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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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  1. Neurons that Function within an Integrator to Promote a Persistent Behavioral State in Drosophila.

    Neuron, January 22, 2020

    Y Jung, A Kennedy, H Chiu, F Mohammad, A Claridge-Chang, and David J. Anderson

  2. Excitatory-inhibitory responses shape coherent neuronal dynamics driven by optogenetic stimulation in the primate brain.

    J Neurosci., January 21, 2020

    RA Shewcraft, HL Dean, MM Fabiszak, MA Hagan, YT Wong, and Bijan Pesaran

  3. The neural mechanisms of face processing: cells, areas, networks, and models.

    Curr Opin Neurobiol., January 17, 2020

    Winrich Freiwald

  4. Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation.

    Elife., January 17, 2020

    A Mahrach, G Chen, Nuo Li, C van Vreeswijk, and D Hansel

  5. A genetic, genomic, and computational resource for exploring neural circuit function.

    Elife., January 15, 2020

    FP Davis, A Nern, S Picard, MB Reiser, Gerald Rubin, SR Eddy, et al.

  6. A distributional code for value in dopamine-based reinforcement learning

    Nature, January 15, 2020

    Will Dabney, Zeb Kurth-Nelson, Naoshige Uchida, Clara Kwon Starkweather, Demis Hassabis, Rémi Munos, et al.

  7. Entorhinal velocity signals reflect environmental geometry

    Nature Neuroscience, January 13, 2020

    Robert G. K. Munn, Caitlin S. Mallory, Kiah Hardcastle, Dane M. Chetkovich, and Lisa Giocomo

  8. Nearest neighbours reveal fast and slow components of motor learning.

    Nature, January 8, 2020

    S Kollmorgen, RHR Hahnloser, and Valerio Mante

  9. Excitatory and Inhibitory Subnetworks Are Equally Selective during Decision-Making and Emerge Simultaneously during Learning.

    Neuron, January 8, 2020

    F Najafi, GF Elsayed, R Cao, Eftychios Pnevmatikakis, Peter Latham, John Cunningham, et al.

  10. Context-dependent representations of objects and space in the primate hippocampus during virtual navigation.

    Nat Neurosci., January 3, 2020

    RA Gulli, LR Duong, BW Corrigan, G Doucet, S Williams, Stefano Fusi, et al.

  11. The contribution of nonhuman primate research to the understanding of emotion and cognition and its clinical relevance.

    Proc Natl Acad Sci U S A, December 23, 2019

    S Bernardi and C. Daniel Salzman

  12. Inferring synaptic inputs from spikes with a conductance-based neural encoding model.

    Elife., December 18, 2019

    KW Latimer, F Rieke, and Jonathan Pillow

  13. A simple linear readout of MT supports motion direction-discrimination performance.

    J Neurophysiol., December 18, 2019

    JL Yates, LN Katz, AJ Levi, Jonathan Pillow, and A Huk

  14. The integration of visual and target signals in V4 and IT during visual object search

    Journal of Neurophysiology, December 13, 2019

    Noam Roth and Nicole Rust

  15. Probabilistic Models of Larval Zebrafish Behavior Reveal Structure on Many Scales.

    Curr Biol., December 13, 2019

    RE Johnson, Scott Linderman, T Panier, CL Wee, E Song, KJ Herrera, et al.

  16. Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis.

    Elife., December 10, 2019

    SD Stavisky, FR Willett, GH Wilson, BA Murphy, P Rezaii, DT Avansino, et al.

  17. Dynamics of social representation in the mouse prefrontal cortex.

    Nat Neurosci., December 3, 2019

    DR Levy, T Tamir, M Kaufman, A Parabucki, A Weissbrod, Elad Schneidman, et al.

  18. Binocular viewing geometry shapes the neural representation of the dynamic three-dimensional environment.

    Nat Neurosci., December 2, 2019

    K Bonnen, TB Czuba, JA Whritner, Adam Kohn, AC Huk, and LK Cormack

  19. Neural circuits for evidence accumulation and decision making in larval zebrafish.

    Nat Neurosci., December 2, 2019

    A Bahl and Florian Engert

  20. Nested Neuronal Dynamics Orchestrate a Behavioral Hierarchy across Timescales

    Neuron, November 27, 2019

    Harris S. Kaplan, Oriana Salazar Thula, Niklas Khoss, and Manuel Zimmer

  21. Distributed coding of choice, action and engagement across the mouse brain

    Nature, November 27, 2019

    Nick Steinmetz, Peter Zatka-Haas, and Matteo Carandini

  22. Elements of a stochastic 3D prediction engine in larval zebrafish prey capture.

    Elife, November 26, 2019

    AD Bolton, M Haesemeyer, J Jordi, U Schaechtle, FA Saad, VK Mansinghka, et al.

  23. Unsupervised identification of the internal states that shape natural behavior

    Nature Neuroscience, November 25, 2019

    Adam Calhoun, Jonathan Pillow, and Mala Murthy

  24. Generation of stable heading representations in diverse visual scenes.

    Nature, November 20, 2019

    SS Kim, AM Hermundstad, S Romani, Larry Abbott, and V Jayaraman

  25. Probabilistic cell typing enables fine mapping of closely related cell types in situ

    Nature Methods, November 18, 2019

    Xiaoyan Qian, Thomas Hauling, Dimitris Nicoloutsopoulos, Ana B. Muñoz-Manchado, Nathan Skene, Jens Hjerling-Leffler, et al.

  26. Spatiotemporal constraints on optogenetic inactivation in cortical circuits.

    Elife., November 18, 2019

    Nuo Li, S Chen, ZV Guo, H Chen, Y Huo, HK Inagaki, et al.

  27. Learning optimal decisions with confidence.

    Proc Natl Acad Sci U S A., November 15, 2019

    J Drugowitsch, AG Mendonça, Zachary Mainen, and Alexandre Pouget

  28. Discovering Precise Temporal Patterns in Large-Scale Neural Recordings through Robust and Interpretable Time Warping.

    Neuron, November 15, 2019

    AH Williams, B Poole, N Maheswaranathan, AK Dhawale, T Fisher, CD Wilson, et al.

  29. Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics.

    Elife., November 14, 2019

    Yoshinori Aso, RP Ray, X Long, D Bushey, K Cichewicz, TT Ngo, et al.

  30. Continual Learning in a Multi-Layer Network of an Electric Fish

    Cell, November 14, 2019

    Salomon Z. Muller, Abigail N. Zadina, Larry Abbott, and Nathaniel B. Sawtell

  31. Functional diversity among sensory neurons from efficient coding principles.

    PLoS Comput Biol., November 14, 2019

    J Gjorgjieva, Miriam Meister, and Haim Sompolinsky

  32. Increasing gender diversity in the STEM research workforce.

    Science, November 8, 2019

    CW Greider, JM Sheltzer, NC Cantalupo, WB Copeland, N Dasgupta, N Hopkins, et al.

  33. Lateral orbitofrontal cortex promotes trial-by-trial learning of risky, but not spatial, biases

    eLife, November 6, 2019

    Christine M Constantinople, Alex T Piet, Peter Bibawi, Athena Akrami, Charles Kopec, and Carlos Brody

  34. Inception loops discover what excites neurons most using deep predictive models.

    Nat Neurosci., November 4, 2019

    EY Walker, FH Sinz, E Cobos, T Muhammad, E Froudarakis, PG Fahey, et al.

  35. Evidence for an attentional priority map in inferotemporal cortex.

    Proc Natl Acad Sci U S A., November 4, 2019

    H Stemmann and Winrich Freiwald

  36. Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer's Disease Mouse Model.

    Cell Rep., November 1, 2019

    EA Jones, Anna Gillespie, SY Yoon, Loren Frank, and Y Huang

  37. Generalization of Object Localization From Whiskers to Other Body Parts in Freely Moving Rats.

    Front Integr Neurosci., October 31, 2019

    D Deutsch, Elad Schneidman, and E Ahissar

  38. Functional clustering of dendritic activity during decision-making.

    Elife., October 30, 2019

    A Kerlin, M Boaz, D Flickinger, BJ MacLennan, MB Dean, C Davis, et al.

  39. Laminar differences in responses to naturalistic texture in macaque V1 and V2.

    J Neurosci., October 30, 2019

    CM Ziemba, RK Perez, J Pai, JG Kelly, LE Hallum, CJ Shooner, et al.

  40. Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies.

    Elife., October 28, 2019

    JH Cornford, MS Mercier, M Leite, V Magloire, Michael Hausser, and DM Kullmann

  41. Coarse Graining, Fixed Points, and Scaling in a Large Population of Neurons

    Physical Review Letters, October 23, 2019

    Leenoy Meshulam, Jeffrey L. Gauthier, Carlos Brody, David W. Tank, and William Bialek

  42. Experience-dependent structural plasticity at pre- and postsynaptic sites of layer 2/3 cells in developing visual cortex.

    Proc Natl Acad Sci U S A., October 22, 2019

    YJ Sun, JS Espinosa, MS Hoseini, and Michael Stryker

  43. A bidirectional network for appetite control in larval zebrafish.

    Elife., October 18, 2019

    CL Wee, EY Song, RE Johnson, D Ailani, O Randlett, JY Kim, et al.

  44. Editorial overview: Computational neuroscience.

    Curr Opin Neurobiol., October 18, 2019

    Brent Doiron and M Lengyel

  45. High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing.

    Cell, October 17, 2019

    YC Sun, H Zhan, JM Kebschull, S Fischer, K Matho, ZJ Huang, et al.

  46. The integration of visual and target signals in V4 and IT during visual object search.

    J Neurophysiol., October 16, 2019

    N Roth and Nicole Rust

  47. A statistical framework to assess cross-frequency coupling while accounting for confounding analysis effects.

    Elife., October 16, 2019

    JK Nadalin, LE Martinet, EB Blackwood, MC Lo, AS Widge, SS Cash, et al.

  48. BRAIN Initiative: Cutting-Edge Tools and Resources for the Community.

    J Neurosci., October 16, 2019

    E Litvina, A Adams, A Barth, M Bruchez, J Carson, JE Chung, et al.

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