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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Value and choice as separable and stable representations in orbitofrontal cortex

    Nat Commun., July 10, 2020

    DL Kimmel, GF Elsayed, John Cunningham, and Bill Newsome

  2. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

    Science, July 10, 2020

    AM Horowitz, X Fan, G Bieri, LK Smith, CI Sanchez-Diaz, AB Schroer, et al.

  3. Functional Architecture of Motion Direction in the Mouse Superior Colliculus.

    Curr Biol., July 9, 2020

    YT Li, Z Turan, and Markus Meister

  4. Finding the Brain in the Nose

    Annual Review of Neuroscience, July 8, 2020

    David H. Brann and Sandeep Robert Datta

  5. Computation Through Neural Population Dynamics

    Annu Rev Neurosci., July 8, 2020

    S Vyas, MD Golub, David Sussillo, and Krishna Shenoy

  6. Movement initiation and grasp representation in premotor and primary motor cortex mirror neurons

    Elife, July 6, 2020

    SJ Jerjian, Maneesh Sahani, and A Kraskov

  7. Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons.

    Proc Natl Acad Sci U S A., July 6, 2020

    B Li, TP Nguyen, C Ma, and Yang Dan

  8. A Causal Network Analysis of Neuromodulation in the Mood Processing Network

    Neuron, July 1, 2020

    S Qiao, JI Sedillo, KA Brown, B Ferrentino, and Bijan Pesaran

  9. Structure and flexibility in cortical representations of odour space

    Nature, July 1, 2020

    SL Pashkovski, G Iurilli, D Brann, D Chicharro, K Drummey, K Franks, et al.

  10. Physiological blood-brain transport is impaired with age by a shift in transcytosis

    Nature, July 1, 2020

    AC Yang, MY Stevens, MB Chen, DP Lee, D Stähli, D Gate, et al.

  11. Complete Connectomic Reconstruction of Olfactory Projection Neurons in the Fly Brain

    Curr Biol., June 29, 2020

    AS Bates, P Schlegel, RJV Roberts, N Drummond, IFM Tamimi, R Turnbull, et al.

  12. BRICseq Bridges Brain-wide Interregional Connectivity to Neural Activity and Gene Expression in Single Animals.

    Cell, June 29, 2020

    L Huang, JM Kebschull, D Fürth, S Musall, MT Kaufman, Anne K. Churchland, et al.

  13. The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection

    Cell, June 28, 2020

    JE Markowitz, WF Gillis, CC Beron, SQ Neufeld, K Robertson, ND Bhagat, et al.

  14. Precision Calcium Imaging of Dense Neural Populations via a Cell-Body-Targeted Calcium Indicator

    Neuron, June 26, 2020

    OA Shemesh, C Linghu, KD Piatkevich, D Goodwin, OT Celiker, HJ Gritton, et al.

  15. Flexible recruitment of memory-based choice representations by the human medial frontal cortex

    Science, June 26, 2020

    J Minxha, Ralph Adolphs, Stefano Fusi, AN Mamelak, and U Rutishauser

  16. Input Connectivity Reveals Additional Heterogeneity of Dopaminergic Reinforcement in Drosophila

    Curr Biol., June 25, 2020

    N Otto, MW Pleijzier, IC Morgan, AJ Edmondson-Stait, KJ Heinz, I Stark, et al.

  17. Anatomy and Function of the Primate Entorhinal Cortex

    Annu Rev Vis Sci ., June 24, 2020

    AD Garcia and Elizabeth A. Buffalo

  18. Combined model-free and model-sensitive reinforcement learning in non-human primates

    PLoS Comput Biol ., June 22, 2020

    B Miranda, WMN Malalasekera, TE Behrens, Peter Dayan, and SW Kennerley

  19. Representation, abstraction, and simple-minded sophisticates

    Behav Brain Sci., June 19, 2020

    Peter Dayan

  20. Flexible coding of object motion in multiple reference frames by parietal cortex neurons

    Nat Neurosci, June 15, 2020

    R Sasaki, A Anzai, Dora Angelaki, and GC DeAngelis

  21. Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times

    Elife, June 10, 2020

    LX Cai, K Pizano, GW Gundersen, CL Hayes, WT Fleming, S Holt, et al.

  22. A Distributed Neural Code in the Dentate Gyrus and in CA1

    Neuron, June 9, 2020

    F Stefanini, L Kushnir, JC Jimenez, JH Jennings, NI Woods, GD Stuber, et al.

  23. Neural Trajectories in the Supplementary Motor Area and Motor Cortex Exhibit Distinct Geometries, Compatible with Different Classes of Computation.

    Neuron, June 8, 2020

    AA Russo, R Khajeh, SR Bittner, SM Perkins, John Cunningham, Larry Abbott, et al.

  24. Rigbox: An Open-Source Toolbox for Probing Neurons and Behavior

    eNeuro, June 3, 2020

    J Bhagat, MJ Wells, Matteo Carandini, and CP Burgess

  25. A map of object space in primate inferotemporal cortex

    Nature, June 3, 2020

    P Bao, L She, M McGill, and Doris Tsao

  26. The impact of learning on perceptual decisions and its implication for speed-accuracy tradeoffs.

    Nat Commun., June 2, 2020

    AG Mendonça, J Drugowitsch, MI Vicente, EEJ DeWitt, Alexandre Pouget, and Zachary Mainen

  27. Noisy Synaptic Conductance: Bug or a Feature?

    Trends Neurosci., June 1, 2020

    DA Rusakov, LP Savtchenko, and Peter Latham

  28. Distinct spatiotemporal mechanisms underlie extra-classical receptive field modulation in macaque V1 microcircuits.

    Elife., May 27, 2020

    Christopher A Henry, Mehrdad Jazayeri, Robert M Shapley, and Michael J Hawken

  29. Hippocampal Network Reorganization Underlies the Formation of a Temporal Association Memory

    Neuron, May 8, 2020

    Mohsin S. Ahmed, James B. Priestley, Angel Castro, Luca Mazzucato, Stefano Fusi, and Attila Losonczy

  30. Time-resolved Correspondences Between Deep Neural Network Layers and EEG Measurements in Object Processing

    Vision Res., May 7, 2020

    Nathan C L Kong, Blair Kaneshiro, Daniel Yamins, and Anthony M Norcia

  31. Understanding Image Memorability.

    Trends Cogn Sci., May 5, 2020

    Nicole Rust and Vahid Mehrpour

  32. Efficient and flexible representation of higher-dimensional cognitive variables with grid cells.

    PLoS Comput Biol., April 28, 2020

    M Klukas, M Lewis, and Ila Fiete

  33. Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma

    Nat Cancer, April 27, 2020

    O Zavidij, NJ Haradhvala, TH Mouhieddine, R Sklavenitis-Pistofidis, S Cai, M Reidy, et al.

  34. Stabilization of a brain-computer interface via the alignment of low-dimensional spaces of neural activity.

    Nat Biomed Eng., April 20, 2020

    AD Degenhart, WE Bishop, ER Oby, EC Tyler-Kabara, SM Chase, AP Batista, et al.

  35. A Gravity-Based Three-Dimensional Compass in the Mouse Brain.

    Nat Commun., April 15, 2020

    Dora Angelaki, J Ng, AM Abrego, HX Cham, EK Asprodini, JD Dickman, et al.

  36. The sifting of visual information in the superior colliculus.

    Elife., April 14, 2020

    KH Lee, A Tran, Z Turan, and Markus Meister

  37. Arousal Modulates Retinal Output

    Neuron., April 13, 2020

    Sylvia Schröder, Nick Steinmetz, Michael Krumin, Marius Pachitariu, Matteo Rizzi, Leon Lagnado, et al.

  38. Localized semi-nonnegative matrix factorization (LocaNMF) of widefield calcium imaging data.

    PLoS Comput Biol., April 13, 2020

    S Saxena, I Kinsella, S Musall, SH Kim, J Meszaros, DN Thibodeaux, et al.

  39. Widespread receptor-driven modulation in peripheral olfactory coding.

    Science., April 10, 2020

    L Xu, W Li, V Voleti, DJ Zou, Elizabeth Hillman, and S Firestein

  40. Development of a neural interface for high-definition, long-term recording in rodents and nonhuman primates.

    Sci Transl Med., April 8, 2020

    CH Chiang, SM Won, AL Orsborn, KJ Yu, M Trumpis, B Bent, et al.

  41. Fundamental bounds on the fidelity of sensory cortical coding.

    Nature, April 7, 2020

    OI Rumyantsev, JA Lecoq, O Hernandez, Y Zhang, J Savall, R Chrapkiewicz, et al.

  42. Spatial contextual effects in primary visual cortex limit feature representation under crowding.

    Nat Commun., April 3, 2020

    CA Henry and Adam Kohn

  43. Rapid mesoscale volumetric imaging of neural activity with synaptic resolution.

    Nat Methods, March 22, 2020

    R Lu, Y Liang, G Meng, P Zhou, Karel Svoboda, Liam Paninski, et al.

  44. Massively parallel microwire arrays integrated with CMOS chips for neural recording.

    Sci Adv., March 20, 2020

    A Obaid, ME Hanna, YW Wu, M Kollo, R Racz, MR Angle, et al.

  45. Brain-wide representations of ongoing behavior: a universal principle?

    Curr Opin Neurobiol., March 19, 2020

    HS Kaplan and Manuel Zimmer

  46. Learning to represent signals spike by spike.

    PLoS Comput Biol, March 16, 2020

    W Brendel, R Bourdoukan, P Vertechi, Christian Machens, and Sophie Denève

  47. Cerebrospinal fluid influx drives acute ischemic tissue swelling

    Science, March 13, 2020

    H Mestre, T Du, AM Sweeney, G Liu, AJ Samson, W Peng, et al.

  48. Hand Knob Area of Premotor Cortex Represents the Whole Body in a Compositional Way.

    Cell, March 13, 2020

    FR Willett, DR Deo, DT Avansino, P Rezaii, LR Hochberg, JM Henderson, et al.

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