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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Altered functional interactions between neurons in primary visual cortex of macaque monkeys with experimental amblyopia.

    J Neurophysiol., September 25, 2019

    K Acar, L Kiorpes, J. Anthony Movshon, and MA Smith

  2. Engineering a Less Artificial Intelligence.

    Neuron., September 25, 2019

    FH Sinz, Xaq Pitkow, J Reimer, M Bethge, and AS Tolias

  3. Single-cell transcriptomic profiling of the aging mouse brain

    Nat Neurosci., September 24, 2019

    M Ximerakis, SL Lipnick, BT Innes, SK Simmons, X Adiconis, D Dionne, et al.

  4. Abstract goal representation in visual search by neurons in the human pre-supplementary motor area.

    Brain., September 24, 2019

    S Wang, AN Mamelak, Ralph Adolphs, and U Rutishauser

  5. Neural Correlates of Optimal Multisensory Decision Making under Time-Varying Reliabilities with an Invariant Linear Probabilistic Population Code.

    Neuron, September 23, 2019

    H Hou, Q Zheng, Y Zhao, Alexandre Pouget, and Y Gu

  6. Reconstruction of 1,000 Projection Neurons Reveals New Cell Types and Organization of Long-Range Connectivity in the Mouse Brain.

    Cell, September 19, 2019

    J Winnubst, E Bas, TA Ferreira, Z Wu, MN Economo, P Edson, et al.

  7. Responses of neurons in macaque MT to unikinetic plaids.

    J Neurophysiol., September 11, 2019

    P Wallisch and J. Anthony Movshon

  8. Control of Non-REM Sleep by Midbrain Neurotensinergic Neurons.

    Neuron., September 6, 2019

    P Zhong, P Zhang, Z Barger, C Ma, D Liu, X Ding, et al.

  9. A canonical computational model of cortical area V2

    Journal of Vision, September 3, 2019

    Timothy D Oleskiw and Eero P. Simoncelli

  10. Simultaneous multi-area recordings suggest that attention improves performance by reshaping stimulus representations

    Nature Neuroscience, September 2, 2019

    Douglas A. Ruff and Marlene Cohen

  11. Population response magnitude variation in inferotemporal cortex predicts image memorability

    eLife, August 29, 2019

    Andrew Jaegle, Vahid Mehrpour, Yalda Mohsenzadeh, Travis Meyer, Aude Oliva, and Nicole Rust

  12. The striatum specifies the statistics of behavior.

    Neuropsychopharmacology, August 29, 2019

    JE Markowitz and Sandeep Robert Datta

  13. Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior

    Neuron, August 26, 2019

    Jianing Yu, Hang Hu, Ariel Agmon, and Karel Svoboda

  14. A point-process matched filter for event detection and decoding from population spike trains.

    J Neural Eng., August 22, 2019

    N Sadras, Bijan Pesaran, and MM Shanechi

  15. A critique of pure learning and what artificial neural networks can learn from animal brains

    Nature Communications, August 21, 2019

    Anthony Zador

  16. A Data-Compressive Wired-OR Readout for Massively Parallel Neural Recording.

    IEEE Trans Biomed Circuits Syst., August 15, 2019

    D Muratore, P Tandon, M Wootters, E. J. Chichilnisky, S Mitra, and B Murmann

  17. Backtracking during navigation is correlated with enhanced anterior cingulate activity and suppression of alpha oscillations and the 'default-mode' network.

    Proc Biol Sci., August 14, 2019

    AH Javadi, EZ Patai, E Marin-Garcia, A Margois, HM Tan, D Kumaran, et al.

  18. Chronically-implanted Neuropixels probes enable high yield recordings in freely moving mice.

    Elife., August 14, 2019

    AL Juavinett, G Bekheet, and Anne K. Churchland

  19. Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior.

    Neuron, August 13, 2019

    J Yu, H Hu, A Agmon, and Karel Svoboda

  20. The intrinsic attractor manifold and population dynamics of a canonical cognitive circuit across waking and sleep

    Nature Neuroscience, August 12, 2019

    Rishidev Chaudhuri, Berk Gerçek, Biraj Pandey, Adrien Peyrache, and Ila Fiete

  21. Training dynamically balanced excitatory-inhibitory networks.

    PLoS One., August 8, 2019

    A Ingrosso and Larry Abbott

  22. Transplanted cells are essential for the induction but not the expression of cortical plasticity.

    J Neurosci., August 7, 2019

    MS Hoseini, B Rakela, Q Flores-Ramirez, AR Hasenstaub, A Alvarez-Buylla, and Michael Stryker

  23. Optimal policy for multi-alternative decisions.

    Nat Neurosci., August 5, 2019

    S Tajima, J Drugowitsch, N Patel, and Alexandre Pouget

  24. Kilohertz frame-rate two-photon tomography.

    Nat Methods., August 1, 2019

    A Kazemipour, O Novak, D Flickinger, JS Marvin, AS Abdelfattah, J King, et al.

  25. Viewpoints: Approaches to defining and investigating fear.

    Nat Neurosci., August 1, 2019

    D Mobbs, Ralph Adolphs, MS Fanselow, LF Barrett, JE LeDoux, K Ressler, et al.

  26. Monitoring Behaviorally Induced Biochemical Changes Using Fluorescence Lifetime Photometry

    Frontiers in Neuroscience, July 31, 2019

    Suk Joon Lee, Yao Chen, Bart Lodder, and Bernardo Sabatini

  27. Convergent Temperature Representations in Artificial and Biological Neural Networks

    Neuron, July 31, 2019

    Martin Haesemeyer, Alexander F. Schier, and Florian Engert

  28. Error-correcting dynamics in visual working memory

    Nature Communications, July 29, 2019

    Matthew F. Panichello, Brian DePasquale, Jonathan Pillow, and Timothy J. Buschman

  29. Zebrafish oxytocin neurons drive nocifensive behavior via brainstem premotor targets

    Nature Neuroscience, July 29, 2019

    Caroline L. Wee, Maxim Nikitchenko, Wei-Chun Wang, Sasha J. Luks-Morgan, Erin Song, James A. Gagnon, et al.

  30. Correlation transfer by layer 5 cortical neurons under recreated synaptic inputs in vitro.

    J Neurosci., July 25, 2019

    D Linaro, GK Ocker, Brent Doiron, and M Giugliano

  31. Decoding Hidden Cognitive States From Behavior and Physiology Using a Bayesian Approach.

    Neural Comput., July 23, 2019

    A Yousefi, I Basu, AC Paulk, N Peled, EN Eskandar, DD Dougherty, et al.

  32. Cortical layer-specific critical dynamics triggering perception.

    Science, July 18, 2019

    JH Marshel, YS Kim, TA Machado, S Quirin, B Benson, J Kadmon, et al.

  33. Cerebellar disruption impairs working memory during evidence accumulation.

    Nat Commun., July 16, 2019

    B Deverett, M Kislin, David W. Tank, and SS Wang

  34. A genetically encoded fluorescent sensor for in vivo imaging of GABA.

    Nat Methods., July 15, 2019

    JS Marvin, Y Shimoda, V Magloire, M Leite, T Kawashima, TP Jensen, et al.

  35. Bayesian Computation through Cortical Latent Dynamics

    Neuron, July 15, 2019

    Hansem Sohn, Devika Narain, Nicolas Meirhaeghe, and Mehrdad Jazayeri

  36. Light-Sheet Microscopy in Neuroscience.

    Annu Rev Neurosci., July 8, 2019

    Elizabeth Hillman, V Voleti, W Li, and H Yu

  37. Visual-Olfactory Integration in the Human Disease Vector Mosquito Aedes aegypti.

    Curr Biol., July 5, 2019

    C Vinauger, F Van Breugel, LT Locke, KKS Tobin, MH Dickinson, Adrienne Fairhall, et al.

  38. Coding Principles in Adaptation.

    Annu Rev Vis Sci., July 5, 2019

    AI Weber, K Krishnamurthy, and Adrienne Fairhall

  39. Single-cell analysis reveals T cell infiltration in old neurogenic niches

    Nature, July 3, 2019

    BW Dulken, MT Buckley, P Navarro Negredo, N Saligrama, R Cayrol, DS Leeman, et al.

  40. A Model-Based Reassessment of the Three-Dimensional Tuning of Head Direction Cells in Rats.

    J Neurophysiol., June 26, 2019

    J Laurens and Dora Angelaki

  41. Predicting perceptual decisions using visual cortical population responses and choice history.

    J Neurosci., June 24, 2019

    AI Jasper, S Tanabe, and Adam Kohn

  42. Learning to use past evidence in a sophisticated world model.

    PLoS Comput Biol., June 24, 2019

    S Ahilan, SB Solomon, YA Breton, K Conover, RK Niyogi, P Shizgal, et al.

  43. Distinct Dopamine Receptor Pathways Underlie the Temporal Sensitivity of Associative Learning

    Cell, June 20, 2019

    A Handler, T Graham, R Cohn, I Morantte, AF Siliciano, J Zeng, et al.

  44. Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior

    Cell, June 20, 2019

    Y Mu, DV Bennett, M Rubinov, S Narayan, CT Yang, M Tanimoto, et al.

  45. Simultaneous motor preparation and execution in alast-moment reach correction task

    Nature Communications, June 20, 2019

    Katherine Cora Ames, S Ryu, and Krishna Shenoy

  46. A microfabricated, 3D-sharpened silicon shuttle for insertion of flexible electrode arrays through dura mater into brain.

    J Neural Eng., June 19, 2019

    HR Joo, JL Fan, S Chen, JA Pebbles, H Liang, JE Chung, et al.

  47. High-performance calcium sensors for imaging activity in neuronal populations and microcompartments.

    Nat Methods., June 17, 2019

    H Dana, Y Sun, B Mohar, BK Hulse, AM Kerlin, JP Hasseman, et al.

  48. Unusual Physiological Properties of Smooth Monostratified Ganglion Cell Types in Primate Retina.

    Neuron, June 10, 2019

    CE Rhoades, NP Shah, MB Manookin, N Brackbill, A Kling, G Goetz, et al.

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