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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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We convene scientists, mathematicians, and thinkers to share ideas and explore new questions.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. On the dimensionality of behavior

    Proc Natl Acad Sci U S A, May 3, 2022

    William Bialek

  2. Cholinergic interneurons mediate cocaine extinction in male mice through plasticity across medium spiny neuron subtypes

    Cell Rep, May 3, 2022

    W Fleming, J Lee, BA Briones, SS Bolkan, and Ilana Witten

  3. On the dimensionality of behavior

    Proc Natl Acad Sci U S A, May 3, 2022

    William Bialek

  4. Nutrition, longevity and disease: From molecular mechanisms to interventions

    Cell, April 28, 2022

    VD Longo and Rozalyn Anderson

  5. PatchWarp: Corrections of non-uniform image distortions in two-photon calcium imaging data by patchwork affine transformations

    Cell Rep Methods, April 27, 2022

    R Hattori and Takaki Komiyama

  6. Methylphenidate as a causal test of translational and basic neural coding hypotheses

    Proc Natl Acad Sci U S A ., April 26, 2022

    Amy Ni, BS Bowes, DA Ruff, and Marlene Cohen

  7. Longitudinal two-photon calcium imaging with ultra-large cranial window for head-fixed mice

    STAR Protoc, April 22, 2022

    R Hattori and Takaki Komiyama

  8. Modulation of inhibitory communication coordinates looking and reaching

    Nature, April 20, 2022

    MA Hagan and Bijan Pesaran

  9. Reward signals in the cerebellum: Origins, targets, and functional implications

    Neuron, April 20, 2022

    D Kostadinov and Michael Hausser

  10. Spatial preferences account for inter-animal variability during the continual learning of a dynamic cognitive task

    Cell Rep, April 19, 2022

    DB Kastner, EA Miller, Z Yang, DK Roumis, DF Liu, Loren Frank, et al.

  11. Direct Discriminative Decoder Models for Analysis of High-Dimensional Dynamical Neural Data

    Neural Comput, April 15, 2022

    MR Rezaei, AE Hadjinicolaou, SS Cash, Uri Eden, and A Yousefi

  12. Direct Discriminative Decoder Models for Analysis of High-Dimensional Dynamical Neural Data

    Neural Comput, April 15, 2022

    MR Rezaei, AE Hadjinicolaou, SS Cash, Uri Eden, and A Yousefi

  13. A network model of glymphatic flow under different experimentally-motivated parametric scenarios

    iScience, April 14, 2022

    J Tithof, KAS Boster, PAR Bork, Maiken Nedergaard, JH Thomas, and DH Kelley

  14. Signatures of rapid plasticity in hippocampal CA1 representations during novel experiences

    Neuron, April 14, 2022

    JB Priestley, JC Bowler, SV Rolotti, Stefano Fusi, and A Losonczy

  15. MR spectroscopy frequency and phase correction using convolutional neural networks

    Magn Reson Med, April 12, 2022

    DJ Ma, HA Le, Y Ye, AF Laine, JA Lieberman, DL Rothman, et al.

  16. Priority coding in the visual system

    Nat Rev Neurosci, April 11, 2022

    Nicole Rust and Marlene Cohen

  17. Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures

    Nature Aging, April 11, 2022

    SR Shuken, J Rutledge, T Iram, PM Losada, EN Wilson, KI Andreasson, et al.

  18. Resilience integrates concepts in aging research

    iScience, April 8, 2022

    D Promislow, Rozalyn Anderson, M Scheffer, B Crespi, J DeGregori, K Harris, et al.

  19. Blind demixing methods for recovering dense neuronal morphology from barcode imaging data

    PLoS Comput Biol, April 8, 2022

    S Chen, J Loper, P Zhou, and Liam Paninski

  20. KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice

    J Neurosci, April 6, 2022

    S Gupta, AJ Moreno, D Wang, J Leon, C Chen, O Hahn, et al.

  21. Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons

    Neuron, April 5, 2022

    JM Stujenske, PK O'Neill, C Fernandes-Henriques, I Nahmoud, SR Goldburg, A Singh, et al.

  22. SLEAP: A deep learning system for multi-animal pose tracking

    Nat Methods, April 4, 2022

    TD Pereira, N Tabris, A Matsliah, DM Turner, J Li, S Ravindranath, et al.

  23. Deep-learning based identification, tracking, pose estimation, and behavior classification of interacting primates and mice in complex environments

    Nat Mach Intell, April 4, 2022

    M Marks, J Qiuhan, O Sturman, L von Ziegler, S Kollmorgen, Valerio Mante, et al.

  24. Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion

    Nat Commun, March 30, 2022

    AJ Christensen and Jonathan Pillow

  25. Dopamine neurons evaluate natural fluctuations in performance quality

    Cell Rep, March 29, 2022

    A Duffy, KW Latimer, JH Goldberg, Adrienne Fairhall, and Vikram Gadagkar

  26. A Variable Clock Underlies Internally Generated Hippocampal Sequences

    J Neurosci, March 28, 2022

    X Deng, S Chen, M Sosa, MP Karlsson, XX Wei, and Loren Frank

  27. Neural mechanisms of persistent aggression

    Curr Opin Neurobiol, March 25, 2022

    EM Guthman and Annegret Falkner

  28. Opponent control of behavior by dorsomedial striatal pathways depends on task demands and internal state

    Nat Neurosci, March 19, 2022

    SS Bolkan, IR Stone, Lucas Pinto, ZC Ashwood, JM Iravedra Garcia, AL Herman, et al.

  29. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Cell, March 17, 2022

    HK Inagaki, S Chen, MC Ridder, P Sah, N Li, Z Yang, et al.

  30. Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice

    Elife, March 17, 2022

    P Balasubramanian, AE Schaar, GE Gustafson, AB Smith, PR Howell, A Greenman, et al.

  31. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Cell, March 17, 2022

    HK Inagaki, S Chen, MC Ridder, P Sah, Nuo Li, Z Yang, et al.

  32. Reconstruction of neocortex: Organelles, compartments, cells, circuits, and activity

    Cell, March 17, 2022

    NL Turner, T Macrina, JA Bae, R Yang, AM Wilson, C Schneider-Mizell, et al.

  33. A midbrain-thalamus-cortex circuit reorganizes cortical dynamics to initiate movement

    Cell, March 17, 2022

    HK Inagaki, S Chen, MC Ridder, P Sah, N Li, Z Yang, et al.

  34. Treatment of a genetic brain disease by CNS-wide microglia replacement

    Sci Transl Med, March 16, 2022

    Y Shibuya, KK Kumar, MM Mader, Y Yoo, LA Ayala, M Zhou, et al.

  35. Cortical ensembles orchestrate social competition through hypothalamic outputs

    Nature, March 16, 2022

    N Padilla-Coreano, K Batra, M Patarino, Z Chen, RR Rock, R Zhang, et al.

  36. Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration

    Proc Natl Acad Sci U S A, March 15, 2022

    RT Vest, CC Chou, H Zhang, MS Haney, L Li, NN Laqtom, et al.

  37. Developmental and evolutionary constraints on olfactory circuit selection

    Proc Natl Acad Sci U S A, March 15, 2022

    N Hiratani and Peter Latham

  38. Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain

    Nature Neuroscience, March 8, 2022

    SE Marsh, AJ Walker, T Kamath, L Dissing-Olesen, TR Hammond, TY de Soysa, et al.

  39. Modeling multiscale causal interactions between spiking and field potential signals during behavior

    J Neural Eng, March 7, 2022

    C Wang, Bijan Pesaran, and MM Shanechi

  40. Molecular hallmarks of heterochronic parabiosis at single-cell resolution

    Neuron, March 2, 2022

    R Pálovics, A Keller, N Schaum, W Tan, T Fehlmann, M Borja, et al.

  41. Feedforward and feedback interactions between visual cortical areas use different population activity patterns

    Nat Commun, March 1, 2022

    JD Semedo, AI Jasper, A Zandvakili, A Krishna, A Aschner, Christian Machens, et al.

  42. Mechanisms of distributed working memory in a large-scale network of macaque neocortex

    eLife, February 24, 2022

    JF Mejías and Xiao-Jing Wang

  43. Blood-brain barrier permeable β-blockers linked to lower risk of Alzheimer's disease in hypertension

    Brain, February 23, 2022

    EE Beaman, AN Bonde, SM Ulv Larsen, B Ozenne, TJ Lohela, Maiken Nedergaard, et al.

  44. The Importance of Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes

    J Neurosci, February 23, 2022

    E Zagha, JC Erlich, S Lee, G Lur, DH O'Connor, Nick Steinmetz, et al.

  45. A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation

    eLife, February 22, 2022

    H Twarkowski, V Steininger, MJ Kim, and Amar Sahay

  46. Can we make drug discovery targeting fundamental mechanisms of aging a reality?

    Expert Opin Drug Discov, February 17, 2022

    DG Le Couteur, Rozalyn Anderson, and R de Cabo

  47. Novel elasticity measurements reveal C. elegans cuticle stiffens with age and in a long-lived mutant

    Biosphys, February 15, 2022

    M Rahimi, S Sohrabi, and Coleen T. Murphy

  48. A human brain vascular atlas reveals diverse mediators of Alzheimer's risk

    Nature, February 14, 2022

    AC Yang, RT Vest, F Kern, DP Lee, M Agam, CA Maat, et al.

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