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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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  1. Circuit mechanisms for the maintenance and manipulation of information in working memory

    Nature Neuroscience, June 10, 2019

    NY Masse, GR Yang, HF Song, Xiao-Jing Wang, and DJ Freedman

  2. New neural activity patterns emerge with long-term learning

    PNAS, June 10, 2019

    ER Oby, MD Golub, JA Hennig, AD Degenhart, EC Tyler-Kabara, Byron Yu, et al.

  3. Striatal circuits for reward learning and decision-making

    Nature Reviews Neuroscience, June 6, 2019

    J Cox and Ilana Witten

  4. Transforming the Choice Outcome to an Action Plan in Monkey Lateral Prefrontal Cortex: A Neural Circuit Model.

    Neuron, June 1, 2019

    MY Yim, X Cai, and Xiao-Jing Wang

  5. Cerebellar Contribution to Preparatory Activity in Motor Neocortex.

    Neuron, May 31, 2019

    FP Chabrol, A Blot, and Thomas Mrsic-Flogel

  6. An Analysis of Decision under Risk in Rats

    Current Biology, May 30, 2019

    Christine M. Constantinople, Alex T. Piet, and Carlos Brody

  7. Q&A: Understanding the composition of behavior.

    BMC Biol., May 29, 2019

    Sandeep Robert Datta

  8. Specialized coding of sensory, motor and cognitive variables in VTA dopamine neurons

    Nature, May 29, 2019

    Ben Engelhard, Joel Finkelstein, Julia Cox, Weston Fleming, Hee Jae Jang, Sharon Ornelas, et al.

  9. Heading direction with respect to a reference point modulates place-cell activity

    Nature Comm, May 27, 2019

    P. E. Jercog, Y. Ahmadian, C. Woodruff, R. Deb-Sen, Larry Abbott, and E. R. Kandel

  10. An Analysis of Decision under Risk in Rats.

    Curr Biol., May 24, 2019

    CM Constantinople, AT Piet, and Carlos Brody

  11. Accurate Estimation of Neural Population Dynamics without Spike Sorting.

    Neuron, May 23, 2019

    EM Trautmann, SD Stavisky, S Lahiri, KC Ames, MT Kaufman, DJ O'Shea, et al.

  12. Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body.

    Elife., May 21, 2019

    MJ Dolan, S Frechter, AS Bates, C Dan, P Huoviala, RJ Roberts, et al.

  13. A mathematical theory of semantic development in deep neural networks.

    Proc Natl Acad Sci U S A., May 17, 2019

    AM Saxe, JL McClelland, and Surya Ganguli

  14. Hierarchical reasoning by neural circuits in the frontal cortex.

    Science, May 17, 2019

    M Sarafyazd and Mehrdad Jazayeri

  15. Sparse model-based estimation of functional dependence in high-dimensional field and spike multiscale networks.

    J Neural Eng., May 17, 2019

    R Bighamian, YT Wong, Bijan Pesaran, and MM Shanechi

  16. Discrete Stepping and Nonlinear Ramping Dynamics Underlie Spiking Responses of LIP Neurons during Decision-Making.

    Neuron, May 16, 2019

    DM Zoltowski, KW Latimer, JL Yates, AC Huk, and Jonathan Pillow

  17. Fast and flexible sequence induction in spiking neural networks via rapid excitability changes

    eLife, May 13, 2019

    Rich Pang and Adrienne Fairhall

  18. Neural population control via deep image synthesis.

    Science., May 3, 2019

    OJ Hénaff, RLT Goris, and Eero P. Simoncelli

  19. Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity.

    Elife., May 3, 2019

    HL Payne, RL French, CC Guo, TB Nguyen-Vu, T Manninen, and Jennifer Raymond

  20. Searching for collective behavior in a small brain.

    Phys Rev E., May 1, 2019

    X Chen, F Randi, Andrew Leifer, and William Bialek

  21. Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics.

    Nature., May 1, 2019

    Y Adam, JJ Kim, S Lou, Y Zhao, ME Xie, D Brinks, et al.

  22. The impact of bilateral ongoing activity on evoked responses in mouse cortex.

    Elife., April 30, 2019

    D Shimaoka, NA Steinmetz, and Matteo Carandini

  23. The impact of bilateral ongoing activity on evoked responses in mouse cortex

    eLife, April 30, 2019

    Daisuke Shimaoka, Nicholas A Steinmetz, and Matteo Carandini

  24. Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses

    Genome Res, April 29, 2019

    Bérénice Benayoun, EA Pollina, PP Singh, S Mahmoudi, I Harel, KM Casey, et al.

  25. Perceptual straightening of natural videos.

    Nat Neurosci., April 29, 2019

    OJ Hénaff, RLT Goris, and Eero P. Simoncelli

  26. Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells.

    Nat Neurosci., April 29, 2019

    D Kostadinov, M Beau, MB Pozo, and Michael Hausser

  27. Evidence that recurrent circuits are critical to the ventral stream’s execution of core object recognition behavior

    Nature Neuroscience, April 29, 2019

    Kohitij Kar, Jonas Kubilius, Kailyn Schmidt, Elias B. Issa, and James DiCarlo

  28. Network cloning using DNA barcodes.

    Proc Natl Acad Sci U S A., April 24, 2019

    SA Shuvaev, B Başerdem, Anthony Zador, and AA Koulakov

  29. Variation in sequence dynamics improves maintenance of stereotyped behavior in an example from bird song.

    Proc Natl Acad Sci U S A., April 23, 2019

    A Duffy, E Abe, DJ Perkel, and Adrienne Fairhall

  30. An Excitatory Circuit in the Perioculomotor Midbrain for Non-REM Sleep Control.

    Cell., April 22, 2019

    Z Zhang, P Zhong, F Hu, Z Barger, Y Ren, X Ding, et al.

  31. Spontaneous behaviors drive multidimensional, brainwide activity.

    Science, April 19, 2019

    C Stringer, M Pachitariu, N Steinmetz, CB Reddy, and Matteo Carandini

  32. Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known.

    Nat Commun., April 17, 2019

    M Wang, C Montanède, C Chandrasekaran, D Peixoto, Krishna Shenoy, and JF Kalaska

  33. Macaque dorsal premotor cortex exhibits decision-related activity only when specific stimulus-response associations are known.

    Nat Commun., April 17, 2019

    M Wang, C Montanède, C Chandrasekaran, D Peixoto, Krishna Shenoy, and JF Kalaska

  34. A virtual burrow assay for head-fixed mice measures habituation, discrimination, exploration and avoidance without training.

    Elife., April 17, 2019

    AJ Fink, Richard Axel, and CE Schoonover

  35. Minimax-optimal decoding of movement goals from local field potentials using complex spectral features.

    J Neural Eng., April 16, 2019

    M Angjelichinoski, T Banerjee, J Choi, Bijan Pesaran, and V Tarokh

  36. The relative contribution of color and material in object selection.

    PLoS Comput Biol., April 12, 2019

    A Radonjić, NP Cottaris, and David H. Brainard

  37. State-dependent geometry of population activity in rat auditory cortex.

    Elife, April 10, 2019

    D Kobak, JL Pardo-Vazquez, M Valente, Christian Machens, and A Renart

  38. Reward prediction error does not explain movement selectivity in DMS-projecting dopamine neurons.

    Elife., April 4, 2019

    RS Lee, MG Mattar, NF Parker, Ilana Witten, and ND Daw

  39. Dopamine Modulation of Prefrontal Cortex Activity Is Manifold and Operates at Multiple Temporal and Spatial Scales.

    Cell Rep., April 2, 2019

    S. Lohani, AK Martig, K Deisseroth, Ilana Witten, and B Moghaddam

  40. Deviation from the matching law reflects an optimal strategy involving learning over multiple timescales

    Nature Communications, April 1, 2019

    Kiyohito Iigaya, Yashar Ahmadian, Leo P. Sugrue, Greg S. Corrado, Yonatan Loewenstein, Bill Newsome, et al.

  41. A computational-observer model of spatial contrast sensitivity: Effects of wave-front-based optics, cone-mosaic structure, and inference engine

    J Vis., April 1, 2019

    NP Cottaris, H Jiang, X Ding, Brian A. Wandell, and David H. Brainard

  42. Towards the neural population doctrine

    COIN, April 1, 2019

    Shreya Saxena and John Cunningham

  43. Grid cell co-activity patterns during sleep reflect spatial overlap of grid fields during active behaviors.

    Nat Neurosci., April 1, 2019

    SG Trettel, JB Trimper, E Hwaun, Ila Fiete, and LL Colgin

  44. Remembered reward locations restructure entorhinal spatial maps.

    Science, March 29, 2019

    WN Butler, K Hardcastle, and Lisa Giocomo

  45. Efficient Decoding of Multi-Dimensional Signals from Population Spiking Activity Using a Gaussian Mixture Particle Filter.

    IEEE Trans Biomed Eng., March 27, 2019

    A Yousefi, Anna Gillespie, JA Guidera, M Karlsson, Lawrence R. Frank, and Uri Eden

  46. Choice-Related Activity during Visual Slant Discrimination in Macaque CIP But Not V3A.

    eNeuro., March 26, 2019

    LC Elmore, A Rosenberg, GC DeAngelis, and Dora Angelaki

  47. Shared Cortex-Cerebellum Dynamics in the Execution and Learning of a Motor Task.

    Cell, March 25, 2019

    MJ Wagner, TH Kim, J Kadmon, ND Nguyen, Surya Ganguli, NJ Schnitzer, et al.

  48. Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus

    Neuron, March 21, 2019

    G Mandelbaum, J Taranda, TM Haynes, DR Hochbaum, KW Huang, M Hyun, et al.

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