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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline

    iScience, September 29, 2022

    TO Lilius, M Rosenholm, L Klinger, KN Mortensen, B Sigurdsson, FL Mogensen, et al.

  2. Correcting motion induced fluorescence artifacts in two-channel neural imaging

    PLoS Comput Biol, September 28, 2022

    MS Creamer, KS Chen, Andrew Leifer, and Jonathan Pillow

  3. Thalamus-driven functional populations in frontal cortex support decision-making

    Nat Neurosci, September 28, 2022

    W Yang, SL Tipparaju, G Chen, and Nuo Li

  4. Pretargeted Imaging beyond the Blood-Brain Barrier-Utopia or Feasible?

    Pharmaceuticals (Basel), September 27, 2022

    S Lopes van den Broek, V Shalgunov, R García Vázquez, N Beschorner, NSR Bidesi, Maiken Nedergaard, et al.

  5. Motor cortical influence relies on task-specific activity covariation

    Cell Rep, September 27, 2022

    CL Warriner, S Fageiry, S Saxena, RM Costa, and Andrew Miri

  6. Deep learning for neural decoding in motor cortex

    J Neural Eng, September 23, 2022

    F Liu, S Meamardoost, R Gunawan, Takaki Komiyama, C Mewes, Y Zhang, et al.

  7. Wireless multi-lateral optofluidic microsystems for real-time programmable optogenetics and photopharmacology

    Nat Commun, September 22, 2022

    Y Wu, M Wu, A Vázquez-Guardado, J Kim, X Zhang, R Avila, et al.

  8. Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation

    Cell Rep Methods, September 21, 2022

    M Simon, J Yang, J Gigas, EJ Earley, E Hillpot, L Zhang, et al.

  9. Oocyte mitophagy is critical for extended reproductive longevity

    PLoS Genet., September 20, 2022

    R Kaletsky, S Sohrabi, V Cota, and Coleen T. Murphy

  10. Independent response modulation of visual cortical neurons by attentional and behavioral states

    Neuron, September 19, 2022

    T Kanamori and Thomas Mrsic-Flogel

  11. Synaptic balancing: A biologically plausible local learning rule that provably increases neural network noise robustness without sacrificing task performance

    PLoS Comput Biol, September 19, 2022

    CH Stock, SE Harvey, SA Ocko, and Surya Ganguli

  12. A temporal sequence of thalamic activity unfolds at transitions in behavioral arousal state

    Nat Commun., September 16, 2022

    B Setzer, NE Fultz, DEP Gomez, SD Williams, G Bonmassar, JR Polimeni, et al.

  13. Cell-type-specific population dynamics of diverse reward computations

    Cell, September 15, 2022

    EL Sylwestrak, Y Jo, S Vesuna, X Wang, B Holcomb, RH Tien, et al.

  14. Versatile treadmill system for measuring locomotion and neural activity in head-fixed mice

    STAR Protoc., September 14, 2022

    EMM Carlsen, Maiken Nedergaard, and RN Rasmussen

  15. A real-time in vivo clearance assay for quantification of glymphatic efflux

    Cell Rep., September 13, 2022

    V Plá, P Bork, P Harnpramukkul, G Olveda, ALadrón-de-Guevara, MJ Giannetto, et al.

  16. ​​Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction

    Neuron, September 13, 2022

    K Akiti, I Tsutsui-Kimura, Y Xie, A Mathis, JE Markowitz, R Anyoha, et al.

  17. Refinements to rodent head fixation and fluid/food control for neuroscience

    J Neurosci Methods, September 9, 2022

    C Barkus, C Bergmann, T Branco, Matteo Carandini, PT Chadderton, GL Galiñanes, et al.

  18. The caudal prethalamus: Inhibitory switchboard for behavioral control?

    Neuron, September 7, 2022

    A Fratzl and Sonja Hofer

  19. Adult fibroblasts use aggresomes only in distinct cell-states

    Sci Rep., September 2, 2022

    CS Morrow, ZP Arndt, PC Klosa, B Peng, EY Zewdie, Bérénice Benayoun, et al.

  20. Reprogramming the topology of the nociceptive circuit in C. elegans reshapes sexual behavior

    Curr Biol, September 1, 2022

    V Pechuk, G Goldman, Y Salzberg, AH Chaubey, RA Bola, JR Hoffman, et al.

  21. Production of MHCII-expressing classical monocytes increases during aging in mice and humans

    Aging Cell, August 30, 2022

    PK Barman, JE Shin, SA Lewis, S Kang, D Wu, Y Wang, et al.

  22. Behaviorally relevant decision coding in primary somatosensory cortex neurons

    Nat Neurosci, August 30, 2022

    C Buetfering, Z Zhang, M Pitsiani, J Smallridge, E Boven, S McElligott, et al.

  23. Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models

    Annu Rev Nutr, August 22, 2022

    Y Chen, M Kim, S Paye, and Bérénice Benayoun

  24. The glymphatic system: Current understanding and modeling

    iScience, August 20, 2022

    T Bohr, PG Hjorth, SC Holst, S Hrabětová, V Kiviniemi, T Lilius, et al.

  25. Value representations in the rodent orbitofrontal cortex drive learning, not choice

    Elife, August 17, 2022

    KJ Miller, MM Botvinick, and Carlos Brody

  26. Probing the Relationship Between Latent Linear Dynamical Systems and Low-Rank Recurrent Neural Network Models

    Neural Comput, August 16, 2022

    A Valente, S Ostojic, and Jonathan Pillow

  27. Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy

    Cell, August 16, 2022

    Z Liu, X Lu, V Villette, Y Gou, KL Colbert, S Lai, et al.

  28. Task specificity in mouse parietal cortex

    Neuron, August 12, 2022

    JJ Lee, M Krumin, and Matteo Carandini

  29. Deep learning of MRI contrast enhancement for mapping cerebral blood volume from single-modal non-contrast scans of aging and Alzheimer's disease brains

    Front Aging Neurosci, August 11, 2022

    C Liu, N Zhu, H Sun, J Zhang, X Feng, S Gjerswold-Selleck, et al.

  30. The glymphatic system: implications for drugs for central nervous system diseases

    Nat Rev Drug Discov, August 10, 2022

    TJ Lohela, TO Lilius, and Maiken Nedergaard

  31. High-throughput sequencing analysis of nuclear-encoded mitochondrial genes reveals a genetic signature of human longevity

    Geroscience, August 10, 2022

    B Gonzalez, A Tare, S Ryu, SC Johnson, G Atzmon, N Barzilai, et al.

  32. Gentle Isolation of Nuclei from the Brain Tissue of Adult African Turquoise Killifish, a Naturally Short-Lived Model for Aging Research

    J Vis Exp., August 9, 2022

    BB Teefy, A Adler, R Bhala, and Bérénice Benayoun

  33. The effect of long-duration spaceflight on perivascular spaces within the brain

    Proc Natl Acad Sci U S A, August 9, 2022

    P Wostyn, TH Mader, CR Gibson, and Maiken Nedergaard

  34. Review of data processing of functional optical microscopy for neuroscience

    Neurophotonics, August 4, 2022

    H Benisty, A Song, Gal Mishne, and AS Charles

  35. Transformations of neural representations in a social behaviour network

    Nature, August 3, 2022

    B Yang, T Karigo, and David J. Anderson

  36. Stochastic consolidation of lifelong memory

    Sci Rep, July 30, 2022

    N Shaham, J Chandra, G Kreiman, and Haim Sompolinsky

  37. Neural network organization for courtship-song feature detection in Drosophila

    Curr Biol, July 28, 2022

    CA Baker, C McKellar, R Pang, A Nern, S Dorkenwald, DA Pacheco, et al.

  38. Cortical feedback loops bind distributed representations of working memory

    Nature, July 27, 2022

    I Voitov and Thomas Mrsic-Flogel

  39. Noise correlations in neural ensemble activity limit the accuracy of hippocampal spatial representations

    Nat Commun, July 25, 2022

    O Hazon, VH Minces, DP Tomàs, Surya Ganguli, Mark Schnitzer, and PE Jercog

  40. Single-cell RNA-seq of primary bone marrow neutrophils from female and male adult mice

    Sci Data, July 23, 2022

    M Kim, RJ lu, and Bérénice Benayoun

  41. A microengineered Brain-Chip to model neuroinflammation in humans

    iScience, July 21, 2022

    I Pediaditakis, KR Kodella, DV Manatakis, CY Le, S Barthakur, A Sorets, et al.

  42. The spectrum of covariance matrices of randomly connected recurrent neuronal networks with linear dynamics

    PLoS Comput Biol, July 21, 2022

    Y Hu and Haim Sompolinsky

  43. The application of artificial intelligence to biology and neuroscience

    Cell, July 21, 2022

    B Richards, Doris Tsao, and Anthony Zador

  44. Ageing and rejuvenation of tissue stem cells and their niches

    Nat Rev Mol Cell Biol, July 20, 2022

    Anne Brunet, MA Goodell, and TA Rando

  45. Neuroscience Cloud Analysis As a Service: An open-source platform for scalable, reproducible data analysis

    Neuron, July 20, 2022

    T Abe, I Kinsella, S Saxena, EK Buchanan, J Couto, J Briggs, et al.

  46. Selective representations of texture and motion in mouse higher visual areas

    Curr Biol, July 11, 2022

    Y Yu, JN Stirman, CR Dorsett, and Spencer Smith

  47. Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling

    Stem Cell Rev Rep, July 9, 2022

    AR Argouarch, N Schultz, AC Yang, Y Jang, K Garcia, CG Cosme, et al.

  48. Theory of the Multiregional Neocortex: Large-Scale Neural Dynamics and Distributed Cognition

    Annu Rev Neurosci, July 8, 2022

    Xiao-Jing Wang

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