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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Synaptic balancing: A biologically plausible local learning rule that provably increases neural network noise robustness without sacrificing task performance

    PLoS Comput Biol, September 19, 2022

    CH Stock, SE Harvey, SA Ocko, and Surya Ganguli

  2. Cell-type-specific population dynamics of diverse reward computations

    Cell, September 15, 2022

    EL Sylwestrak, Y Jo, S Vesuna, X Wang, B Holcomb, RH Tien, et al.

  3. ​​Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

    Neuron, September 13, 2022

    K Akiti, I Tsutsui-Kimura, Y Xie, A Mathis, JE Markowitz, R Anyoha, et al.

  4. Refinements to rodent head fixation and fluid/food control for neuroscience

    J Neurosci Methods, September 9, 2022

    C Barkus, C Bergmann, T Branco, Matteo Carandini, PT Chadderton, GL Galiñanes, et al.

  5. The caudal prethalamus: Inhibitory switchboard for behavioral control?

    Neuron, September 7, 2022

    A Fratzl and Sonja Hofer

  6. Reprogramming the topology of the nociceptive circuit in C. elegans reshapes sexual behavior

    Curr Biol, September 1, 2022

    V Pechuk, G Goldman, Y Salzberg, AH Chaubey, RA Bola, JR Hoffman, et al.

  7. Behaviorally relevant decision coding in primary somatosensory cortex neurons

    Nat Neurosci, August 30, 2022

    C Buetfering, Z Zhang, M Pitsiani, J Smallridge, E Boven, S McElligott, et al.

  8. Value representations in the rodent orbitofrontal cortex drive learning, not choice

    Elife, August 17, 2022

    KJ Miller, MM Botvinick, and Carlos Brody

  9. Probing the Relationship Between Latent Linear Dynamical Systems and Low-Rank Recurrent Neural Network Models

    Neural Comput, August 16, 2022

    A Valente, S Ostojic, and Jonathan Pillow

  10. Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy

    Cell, August 16, 2022

    Z Liu, X Lu, V Villette, Y Gou, KL Colbert, S Lai, et al.

  11. Task specificity in mouse parietal cortex

    Neuron, August 12, 2022

    JJ Lee, M Krumin, and Matteo Carandini

  12. Review of data processing of functional optical microscopy for neuroscience

    Neurophotonics, August 4, 2022

    H Benisty, A Song, Gal Mishne, and AS Charles

  13. Transformations of neural representations in a social behaviour network

    Nature, August 3, 2022

    B Yang, T Karigo, and David J. Anderson

  14. Stochastic consolidation of lifelong memory

    Sci Rep, July 30, 2022

    N Shaham, J Chandra, G Kreiman, and Haim Sompolinsky

  15. Neural network organization for courtship-song feature detection in Drosophila

    Curr Biol, July 28, 2022

    CA Baker, C McKellar, R Pang, A Nern, S Dorkenwald, DA Pacheco, et al.

  16. Cortical feedback loops bind distributed representations of working memory

    Nature, July 27, 2022

    I Voitov and Thomas Mrsic-Flogel

  17. Noise correlations in neural ensemble activity limit the accuracy of hippocampal spatial representations

    Nat Commun, July 25, 2022

    O Hazon, VH Minces, DP Tomàs, Surya Ganguli, Mark Schnitzer, and PE Jercog

  18. The spectrum of covariance matrices of randomly connected recurrent neuronal networks with linear dynamics

    PLoS Comput Biol, July 21, 2022

    Y Hu and Haim Sompolinsky

  19. The application of artificial intelligence to biology and neuroscience

    Cell, July 21, 2022

    B Richards, Doris Tsao, and Anthony Zador

  20. Neuroscience Cloud Analysis As a Service: An open-source platform for scalable, reproducible data analysis

    Neuron, July 20, 2022

    T Abe, I Kinsella, S Saxena, EK Buchanan, J Couto, J Briggs, et al.

  21. Selective representations of texture and motion in mouse higher visual areas

    Curr Biol, July 11, 2022

    Y Yu, JN Stirman, CR Dorsett, and Spencer Smith

  22. Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition

    Annu Rev Neurosci, July 8, 2022

    Xiao-Jing Wang

  23. Neural Algorithms and Circuits for Motor Planning

    Annu Rev Neurosci, July 8, 2022

    HK Inagaki, S Chen, K Daie, A Finkelstein, L Fontolan, S Romani, et al.

  24. A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning

    Nat Neurosci, July 7, 2022

    R Amo, S Matias, A Yamanaka, KF Tanaka, Naoshige Uchida, and M Watabe-Uchida

  25. A Theoretical Framework for Human and Nonhuman Vocal Interaction

    Annual Review of Neuroscience, July 7, 2022

    GA Castellucci, FH Guenther, and Michael A. Long

  26. A transcriptomic axis predicts state modulation of cortical interneurons

    Nature, July 6, 2022

    S Bugeon, J Duffield, M Dipoppa, A Ritoux, I Prankerd, D Nicoloutsopoulos, et al.

  27. A call for more clarity around causality in neuroscience

    Trends Neurosci, July 6, 2022

    DL Barack, EK Miller, CI Moore, AM Packer, L Pessoa, LN Ross, et al.

  28. Action suppression reveals opponent parallel control via striatal circuits

    Nature, July 6, 2022

    BF Cruz, G Guiomar, S Soares, A Motiwala, Christian Machens, and Joseph Paton

  29. Oculomotor plant and neural dynamics suggest gaze control requires integration on distributed timescales

    J Physiol, July 5, 2022

    Andrew Miri, BJ Bhasin, Emre Aksay, David W. Tank, and Mark S. Goldman

  30. A set of hub neurons and non-local connectivity features support global brain dynamics in C. elegans

    Curr Biol, July 1, 2022

    K Uzel, S Kato, and Manuel Zimmer

  31. Freezing revisited: coordinated autonomic and central optimization of threat coping

    Nat Rev Neurosci, June 27, 2022

    K Roelofs and Peter Dayan

  32. Gradient-based learning drives robust representations in recurrent neural networks by balancing compression and expansion

    Nature Machine Intelligence, June 22, 2022

    M Farrell, S Recanatesi, T Moore, Guillaume Lajoie, and E Shea-Brown

  33. Towards a more general understanding of the algorithmic utility of recurrent connections

    PLoS Comput Biol, June 21, 2022

    BW Larsen and Shaul Druckmann

  34. Recurrent Connections in the Primate Ventral Visual Stream Mediate a Trade-Off Between Task Performance and Network Size During Core Object Recognition

    Neural Comput, June 20, 2022

    A Nayebi, J Sagastuy-Brena, DM Bear, K Kar, J Kubilius, Surya Ganguli, et al.

  35. Multiple timescales of sensory-evidence accumulation across the dorsal cortex

    Elife, June 16, 2022

    Lucas Pinto, David W. Tank, and Carlos Brody

  36. Emerging principles of spacetime in brains: Meeting report on spatial neurodynamics

    Neuron, June 15, 2022

    S Grün, J Li, B McNaughton, C Petersen, D McCormick, D Robson, et al.

  37. Dynamic task-belief is an integral part of decision-making

    Neuron, June 13, 2022

    C Xue, LE Kramer, and Marlene Cohen

  38. Efficient coding of cognitive variables underlies dopamine response and choice behavior

    Nat Neurosci, June 10, 2022

    A Motiwala, S Soares, BV Atallah, Joseph Paton, and Christian Machens

  39. Stable choice coding in rat frontal orienting fields across model-predicted changes of mind

    Nat Commun, June 10, 2022

    JT Boyd-Meredith, AT Piet, EJ Dennis, A El Hady, and Carlos Brody

  40. Dynamic causal communication channels between neocortical areas

    Neuron, June 7, 2022

    M Javadzadeh and Sonja Hofer

  41. A general decoding strategy explains the relationship between behavior and correlated variability

    Elife, June 6, 2022

    Amy Ni, C Huang, Brent Doiron, and Marlene Cohen

  42. Conserved circuits for direction selectivity in the primate retina

    Curr Biol, June 6, 2022

    SS Patterson, BN Bembry, MA Mazzaferri, M Neitz, Fred Rieke, R Soetedjo, et al.

  43. Learning binds new inputs into functional synaptic clusters via spinogenesis

    Nat Neurosci, June 3, 2022

    NG Hedrick, Z Lu, E Bushong, S Singhi, P Nguyen, Y Magaña, et al.

  44. Internally generated population activity in cortical networks hinders information transmission

    Sci Adv, June 3, 2022

    Chengcheng Huang, Alexandre Pouget, and Brent Doiron

  45. Learning binds new inputs into functional synaptic clusters via spinogenesis

    Nat Neurosci, June 2, 2022

    NG Hedrick, Z Lu, E Bushong, S Singhi, P Nguyen, Y Magaña, et al.

  46. A neural mechanism for detecting object motion during self-motion

    Elife, June 1, 2022

    HR Kim, Dora Angelaki, and GC DeAngelis

  47. Minian, an open-source miniscope analysis pipeline

    Elife, June 1, 2022

    Z Dong, W Mau, Y Feng, ZT Pennington, L Chen, Y Zaki, et al.

  48. Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes

    Cell Rep, May 31, 2022

    W Fleming, J Lee, BA, SS Bolkan, and Ilana Witten

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