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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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  1. Motor Cortex Embeds Muscle-like Commands in an Untangled Population Response

    Neuron, February 1, 2018

    Abigail A. Russo, Sean R. Bittner, Sean M. Perkins, Jeffrey S.Seely, Brian M. London, Antonio H. Lara, et al.

  2. Challenges and opportunities for large-scale electrophysiology with Neuropixels probes.

    Curr Opin Neurobiol, February 1, 2018

    NA Steinmetz, C Koch, and Matteo Carandini

  3. Neurons in primate entorhinal cortex represent gaze position in multiple spatial reference frames.

    J Neurosci, January 31, 2018

    MLR Meister and Elizabeth A. Buffalo

  4. Dethroning the Fano Factor: A Flexible, Model-Based Approach to Partitioning Neural Variability.

    Neural Comput, January 30, 2018

    AS Charles, M Park, JP Weller, GD Horwitz, and Jonathan Pillow

  5. A disinhibitory circuit motif and flexible information routing in the brain.

    Curr Opin Neurobiol, January 26, 2018

    Xiao-Jing Wang and GR Yang

  6. Learning and attention reveal a general relationship between population activity and behavior.

    Science, January 26, 2018

    Amy Ni, DA Ruff, JJ Alberts, J Symmonds, and Marlene Cohen

  7. The Brain Compass: A Perspective on How Self-Motion Updates the Head Direction Cell Attractor

    Neuron, January 17, 2018

    Jean Laurens and Dora Angelaki

  8. Interrupting behaviour: Minimizing decision costs via temporal commitment and low-level interrupts.

    PLoS Comput Biol., January 16, 2018

    K Lloyd and Peter Dayan

  9. Grid scale drives the scale and long-term stability of place maps.

    Nature Neuroscience, January 15, 2018

    Caitlin S. Mallory, Kiah Hardcastle, Jason S. Bant, and Lisa Giocomo

  10. Reward-based training of recurrent neural networks for cognitive and value-based tasks.

    Elife, January 13, 2018

    HF Song, GR Wang, and Xiao-Jing Wang

  11. Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice.

    Elife, January 5, 2018

    W Menegas, BM Babayan, Naoshige Uchida, and M Watabe-Uchida

  12. Mice use robust and common strategies to discriminate natural scenes.

    Sci Rep, January 2, 2018

    Y Yu, R Hira, JN Stirman, W Yu, IT Smith, and Spencer Smith

  13. Differential Contribution of Low- and High-level Image Content to Eye Movements in Monkeys and Humans.

    Cereb Cortex., January 1, 2018

    N Wilming, TC Kietzmann, M Jutras, C Xue, S Treue, Elizabeth A. Buffalo, et al.

  14. Why Do Similarity Matching Objectives Lead to Hebbian / Anti-Hebbian Networks?

    Neural Computation, January 1, 2018

    Cengiz Pehlevan, Anirvan M Sengupta, and Dmitri "Mitya" Chklovskii

  15. ERAASR: An algorithm for removing electrical stimulation artifacts from multielectrode array recordings.

    J Neural Eng., December 21, 2017

    DJ O'Shea and Krishna Shenoy

  16. An International Laboratory for Systems and Computational Neuroscience.

    Neuron, December 20, 2017

    International Brain Laboratory

  17. Building a state space for song learning.

    Curr Opin Neurobiol, December 18, 2017

    EL Mackevicius and Michale Fee

  18. Working Memory and Decision-Making in a Frontoparietal Circuit Model.

    J Neurosci, December 13, 2017

    JD Murray, J Jaramillo, and Xiao-Jing Wang

  19. The representation of colored objects in macaque color patches.

    Nat Commun, December 12, 2017

    L Chang, P Bao, and Doris Tsao

  20. A unifying motif for spatial and directional surround suppression.

    J Neurosci, December 11, 2017

    LD Liu, Kenneth Miller, and CC Pack

  21. Combined Social and Spatial Coding in a Descending Projection from the Prefrontal Cortex.

    Cell, December 7, 2017

    Malavika Murugan, Hee Jae Jan, Michelle Park, Ellia M. Miller, Julia Cox, Joshua P. Taliaferro, et al.

  22. Flexible timing by temporal scaling of cortical responses.

    Nature Neuroscience, December 4, 2017

    Jing Wang, Devika Narain, Eghbal A. Hosseini, and Mehrdad Jazayeri

  23. The central amygdala controls learning in the lateral amygdala.

    Nat Neurosci, December 1, 2017

    K Yu, S Ahrens, X Zhang, H Schiff, C Ramakrishnan, L Fenno, et al.

  24. The Impact of Anesthetic State on Spike-Sorting Success in the Cortex: A Comparison of Ketamine and Urethane Anesthesia.

    Front Neural Circuits, 2017

    KJ Hildebrandt, Maneesh Sahani, and JF Linden

  25. Clustering of Heading Selectivity and Perception-Related Activity in the Ventral Intraparietal Area.

    J Neurophysiol, November 29, 2017

    M Shao, GC DeAngelis, Dora Angelaki, and A Chen

  26. Efficient in situ barcode sequencing using padlock probe-based BaristaSeq.

    Nucleic Acids Res, November 28, 2017

    X Chen, YC Sun, GM Church, JH Lee, and Anthony Zador

  27. Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior.

    Sci Rep, November 24, 2017

    SJG Sylvester, MM Lee, AD Ramirez, S Lim, and MS Goldman

  28. Expansion microscopy of zebrafish for neuroscience and developmental biology studies.

    Proc Natl Acad Sci U S A, November 21, 2017

    L Freifeld, I Odstrcil, D Förster, A Ramirez, JA Gagnon, O Randlett, et al.

  29. Modular organization of the brainstem noradrenaline system coordinates opposing learning states.

    Nat Neurosci, November 20, 2017

    A Uematsu, AZ Tan, EA Ycu, JS Cuevas, J Koivumaa, F Junyent, et al.

  30. Decision-making behaviors: weighing ethology, complexity, and sensorimotor compatibility

    Curr Opin Neurobiol, November 20, 2017

    Ashley L Juavinett, Jeffrey C Erlich, and Anne K. Churchland

  31. Neural mechanisms of movement planning: motor cortex and beyond.

    Curr Opin Neurobiol, November 20, 2017

    Karel Svoboda and Nuo Li

  32. Collective Behavior of Place and Non-place Neurons in the Hippocampal Network.

    Neuron, November 15, 2017

    L Meshulam, JL Gauthier, Carlos Brody, D.W. Tank, and William Bialek

  33. Dissociation of Self-Motion and Object Motion by Linear Population Decoding That Approximates Marginalization.

    J Neurosci, November 15, 2017

    R Sasaki, Dora Angelaki, and GC DeAngelis

  34. Electrical stimulus artifact cancellation and neural spike detection on large multi-electrode arrays.

    PLoS Comput Biol, November 13, 2017

    GE Mena, LE Grosberg, S Madugula, P Hottowy, A Litke, John Cunningham, et al.

  35. Augmenting intracortical brain-machine interface with neurally driven error detectors.

    J Neural Eng, November 13, 2017

    N Even-Chen, SD Stavisky, JC Kao, SI Ryu, and Krishna Shenoy

  36. Ultra-selective looming detection from radial motion opponency.

    Nature, November 8, 2017

    NC Klapoetke, A Nern, MY Peek, EM Rogers, P Breads, Gerald Rubin, et al.

  37. Fully integrated silicon probes for high-density recording of neural activity.

    Nature, November 8, 2017

    JJ Jun, NA Steinmetz, JH Siegle, DJ Denman, M Bauza, B Barbarits, et al.

  38. Drosophila Connectomics: Mapping the Larval Eye's Mind.

    Curr Biol, November 6, 2017

    C Friedrich-Reed Wienecke and Thomas R. Clandinin

  39. Balanced excitation and inhibition are required for high-capacity, noise-robust neuronal selectivity.

    Proceedings of the National Academy of Sciences of the United States of America, October 31, 2017

    R. Rubin, Larry Abbott, and Haim Sompolinsky

  40. Hippocampal-prefrontal reactivation during learning is stronger in awake as compared to sleep states.

    J Neurosci, October 31, 2017

    W Tang, JD Shin, Loren Frank, and SP Jadhav

  41. Deep Learning Predicts Correlation between a Functional Signature of Higher Visual Areas and Sparse Firing of Neurons.

    Front Comput Neurosci, October 30, 2017

    C Zhuang, Yi Wang, Daniel Yamins, and X Hu

  42. Cell types for our sense of location: where we are and where we are going.

    Nature Neuroscience, October 26, 2017

    K. Hardcastle, Surya Ganguli, and Lisa Giocomo

  43. Assessing the role of inhibition in stabilizing neocortical networks requires large-scale perturbation of the inhibitory population.

    Journal of Neuroscience, October 26, 2017

    S. Sadeh, R.A. Silver, Thomas Mrsic-Flogel, and R. Muir

  44. A unified internal model theory to resolve the paradox of active versus passive self-motion sensation.

    Elife, October 18, 2017

    J. Laurens and Dora Angelaki

  45. Dissociation of self-motion and object motion by linear population decoding that approximates marginalization.

    Journal of Neuroscience, October 13, 2017

    R. Sasaki, Dora Angelaki, and G. C. DeAngelis

  46. Hebbian Learning in a Random Network Captures Selectivity Properties of Prefrontal Cortex.

    Journal of Neuroscience, October 11, 2017

    G.W. Lindsay, M. Rigotti, M.R. Warden, E.K. Miller, and Stefano Fusi

  47. Brain-wide Maps Reveal StereotyType-Based Cortical Architecture and Subcortical Sexual Dimorphism.

    Cell, October 5, 2017

    Y. Kim, G.R. Yang, K. Pradhan, K.U. Venkataraju, M. Bota, L.C. Garcia Del Molino, et al.

  48. The many worlds hypothesis of dopamine prediction error: implications of a parallel circuit architecture in the basal ganglia.

    Current Opinion in Neurobiology, October 3, 2017

    B. Lau, T. Monteiro, and Joseph Paton

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