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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Spatial modulation of visual responses arises in cortex with active navigation

    Elife, February 4, 2021

    EM Diamanti, CB Reddy, S Schröder, T Muzzu, AB Saleem, and Matteo Carandini

  2. Systems Neuroscience of Natural Behaviors in Rodents

    J Neurosci, February 3, 2021

    EJ Dennis, A Hady, A Michaiel, A Clemens, DRG Tervo, J Voigts, et al.

  3. DYNAMICS OF HEADING AND CHOICE-RELATED SIGNALS IN THE PARIETO-INSULAR VESTIBULAR CORTEX OF MACAQUE MONKEYS

    J Neurosci, February 2, 2021

    A Chen, F Zeng, GC DeAngelis, and Dora Angelaki

  4. New role for circuit expansion for learning in neural networks

    Phys Rev E, February 1, 2021

    J Steinberg, M Advani, and Haim Sompolinsky

  5. Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation

    Nat Biomed Eng, February 1, 2021

    Y Yang, S Qiao, OG Sani, JI Sedillo, B Ferrentino, Bijan Pesaran, et al.

  6. Cerebral gray and white matter hemodynamic function across the adult lifespan

    Neuroimage, January 29, 2021

    MR Juttukonda, B Li, R Almaktoum, KA Stephens, KM Yochim, Randy Buckner, et al.

  7. Mouse entorhinal cortex encodes a diverse repertoire of self-motion signals

    Nat Commun., January 28, 2021

    CS Mallory, K Hardcastle, MG Campbell, A Attinger, IIC Low, Jennifer Raymond, et al.

  8. Measurement, manipulation and modeling of brain-wide neural population dynamics

    Nat Commun., January 27, 2021

    Krishna Shenoy and JC Kao

  9. Multiscale low-dimensional motor cortical state dynamics predict naturalistic reach-and-grasp behavior

    Nat Commun., January 27, 2021

    H Abbaspourazad, M Choudhury, YT Wong, Bijan Pesaran, and MM Shanechi

  10. Targeted photostimulation uncovers circuit motifs supporting short-term memory

    Nat Neurosci., January 25, 2021

    K Daie, Karel Svoboda, and Shaul Druckmann

  11. The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia

    eNeuro, January 22, 2021

    A Rastogi, FR Willett, J Abreu, DC Crowder, BA Murphy, WD Memberg, et al.

  12. Methods to investigate intrathecal adaptive immunity in neurodegeneration

    Mol Neurodegener, January 22, 2021

    H Oh, O Leventhal, D Channappa, VW Henderson, Tony Wyss-Coray, B Lehallier, et al.

  13. Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

    Mol Psychiatry, January 22, 2021

    X Jia, FA Goes, AE Locke, D Palmer, W Wang, S Cohen-Woods, et al.

  14. Decoding and perturbing decision states in real time

    Nature, January 20, 2021

    D Peixoto, JR Verhein, Roozbeh Kiani, JC Kao, P Nuyujukian, C Chandrasekaran, et al.

  15. Striatal activity topographically reflects cortical activity

    Nature, January 20, 2021

    AJ Peters, JMJ Fabre, Nick Steinmetz, and Matteo Carandini

  16. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

    Nat Commun., January 20, 2021

    JC Reynolds, RW Lai, JST Woodhead, JH Joly, CJ Mitchell, D Cameron-Smith, et al.

  17. Unsupervised neural network models of the ventral visual stream

    Proc Natl Acad Sci U S A., January 19, 2021

    C Zhuang, S Yan, A Nayebi, M Schrimpf, MC Frank, James DiCarlo, et al.

  18. Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

    bioRxiv, January 19, 2021

    RE Mukamel, RE Handsaker, MA Sherman, AR Barton, Y Zheng, Steven McCarroll, et al.

  19. The geometry of neuronal representations during rule learning reveals complementary roles of cingulate cortex and putamen

    Neuron, January 16, 2021

    Y Cohen, Elad Schneidman, and R Paz

  20. Supporting generalization in non-human primate behavior by tapping into structural knowledge: Examples from sensorimotor mappings, inference, and decision-making

    Prog Neurobiol., January 14, 2021

    JP Noel, B Caziot, S Bruni, NE Fitzgerald, E Avila, and Dora Angelaki

  21. Recurrent network dynamics shape direction selectivity in primary auditory cortex

    Nat Commun., January 12, 2021

    DA Aponte, G Handy, AM Kline, H Tsukano, Brent Doiron, and HK Kato

  22. Lapses in perceptual decisions reflect exploration

    Elife, January 11, 2021

    S Pisupati, L Chartarifsky-Lynn, A Khanal, and Anne K. Churchland

  23. Mapping of CSF transport using high spatiotemporal resolution dynamic contrast-enhanced MRI in mice: Effect of anesthesia

    Magn Reson Med., January 11, 2021

    EH Stanton, NDÅ Persson, RS Gomolka, T Lilius, B Sigurðsson, H Lee, et al.

  24. Citric Acid Water as an Alternative to Water Restriction for High-Yield Mouse Behavior

    eNeuro, January 8, 2021

    AE Urai, V Aguillon-Rodriguez, IC Laranjeira, F Cazettes, International Brain Lab, Zachary Mainen, et al.

  25. Social isolation uncovers a circuit underlying context-dependent territory-covering micturition

    Proc Natl Acad Sci U S A, January 5, 2021

    M Hyun, J Taranda, G Radeljic, L Miner, W Wang, N Ochandarena, et al.

  26. Genome-wide surveillance of transcription errors in response to genotoxic stress

    Proc Natl Acad Sci U S A., January 5, 2021

    C Fritsch, JF Gout, S Haroon, A Towheed, C Chung, J LaGosh, et al.

  27. Heterogeneity of Cerebral White Matter Lesions and Clinical Correlates in Older Adults

    Stroke, January 5, 2021

    KH Jung, KA Stephens, KM Yochim, JM Riphagen, CM Kim, Randy Buckner, et al.

  28. Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes

    J Alzheimers Dis., January 3, 2021

    I Driscoll, Y Ma, CL Gallagher, SC Johnson, S Asthana, BP Hermann, et al.

  29. Asynchronous, contagious and digital aging

    Nat Aging, January 1, 2021

    TA Rando and Tony Wyss-Coray

  30. ARDD 2020: from aging mechanisms to interventions

    Aging (Albany NY), December 30, 2020

    GV Mkrtchyan, K Abdelmohsen, P Andreux, I Bagdonaite, N Barzilai, S Brunak, et al.

  31. Multiregional communication and the channel modulation hypothesis

    Curr Opin Neurobiol., December 24, 2020

    Bijan Pesaran, M Hagan, S Qiao, and R Shewcraft

  32. Supplying the sleeping brain

    Elife, https://pubmed.ncbi.nlm.nih.gov/33355090/, December 23, 2020

    SD Williams and Laura Lewis

  33. Supplying the sleeping brain

    Elife., December 23, 2020

    SD Williams and Laura Lewis

  34. NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans

    Cell, December 23, 2020

    E Yemini, A Lin, A Nejatbakhsh, E Varol, R Sun, GE Mena, et al.

  35. A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

    Neuron, December 23, 2020

    AJ Kellar, M Dipoppa, MM Roth, MS Caudill, A Ingrosso, Kenneth Miller, et al.

  36. Direct Measurement of Cerebrospinal Fluid Production in Mice

    Cell Rep., December 22, 2020

    G Liu, H Mestre, AM Sweeney, Q Sun, P Weikop, T Du, et al.

  37. Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice

    Nat Neurosci., December 22, 2020

    M Yilmaz, E Yalcin, J Presumey, E Aw, M Ma, CW Whelan, et al.

  38. A circuit logic for sexually shared and dimorphic aggressive behaviors in Drosophila

    Cell, December 22, 2020

    H Chiu, ED Hoopfer, ML Coughlan, and David J. Anderson

  39. Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation

    Cell Rep., December 22, 2020

    S Tsutsumi, O Chadney, TL Yiu, E Bäumler, L Faraggiana, M Beau, et al.

  40. Neural Encoding and Representation of Time for Sensorimotor Control and Learning

    J Neurosci., December 21, 2020

    R Balasubramaniam, S Haegens, Mehrdad Jazayeri, H Merchant, D Sternad, and JH Song

  41. Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task

    Elife, December 21, 2020

    I Tsutsui-Kimura, H Matsumoto, K Akiti, MM Yamada, Naoshige Uchida, and M Watabe-Uchida

  42. A Network Perspective on Sensorimotor Learning

    Trends Neurosci., December 18, 2020

    H Sohn, N Meirhaeghe, R Rajalingham, and Mehrdad Jazayeri

  43. High-fidelity musculoskeletal modeling reveals a motor planning contribution to the speed-accuracy tradeoff

    Elife., December 16, 2020

    M AI Borno, S Vyas, KV Shenoy, and SL Delp

  44. The sensory representation of causally controlled objects

    Neuron, December 15, 2020

    KB Clancy and Thomas Mrsic-Flogel

  45. A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory

    Cell Rep., December 15, 2020

    JY Choi, HJ Jang, S Ornelas, WT Fleming, D Fürth, J Au, et al.

  46. The connectome of the adult Drosophila mushroom body provides insights into function

    Elife., December 14, 2020

    F Li, JW Lindsey, EC Marin, N Otto, M Dreher, G Dempsey, et al.

  47. Modeling statistical dependencies in multi-region spike train data

    Curr Opin Neurobiol., December 14, 2020

    Sl Keeley, DM Zoltowski, MC Aoi, and Jonathan Pillow

  48. Differential encoding in prefrontal cortex projection neuron classes across cognitive tasks

    Cell., December 11, 2020

    JH Lui, ND Nguyen, SM Grutzner, S Darmanis, D Peixoto, MJ Wagner, et al.

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