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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Face familiarity detection with complex synapses

    iScience, December 22, 2022

    L Ji-An, F Stefanini, MK Benna, and Stefano Fusi

  2. Neural ensembles in navigation: From single cells to population codes

    Curr Opin Neurobiol, December 19, 2022

    EA Aery Jones and Lisa Giocomo

  3. Minimum perturbation theory of deep perceptual learning

    Phys Rev E, December 18, 2022

    H Shan and Haim Sompolinsky

  4. Associative memory of structured knowledge

    Sci Rep, December 17, 2022

    J Steinberg and Haim Sompolinsky

  5. Cortical-hippocampal coupling during manifold exploration in motor cortex

    Nature, December 14, 2022

    J Kim, A Joshi, Loren Frank, and K Ganguly

  6. Sparse RNNs can support high-capacity classification

    PLoS Comput Biol, December 14, 2022

    D Turcu and Larry Abbott

  7. A large-scale neural network training framework for generalized estimation of single-trial population dynamics

    Nat Methods, December 5, 2022

    MR Keshtkaran, AR Sedler, RH Chowdhury, R Tandon, D Basrai, SL Nguyen, et al.

  8. Input correlations impede suppression of chaos and learning in balanced firing-rate networks

    PLoS Comput Biol, December 5, 2022

    R Engelken, A Ingrosso, R Khajeh, S Goedeke, and Larry Abbott

  9. Optimal Quadratic Binding for Relational Reasoning in Vector Symbolic Neural Architectures

    Neural Comput, December 1, 2022

    N Hiratani and Haim Sompolinsky

  10. Coordinated multiplexing of information about separate objects in visual cortex

    Elife, November 29, 2022

    NY Jun, DA Ruff, LE Kramer, B Bowes, ST Tokdar, Marlene Cohen, et al.

  11. Modeling and inference methods for switching regime-dependent dynamical systems with multiscale neural observations

    J Neural Eng, November 28, 2022

    CY Song, HL Hsieh, Bijan Pesaran, and MM Shanechi

  12. Unraveling the Entangled Brain: How Do We Go About It?

    J Cogn Neurosci, November 28, 2022

    Shaul Druckmann and Nicole Rust

  13. A deep learning framework for inference of single-trial neural population dynamics from calcium imaging with subframe temporal resolution

    Nat Neurosci, November 24, 2022

    F Zhu, HA Grier, R Tandon, C Cai, A Agarwal, A Giovannucci, et al.

  14. The tricky business of defining brain functions

    Trends Neurosci, November 22, 2022

    Nicole Rust and JE LeDoux

  15. Systematic reduction of the dimensionality of natural scenes allows accurate predictions of retinal ganglion cell spike outputs

    Proc Natl Acad Sci U S A, November 16, 2022

    J Freedland and Fred Rieke

  16. Feature representation under crowding in macaque V1 and V4 neuronal populations

    Curr Biol, November 11, 2022

    CA Henry and Adam Kohn

  17. Neural Mechanisms that Make Perceptual Decisions Flexible

    Annu Rev Physiol, November 7, 2022

    G Okazawa and Roozbeh Kiani

  18. Neural circuit dynamics of drug-context associative learning in the mouse hippocampus

    Nat Commun, November 7, 2022

    Y Sun and Lisa Giocomo

  19. Refinements to rodent head fixation and fluid/food control for neuroscience

    J Neurosci Methods, November 7, 2022

    C Barkus, C Bergmann, T Branco, Matteo Carandini, PT Chadderton, GL Galiñanes, et al.

  20. From Rats to Humans: how novel behavioral paradigms and reinforcement learning can bridge the gap in translation

    Lab Anim (NY), November 7, 2022

    A Gonzalez and Lisa Giocomo

  21. Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types

    Science, November 4, 2022

    M Kannan, G Vasan, S Haziza, C Huang, R Chrapkiewicz, J Luo, et al.

  22. Attractor and integrator networks in the brain

    Nat Rev Neurosci, November 3, 2022

    M Khona and Ila Fiete

  23. Imagination as a fundamental function of the hippocampus

    Philos Trans R Soc Lond B Biol Sci, October 31, 2022

    AE Comrie, Loren Frank, and K Kay

  24. The implications of categorical and category-free mixed selectivity on representational geometries

    Curr Opin Neurobiol, October 28, 2022

    Matthew Kaufman, MK Benna, M Rigotti, F Stefanini, Stefano Fusi, and Anne K. Churchland

  25. Visual and motor signatures of locomotion dynamically shape a population code for feature detection in Drosophila

    Elife, October 27, 2022

    MH Turner, A Krieger, MM Pang, and Thomas R. Clandinin

  26. A unified theory for the computational and mechanistic origins of grid cells

    Neuron, October 26, 2022

    B Sorscher, GC Mel, SA Ocko, Lisa Giocomo, and Surya Ganguli

  27. Measuring the dimensionality of behavior

    Proc Natl Acad Sci U S A, October 25, 2022

    Surya Ganguli

  28. Neural representational geometry underlies few-shot concept learning

    Proc Natl Acad Sci U S A, October 25, 2022

    B Sorscher, Surya Ganguli, and Haim Sompolinsky

  29. Coding of latent variables in sensory, parietal, and frontal cortices during closed-loop virtual navigation

    Elife, October 25, 2022

    JP Noel, E Balzani, E Avila, KJ Lakshminarasimhan, S Bruni, P Alefantis, et al.

  30. Learning shapes cortical dynamics to enhance integration of relevant sensory input

    Neuron, October 21, 2022

    A Chadwick, AG Khan, J Poort, A Blot, Sonja Hofer, Thomas Mrsic-Flogel, et al.

  31. Modeling and inference methods for switching regime-dependent dynamical systems with multiscale neural observations

    J Neural Eng, October 19, 2022

    CY Song, HL Hsieh, Bijan Pesaran, and MM Shanechi

  32. Behavioural and dopaminergic signatures of resilience

    Nature, October 19, 2022

    L Willmore, C Cameron, J Yang, Ilana Witten, and Annegret Falkner

  33. Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex

    Cell Rep, October 18, 2022

    AJ Peters, AM Marica, JMJ Fabre, and Matteo Carandini

  34. Optimal noise level for coding with tightly balanced networks of spiking neurons in the presence of transmission delays

    PLoS Comput Biol, October 17, 2022

    J Timcheck, J Kadmon, K Boahen, and Surya Ganguli

  35. A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations

    Nat Commun, October 12, 2022

    AA Liu, S Henin, S Abbaspoor, A Bragin, Elizabeth A. Buffalo, JS Farrell, et al.

  36. A topological solution to object segmentation and tracking

    Proc Natl Acad Sci U S A, October 11, 2022

    T Tsao and Doris Tsao

  37. Next-generation brain observatories

    Neuron, October 11, 2022

    C Koch, Karel Svoboda, A Bernard, MA Basso, Anne K. Churchland, Adrienne Fairhall, et al.

  38. Structured random receptive fields enable informative sensory encodings

    PLoS Comput Biol, October 10, 2022

    B Pandey, M Pachitariu, and BW Brunton

  39. Flexible neural control of motor units

    Nat Neurosci, October 10, 2022

    NJ Marshall, JI Glaser, EM Trautmann, EA Amematsro, SM Perkins, MN Shadlen, et al.

  40. Recurrent neural networks with explicit representation of dynamic latent variables can mimic behavioral patterns in a physical inference task

    Nat Commun, October 4, 2022

    R Rajalingham, A Piccato, and Mehrdad Jazayeri

  41. The Neurodata Without Borders ecosystem for neurophysiological data science

    Elife, October 4, 2022

    O Rübel, A Tritt, R Ly, BK Dichter, S Ghosh, L Niu, et al.

  42. Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents

    Nat Biomed Eng, October 3, 2022

    Z Zhao, H Zhu, X Li, L Sun, F He, JE Chung, et al.

  43. Correcting motion induced fluorescence artifacts in two-channel neural imaging

    PLoS Comput Biol, September 28, 2022

    MS Creamer, KS Chen, Andrew Leifer, and Jonathan Pillow

  44. Thalamus-driven functional populations in frontal cortex support decision-making

    Nat Neurosci, September 28, 2022

    W Yang, SL Tipparaju, G Chen, and Nuo Li

  45. Motor cortical influence relies on task-specific activity covariation

    Cell Rep, September 27, 2022

    CL Warriner, S Fageiry, S Saxena, RM Costa, and Andrew Miri

  46. Deep learning for neural decoding in motor cortex

    J Neural Eng, September 23, 2022

    F Liu, S Meamardoost, R Gunawan, Takaki Komiyama, C Mewes, Y Zhang, et al.

  47. Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology

    Nat Commun, September 22, 2022

    Y Wu, M Wu, A Vázquez-Guardado, J Kim, X Zhang, R Avila, et al.

  48. Independent response modulation of visual cortical neurons by attentional and behavioral states

    Neuron, September 19, 2022

    T Kanamori and Thomas Mrsic-Flogel

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