mice

    Bio Protoc, February 5, 2021

    AL Juavinett, G Bekheet, and Anne K. Churchland

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