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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Foraging for foundations in decision neuroscience: insights from ethology.

    Nat Rev Neurosci., May 11, 2018

    D Mobbs, PC Trimmer, DT Blumstein, and Peter Dayan

  2. The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection.

    Cell, May 10, 2018

    Jeffrey E. Markowitz, Winthrop F. Gillis, Celia C. Beron, Shay Q. Neufeld, Keiramarie Robertson, Neha D. Bhagat, et al.

  3. Construction of an Improved Multi-Tetrode Hyperdrive for Large-Scale Neural Recording in Behaving Rats.

    J Vis Exp., May 9, 2018

    L Lu, B Popeney, JD Dickman, and Dora Angelaki

  4. Three brain states in the hippocampus and cortex.

    Hippocampus, May 3, 2018

    K Kay and Loren Frank

  5. Representation of multiple objects in macaque category-selective areas.

    Nat Commun., May 2, 2018

    P Bao and Doris Tsao

  6. Development of an optogenetic toolkit for neural circuit dissection in squirrel monkeys.

    Sci Rep., April 30, 2018

    DJ O'Shea, P Kalanithi, EA Ferenczi, B Hsueh, C Chandrasekaran, W Goo, et al.

  7. Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals.

    J Neurophysiol., April 25, 2018

    T Milekovic, AA Sarma, D Bacher, JD Simeral, J Saab, C Pandarinath, et al.

  8. Genetic Dissection of Neural Circuits: A Decade of Progress

    Neuron, April 18, 2018

    Liqun Luo, Edward M. Callaway, and Karel Svoboda

  9. A Task-Optimized Neural Network Replicates Human Auditory Behavior, Predicts Brain Responses, and Reveals a Cortical Processing Hierarchy.

    Neuron, April 17, 2018

    AJE Kell, Daniel Yamins, EN Shook, SV Norman-Haignere, and JH McDermott

  10. SuperSpike: Supervised Learning in Multilayer Spiking Neural Networks.

    Neural Comput, April 13, 2018

    F Zenke and Surya Ganguli

  11. Activation of Gαq Signaling Enhances Memory Consolidation and Slows Cognitive Decline

    Neuron, April 12, 2018

    RN Arey, GM Stein, R Kaletsky, A Kauffman, and CT Murphy

  12. Contextual modulation of sensitivity to naturalistic image structure in macaque V2.

    J Neurophysiol, April 11, 2018

    CM Ziemba, Jeremy Freeman, Eero P. Simoncelli, and J. Anthony Movshon

  13. Vision and Locomotion Shape the Interactions between Neuron Types in Mouse Visual Cortex.

    Neuron, April 11, 2018

    M Dipoppa, A Ranson, M Krumin, M Pachitariu, and Matteo Carandini

  14. The Medial Prefrontal Cortex Shapes Dopamine Reward Prediction Errors under State Uncertainty.

    Neuron, April 9, 2018

    CK Starkweather, SJ Gershman, and Naoshige Uchida

  15. High-speed 3D imaging of cellular activity in the brain using axially-extended beams and light sheets.

    Curr Opin Neurobiol, April 7, 2018

    Elizabeth Hillman, V Voleti, K Patel, W Li, H Yu, C Perez-Campos, et al.

  16. Learning by neural reassociation.

    Nat Neurosci, April 1, 2018

    MD Golub, PT Sadtler, ER Oby, KM Quick, SI Ryu, EC Tyler-Kabara, et al.

  17. A transformation from temporal to ensemble coding in a model of piriform cortex.

    Elife, March 29, 2018

    M Stern, KA Bolding, Larry Abbott, and KM Franks

  18. The logic of single-cell projections from visual cortex.

    Nature, March 28, 2018

    Y Han, JM Kebschull, RAA Campbell, D Cowan, F Imhof, Anthony Zador, et al.

  19. Low-dimensional and monotonic preparatory activity in mouse anterior lateral motor cortex.

    J Neurosci., March 28, 2018

    HK Inagaki, M Inagaki, S Romani, and Karel Svoboda

  20. Inter-areal Balanced Amplification Enhances Signal Propagation in a Large-Scale Circuit Model of the Primate Cortex

    Neuron, March 22, 2018

    Madhura R. Joglekar, Jorge F. Mejias, Guangyu Robert Yang, and Xiao-Jing Wang

  21. Effects of Arousal on Mouse Sensory Cortex Depend on Modality.

    Cell Rep., March 20, 2018

    Shimaoka D and Matteo Carandini

  22. Flexible egocentric and allocentric representations of heading signals in parietal cortex.

    Proc Natl Acad Sci USA, March 19, 2018

    Chen X, DeAngelis GC, and Dora Angelaki

  23. Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers.

    Sci Rep., March 13, 2018

    Pisanello M, Pisano F, Sileo L, Maglie E, Bellistri E, Spagnolo B, et al.

  24. Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization

    Nat Med., March 12, 2018

    N Guo, ME Soden, C Herber, MT Kim, A Besnard, P Lin, et al.

  25. Single-exposure visual memory judgments are reflected in inferotemporal cortex

    eLife, March 8, 2018

    Travis Meyer and Nicole Rust

  26. Probabilistic models of individual and collective animal behavior.

    PLoS One., March 7, 2018

    Bod'ová K, Mitchell GJ, Harpaz R, Elad Schneidman, and Tkačik G

  27. Minimally invasive multimode optical fiber microendoscope for deep brain fluorescence imaging.

    Biomed Opt Express, March 6, 2018

    S Ohayon, A Caravaca-Aguirre, R Piestun, and James DiCarlo

  28. Heterogeneity in hippocampal place coding.

    Curr Opin Neurobiol., March 6, 2018

    Mallory CS and Lisa Giocomo

  29. An Accumulation-of-Evidence Task Using Visual Pulses for Mice Navigating in Virtual Reality.

    Front. Behav. Neurosci., March 6, 2018

    Lucas Pinto, Sue A. Koay, Ben Engelhard, Alice M. Yoon, Ben Deverett, Stephan Y. Thiberge, et al.

  30. Integration of speed and time for estimating time to contact.

    Proc Natl Acad Sci U S A, March 5, 2018

    Chang CJ and Mehrdad Jazayeri

  31. Systematic misperceptions of 3-D motion explained by Bayesian inference.

    J Vis., March 1, 2018

    B Rokers, JM Fulvio, Jonathan Pillow, and EA Cooper

  32. Entorhinal cortex receptive fields are modulated by spatial attention, even without movement.

    Elife, March 1, 2018

    Wilming N, König P, König S, and Elizabeth A. Buffalo

  33. Integrative whole-brain neuroscience in larval zebrafish.

    Curr Opin Neurobiol., February 24, 2018

    Vanwalleghem GC, Misha Ahrens, and Scott EK

  34. Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data.

    Elife, February 22, 2018

    P Zhou, SL Resendez, J Rodriguez-Romaguera, JC Jimenez, SQ Neufeld, Andrea Giovannucci, et al.

  35. Shared neural coding for social hierarchy and reward value in primate amygdala.

    Nat Neurosci, February 19, 2018

    J Munuera, M Rigotti, and C. Daniel Salzman

  36. Neural Population Dynamics Underlying Motor Learning Transfer.

    Neuron, February 15, 2018

    S Vyas, N Even-Chen, SD Stavisky, SI Ryu, P Nuyujukian, and Krishna Shenoy

  37. Posterior parietal cortex represents sensory history and mediates its effects on behaviour.

    Nature, February 7, 2018

    A Akrami, CD Kopec, ME Diamond, and Carlos Brody

  38. full-FORCE: A target-based method for training recurrent networks.

    PLoS One, February 7, 2018

    B DePasquale, CJ Cueva, K Rajan, GS Escola, and Larry Abbott

  39. Training and Spontaneous Reinforcement of Neuronal Assemblies by Spike Timing Plasticity

    Cerebral Cortex, February 3, 2018

    Gabriel Koch Ocker and Brent Doiron

  40. A cerebellar mechanism for learning prior distributions of time intervals

    Nature, February 1, 2018

    Devika Narain, Evan D. Remington, Chris I. De Zeeuw, and Mehrdad Jazayeri

  41. Motor Cortex Embeds Muscle-like Commands in an Untangled Population Response

    Neuron, February 1, 2018

    Abigail A. Russo, Sean R. Bittner, Sean M. Perkins, Jeffrey S.Seely, Brian M. London, Antonio H. Lara, et al.

  42. Challenges and opportunities for large-scale electrophysiology with Neuropixels probes.

    Curr Opin Neurobiol, February 1, 2018

    NA Steinmetz, C Koch, and Matteo Carandini

  43. Neurons in primate entorhinal cortex represent gaze position in multiple spatial reference frames.

    J Neurosci, January 31, 2018

    MLR Meister and Elizabeth A. Buffalo

  44. Dethroning the Fano Factor: A Flexible, Model-Based Approach to Partitioning Neural Variability.

    Neural Comput, January 30, 2018

    AS Charles, M Park, JP Weller, GD Horwitz, and Jonathan Pillow

  45. A disinhibitory circuit motif and flexible information routing in the brain.

    Curr Opin Neurobiol, January 26, 2018

    Xiao-Jing Wang and GR Yang

  46. Learning and attention reveal a general relationship between population activity and behavior.

    Science, January 26, 2018

    Amy Ni, DA Ruff, JJ Alberts, J Symmonds, and Marlene Cohen

  47. The Brain Compass: A Perspective on How Self-Motion Updates the Head Direction Cell Attractor

    Neuron, January 17, 2018

    Jean Laurens and Dora Angelaki

  48. Interrupting behaviour: Minimizing decision costs via temporal commitment and low-level interrupts.

    PLoS Comput Biol., January 16, 2018

    K Lloyd and Peter Dayan

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