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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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  1. Whole-Neuron Synaptic Mapping Reveals Spatially Precise Excitatory/Inhibitory Balance Limiting Dendritic and Somatic Spiking.

    Neuron, March 12, 2020

    DM Iascone, Y Li, U Sümbül, M Doron, H Chen, V Andreu, et al.

  2. Inference of nonlinear receptive field subunits with spike-triggered clustering.

    Elife., March 9, 2020

    NP Shah, N Brackbill, C Rhoades, A Kling, G Goetz, AM Goetz, et al.

  3. Visual cue-related activity of cells in the medial entorhinal cortex during navigation in virtual reality.

    Elife, March 9, 2020

    AA Kinkhabwala, Y Gu, D Aronov, and David W. Tank

  4. Tracking the Mind's Eye: Primate Gaze Behavior during Virtual Visuomotor Navigation Reflects Belief Dynamics.

    Neuron, March 6, 2020

    KJ Lakshminarasimhan, E Avila, E Neyhart, GC DeAngelis, Xaq Pitkow, and Dora Angelaki

  5. Efficient inverse graphics in biological face processing.

    Sci Adv., March 4, 2020

    I Yildirim, M Belledonne, Winrich Freiwald, and J Tenenbaum

  6. Recurrent interactions in local cortical circuits.

    Nature, March 4, 2020

    S Peron, R Pancholi, B Voelcker, JD Wittenbach, HF Ólafsdóttir, Jeremy Freeman, et al.

  7. Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo.

    Cell Rep., March 3, 2020

    C Arlt and Michael Hausser

  8. Multiple head direction signals within entorhinal cortex: origin and function

    Current Opinion in Neurobiology, February 29, 2020

    Robert GK Munn and Lisa Giocomo

  9. Transcriptome analysis reveals the difference between "healthy" and "common" aging and their connection with age-related diseases

    Aging Cell, February 19, 2020

    L Zeng, J Yang, S Peng, J Zhu, B Zhang, Yousin Suh, et al.

  10. Dorsal and Ventral Hippocampal Sharp-Wave Ripples Activate Distinct Nucleus Accumbens Networks.

    Neuron, February 19, 2020

    M Sosa, HR Joo, and Loren Frank

  11. Topography in the Bursting Dynamics of Entorhinal Neurons.

    Cell Rep., February 18, 2020

    JS Bant, K Hardcastle, SA Ocko, and Lisa Giocomo

  12. Inference-Based Decisions in a Hidden State Foraging Task: Differential Contributions of Prefrontal Cortical Areas

    Neuron, February 11, 2020

    Pietro Vertechi, Eran Lottem, Dario Sarra, Beatriz Godinho, Isaac Treves, Tiago Quendera, et al.

  13. Context-Dependent Decision Making in a Premotor Circuit.

    Neuron, February 8, 2020

    Z Wu, A Litwin-Kumar, P Shamash, A Taylor, Richard Axel, and MN Shadlen

  14. Macroscopic gradients of synaptic excitation and inhibition in the neocortex.

    Nat Rev Neurosci., February 6, 2020

    Xiao-Jing Wang

  15. Causal Role of Motor Preparation during Error-Driven Learning.

    Neuron, February 6, 2020

    S Vyas, DJ O'Shea, SI Ryu, and Krishna Shenoy

  16. Separability and geometry of object manifolds in deep neural networks.

    Nat Commun., February 6, 2020

    U Cohen, S Chung, DD Lee, and Haim Sompolinsky

  17. Speech-related dorsal motor cortex activity does not interfere with iBCI cursor control.

    J Neural Eng., February 5, 2020

    SD Stavisky, FR Willett, DT Avansino, LR Hochberg, Krishna Shenoy, and JM Henderson

  18. Space, Time, and Fear: Survival Computations along Defensive Circuits.

    Trends Cogn Sci., February 3, 2020

    D Mobbs, DB Headley, W Ding, and Peter Dayan

  19. Hippocampal Pathology in Clinical High-Risk Patients and the Onset of Schizophrenia

    Biol Psychiatry, February 1, 2020

    FA Provenzano, J Guo, MM Wall, X Feng, HC Sigmon, G Brucato, et al.

  20. Neural Correlates of Learning Pure Tones or Natural Sounds in the Auditory Cortex.

    Front Neural Circuits., January 28, 2020

    I Maor, R Shwartz-Ziv, L Feigin, Y Elyada, Haim Sompolinsky, and A Mizrahi

  21. Constant Sub-second Cycling between Representations of Possible Futures in the Hippocampus.

    Cell, January 28, 2020

    K Kay, JE Chung, M Sosa, JS Schor, MP Karlsson, MC Larkin, et al.

  22. Cerebellar Neurodynamics Predict Decision Timing and Outcome on the Single-Trial Level.

    Cell, 2020

    Q Lin, J Manley, M Helmreich, F Schlumm, JM Li, DN Robson, et al.

  23. Simple spike dynamics of Purkinje cells in the macaque vestibulo-cerebellum during passive whole-body self-motion.

    Proc Natl Acad Sci U S A., January 27, 2020

    J Laurens and Dora Angelaki

  24. Toward nanoscale localization of memory engrams in Drosophila.

    J Neurogenet., January 27, 2020

    Y Aso and Gerald Rubin

  25. A common hub for sleep and motor control in the substantia nigra.

    Science, January 24, 2020

    D Liu, W Li, C Ma, W Zheng, Y Yao, CF Tso, et al.

  26. Communication, Cross Talk, and Signal Integration in the Adult Hippocampal Neurogenic Niche

    Neuron, January 22, 2020

    C Vicidomini, N Guo, and Amar Sahay

  27. International Brain Initiative: An Innovative Framework for Coordinated Global Brain Research Efforts.

    Neuron, January 22, 2020

    International Brain Initiative

  28. Neurons that Function within an Integrator to Promote a Persistent Behavioral State in Drosophila.

    Neuron, January 22, 2020

    Y Jung, A Kennedy, H Chiu, F Mohammad, A Claridge-Chang, and David J. Anderson

  29. Excitatory-inhibitory responses shape coherent neuronal dynamics driven by optogenetic stimulation in the primate brain.

    J Neurosci., January 21, 2020

    RA Shewcraft, HL Dean, MM Fabiszak, MA Hagan, YT Wong, and Bijan Pesaran

  30. The neural mechanisms of face processing: cells, areas, networks, and models.

    Curr Opin Neurobiol., January 17, 2020

    Winrich Freiwald

  31. Mechanisms underlying the response of mouse cortical networks to optogenetic manipulation.

    Elife., January 17, 2020

    A Mahrach, G Chen, Nuo Li, C van Vreeswijk, and D Hansel

  32. A genetic, genomic, and computational resource for exploring neural circuit function.

    Elife., January 15, 2020

    FP Davis, A Nern, S Picard, MB Reiser, Gerald Rubin, SR Eddy, et al.

  33. A distributional code for value in dopamine-based reinforcement learning

    Nature, January 15, 2020

    Will Dabney, Zeb Kurth-Nelson, Naoshige Uchida, Clara Kwon Starkweather, Demis Hassabis, Rémi Munos, et al.

  34. Entorhinal velocity signals reflect environmental geometry

    Nature Neuroscience, January 13, 2020

    Robert G. K. Munn, Caitlin S. Mallory, Kiah Hardcastle, Dane M. Chetkovich, and Lisa Giocomo

  35. Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

    Nat Rev Neurosci., January 8, 2020

    JV Pluvinage and Tony Wyss-Coray

  36. Nearest neighbours reveal fast and slow components of motor learning.

    Nature, January 8, 2020

    S Kollmorgen, RHR Hahnloser, and Valerio Mante

  37. Excitatory and Inhibitory Subnetworks Are Equally Selective during Decision-Making and Emerge Simultaneously during Learning.

    Neuron, January 8, 2020

    F Najafi, GF Elsayed, R Cao, Eftychios Pnevmatikakis, Peter Latham, John Cunningham, et al.

  38. Context-dependent representations of objects and space in the primate hippocampus during virtual navigation.

    Nat Neurosci., January 3, 2020

    RA Gulli, LR Duong, BW Corrigan, G Doucet, S Williams, Stefano Fusi, et al.

  39. The contribution of nonhuman primate research to the understanding of emotion and cognition and its clinical relevance.

    Proc Natl Acad Sci U S A, December 23, 2019

    S Bernardi and C. Daniel Salzman

  40. Inferring synaptic inputs from spikes with a conductance-based neural encoding model.

    Elife., December 18, 2019

    KW Latimer, F Rieke, and Jonathan Pillow

  41. A simple linear readout of MT supports motion direction-discrimination performance.

    J Neurophysiol., December 18, 2019

    JL Yates, LN Katz, AJ Levi, Jonathan Pillow, and A Huk

  42. The integration of visual and target signals in V4 and IT during visual object search

    Journal of Neurophysiology, December 13, 2019

    Noam Roth and Nicole Rust

  43. Probabilistic Models of Larval Zebrafish Behavior Reveal Structure on Many Scales.

    Curr Biol., December 13, 2019

    RE Johnson, Scott Linderman, T Panier, CL Wee, E Song, KJ Herrera, et al.

  44. Neural ensemble dynamics in dorsal motor cortex during speech in people with paralysis.

    Elife., December 10, 2019

    SD Stavisky, FR Willett, GH Wilson, BA Murphy, P Rezaii, DT Avansino, et al.

  45. Dynamics of social representation in the mouse prefrontal cortex.

    Nat Neurosci., December 3, 2019

    DR Levy, T Tamir, M Kaufman, A Parabucki, A Weissbrod, Elad Schneidman, et al.

  46. Binocular viewing geometry shapes the neural representation of the dynamic three-dimensional environment.

    Nat Neurosci., December 2, 2019

    K Bonnen, TB Czuba, JA Whritner, Adam Kohn, AC Huk, and LK Cormack

  47. Neural circuits for evidence accumulation and decision making in larval zebrafish.

    Nat Neurosci., December 2, 2019

    A Bahl and Florian Engert

  48. Nested Neuronal Dynamics Orchestrate a Behavioral Hierarchy across Timescales

    Neuron, November 27, 2019

    Harris S. Kaplan, Oriana Salazar Thula, Niklas Khoss, and Manuel Zimmer

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