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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Value representation in the monkey hippocampus

    Trends Cogn Sci, October 27, 2021

    SM Landi and Elizabeth A. Buffalo

  2. Olfactory landmarks and path integration converge to form a cognitive spatial map

    Neuron, October 25, 2021

    W Fischler-Ruiz, DG Clark, N Joshi, V Devi-Chou, L Kitch, Mark Schnitzer, et al.

  3. Subpopulations of neurons in lOFC encode previous and current rewards at time of choice

    Elife, October 25, 2021

    DL Hocker, Carlos Brody, C Savin, and CM Constantinople

  4. Rats use memory confidence to guide decisions

    Curr Biol, October 25, 2021

    HR Joo, H Liang, JE Chung, C Geaghan-Breiner, JL Fan, BP Nachman, et al.

  5. Attention improves information flow between neuronal populations without changing the communication subspace

    Curr Biol, October 20, 2021

    R Srinath, DA Ruff, and Marlene Cohen

  6. Flexible filtering by neural inputs supports motion computation across states and stimuli

    Curr Biol, October 14, 2021

    JR Kohn, JP Portes, MP Christenson, Larry Abbott, and R Behnia

  7. How learning unfolds in the brain: toward an optimization view

    Neuron, October 8, 2021

    JA Hennig, ER Oby, DM Losey, AP Batista, Byron Yu, and SM Chase

  8. Cellular anatomy of the mouse primary motor cortex

    Nature, October 7, 2021

    R Muñoz-Castañeda, et al.

  9. Evolving the olfactory system with machine learning

    Neuron, October 6, 2021

    PY Wang, Y Sun, Richard Axel, Larry Abbott, and GR Yang

  10. The Learning Salon: Toward a new participatory science

    Neuron, October 6, 2021

    I Momennejad, JW Krakauer, C Sun, E Yezerets, Kanaka Rajan, JT Vogelstein, et al.

  11. Spatial modulation of hippocampal activity in freely moving macaques

    Neuron, October 1, 2021

    D Mao, E Avila, B Caziot, J Laurens, JD Dickman, and Dora Angelaki

  12. Bayesian inference with incomplete knowledge explains perceptual confidence and its deviations from accuracy

    Nat Commun, September 29, 2021

    K Khalvati, Roozbeh Kiani, and RPN Rao

  13. Hippocampal replay of experience at real-world speeds

    Elife, September 27, 2021

    EL Denovellis, Anna Gillespie, ME Coulter, M Sosa, JE Chung, Uri Eden, et al.

  14. A stable population code for attention in prefrontal cortex leads a dynamic attention code in visual cortex

    J Neurosci, September 27, 2021

    AC Snyder, Byron Yu, and MA Smith

  15. Partitioning variability in animal behavioral videos using semi-supervised variational autoencoders

    PLoS Comput Biol, September 22, 2021

    MR Whiteway, D Biderman, Y Friedman, M Dipoppa, EK Buchanan, A Wu, et al.

  16. Cognitive, Systems, and Computational Neurosciences of the Self in Motion

    Annu Rev Psychol, September 21, 2021

    JP Noel and Dora Angelaki

  17. Improving rigor and reproducibility in nonhuman primate research

    Am J Primatol, September 20, 2021

    E Bliss-Moreau, RR Amara, Elizabeth A. Buffalo, RJ Colman, ME Embers, JH Morrison, et al.

  18. A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging

    Nat Neurosci, September 16, 2021

    P Rupprecht, S Carta, A Hoffmann, M Echizen, A Blot, AC Kwan, et al.

  19. Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation

    PLoS Biol, September 16, 2021

    JY Yu and Loren Frank

  20. Interpreting neural computations by examining intrinsic and embedding dimensionality of neural activity

    Curr Opin Neurobiol, September 16, 2021

    Mehrdad Jazayeri and S Ostojic

  21. A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex

    Neuron, September 15, 2021

    S Froudist-Walsh, DP Bliss, X Ding, L Rapan, M Niu, K Knoblauch, et al.

  22. A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex

    Neuron, September 15, 2021

    N Meirhaeghe, H Sohn, and Mehrdad Jazayeri

  23. Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

    Elife, September 14, 2021

    D London, A Fazl, K Katlowitz, M Soula, M Pourfar, A Mogilner, et al.

  24. Predictive encoding of motion begins in the primate retina

    Nat Neurosci, September 13, 2021

    B Liu, A Hong, Fred Rieke, and MB Manookin

  25. Distance-tuned neurons drive specialized path integration calculations in medial entorhinal cortex

    Cell Rep, September 7, 2021

    MG Campbell, A Attinger, SA Ocko, Surya Ganguli, and Lisa Giocomo

  26. Electrode pooling can boost the yield of extracellular recordings with switchable silicon probes

    Nat Commun, September 2, 2021

    KH Lee, YL Ni, J Colonell, B Karsh, J Putzeys, M Pachitariu, et al.

  27. Mechanosensory input during circuit formation shapes Drosophila motor behavior through patterned spontaneous network activity

    Curr Biol, September 1, 2021

    A Carreira-Rosario, RA York, M Choi, CQ Doe, and Thomas R. Clandinin

  28. Chronically implantable LED arrays for behavioral optogenetics in primates

    Nat Methods, August 30, 2021

    R Rajalingham, M Sorenson, R Azadi, S Bohn, James DiCarlo, and A Afraz

  29. What is the dynamical regime of cerebral cortex?

    Neuron, August 30, 2021

    Y Ahmadian and Kenneth Miller

  30. Decoding locomotion from population neural activity in moving C. elegans

    Elife, August 29, 2021

    KM Hallinen, R Dempsey, M Scholz, X Yu, A Linder, F Randi, et al.

  31. The grid code for ordered experience

    Nat Rev Neurosci, August 27, 2021

    JW Rueckemann, M Sosa, Lisa Giocomo, and Elizabeth A. Buffalo

  32. What is the dynamical regime of cerebral cortex?

    Neuron, August 26, 2021

    Y Ahmadian and Kenneth Miller

  33. Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice

    Neuron, August 23, 2021

    Anna Gillespie, DA Astudillo Maya, EL Denovellis, DF Liu, DB Kastner, ME Coulter, et al.

  34. Using focal cooling to link neural dynamics and behavior

    Neuron, August 18, 2021

    A Banerjee, R Egger, and Michael A. Long

  35. Joint encoding of facial identity, orientation, gaze, and expression in the middle dorsal face area

    Proc Natl Acad Sci U S A, August 17, 2021

    Z Yang and Winrich Freiwald

  36. Locally ordered representation of 3D space in the entorhinal cortex

    Nature, August 11, 2021

    G Ginosar, J Aljadeff, Y Burak, Haim Sompolinsky, L Las, and N Ulanovsky

  37. Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by non-visual input

    J Neurophysiol, August 4, 2021

    A Fanning, A Shakhawat, and Jennifer Raymond

  38. Predictive encoding of motion begins in the primate retina

    Nat Neurosci, August 2, 2021

    B Liu, A Hong, Fred Rieke, and MB Manookin

  39. A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging

    Nat Neurosci, August 2, 2021

    P Rupprecht, S Carta, A Hoffmann, M Echizen, A Blot, AC Kwan, et al.

  40. Sensory coding and the causal impact of mouse cortex in a visual decision

    Elife, July 30, 2021

    P Zatka-Haas, Nick Steinmetz, and Matteo Carandini

  41. Dynamic and reversible remapping of network representations in an unchanging environment

    Neuron, July 30, 2021

    IIC Low, AH Williams, MG Campbell, Scott Linderman, and Lisa Giocomo

  42. Interrogating theoretical models of neural computation with emergent property inference

    Elife, July 29, 2021

    SR Bittner, Agostina Palmigiano, AT Piet, Chunyu Ann Duan, Carlos Brody, Kenneth Miller, et al.

  43. Active dendrites enable strong but sparse inputs to determine orientation selectivity

    Proc Natl Acad Sci U S A., July 27, 2021

    L Goetz, A Roth, and Michael Hausser

  44. Structural Attributes and Principles of the Neocortical Connectome in the Marmoset Monkey

    Cereb Cortex, July 19, 2021

    P Theodoni, P Majka, DH Reser, DK Wójcik, MGP Rosa, and Xiao-Jing Wang

  45. Remembering the Past to See the Future

    Annu Rev Vis Sci, July 16, 2021

    Nicole Rust and SE Palmer

  46. Bridging neuronal correlations and dimensionality reduction

    Neuron, July 16, 2021

    A Umakantha, R Morina, BR Cowley, AC Snyder, MA Smith, and Byron Yu

  47. Fast deep neural correspondence for tracking and identifying neurons in C. elegans using semi-synthetic training

    Elife, July 14, 2021

    X Yu, MS Creamer, F Randi, AK Sharma, Scott Linderman, and Andrew Leifer

  48. Dopamine axons in dorsal striatum encode contralateral visual stimuli and choices

    J Neurosci, July 12, 2021

    MM Moss, P Zatka-Haas, Matteo Carandini, and A Lak

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