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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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  1. Decoding Hidden Cognitive States From Behavior and Physiology Using a Bayesian Approach.

    Neural Comput., July 23, 2019

    A Yousefi, I Basu, AC Paulk, N Peled, EN Eskandar, DD Dougherty, et al.

  2. Cortical layer-specific critical dynamics triggering perception.

    Science, July 18, 2019

    JH Marshel, YS Kim, TA Machado, S Quirin, B Benson, J Kadmon, et al.

  3. Cerebellar disruption impairs working memory during evidence accumulation.

    Nat Commun., July 16, 2019

    B Deverett, M Kislin, David W. Tank, and SS Wang

  4. A genetically encoded fluorescent sensor for in vivo imaging of GABA.

    Nat Methods., July 15, 2019

    JS Marvin, Y Shimoda, V Magloire, M Leite, T Kawashima, TP Jensen, et al.

  5. Bayesian Computation through Cortical Latent Dynamics

    Neuron, July 15, 2019

    Hansem Sohn, Devika Narain, Nicolas Meirhaeghe, and Mehrdad Jazayeri

  6. Light-Sheet Microscopy in Neuroscience.

    Annu Rev Neurosci., July 8, 2019

    Elizabeth Hillman, V Voleti, W Li, and H Yu

  7. Visual-Olfactory Integration in the Human Disease Vector Mosquito Aedes aegypti.

    Curr Biol., July 5, 2019

    C Vinauger, F Van Breugel, LT Locke, KKS Tobin, MH Dickinson, Adrienne Fairhall, et al.

  8. Coding Principles in Adaptation.

    Annu Rev Vis Sci., July 5, 2019

    AI Weber, K Krishnamurthy, and Adrienne Fairhall

  9. A Model-Based Reassessment of the Three-Dimensional Tuning of Head Direction Cells in Rats.

    J Neurophysiol., June 26, 2019

    J Laurens and Dora Angelaki

  10. Predicting perceptual decisions using visual cortical population responses and choice history.

    J Neurosci., June 24, 2019

    AI Jasper, S Tanabe, and Adam Kohn

  11. Learning to use past evidence in a sophisticated world model.

    PLoS Comput Biol., June 24, 2019

    S Ahilan, SB Solomon, YA Breton, K Conover, RK Niyogi, P Shizgal, et al.

  12. Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning

    Cell, June 20, 2019

    A Handler, T Graham, R Cohn, I Morantte, AF Siliciano, J Zeng, et al.

  13. Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior

    Cell, June 20, 2019

    Y Mu, DV Bennett, M Rubinov, S Narayan, CT Yang, M Tanimoto, et al.

  14. Simultaneous motor preparation and execution in alast-moment reach correction task

    Nature Communications, June 20, 2019

    Katherine Cora Ames, S Ryu, and Krishna Shenoy

  15. A microfabricated, 3D-sharpened silicon shuttle for insertion of flexible electrode arrays through dura mater into brain.

    J Neural Eng., June 19, 2019

    HR Joo, JL Fan, S Chen, JA Pebbles, H Liang, JE Chung, et al.

  16. High-performance calcium sensors for imaging activity in neuronal populations and microcompartments.

    Nat Methods., June 17, 2019

    H Dana, Y Sun, B Mohar, BK Hulse, AM Kerlin, JP Hasseman, et al.

  17. Unusual Physiological Properties of Smooth Monostratified Ganglion Cell Types in Primate Retina.

    Neuron, June 10, 2019

    CE Rhoades, NP Shah, MB Manookin, N Brackbill, A Kling, G Goetz, et al.

  18. Circuit mechanisms for the maintenance and manipulation of information in working memory

    Nature Neuroscience, June 10, 2019

    NY Masse, GR Yang, HF Song, Xiao-Jing Wang, and DJ Freedman

  19. New neural activity patterns emerge with long-term learning

    PNAS, June 10, 2019

    ER Oby, MD Golub, JA Hennig, AD Degenhart, EC Tyler-Kabara, Byron Yu, et al.

  20. Striatal circuits for reward learning and decision-making

    Nature Reviews Neuroscience, June 6, 2019

    J Cox and Ilana Witten

  21. Transforming the Choice Outcome to an Action Plan in Monkey Lateral Prefrontal Cortex: A Neural Circuit Model.

    Neuron, June 1, 2019

    MY Yim, X Cai, and Xiao-Jing Wang

  22. Cerebellar Contribution to Preparatory Activity in Motor Neocortex.

    Neuron, May 31, 2019

    FP Chabrol, A Blot, and Thomas Mrsic-Flogel

  23. An Analysis of Decision under Risk in Rats

    Current Biology, May 30, 2019

    Christine M. Constantinople, Alex T. Piet, and Carlos Brody

  24. Q&A: Understanding the composition of behavior.

    BMC Biol., May 29, 2019

    Sandeep Robert Datta

  25. Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons

    Nature, May 29, 2019

    Ben Engelhard, Joel Finkelstein, Julia Cox, Weston Fleming, Hee Jae Jang, Sharon Ornelas, et al.

  26. Heading direction with respect to a reference point modulates place-cell activity

    Nature Comm, May 27, 2019

    P. E. Jercog, Y. Ahmadian, C. Woodruff, R. Deb-Sen, Larry Abbott, and E. R. Kandel

  27. An Analysis of Decision under Risk in Rats.

    Curr Biol., May 24, 2019

    CM Constantinople, AT Piet, and Carlos Brody

  28. Accurate Estimation of Neural Population Dynamics without Spike Sorting.

    Neuron, May 23, 2019

    EM Trautmann, SD Stavisky, S Lahiri, KC Ames, MT Kaufman, DJ O'Shea, et al.

  29. Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body.

    Elife., May 21, 2019

    MJ Dolan, S Frechter, AS Bates, C Dan, P Huoviala, RJ Roberts, et al.

  30. A mathematical theory of semantic development in deep neural networks.

    Proc Natl Acad Sci U S A., May 17, 2019

    AM Saxe, JL McClelland, and Surya Ganguli

  31. Hierarchical reasoning by neural circuits in the frontal cortex.

    Science, May 17, 2019

    M Sarafyazd and Mehrdad Jazayeri

  32. Sparse model-based estimation of functional dependence in high-dimensional field and spike multiscale networks.

    J Neural Eng., May 17, 2019

    R Bighamian, YT Wong, Bijan Pesaran, and MM Shanechi

  33. Discrete Stepping and Nonlinear Ramping Dynamics Underlie Spiking Responses of LIP Neurons during Decision-Making.

    Neuron, May 16, 2019

    DM Zoltowski, KW Latimer, JL Yates, AC Huk, and Jonathan Pillow

  34. Fast and flexible sequence induction in spiking neural networks via rapid excitability changes

    eLife, May 13, 2019

    Rich Pang and Adrienne Fairhall

  35. Neural population control via deep image synthesis.

    Science., May 3, 2019

    OJ Hénaff, RLT Goris, and Eero P. Simoncelli

  36. Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity.

    Elife., May 3, 2019

    HL Payne, RL French, CC Guo, TB Nguyen-Vu, T Manninen, and Jennifer Raymond

  37. Searching for collective behavior in a small brain.

    Phys Rev E., May 1, 2019

    X Chen, F Randi, Andrew Leifer, and William Bialek

  38. Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics.

    Nature., May 1, 2019

    Y Adam, JJ Kim, S Lou, Y Zhao, ME Xie, D Brinks, et al.

  39. The impact of bilateral ongoing activity on evoked responses in mouse cortex.

    Elife., April 30, 2019

    D Shimaoka, NA Steinmetz, and Matteo Carandini

  40. The impact of bilateral ongoing activity on evoked responses in mouse cortex

    eLife, April 30, 2019

    Daisuke Shimaoka, Nicholas A Steinmetz, and Matteo Carandini

  41. Perceptual straightening of natural videos.

    Nat Neurosci., April 29, 2019

    OJ Hénaff, RLT Goris, and Eero P. Simoncelli

  42. Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells.

    Nat Neurosci., April 29, 2019

    D Kostadinov, M Beau, MB Pozo, and Michael Hausser

  43. Evidence that recurrent circuits are critical to the ventral stream’s execution of core object recognition behavior

    Nature Neuroscience, April 29, 2019

    Kohitij Kar, Jonas Kubilius, Kailyn Schmidt, Elias B. Issa, and James DiCarlo

  44. Network cloning using DNA barcodes.

    Proc Natl Acad Sci U S A., April 24, 2019

    SA Shuvaev, B Başerdem, Anthony Zador, and AA Koulakov

  45. Variation in sequence dynamics improves maintenance of stereotyped behavior in an example from bird song.

    Proc Natl Acad Sci U S A., April 23, 2019

    A Duffy, E Abe, DJ Perkel, and Adrienne Fairhall

  46. An Excitatory Circuit in the Perioculomotor Midbrain for Non-REM Sleep Control.

    Cell., April 22, 2019

    Z Zhang, P Zhong, F Hu, Z Barger, Y Ren, X Ding, et al.

  47. Spontaneous behaviors drive multidimensional, brainwide activity.

    Science, April 19, 2019

    C Stringer, M Pachitariu, N Steinmetz, CB Reddy, and Matteo Carandini

  48. Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known.

    Nat Commun., April 17, 2019

    M Wang, C Montanède, C Chandrasekaran, D Peixoto, Krishna Shenoy, and JF Kalaska

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