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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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  1. Sensory Evidence Accumulation Using Optic Flow in a Naturalistic Navigation Task

    J Neurosci, May 31, 2022

    P Alefantis, KJ Lakshminarasimhan, E Avila, JP Noel, Xaq Pitkow, and Dora Angelaki

  2. The geometry of robustness in spiking neural networks

    Elife, May 30, 2022

    N Calaim, FA Dehmelt, PJ Gonçalves, and Christian Machens

  3. Motor cortex activity across movement speeds is predicted by network-level strategies for generating muscle activity

    eLife, May 27, 2022

    S Saxena, AA Russo, John Cunningham, and Mark M. Churchland

  4. Limitations of a proposed correction for slow drifts in decision criterion

    NBDT, May 24, 2022

    D Gupta and Carlos Brody

  5. Learning, fast and slow

    Curr Opin Neurobiol, May 23, 2022

    Markus Meister

  6. Emergent reliability in sensory cortical coding and inter-area communication

    Nature, May 19, 2022

    S Ebrahimi, J Lecoq, O Rumyantsev, T Tasci, Y Zhang, C Irimia, et al.

  7. Selective representations of texture and motion in mouse higher visual areas

    Curr Biol, May 17, 2022

    Y Yu, JN Stirman, CR Dorsett, and Spencer Smith

  8. Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning

    Cell Rep, May 17, 2022

    NF Parker, A Baidya, J Cox, LM Haetzel, A Zhukovskaya, M Murugan, et al.

  9. Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning

    Neuron, May 12, 2022

    C Ren, K Peng, R Yang, W Liu, C Liu, and Takaki Komiyama

  10. Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish

    Nat Commun, May 11, 2022

    CL Wee, E Song, M Nikitchenko, KJ Herrera, S Wong, Florian Engert, et al.

  11. Neurofeedback through the lens of reinforcement learning

    Trends Neurosci, May 9, 2022

    N Lubianiker, C Paret, Peter Dayan, and T Hendler

  12. GraFT: Graph Filtered Temporal Dictionary Learning for Functional Neural Imaging

    IEEE Trans Image Process, May 9, 2022

    AS Charles, N Cermak, R Affan, B Scott, J Schiller, and Gal Mishne

  13. The geometry of domain-general performance monitoring in the human medial frontal cortex

    Science, May 6, 2022

    Z Fu, D Beam, JM Chung, CM Reed, AN Mamelak, Ralph Adolphs, et al.

  14. On the dimensionality of behavior

    Proc Natl Acad Sci U S A, May 3, 2022

    William Bialek

  15. Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes

    Cell Rep, May 3, 2022

    W Fleming, J Lee, BA Briones, SS Bolkan, and Ilana Witten

  16. On the dimensionality of behavior

    Proc Natl Acad Sci U S A, May 3, 2022

    William Bialek

  17. PatchWarp: Corrections of non-uniform image distortions in two-photon calcium imaging data by patchwork affine transformations

    Cell Rep Methods, April 27, 2022

    R Hattori and Takaki Komiyama

  18. Methylphenidate as a causal test of translational and basic neural coding hypotheses

    Proc Natl Acad Sci U S A ., April 26, 2022

    Amy Ni, BS Bowes, DA Ruff, and Marlene Cohen

  19. Longitudinal two-photon calcium imaging with ultra-large cranial window for head-fixed mice

    STAR Protoc, April 22, 2022

    R Hattori and Takaki Komiyama

  20. Modulation of inhibitory communication coordinates looking and reaching

    Nature, April 20, 2022

    MA Hagan and Bijan Pesaran

  21. Reward signals in the cerebellum: Origins, targets, and functional implications

    Neuron, April 20, 2022

    D Kostadinov and Michael Hausser

  22. Spatial preferences account for inter-animal variability during the continual learning of a dynamic cognitive task

    Cell Rep, April 19, 2022

    DB Kastner, EA Miller, Z Yang, DK Roumis, DF Liu, Loren Frank, et al.

  23. Direct Discriminative Decoder Models for Analysis of High-Dimensional Dynamical Neural Data

    Neural Comput, April 15, 2022

    MR Rezaei, AE Hadjinicolaou, SS Cash, Uri Eden, and A Yousefi

  24. Direct Discriminative Decoder Models for Analysis of High-Dimensional Dynamical Neural Data

    Neural Comput, April 15, 2022

    MR Rezaei, AE Hadjinicolaou, SS Cash, Uri Eden, and A Yousefi

  25. Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences

    Neuron, April 14, 2022

    JB Priestley, JC Bowler, SV Rolotti, Stefano Fusi, and A Losonczy

  26. Priority coding in the visual system

    Nat Rev Neurosci, April 11, 2022

    Nicole Rust and Marlene Cohen

  27. Blind demixing methods for recovering dense neuronal morphology from barcode imaging data

    PLoS Comput Biol, April 8, 2022

    S Chen, J Loper, P Zhou, and Liam Paninski

  28. Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons

    Neuron, April 5, 2022

    JM Stujenske, PK O'Neill, C Fernandes-Henriques, I Nahmoud, SR Goldburg, A Singh, et al.

  29. SLEAP: A deep learning system for multi-animal pose tracking

    Nat Methods, April 4, 2022

    TD Pereira, N Tabris, A Matsliah, DM Turner, J Li, S Ravindranath, et al.

  30. Deep-learning based identification, tracking, pose estimation, and behavior classification of interacting primates and mice in complex environments

    Nat Mach Intell, April 4, 2022

    M Marks, J Qiuhan, O Sturman, L von Ziegler, S Kollmorgen, Valerio Mante, et al.

  31. Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion

    Nat Commun, March 30, 2022

    AJ Christensen and Jonathan Pillow

  32. Dopamine neurons evaluate natural fluctuations in performance quality

    Cell Rep, March 29, 2022

    A Duffy, KW Latimer, JH Goldberg, Adrienne Fairhall, and Vikram Gadagkar

  33. A Variable Clock Underlies Internally Generated Hippocampal Sequences

    J Neurosci, March 28, 2022

    X Deng, S Chen, M Sosa, MP Karlsson, XX Wei, and Loren Frank

  34. Neural mechanisms of persistent aggression

    Curr Opin Neurobiol, March 25, 2022

    EM Guthman and Annegret Falkner

  35. Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

    Nat Neurosci, March 19, 2022

    SS Bolkan, IR Stone, Lucas Pinto, ZC Ashwood, JM Iravedra Garcia, AL Herman, et al.

  36. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Cell, March 17, 2022

    HK Inagaki, S Chen, MC Ridder, P Sah, N Li, Z Yang, et al.

  37. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Cell, March 17, 2022

    HK Inagaki, S Chen, MC Ridder, P Sah, Nuo Li, Z Yang, et al.

  38. Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity

    Cell, March 17, 2022

    NL Turner, T Macrina, JA Bae, R Yang, AM Wilson, C Schneider-Mizell, et al.

  39. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Cell, March 17, 2022

    HK Inagaki, S Chen, MC Ridder, P Sah, N Li, Z Yang, et al.

  40. Cortical ensembles orchestrate social competition through hypothalamic outputs

    Nature, March 16, 2022

    N Padilla-Coreano, K Batra, M Patarino, Z Chen, RR Rock, R Zhang, et al.

  41. Developmental and evolutionary constraints on olfactory circuit selection

    Proc Natl Acad Sci U S A, March 15, 2022

    N Hiratani and Peter Latham

  42. Modeling multiscale causal interactions between spiking and field potential signals during behavior

    J Neural Eng, March 7, 2022

    C Wang, Bijan Pesaran, and MM Shanechi

  43. Feedforward and feedback interactions between visual cortical areas use different population activity patterns

    Nat Commun, March 1, 2022

    JD Semedo, AI Jasper, A Zandvakili, A Krishna, A Aschner, Christian Machens, et al.

  44. Mechanisms of distributed working memory in a large-scale network of macaque neocortex

    eLife, February 24, 2022

    JF Mejías and Xiao-Jing Wang

  45. The Importance of Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes

    J Neurosci, February 23, 2022

    E Zagha, JC Erlich, S Lee, G Lur, DH O'Connor, Nick Steinmetz, et al.

  46. Sparse balance: Excitatory-inhibitory networks with small bias currents and broadly distributed synaptic weights

    PLoS Comput Biol, February 9, 2022

    R Khajeh, F Fumarola, and Larry Abbott

  47. Hierarchical timescales in the neocortex: Mathematical mechanism and biological insights

    Proc Natl Acad Sci U S A, February 8, 2022

    S Li and Xiao-Jing Wang

  48. Mice alternate between discrete strategies during perceptual decision-making

    Nat Neurosci, February 7, 2022

    ZC Ashwood, NA Roy, IR Stone, International Brain Laboratory, AE Urai, Anne K. Churchland, et al.

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