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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. IAN: Iterated Adaptive Neighborhoods for Manifold Learning and Dimensionality Estimation

    Neural Comput, February 2, 2023

    L Dyballa and Steven Zucker

  2. Sensitivity to naturalistic texture relies primarily on high spatial frequencies

    J Vis, February 1, 2023

    JD Lieber, GM Lee, NJ Majaj, and J. Anthony Movshon

  3. Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer

    Proc Natl Acad Sci U S A, January 24, 2023

    AMG Jensen, Y Kitago, E Fazeli, CB Vægter, Scott Small, GA Petsko, et al.

  4. Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila

    Elife, January 24, 2023

    D Yamada, D Bushey, F Li, KL Hibbard, M Sammons, J Funke, et al.

  5. Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making

    Nat Neurosci, January 23, 2023

    S Musall, XR Sun, H Mohan, X An, S Gluf, SJ Li, et al.

  6. Optimal Quadratic Binding for Relational Reasoning in Vector Symbolic Neural Architectures

    Neural Comput, January 20, 2023

    N Hiratani and Haim Sompolinsky

  7. Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency mode

    Transl Med Aging, January 19, 2023

    K Mehalko, M Kim, S Paye, K Koh, RJ Lu, and Bérénice Benayoun

  8. Spontaneous behaviour is structured by reinforcement without explicit reward

    Nature, January 18, 2023

    JE Markowitz, WF Gillis, M Jay, J Wood, RW Harris, R Cieszkowski, et al.

  9. Blood-to-brain communication in aging and rejuvenation

    Nat Neurosci, January 16, 2023

    G Bieri, AB Schroer, and Saul Villeda

  10. A neural substrate of sex-dependent modulation of motivation

    Nat Neurosci, January 16, 2023

    J Cox, AR Minerva, WT Fleming, CA Zimmerman, C Hayes, S Zorowitz, et al.

  11. Parametric control of flexible timing through low-dimensional neural manifolds

    Neuron, January 14, 2023

    M Beiran, N Meirhaeghe, H Sohn, Mehrdad Jazayeri, and S Ostojic

  12. All-optical physiology resolves a synaptic basis for behavioral timescale plasticity

    Cell, January 13, 2023

    LZ Fan, DK Kim, JH Jennings, H Tian, PY Wang, C Ramakrishnan, et al.

  13. Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons

    Cell Rep, January 12, 2023

    O Pietiläinen, A Trehan, D Meyer, J Mitchell, M Tegtmeyer, V Valakh, et al.

  14. Residual dynamics resolves recurrent contributions to neural computation

    Nat Neurosci, January 12, 2023

    AR Galgali, Maneesh Sahani, and Valerio Mante

  15. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

    Stem Cell Reports, January 10, 2023

    F Rapino, T Natoli, F Limone, E O'Connor, J Blank, M Tegtmeyer, et al.

  16. Choice selective inhibition drives stability and competition in decision circuits

    Nat Commun, January 10, 2023

    JP Roach, Anne K. Churchland, and Tatiana Engel

  17. X chromosome factor Kdm6a enhances cognition independent of its demethylase function in the aging XY male brain

    J Gerontol A Biol Sci Med Sci, January 9, 2023

    CK Shaw, S Abdulai-Saiku, F Marino, D Wang, EJ Davis, B Panning, et al.

  18. Behavioral origin of sound-evoked activity in mouse visual cortex

    Nat Neurosci, January 9, 2023

    C Bimbard, TPH Sit, A Lebedeva, CB Reddy, and Matteo Carandini

  19. A General Framework for Inferring Bayesian Ideal Observer Models from Psychophysical Data

    eNeuro, January 9, 2023

    TS Manning, BN Naecker, IR McLean, B Rokers, Jonathan Pillow, and EA Cooper

  20. Parametric control of flexible timing through low-dimensional neural manifolds

    Neuron, January 9, 2023

    M Beiran, N Meirhaeghe, H Sohn, Mehrdad Jazayeri, and S Ostojic

  21. The geometry of cortical representations of touch in rodents

    Nat Neurosci, January 9, 2023

    R Nogueira, CC Rodgers, RM Bruno, and Stefano Fusi

  22. Formalising social representation to explain psychiatric symptoms

    Trends Cogn Sci, January 7, 2023

    JM Barnby, Peter Dayan, and V Bell

  23. A mesothelium divides the subarachnoid space into functional compartments

    Science, January 6, 2023

    K Møllgård, FRM Beinlich, P Kusk, LM Miyakoshi, C Delle, V Plá, et al.

  24. One dimensional approximations of neuronal dynamics reveal computational strategy

    PLoS Comput Biol, January 6, 2023

    C Brennan, A Aggarwal, R Pei, David Sussillo, and A Proekt

  25. The centrality of population-level factors to network computation is demonstrated by a versatile approach for training spiking networks

    Neuron, January 5, 2023

    B DePasquale, David Sussillo, Larry Abbott, and Mark M. Churchland

  26. An approximate line attractor in the hypothalamus encodes an aggressive state

    Cell, January 5, 2023

    A Nair, T Karigo, B Yang, Surya Ganguli, Mark Schnitzer, Scott Linderman, et al.

  27. Differential Expression Analysis of Nothobranchius furzeri Transposable Elements from RNA-seq Data

    Cold Spring Harb Protoc, January 3, 2023

    B Teefy, M Malone, and Bérénice Benayoun

  28. The centrality of population-level factors to network computation is demonstrated by a versatile approach for training spiking networks

    Neuron, December 30, 2022

    JDS Reggiani, Q Jiang, M Barbini, A Lutas, Liang Liang, J Fernando, et al.

  29. Dimensionality reduction of calcium-imaged neuronal population activity

    Nature Computational Science, December 29, 2022

    TH Koh, WE Bishop, T Kawashima, BB Jeon, R Srinivasan, Y Mu, et al.

  30. Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish

    Genome Res, December 28, 2022

    BB Teefy, A Adler, A Xu, K Hsu, PP Singh, and Bérénice Benayoun

  31. The role of the lateral orbitofrontal cortex in creating cognitive maps

    Nat Neurosci, December 22, 2022

    KM Costa, R Scholz, K Lloyd, P Moreno-Castilla, MPH Gardner, Peter Dayan, et al.

  32. A brainstem integrator for self-location memory and positional homeostasis in zebrafish

    Cell, December 22, 2022

    E Yang, MF Zwart, B James, M Rubinov, Z Wei, S Narayan, et al.

  33. Face familiarity detection with complex synapses

    iScience, December 22, 2022

    L Ji-An, F Stefanini, MK Benna, and Stefano Fusi

  34. Neural ensembles in navigation: From single cells to population codes

    Curr Opin Neurobiol, December 19, 2022

    EA Aery Jones and Lisa Giocomo

  35. Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain

    Nature Aging, December 19, 2022

    MT Buckley, ED Sun, BM George, L Liu, N Schaum, L Xu, et al.

  36. Minimum perturbation theory of deep perceptual learning

    Phys Rev E, December 18, 2022

    H Shan and Haim Sompolinsky

  37. Associative memory of structured knowledge

    Sci Rep, December 17, 2022

    J Steinberg and Haim Sompolinsky

  38. Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies

    Fluids Barriers CNS, December 15, 2022

    G Liu, A Ladrón-de-Guevara, Y Izhiman, Maiken Nedergaard, and T Du

  39. Cortical-hippocampal coupling during manifold exploration in motor cortex

    Nature, December 14, 2022

    J Kim, A Joshi, Loren Frank, and K Ganguly

  40. Sparse RNNs can support high-capacity classification

    PLoS Comput Biol, December 14, 2022

    D Turcu and Larry Abbott

  41. Cerebrospinal fluid immune dysregulation during healthy brain aging and cognitive impairment

    Cell, December 7, 2022

    N Piehl, L van Olst, A Ramakrishnan, V Teregulova, B Simonton, Z Zhang, et al.

  42. Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer's Disease

    J Alzheimers Dis, December 7, 2022

    JM Gaitán, S Asthana, CM Carlsson, CD Engelman, SC Johnson, MA Sager, et al.

  43. AD-associated CSF biomolecular changes are attenuated in KL-VS heterozygotes

    Alzheimers Dement (Amst), December 7, 2022

    I Driscoll, Y Ma, SR Lose, CL Gallagher, SC Johnson, S Asthana, et al.

  44. Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

    Stem Cell Reports, December 6, 2022

    F Rapino, T Natoli, F Limone, E O'Connor, J Blank, M Tegtmeyer, et al.

  45. A large-scale neural network training framework for generalized estimation of single-trial population dynamics

    Nat Methods, December 5, 2022

    MR Keshtkaran, AR Sedler, RH Chowdhury, R Tandon, D Basrai, SL Nguyen, et al.

  46. Input correlations impede suppression of chaos and learning in balanced firing-rate networks

    PLoS Comput Biol, December 5, 2022

    R Engelken, A Ingrosso, R Khajeh, S Goedeke, and Larry Abbott

  47. Optimal Quadratic Binding for Relational Reasoning in Vector Symbolic Neural Architectures

    Neural Comput, December 1, 2022

    N Hiratani and Haim Sompolinsky

  48. Could dexmedetomidine be repurposed as a glymphatic enhancer?

    Trends Pharmacol Sci, December 1, 2022

    NDÅ Persson, P Uusalo, Maiken Nedergaard, TJ Lohela, and TO Lohela

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