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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Sustained Activation of PV+ Interneurons in Core Auditory Cortex Enables Robust Divisive Gain Control for Complex and Naturalistic Stimuli

    Cereb Cortex., December 10, 2020

    T Gothner, PJ Gonçalves, Maneesh Sahani, JF Linden, and KJ Hildebrandt

  2. Unsupervised learning of control signals and their encodings in Caenorhabditis elegans whole-brain recordings

    J R Soc Interface., December 9, 2020

    C Fieseler, Manuel Zimmer, and JN Kutz

  3. Diversity and dynamism in the cerebellum

    Nat Neurosci., December 7, 2020

    CI De Zeeuw, SG Lisberger, and Jennifer Raymond

  4. Larval Zebrafish Use Olfactory Detection of Sodium and Chloride to Avoid Salt Water

    Curr Biol., December 7, 2020

    KJ Herrera, T Panier, D Guggiana-Nilo, and Florian Engert

  5. The macaque face patch system: a turtle's underbelly for the brain

    Nat Rev Neurosci, December 3, 2020

    JK Hesse and Doris Tsao

  6. Measuring and modeling whole-brain neural dynamics in Caenorhabditis elegans

    Curr Opin Neurobiol., December 3, 2020

    F Randi and Andrew Leifer

  7. CoolMPS for robust sequencing of single-nuclear RNAs captured by droplet-based method

    Nucleic Acids Res., December 2, 2020

    O Hahn, T Fehlmann, H Zhang, CN Munson, RT Vest, A Borcherding, et al.

  8. Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice

    Nature., December 2, 2020

    T Karigo, A Kennedy, B Yang, M Liu, D Tai, IA Wahle, et al.

  9. Amplitude modulations of cortical sensory responses in pulsatile evidence accumulation

    Elife., December 2, 2020

    SA Koay, S Thiberge, Carlos Brody, and David W. Tank

  10. The Glymphatic System and Pain

    Med Acupunct., December 1, 2020

    N Goldman, LM Hablitz, Y Mori, and Maiken Nedergaard

  11. Reinforcement regulates timing variability in thalamus

    Elife., December 1, 2020

    J Wang, E Hosseini, N Meirhaeghe, A Akkad, and Mehrdad Jazayeri

  12. Brain connectomes come of age

    Curr Opin Neurobiol., December 1, 2020

    Xiao-Jing Wang, U Pereira, MG Rosa, and H Kennedy

  13. Efficient Inference in Structured Spaces

    Cell, November 25, 2020

    H Sanders, M Wilson, M Klukas, S Sharma, and Ila Fiete

  14. A Unified Framework for Dopamine Signals across Timescales

    Cell, November 25, 2020

    HR Kim, AN Malik, JG Mikhael, P Bech, I Tsutsui-Kimura, F Sun, et al.

  15. Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans

    Sci Transl Med., November 25, 2020

    S Simoes, JL Neufeld, G Triana-Baltzer, S Moughadam, EI Chen, M Kothiya, et al.

  16. Low rank mechanisms underlying flexible visual representations

    Proc Natl Acad Sci U S A., November 24, 2020

    DA Ruff, C Xue, LE Kramer, F Baqai, and Marlene Cohen

  17. Rational thoughts in neural codes

    Proc Natl Acad Sci U S A, November 24, 2020

    Z Wu, M Kwon, S Daptardar, P Schrater, and Xaq Pitkow

  18. Common diseases alter the physiological age-related blood microRNA profile

    Nat Commun., November 24, 2020

    T Fehlmann, B Lehallier, N Schaum, O Hahn, M Kahraman, Y Li, et al.

  19. Real-Time Point Process Filter for Multidimensional Decoding Problems Using Mixture Models

    J Neurosci Methods, November 21, 2020

    MR Rezaei, K Arai, Loren Frank, Uri Eden, and A Yousefi

  20. Poisson balanced spiking networks

    PLoS Comput Biol., November 20, 2020

    CE Rullán Buxó and Jonathan Pillow

  21. Approaches to inferring multi-regional interactions from simultaneous population recordings: Inferring multi-regional interactions from simultaneous population recordings

    Curr Opin Neurobiol., November 20, 2020

    B Kang and Shaul Druckmann

  22. Young adult-born neurons improve odor coding by mitral cells

    Nat Commun., November 17, 2020

    H Shani-Narkiss, A Vinograd, ID Landau, G Tasaka, N Yayon, S Terletsky, et al.

  23. The Geometry of Abstraction in the Hippocampus and Prefrontal Cortex

    Cell, November 12, 2020

    S Bernardi, MK Benna, M Rigotti, J Munuera, Stefano Fusi, and C. Daniel Salzman

  24. Spatial connectivity matches direction selectivity in visual cortex

    Nature, November 11, 2020

    LF Rossi and Matteo Carandini

  25. A new no-report paradigm reveals that face cells encode both consciously perceived and suppressed stimuli

    Elife, November 11, 2020

    JK Hesse and Doris Tsao

  26. Dopamine signals as temporal difference errors: recent advances

    Curr Opin Neurobiol, November 10, 2020

    CK Starkweather and Naoshige Uchida

  27. Modeling behaviorally relevant neural dynamics enabled by preferential subspace identification

    Nat Neurosci., November 9, 2020

    OG Sani, H Abbaspourazad, YT Wong, Bijan Pesaran, and MM Shanechi

  28. Reconstruction of natural images from responses of primate retinal ganglion cells

    Elife, November 4, 2020

    N Brackbill, C Rhoades, A Kling, NP Shah, A Sher, AM Litke, et al.

  29. Cell types and neuronal circuitry underlying female aggression in Drosophila

    Elife, November 3, 2020

    CE Schretter, Yoshinori Aso, AA Robie, M Dreher, MJ Dolan, N Chen, et al.

  30. Anterolateral entorhinal cortex volume is associated with memory retention in clinically unimpaired older adults

    Neurobiol Aging, November 2, 2020

    LK Yeung, C Hale, B Rizvi, K Igwe, RP Sloan, LS Honig, et al.

  31. BAcTrace, a tool for retrograde tracing of neuronal circuits in Drosophila

    Nat Methods., November 2, 2020

    S Cachero, M Gkantia, AS Bates, S Frechter, L Blackie, A McCarthy, et al.

  32. Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model

    Nat Neurosci., November 2, 2020

    ML Donegan, F Stefanini, T Meira, JA Gordon, Stefano Fusi, and SA Siegelbaum

  33. Circadian control of brain glymphatic and lymphatic fluid flow

    Nat Commun., November 2, 2020

    LM Hablitz, V Plá, M Giannetto, HS Vinitsky, FF Stæger, T Metcalfe, et al.

  34. The Effects of Depth Cues and Vestibular Translation Signals on the Rotation Tolerance of Heading Tuning in Macaque Area MSTd

    eNeuro., October 30, 2020

    A Danz, Dora Angelaki, and GC DeAngelis

  35. Targeted Activation of Hippocampal Place Cells Drives Memory-Guided Spatial Behavior

    Cell, October 30, 2020

    NTM Robinson, LAL Descamps, LE Russell, MO Buchholz, BA Bicknell, GK Antonov, et al.

  36. The Anterior Cingulate Cortex Predicts Future States to Mediate Model-Based Action Selection

    Neuron, October 27, 2020

    T Akam, I Rodrigues-Vaz, I Marcelo, X Zhang, M Pereira, RF Oliveira, et al.

  37. How many neurons are sufficient for perception of cortical activity?

    Elife, October 26, 2020

    HWP Dalgleish, LE Russell, AM Packer, A Roth, OM Gauld, F Greenstreet, et al.

  38. An approach for long-term, multi-probe Neuropixels recordings in unrestrained rats

    Elife., October 22, 2020

    TZ Luo, AG Bondy, D Gupta, VA Elliott, CD Kopec, and Carlos Brody

  39. Metformin rescues Parkinson's disease phenotypes caused by hyperactive mitochondria

    Proc Natl Acad Sci USA., October 20, 2020

    DE Mor, S Sohrabi, R Kaletsky, W Keyes, A Tartici, V Kalia, et al.

  40. Brain-wide, scale-wide physiology underlying behavioral flexibility in zebrafish

    Curr Opin Neurobiol., October 19, 2020

    Y Mu, S Narayan, BD Mensh, and Misha Ahrens

  41. Distributional Reinforcement Learning in the Brain

    Trends Neurosci., October 19, 2020

    AS Lowet, Q Zheng, S Matias, J Drugowitsch, and Naoshige Uchida

  42. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis

    JAMA Neurol., October 19, 2020

    BW Kunkle, M Schmidt, HU Klein, AC Naj, KL Hamilton-Nelson, EB Larson, et al.

  43. Social interaction networks in the primate brain

    Curr Opin Neurobiol., October 13, 2020

    Winrich Freiwald

  44. Fast Recurrent Processing via Ventrolateral Prefrontal Cortex Is Needed by the Primate Ventral Stream for Robust Core Visual Object Recognition

    Neuron, October 8, 2020

    K Kar and James DiCarlo

  45. Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging

    Aging Cell., October 8, 2020

    B Lehallier, MN Shokhirev, Tony Wyss-Coray, and AA Johnson

  46. An avian cortical circuit for chunking tutor song syllables into simple vocal-motor units

    Nat Commun., October 6, 2020

    EL Mackevicius, MTL Happ, and Michale Fee

  47. Prefrontal cortex exhibits multidimensional dynamic encoding during decision-making

    Nat Neurosci., October 5, 2020

    MC Aoi, Valerio Mante, and Jonathan Pillow

  48. Statistical methods for dissecting interactions between brain areas

    Curr Opin Neurobiol., October 3, 2020

    JD Semedo, E Gokcen, Christian Machens, Adam Kohn, and Byron Yu

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