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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Neural Algorithms and Circuits for Motor Planning

    Annu Rev Neurosci, July 8, 2022

    HK Inagaki, S Chen, K Daie, A Finkelstein, L Fontolan, S Romani, et al.

  2. Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

    Nat Neurosci, July 7, 2022

    C Kjaerby, M Andersen, N Hauglund, V Untiet, C Dall, B Sigurdsson, et al.

  3. A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning

    Nat Neurosci, July 7, 2022

    R Amo, S Matias, A Yamanaka, KF Tanaka, Naoshige Uchida, and M Watabe-Uchida

  4. A Theoretical Framework for Human and Nonhuman Vocal Interaction

    Annual Review of Neuroscience, July 7, 2022

    GA Castellucci, FH Guenther, and Michael A. Long

  5. Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer's disease

    Nat Commun, July 6, 2022

    H Mestre, N Verma, TD Greene, LA Lin, A Ladron-de-Guevara, AM Sweeney, et al.

  6. A transcriptomic axis predicts state modulation of cortical interneurons

    Nature, July 6, 2022

    S Bugeon, J Duffield, M Dipoppa, A Ritoux, I Prankerd, D Nicoloutsopoulos, et al.

  7. A call for more clarity around causality in neuroscience

    Trends Neurosci, July 6, 2022

    DL Barack, EK Miller, CI Moore, AM Packer, L Pessoa, LN Ross, et al.

  8. Action suppression reveals opponent parallel control via striatal circuits

    Nature, July 6, 2022

    BF Cruz, G Guiomar, S Soares, A Motiwala, Christian Machens, and Joseph Paton

  9. Oculomotor plant and neural dynamics suggest gaze control requires integration on distributed timescales

    J Physiol, July 5, 2022

    Andrew Miri, BJ Bhasin, Emre Aksay, David W. Tank, and Mark S. Goldman

  10. A set of hub neurons and non-local connectivity features support global brain dynamics in C. elegans

    Curr Biol, July 1, 2022

    K Uzel, S Kato, and Manuel Zimmer

  11. Freezing revisited: coordinated autonomic and central optimization of threat coping

    Nat Rev Neurosci, June 27, 2022

    K Roelofs and Peter Dayan

  12. Gradient-based learning drives robust representations in recurrent neural networks by balancing compression and expansion

    Nature Machine Intelligence, June 22, 2022

    M Farrell, S Recanatesi, T Moore, Guillaume Lajoie, and E Shea-Brown

  13. Towards a more general understanding of the algorithmic utility of recurrent connections

    PLoS Comput Biol, June 21, 2022

    BW Larsen and Shaul Druckmann

  14. Recurrent Connections in the Primate Ventral Visual Stream Mediate a Trade-Off Between Task Performance and Network Size During Core Object Recognition

    Neural Comput, June 20, 2022

    A Nayebi, J Sagastuy-Brena, DM Bear, K Kar, J Kubilius, Surya Ganguli, et al.

  15. Unraveling protein dynamics to understand the brain - the next molecular frontier

    Mol Neurodegener, June 18, 2022

    KD Brewer, SM Shi, and Tony Wyss-Coray

  16. Measuring biological age using omics data

    Nature Reviews Genetics, June 17, 2022

    J Rutledge, H Oh, and Tony Wyss-Coray

  17. Multiple timescales of sensory-evidence accumulation across the dorsal cortex

    Elife, June 16, 2022

    Lucas Pinto, David W. Tank, and Carlos Brody

  18. Emerging principles of spacetime in brains: Meeting report on spatial neurodynamics

    Neuron, June 15, 2022

    S Grün, J Li, B McNaughton, C Petersen, D McCormick, D Robson, et al.

  19. Dynamic task-belief is an integral part of decision-making

    Neuron, June 13, 2022

    C Xue, LE Kramer, and Marlene Cohen

  20. Efficient coding of cognitive variables underlies dopamine response and choice behavior

    Nat Neurosci, June 10, 2022

    A Motiwala, S Soares, BV Atallah, Joseph Paton, and Christian Machens

  21. Stable choice coding in rat frontal orienting fields across model-predicted changes of mind

    Nat Commun, June 10, 2022

    JT Boyd-Meredith, AT Piet, EJ Dennis, A El Hady, and Carlos Brody

  22. Dynamic causal communication channels between neocortical areas

    Neuron, June 7, 2022

    M Javadzadeh and Sonja Hofer

  23. Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment

    J Theor Biol, June 7, 2022

    A Ladrón-de-Guevara, JK Shang, Maiken Nedergaard, and DH Kelley

  24. A general decoding strategy explains the relationship between behavior and correlated variability

    Elife, June 6, 2022

    Amy Ni, C Huang, Brent Doiron, and Marlene Cohen

  25. Conserved circuits for direction selectivity in the primate retina

    Curr Biol, June 6, 2022

    SS Patterson, BN Bembry, MA Mazzaferri, M Neitz, Fred Rieke, R Soetedjo, et al.

  26. Learning binds new inputs into functional synaptic clusters via spinogenesis

    Nat Neurosci, June 3, 2022

    NG Hedrick, Z Lu, E Bushong, S Singhi, P Nguyen, Y Magaña, et al.

  27. Internally generated population activity in cortical networks hinders information transmission

    Sci Adv, June 3, 2022

    Chengcheng Huang, Alexandre Pouget, and Brent Doiron

  28. Learning binds new inputs into functional synaptic clusters via spinogenesis

    Nat Neurosci, June 2, 2022

    NG Hedrick, Z Lu, E Bushong, S Singhi, P Nguyen, Y Magaña, et al.

  29. A neural mechanism for detecting object motion during self-motion

    Elife, June 1, 2022

    HR Kim, Dora Angelaki, and GC DeAngelis

  30. Minian, an open-source miniscope analysis pipeline

    Elife, June 1, 2022

    Z Dong, W Mau, Y Feng, ZT Pennington, L Chen, Y Zaki, et al.

  31. Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes

    Cell Rep, May 31, 2022

    W Fleming, J Lee, BA, SS Bolkan, and Ilana Witten

  32. Sensory Evidence Accumulation Using Optic Flow in a Naturalistic Navigation Task

    J Neurosci, May 31, 2022

    P Alefantis, KJ Lakshminarasimhan, E Avila, JP Noel, Xaq Pitkow, and Dora Angelaki

  33. The geometry of robustness in spiking neural networks

    Elife, May 30, 2022

    N Calaim, FA Dehmelt, PJ Gonçalves, and Christian Machens

  34. Motor cortex activity across movement speeds is predicted by network-level strategies for generating muscle activity

    eLife, May 27, 2022

    S Saxena, AA Russo, John Cunningham, and Mark M. Churchland

  35. Limitations of a proposed correction for slow drifts in decision criterion

    NBDT, May 24, 2022

    D Gupta and Carlos Brody

  36. Learning, fast and slow

    Curr Opin Neurobiol, May 23, 2022

    Markus Meister

  37. Emergent reliability in sensory cortical coding and inter-area communication

    Nature, May 19, 2022

    S Ebrahimi, J Lecoq, O Rumyantsev, T Tasci, Y Zhang, C Irimia, et al.

  38. Selective representations of texture and motion in mouse higher visual areas

    Curr Biol, May 17, 2022

    Y Yu, JN Stirman, CR Dorsett, and Spencer Smith

  39. Choice-selective sequences dominate in cortical relative to thalamic inputs to NAc to support reinforcement learning

    Cell Rep, May 17, 2022

    NF Parker, A Baidya, J Cox, LM Haetzel, A Zhukovskaya, M Murugan, et al.

  40. Physiological Mechanisms and Significance of Intracranial B Waves

    Front Neurol, May 16, 2022

    DW Newell, Maiken Nedergaard, and R Aaslid

  41. The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans

    Science, May 13, 2022

    Tabula Sapiens Consortium, et al.

  42. Global and subtype-specific modulation of cortical inhibitory neurons regulated by acetylcholine during motor learning

    Neuron, May 12, 2022

    C Ren, K Peng, R Yang, W Liu, C Liu, and Takaki Komiyama

  43. Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish

    Nat Commun, May 11, 2022

    CL Wee, E Song, M Nikitchenko, KJ Herrera, S Wong, Florian Engert, et al.

  44. Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17

    Nature, May 11, 2022

    T Iram, F Kern, A Kaur, S Myneni, AR Morningstar, H Shin, et al.

  45. Neurofeedback through the lens of reinforcement learning

    Trends Neurosci, May 9, 2022

    N Lubianiker, C Paret, Peter Dayan, and T Hendler

  46. GraFT: Graph Filtered Temporal Dictionary Learning for Functional Neural Imaging

    IEEE Trans Image Process, May 9, 2022

    AS Charles, N Cermak, R Affan, B Scott, J Schiller, and Gal Mishne

  47. The geometry of domain-general performance monitoring in the human medial frontal cortex

    Science, May 6, 2022

    Z Fu, D Beam, JM Chung, CM Reed, AN Mamelak, Ralph Adolphs, et al.

  48. Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits

    Sci Adv, May 6, 2022

    D Yu, T Li, JC Delpech, B Zhu, P Kishore, T Koshi, et al.

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