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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Glymphatic failure as a final common pathway to dementia

    Science., October 2, 2020

    Maiken Nedergaard and SA Goldman

  2. Robust parallel decision-making in neural circuits with nonlinear inhibition

    Proc Natl Acad Sci U S A., October 2, 2020

    B Kriener, R Chaudhuri, and Ila Fiete

  3. An Open Resource for Non-human Primate Optogenetics

    Neuron, October 1, 2020

    S Tremblay, L Acker, A Afraz, DL Albaugh, H Amita, AR Andrei, et al.

  4. Sex difference in Alzheimer's disease: An updated, balanced and emerging perspective on differing vulnerabilities

    Handb Clin Neurol., October 1, 2020

    Dena Dubal

  5. Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice

    Sci Rep., September 30, 2020

    M Giannetto, M Xia, FF Stæger, T Metcalfe, HS Vinitsky, JAML Dang, et al.

  6. Anatomically segregated basal ganglia pathways allow parallel behavioral modulation

    Nat Neurosci., September 28, 2020

    J Lee, W Wang, and Bernardo Sabatini

  7. Anatomically segregated basal ganglia pathways allow parallel behavioral modulation

    Nat. Neuro., September 28, 2020

    J Lee, W Wengang, and Bernardo Sabatini

  8. Artificial Neural Networks for Neuroscientists: A Primer

    Neuron, September 23, 2020

    GR Yang and Xiao-Jing Wang

  9. Cortico-cerebellar interactions during goal-directed behavior

    Curr Opin Neurobiol., September 23, 2020

    Nuo Li and Thomas Mrsic-Flogel

  10. Revealing the structure of pharmacobehavioral space through motion sequencing

    Nat Neurosci., September 21, 2020

    AB Wiltschko, T Tsukahara, A Zeine, R Anyoha, WF Gillis, JE Markowitz, et al.

  11. Assessing Goodness-of-Fit in Marked Point Process Models of Neural Population Coding via Time and Rate Rescaling

    Neural Comput., September 18, 2020

    A Yousefi, Y Amidi, B Nazari, and UT Eden

  12. Learning probabilistic neural representations with randomly connected circuits

    Proc Natl Acad Sci U S A., September 18, 2020

    O Maoz, G Tkačik, MS Esteki, Roozbeh Kiani, and Elad Schneidman

  13. The Mind of a Mouse

    Cell., September 17, 2020

    LF Abbott, DD Bock, EM Callaway, W Denk, C Dulac, Adrienne Fairhall, et al.

  14. Dampening the Power of the Brain-When Aging Meets Cognition

    J Gerontol A Biol Sci Med Sci., September 16, 2020

    JM Shea and Saul Villeda

  15. Stimulus-specific hypothalamic encoding of a persistent defensive state

    Nature., September 16, 2020

    A Kennedy, PS Kunwar, LY Li, S Stagkourakis, DA Wagenaar, and David J. Anderson

  16. A comparison of neuronal population dynamics measured with calcium imaging and electrophysiology

    PLoS Comput Biol., September 15, 2020

    Z Wei, BJ Lin, TW Chen, K Daie, Karel Svoboda, and Shaul Druckmann

  17. Capturing Multiple Timescales of Adaptation to Second-Order Statistics With Generalized Linear Models: Gain Scaling and Fractional Differentiation

    Front Syst Neurosci., September 9, 2020

    KW Latimer and Adrienne Fairhall

  18. Integrative Benchmarking to Advance Neurally Mechanistic Models of Human Intelligence

    Neuron., September 8, 2020

    M Schrimpf, J Kubilius, MJ Lee, NA Ratan Murty, R Ajemian, and James DiCarlo

  19. Computational neuroscience: a frontier of the 21st century

    National Science Review, September 7, 2020

    Xiao-Jing Wang, H Hu, C Huang, H Kennedy, CT Li, N Logothetis, et al.

  20. Systematic errors in connectivity inferred from activity in strongly recurrent networks

    Nature Neuroscience, September 7, 2020

    A Das and Ila Fiete

  21. Old and new models for the study of human ageing

    Nat Rev Mol Cell Biol., September 6, 2020

    Anne Brunet

  22. High-dimensional dynamics of generalization error in neural networks

    Neural Netw., September 5, 2020

    MS Advani, AM Saxe, and Haim Sompolinsky

  23. A connectome and analysis of the adult Drosophila central brain

    Elife., September 3, 2020

    LK Scheffer, CS Xu, M Januszewski, Z Lu, SY Takemura, KJ Hayworth, et al.

  24. Inactivation of the Medial Entorhinal Cortex Selectively Disrupts Learning of Interval Timing

    Cell Reports, September 1, 2020

    J Heys, Z Wu, A Letizia, A Mascaro, and DA Dombeck

  25. The Neuroanatomical Ultrastructure and Function of a Biological Ring Attractor

    Neuron, September 1, 2020

    DB Turner-Evans, KT Jensen, S Ali, T Paterson, A Sheridan, RP Ray, et al.

  26. Low-dimensional dynamics for working memory and time encoding

    Proc Natl Acad Sci U S A., August 28, 2020

    CJ Cueva, A Saez, E Marcos, A Genovesio, Mehrdad Jazayeri, R Romo, et al.

  27. Decision Signals in the Local Field Potentials of Early and Mid-Level Macaque Visual Cortex

    Cereb Cortex., August 27, 2020

    A Krishna, S Tanabe, and Adam Kohn

  28. Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation

    PNAS, August 26, 2020

    Charles W. White III, Xuelai Fan, Jason C. Maynard, Elizabeth G. Wheatley, Gregor Bieri, Julien Couthouis, et al.

  29. A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease

    Science Translational Medicine, August 26, 2020

    Emily J Davis, Lauren Broestl, Samira Abdulai-Saiku, Kurtresha Worden, Luke W Bonham, Elena Miñones-Moyano, et al.

  30. Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans

    Nat Neurosci., August 17, 2020

    D Vormstein-Schneider, JD Lin, KA Pelkey, R Chittajallu, B Guo, MA Arias-Garcia, et al.

  31. Transient and Persistent Representations of Odor Value in Prefrontal Cortex

    Neuron, August 13, 2020

    PY Wang, C Boboila, M Chin, A Higashi-Howard, P Shamash, Z Wu, et al.

  32. Engineering recurrent neural networks from task-relevant manifolds and dynamics

    PLoS Comput Biol., August 12, 2020

    E Pollock and Mehrdad Jazayeri

  33. Slow Drift of Neural Activity as a Signature of Impulsivity in Macaque Visual and Prefrontal Cortex

    Neuron, August 12, 2020

    BR Cowley, AC Synder, K Acar, RC Williamson, Byron Yu, and MA Smith

  34. Structure in Neural Activity during Observed and Executed Movements Is Shared at the Neural Population Level, Not in Single Neurons

    Cell Rep., August 11, 2020

    X Jiang, H Saggar, SI Ryu, Krishna Shenoy, and JC Kao

  35. A neural circuit model for human sensorimotor timing

    Nature Communications, August 7, 2020

    Seth W. Egger, Nhat M. Le, and Mehrdad Jazayeri

  36. Aging and Rejuvenation of Neural Stem Cells and Their Niches

    Cell Stem Cell, August 6, 2020

    PN Negredo, RW Yeo, and Anne Brunet

  37. A data resource from concurrent intracranial stimulation and functional MRI of the human brain

    Sci Data., August 5, 2020

    WH Thompson, R Nair, H Oya, O Esteban, JM Shine, CI Petkov, et al.

  38. Principles of Corticocortical Communication: Proposed Schemes and Design Considerations

    Trends Neurosci., August 5, 2020

    Adam Kohn, AI Jasper, JD Semedo, E Gokcen, Christian Machens, and Byron Yu

  39. The aged hematopoietic system promotes hippocampal-dependent cognitive decline

    Aging Cell., August 4, 2020

    LK Smith, E Verovskaya, G Bieri, AM Horowitz, SNI von Ungern-Sternberg, K Lin, et al.

  40. The inferior temporal cortex is a potential cortical precursor of orthographic processing in untrained monkeys

    Nat Commun., August 4, 2020

    R Rajalingham, K Kar, S Sanghavi, S Dehaene, and James DiCarlo

  41. Mouse Visual Cortex Is Modulated by Distance Traveled and by Theta Oscillations

    Curr Biol., August 4, 2020

    J Fournier, AB Saleem, EM Diamanti, MJ Wells, and Matteo Carandini

  42. Memory Alone Does Not Account for the Way Rats Learn a Simple Spatial Alternation Task

    J Neurosci., August 4, 2020

    DB Kastner, Anna Gillespie, Peter Dayan, and Loren Frank

  43. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age

    Nat Metab., August 3, 2020

    D Brigger, C Riether, R van Brummelen, KI Mosher, A Shiu, Z Ding, et al.

  44. A temporal record of the past with a spectrum of time constants in the monkey entorhinal cortex

    Proc Natl Acad Sci U S A., August 3, 2020

    IM Bright, MLR Meister, NA Cruzado, Z Tiganj, Elizabeth A. Buffalo, and MW Howard

  45. Rapid Bayesian learning in the mammalian olfactory system

    Nat Commun, July 31, 2020

    N Hiratani and Peter Latham

  46. Brain regions vulnerable and resistant to aging without Alzheimer's disease

    PLoS One., July 29, 2020

    X Feng, J Guo, HC Sigmon, RP Sloan, AM Brickman, FA Provenzano, et al.

  47. A low-power band of neuronal spiking activity dominated by local single units improves the performance of brain-machine interfaces

    Nat Biomed Eng., July 27, 2020

    SR Nason, AK Vaskov, MS Willsey, EJ Welle, H An, PP Vu, et al.

  48. The microbiome: an emerging key player in aging and longevity

    Transl Med Aging., July 21, 2020

    M Kim and Bérénice Benayoun

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