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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Sparse balance: Excitatory-inhibitory networks with small bias currents and broadly distributed synaptic weights

    PLoS Comput Biol, February 9, 2022

    R Khajeh, F Fumarola, and Larry Abbott

  2. Hierarchical timescales in the neocortex: Mathematical mechanism and biological insights

    Proc Natl Acad Sci U S A, February 8, 2022

    S Li and Xiao-Jing Wang

  3. Cell types of origin of the cell-free transcriptome

    Nat Biotechnol, February 7, 2022

    SK Vorperian, MN Moufarrej, Tabula Sapiens Consortium, and SR Quake

  4. Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations

    J Neurosci, February 7, 2022

    H Helakari, V Korhonen, SC Holst, J Piispala, M Kallio, T Väyrynen, et al.

  5. Mice alternate between discrete strategies during perceptual decision-making

    Nat Neurosci, February 7, 2022

    ZC Ashwood, NA Roy, IR Stone, International Brain Laboratory, AE Urai, Anne K. Churchland, et al.

  6. Deep phenotyping of Alzheimer’s disease leveraging electronic medical records identifies sex-specific clinical associations

    Nature Communications, February 3, 2022

    AS Tang, T Oskotsky, S Havaldar, WG Mantyh, M Bicak, CW Solsberg, et al.

  7. High-performance microbial opsins for spatially and temporally precise perturbations of large neuronal networks

    Neuron, February 3, 2022

    S Sridharan, MA Gajowa, MB Ogando, UK Jagadisan, L Abdeladim, M Sadahiro, et al.

  8. Novel stimuli evoke excess activity in the mouse primary visual cortex

    Proc Natl Acad Sci U S A, February 1, 2022

    J Homann, SA Koay, KS Chen, David W. Tank, and MJ Berry 2nd

  9. Large-scale neural recordings with single neuron resolution using Neuropixels probes in human cortex

    Nat Neurosci, January 31, 2022

    AC Paulk, Y Kfir, AR Khanna, ML Mustroph, EM Trautmann, DJ Soper, et al.

  10. Sparse connectivity for MAP inference in linear models using sister mitral cells

    PLoS Comput Biol, January 31, 2022

    S Tootoonian, AT Schaefer, and Peter Latham

  11. A high-throughput method to deliver targeted optogenetic stimulation to moving C. elegans populations

    PLoS Biol, January 28, 2022

    M Liu, S Kumar, AK Sharma, and Andrew Leifer

  12. Meeting Report: Aging Research and Drug Discovery

    Aging (Albany NY), January 28, 2022

    E Meron, M Thaysen, S Angeli, A Antebi, N Barzilai, JA Baur, et al.

  13. Large-scale neural recordings call for new insights to link brain and behavior

    Nat Neurosci, January 28, 2022

    A Urai, Brent Doiron, Andrew Leifer, and Anne K. Churchland

  14. A high-throughput method to deliver targeted optogenetic stimulation to moving C. elegans populations

    PLoS Biol, January 28, 2022

    M Liu, S Kumar, AK Sharma, and Andrew Leifer

  15. The role of state uncertainty in the dynamics of dopamine

    Curr Biol, January 28, 2022

    JG Mikhael, HR Kim, Naoshige Uchida, and SJ Gershman

  16. FOS licenses early events in stem cell activation driving skeletal muscle regeneration

    Cell Rep., January 26, 2022

    AE Almada, N Horwitz, FD Price, AE Gonzalez, M Ko, OV Bolukbasi, et al.

  17. Cortical preparatory activity indexes learned motor memories

    Nature, January 26, 2022

    X Sun, DJ O'Shea, MD Golub, EM Trautmann, S Vyas, SI Ryu, et al.

  18. Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish

    Neuron, January 24, 2022

    UL Böhm, Y Kimura, T Kawashima, Misha Ahrens, SI Higashijima, Florian Engert, et al.

  19. The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer's disease

    Cell Rep, January 18, 2022

    YH Qureshi, DE Berman, SE Marsh, RL Klein, VM Patel, S Simoes, et al.

  20. Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

    Human Brain Mapp, January 13, 2022

    D Dima, et al.

  21. Lapses in perceptual decisions reflect exploration

    Elife, January 11, 2022

    S Pisupati, L Chartarifsky-Lynn, A Khanal, and Anne K. Churchland

  22. Fluorescence imaging of large-scale neural ensemble dynamics

    Cell, January 6, 2022

    TH Kim and Mark Schnitzer

  23. A speech planning network for interactive language use

    Nature, January 5, 2022

    GA Castellucci, CK Kovach, MA Howard 3rd, JDW Greenlee, and Michael A. Long

  24. Neurophotonic tools for microscopic measurements and manipulation: status report

    Neurophotonics, January 4, 2022

    AS Abdelfattah, S Ahuja, T Akkin, SR Allu, J Brake, DA Boas, et al.

  25. Transcriptional regulation of neural stem cell expansion in the adult hippocampus

    eLife, January 4, 2022

    N Guo, KD McDermott, YT Shih, H Zanga, D Ghosh, C Herber, et al.

  26. Circulating klotho is elevated in cerebrospinal fluid, but not serum, among KLOTHO KL-VS allele carriers at risk for Alzheimer’s disease

    Alzheimers Dement, December 31, 2021

    JM Gaitán, Dena Dubal, and OC Okonkwo

  27. Disruption of Brainstem Structural Connectivity in REM Sleep Behavior Disorder Using 7 Tesla Magnetic Resonance Imaging

    Mov Disord, December 29, 2021

    MG García-Gomar, A Videnovic, K Singh, M Stauder, Laura Lewis, LL Wald, et al.

  28. Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling

    Cell Rep, December 28, 2021

    S Simoes, J Guo, L Buitrago, YH Qureshi, X Feng, M Kothiya, et al.

  29. Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1

    Cell Rep., December 28, 2021

    EA Aery Jones, A Rao, M Zilberter, B Djukic, JS Bant, Anna Gillespie, et al.

  30. Make war not love: The neural substrate underlying a state-dependent switch in female social behavior

    Neuron, December 23, 2021

    M Liu, DW Kim, H Zeng, and David J. Anderson

  31. FlyWire: online community for whole-brain connectomics

    Nat Methods, December 23, 2021

    S Dorkenwald, CE McKellar, T Macrina, N Kemnitz, K Lee, R Lu, et al.

  32. Direct Measurement of Cerebrospinal Fluid Production in Mice

    Cell Rep, December 22, 2021

    G Liu, H Mestre, AM Sweeney, Q Sun, P Weikop, T Du, et al.

  33. A transcriptional rheostat couples past activity to future sensory responses

    Cell, December 22, 2021

    T Tsukahara, H Brann, SL Pashkovski, G Guitchounts, T Bozza, and Sandeep Robert Datta

  34. Spatial maps in piriform cortex during olfactory navigation

    Nature, December 22, 2021

    Cindy Poo, G Agarwal, N Bonacchi, and Zachary Mainen

  35. Supramammillary regulation of locomotion and hippocampal activity

    Science, December 17, 2021

    JS Farrell, M Lovett-Barron, PM Klein, FT Sparks, T Gschwind, AL Ortiz, et al.

  36. Supramammillary regulation of locomotion and hippocampal activity

    Science, December 17, 2021

    JS Farrell, M Lovett-Barron, PM Klein, FT Sparks, T Gschwind, AL Ortiz, et al.

  37. Transforming representations of movement from body- to world-centric space

    Nature, December 15, 2021

    J Lu, AH Behbahani, L Hamburg, EA Westeinde, PM Dawson, C Lyu, et al.

  38. A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory

    Cell Rep, December 15, 2021

    JY Choi, HJ Jang, S Ornelas, WT Fleming, D Fürth, J Au, et al.

  39. Building an allocentric travelling direction signal via vector computation

    Nature, December 15, 2021

    C Lyu, Larry Abbott, and G Maimon

  40. Learning and attention increase visual response selectivity through distinct mechanisms

    Neuron, December 9, 2021

    J Poort, KA Wilmes, A Blot, A Chadwick, Maneesh Sahani, C Clopath, et al.

  41. Exercise plasma boosts memory and dampens brain inflammation via clusterin

    Nature, December 8, 2021

    Z De Miguel, N Khoury, MJ Betley, B Lehallier, D Willoughby, N Olsson, et al.

  42. Supervised Multisensory Calibration Signals Are Evident in VIP But Not MSTd

    J Neurosci, December 8, 2021

    A Zaidel, J Laurens, GC DeAngelis, and Dora Angelaki

  43. Pregnancy, preeclampsia and maternal aging: From epidemiology to functional genomics

    Ageing Res Rev, December 3, 2021

    EC Miller, A Wilczek, NA Bello, S Tom, R Wapner, and Yousin Suh

  44. Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics

    Am J Hum Genet, December 2, 2021

    Z He, Y Le Guen, L Liu, J Lee, S Ma, AC Yang, et al.

  45. The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Elife, https://pubmed.ncbi.nlm.nih.gov/34846301/, November 30, 2021

    C Segalin, J Williams, T Karigo, M Hui, M Zelikowsky, JJ Sun, et al.

  46. The Mouse Action Recognition System (MARS) software pipeline for automated analysis of social behaviors in mice

    Elife, November 30, 2021

    C Segalin, J Williams, T Karigo, M Hui, M Zelikowsky, JJ Sun, et al.

  47. Estimating the dimensionality of the manifold underlying multi-electrode neural recordings

    PLoS Comput Biol, November 29, 2021

    E Altan, SA Solla, LE Miller, and EJ Perreault

  48. Dynamics on the manifold: Identifying computational dynamical activity from neural population recordings

    Curr Opin Neurobiol, November 24, 2021

    L Duncker and Maneesh Sahani

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