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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Coordinated multiplexing of information about separate objects in visual cortex

    Elife, November 29, 2022

    NY Jun, DA Ruff, LE Kramer, B Bowes, ST Tokdar, Marlene Cohen, et al.

  2. Modeling and inference methods for switching regime-dependent dynamical systems with multiscale neural observations

    J Neural Eng, November 28, 2022

    CY Song, HL Hsieh, Bijan Pesaran, and MM Shanechi

  3. Unraveling the Entangled Brain: How Do We Go About It?

    J Cogn Neurosci, November 28, 2022

    Shaul Druckmann and Nicole Rust

  4. A deep learning framework for inference of single-trial neural population dynamics from calcium imaging with subframe temporal resolution

    Nat Neurosci, November 24, 2022

    F Zhu, HA Grier, R Tandon, C Cai, A Agarwal, A Giovannucci, et al.

  5. B lymphocytes ameliorate Alzheimer's disease-like neuropathology via interleukin-35

    Brain Behav Immun, November 24, 2022

    W Feng, Y Zhang, S Ding, S Chen, T Wang, Z Wang, et al.

  6. The tricky business of defining brain functions

    Trends Neurosci, November 22, 2022

    Nicole Rust and JE LeDoux

  7. Systematic reduction of the dimensionality of natural scenes allows accurate predictions of retinal ganglion cell spike outputs

    Proc Natl Acad Sci U S A, November 16, 2022

    J Freedland and Fred Rieke

  8. Ascertaining cells' synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries

    Nat Commun, November 16, 2022

    A Saunders, KW Huang, C Vondrak, C Hughes, K Smolyar, H Sen, et al.

  9. Theory of sleep/wake cycles affecting brain elastography

    Phys Med Biol, November 16, 2022

    GR Ge, W Song, Maiken Nedergaard, JP Rolland, and KJ Parker

  10. Feature representation under crowding in macaque V1 and V4 neuronal populations

    Curr Biol, November 11, 2022

    CA Henry and Adam Kohn

  11. Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities

    Sci Adv, November 11, 2022

    JKE Spetz, MHC Florido, CS Fraser, X Qin, J Choiniere, SJ Yu, et al.

  12. An automated feeding system for the African killifish reveals effects of dietary restriction on lifespan and allows scalable assessment of associative learning

    Elife, November 10, 2022

    A McKay, EK Costa, J Chen, CK Hu, X Chen, CN Bedbrook, et al.

  13. Anatomical biology guides a search for nutrients for the aging brain

    Mol Aspects Med, November 10, 2022

    V Lauriola, AM Brickman, RP Sloan, and Scott Small

  14. Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function

    Cell Rep, November 8, 2022

    KJB Pratt, JM Shea, L Remesal-Gomez, G Bieri, LK Smith, J Couthouis, et al.

  15. Neural Mechanisms that Make Perceptual Decisions Flexible

    Annu Rev Physiol, November 7, 2022

    G Okazawa and Roozbeh Kiani

  16. Neural circuit dynamics of drug-context associative learning in the mouse hippocampus

    Nat Commun, November 7, 2022

    Y Sun and Lisa Giocomo

  17. Refinements to rodent head fixation and fluid/food control for neuroscience

    J Neurosci Methods, November 7, 2022

    C Barkus, C Bergmann, T Branco, Matteo Carandini, PT Chadderton, GL Galiñanes, et al.

  18. From Rats to Humans: how novel behavioral paradigms and reinforcement learning can bridge the gap in translation

    Lab Anim (NY), November 7, 2022

    A Gonzalez and Lisa Giocomo

  19. Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types

    Science, November 4, 2022

    M Kannan, G Vasan, S Haziza, C Huang, R Chrapkiewicz, J Luo, et al.

  20. Attractor and integrator networks in the brain

    Nat Rev Neurosci, November 3, 2022

    M Khona and Ila Fiete

  21. Microglia states and nomenclature: A field at its crossroads

    Neuron, November 2, 2022

    RC Paolicelli, A Sierra, Beth Stevens, ME Tremblay, A Aguzzi, B Ajami, et al.

  22. Microglia states and nomenclature: A field at its crossroads

    Neuron, November 2, 2022

    RC Paolicelli, A Sierra, Beth Stevens, SA Wolf, LJ Wu, and Tony Wyss-Coray

  23. Imagination as a fundamental function of the hippocampus

    Philos Trans R Soc Lond B Biol Sci, October 31, 2022

    AE Comrie, Loren Frank, and K Kay

  24. The implications of categorical and category-free mixed selectivity on representational geometries

    Curr Opin Neurobiol, October 28, 2022

    Matthew Kaufman, MK Benna, M Rigotti, F Stefanini, Stefano Fusi, and Anne K. Churchland

  25. Visual and motor signatures of locomotion dynamically shape a population code for feature detection in Drosophila

    Elife, October 27, 2022

    MH Turner, A Krieger, MM Pang, and Thomas R. Clandinin

  26. A unified theory for the computational and mechanistic origins of grid cells

    Neuron, October 26, 2022

    B Sorscher, GC Mel, SA Ocko, Lisa Giocomo, and Surya Ganguli

  27. Measuring the dimensionality of behavior

    Proc Natl Acad Sci U S A, October 25, 2022

    Surya Ganguli

  28. Neural representational geometry underlies few-shot concept learning

    Proc Natl Acad Sci U S A, October 25, 2022

    B Sorscher, Surya Ganguli, and Haim Sompolinsky

  29. Coding of latent variables in sensory, parietal, and frontal cortices during closed-loop virtual navigation

    Elife, October 25, 2022

    JP Noel, E Balzani, E Avila, KJ Lakshminarasimhan, S Bruni, P Alefantis, et al.

  30. Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer's Disease

    J Alzheimers Dis, October 22, 2022

    JM Gaitán, S Asthana, CM Carlsson, CD Engelman, SC Johnson, MA Sager, et al.

  31. Production of MHCII-expressing classical monocytes increases during aging in mice and humans

    Aging Cell, October 21, 2022

    PK Barman, JE Shin, SA Lewis, S Kang, D Wu, Y Wang, et al.

  32. Could dexmedetomidine be repurposed as a glymphatic enhancer?

    Trends Pharmacol Sci, October 21, 2022

    NDÅ Persson, P Uusalo, Maiken Nedergaard, TJ Lohela, and TO Lilius

  33. Learning shapes cortical dynamics to enhance integration of relevant sensory input

    Neuron, October 21, 2022

    A Chadwick, AG Khan, J Poort, A Blot, Sonja Hofer, Thomas Mrsic-Flogel, et al.

  34. Modeling and inference methods for switching regime-dependent dynamical systems with multiscale neural observations

    J Neural Eng, October 19, 2022

    CY Song, HL Hsieh, Bijan Pesaran, and MM Shanechi

  35. Behavioural and dopaminergic signatures of resilience

    Nature, October 19, 2022

    L Willmore, C Cameron, J Yang, Ilana Witten, and Annegret Falkner

  36. Visuomotor learning promotes visually evoked activity in the medial prefrontal cortex

    Cell Rep, October 18, 2022

    AJ Peters, AM Marica, JMJ Fabre, and Matteo Carandini

  37. Optimal noise level for coding with tightly balanced networks of spiking neurons in the presence of transmission delays

    PLoS Comput Biol, October 17, 2022

    J Timcheck, J Kadmon, K Boahen, and Surya Ganguli

  38. Differential Expression Analysis of Nothobranchius furzeri Transposable Elements from RNA-seq Data

    Cold Spring Harb Protoc, October 12, 2022

    B Teefy, M Malone, and Bérénice Benayoun

  39. A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations

    Nat Commun, October 12, 2022

    AA Liu, S Henin, S Abbaspoor, A Bragin, Elizabeth A. Buffalo, JS Farrell, et al.

  40. A topological solution to object segmentation and tracking

    Proc Natl Acad Sci U S A, October 11, 2022

    T Tsao and Doris Tsao

  41. Next-generation brain observatories

    Neuron, October 11, 2022

    C Koch, Karel Svoboda, A Bernard, MA Basso, Anne K. Churchland, Adrienne Fairhall, et al.

  42. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

    EMBO, October 10, 2022

    M Simon, J Yang, J Gigas, EJ Earley, E Hillpot, L Zhang, et al.

  43. Structured random receptive fields enable informative sensory encodings

    PLoS Comput Biol, October 10, 2022

    B Pandey, M Pachitariu, and BW Brunton

  44. Flexible neural control of motor units

    Nat Neurosci, October 10, 2022

    NJ Marshall, JI Glaser, EM Trautmann, EA Amematsro, SM Perkins, MN Shadlen, et al.

  45. Glial control of sphingolipid levels sculpts diurnal remodeling in a circadian circuit

    Neuron, October 5, 2022

    JP Vaughen, E Theisen, IM Rivas-Serna, AB Berger, P Kalakuntla, I Anreiter, et al.

  46. Recurrent neural networks with explicit representation of dynamic latent variables can mimic behavioral patterns in a physical inference task

    Nat Commun, October 4, 2022

    R Rajalingham, A Piccato, and Mehrdad Jazayeri

  47. The Neurodata Without Borders ecosystem for neurophysiological data science

    Elife, October 4, 2022

    O Rübel, A Tritt, R Ly, BK Dichter, S Ghosh, L Niu, et al.

  48. Ultraflexible electrode arrays for months-long high-density electrophysiological mapping of thousands of neurons in rodents

    Nat Biomed Eng, October 3, 2022

    Z Zhao, H Zhu, X Li, L Sun, F He, JE Chung, et al.

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