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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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  1. High-performance microbial opsins for spatially and temporally precise perturbations of large neuronal networks

    Neuron, February 3, 2022

    S Sridharan, MA Gajowa, MB Ogando, UK Jagadisan, L Abdeladim, M Sadahiro, et al.

  2. Novel stimuli evoke excess activity in the mouse primary visual cortex

    Proc Natl Acad Sci U S A, February 1, 2022

    J Homann, SA Koay, KS Chen, David W. Tank, and MJ Berry 2nd

  3. Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex

    Nat Neurosci, January 31, 2022

    AC Paulk, Y Kfir, AR Khanna, ML Mustroph, EM Trautmann, DJ Soper, et al.

  4. Sparse connectivity for MAP inference in linear models using sister mitral cells

    PLoS Comput Biol, January 31, 2022

    S Tootoonian, AT Schaefer, and Peter Latham

  5. A high-throughput method to deliver targeted optogenetic stimulation to moving C. elegans populations

    PLoS Biol, January 28, 2022

    M Liu, S Kumar, AK Sharma, and Andrew Leifer

  6. Large-scale neural recordings call for new insights to link brain and behavior

    Nat Neurosci, January 28, 2022

    A Urai, Brent Doiron, Andrew Leifer, and Anne K. Churchland

  7. A high-throughput method to deliver targeted optogenetic stimulation to moving C. elegans populations

    PLoS Biol, January 28, 2022

    M Liu, S Kumar, AK Sharma, and Andrew Leifer

  8. The role of state uncertainty in the dynamics of dopamine

    Curr Biol, January 28, 2022

    JG Mikhael, HR Kim, Naoshige Uchida, and SJ Gershman

  9. Cortical preparatory activity indexes learned motor memories

    Nature, January 26, 2022

    X Sun, DJ O'Shea, MD Golub, EM Trautmann, S Vyas, SI Ryu, et al.

  10. Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish

    Neuron, January 24, 2022

    UL Böhm, Y Kimura, T Kawashima, Misha Ahrens, SI Higashijima, Florian Engert, et al.

  11. Lapses in perceptual decisions reflect exploration

    Elife, January 11, 2022

    S Pisupati, L Chartarifsky-Lynn, A Khanal, and Anne K. Churchland

  12. Fluorescence imaging of large-scale neural ensemble dynamics

    Cell, January 6, 2022

    TH Kim and Mark Schnitzer

  13. A speech planning network for interactive language use

    Nature, January 5, 2022

    GA Castellucci, CK Kovach, MA Howard 3rd, JDW Greenlee, and Michael A. Long

  14. Neurophotonic tools for microscopic measurements and manipulation: status report

    Neurophotonics, January 4, 2022

    AS Abdelfattah, S Ahuja, T Akkin, SR Allu, J Brake, DA Boas, et al.

  15. Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1

    Cell Rep., December 28, 2021

    EA Aery Jones, A Rao, M Zilberter, B Djukic, JS Bant, Anna Gillespie, et al.

  16. Make war not love: The neural substrate underlying a state-dependent switch in female social behavior

    Neuron, December 23, 2021

    M Liu, DW Kim, H Zeng, and David J. Anderson

  17. FlyWire: online community for whole-brain connectomics

    Nat Methods, December 23, 2021

    S Dorkenwald, CE McKellar, T Macrina, N Kemnitz, K Lee, R Lu, et al.

  18. A transcriptional rheostat couples past activity to future sensory responses

    Cell, December 22, 2021

    T Tsukahara, H Brann, SL Pashkovski, G Guitchounts, T Bozza, and Sandeep Robert Datta

  19. Spatial maps in piriform cortex during olfactory navigation

    Nature, December 22, 2021

    Cindy Poo, G Agarwal, N Bonacchi, and Zachary Mainen

  20. Supramammillary regulation of locomotion and hippocampal activity

    Science, December 17, 2021

    JS Farrell, M Lovett-Barron, PM Klein, FT Sparks, T Gschwind, AL Ortiz, et al.

  21. Supramammillary regulation of locomotion and hippocampal activity

    Science, December 17, 2021

    JS Farrell, M Lovett-Barron, PM Klein, FT Sparks, T Gschwind, AL Ortiz, et al.

  22. Transforming representations of movement from body- to world-centric space

    Nature, December 15, 2021

    J Lu, AH Behbahani, L Hamburg, EA Westeinde, PM Dawson, C Lyu, et al.

  23. A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory

    Cell Rep, December 15, 2021

    JY Choi, HJ Jang, S Ornelas, WT Fleming, D Fürth, J Au, et al.

  24. Building an allocentric travelling direction signal via vector computation

    Nature, December 15, 2021

    C Lyu, Larry Abbott, and G Maimon

  25. Learning and attention increase visual response selectivity through distinct mechanisms

    Neuron, December 9, 2021

    J Poort, KA Wilmes, A Blot, A Chadwick, Maneesh Sahani, C Clopath, et al.

  26. Supervised Multisensory Calibration Signals Are Evident in VIP But Not MSTd

    J Neurosci, December 8, 2021

    A Zaidel, J Laurens, GC DeAngelis, and Dora Angelaki

  27. The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Elife, https://pubmed.ncbi.nlm.nih.gov/34846301/, November 30, 2021

    C Segalin, J Williams, T Karigo, M Hui, M Zelikowsky, JJ Sun, et al.

  28. The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Elife, November 30, 2021

    C Segalin, J Williams, T Karigo, M Hui, M Zelikowsky, JJ Sun, et al.

  29. Estimating the dimensionality of the manifold underlying multi-electrode neural recordings

    PLoS Comput Biol, November 29, 2021

    E Altan, SA Solla, LE Miller, and EJ Perreault

  30. Dynamics on the manifold: Identifying computational dynamical activity from neural population recordings

    Curr Opin Neurobiol, November 24, 2021

    L Duncker and Maneesh Sahani

  31. Meta-learning synaptic plasticity and memory addressing for continual familiarity detection

    Neuron, November 24, 2021

    D Tyulmankov, GR Yang, and Larry Abbott

  32. Wide-field calcium imaging of cortex-wide activity in awake, head-fixed mice

    STAR Protoc, November 20, 2021

    C Ren and Takaki Komiyama

  33. Neural population geometry: An approach for understanding biological and artificial neural networks

    Curr Opin Neurobiol, November 19, 2021

    S Chung and Larry Abbott

  34. Context-dependent persistency as a coding mechanism for robust and widely distributed value coding

    Neuron, November 18, 2021

    R Hattori and Takaki Komiyama

  35. Flexible simultaneous mesoscale two-photon imaging of neural activity at high speeds

    Nat Commun, November 17, 2021

    M Clough, IA Chen, SW Park, AM Ahrens, JN Stirman, Spencer Smith, et al.

  36. Diesel2p mesoscope with dual independent scan engines for flexible capture of dynamics in distributed neural circuitry

    Nat Commun, November 17, 2021

    CH Yu, JN Stirman, Y Yu, R Hira, and Spencer Smith

  37. Revealing nonlinear neural decoding by analyzing choices

    Nature Communications, November 16, 2021

    Q Yang, E Walker, RJ Cotton, AS Tolias, and Xaq Pitkow

  38. Sequential and efficient neural-population coding of complex task information

    Neuron, November 13, 2021

    SA Koay, AS Charles, SY Thiberge, Carlos Brody, and David W. Tank

  39. Primary visual cortex straightens natural video trajectories

    Nat Commun, November 13, 2021

    OJ Hénaff, Y Bai, JA Charlton, I Nauhaus, Eero P. Simoncelli, and RLT Goris

  40. Accurate Localization of Linear Probe Electrode Arrays across Multiple Brains

    eNeuro, November 12, 2021

    LD Liu, S Chen, H Hou, SJ West, M Faulkner, MN Economo, et al.

  41. Unsupervised deep learning identifies semantic disentanglement in single inferotemporal face patch neurons

    Nat Commun, November 9, 2021

    I Higgins, L Chang, V Langston, D Hassabis, C Summerfield, Doris Tsao, et al.

  42. Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways

    Nat Neurosci, November 9, 2021

    A Zolin, R Cohn, R Pang, AF Siliciano, Adrienne Fairhall, and Vanessa Ruta

  43. Striatal indirect pathway mediates exploration via collicular competition

    Nature, November 3, 2021

    J Lee and Bernardo Sabatini

  44. Reverse engineering recurrent neural networks with Jacobian switching linear dynamical systems

    Advances in Neural Information Processing Systems (NeurIPS), November 1, 2021

    JTH Smith, SW Linderman, and David Sussillo

  45. 50 years of mnemonic persistent activity: quo vadis?

    Trends Neurosci, November 1, 2021

    Xiao-Jing Wang

  46. Supervised multisensory calibration signals are evident in VIP but not MSTd

    J Neurosci, October 29, 2021

    A Zaidel, J Laurens, GC DeAngelis, and Dora Angelaki

  47. Metastable attractors explain the variable timing of stable behavioral action sequences

    Neuron, October 29, 2021

    S Recanatesi, U Pereira-Obilinovic, M Murakami, Zachary Mainen, and L Mazzucato

  48. Individual bitter-sensing neurons in Drosophila exhibit both ON and OFF responses that influence synaptic plasticity

    Curr Biol, October 28, 2021

    AV Devineni, JU Deere, B Sun, and Richard Axel

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