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Bringing people and ideas together to fund, conduct, and share transformative science.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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  1. Learning is shaped by abrupt changes in neural engagement

    Nat Neurosci, March 29, 2021

    JA Hennig, EF Oby, MD Golub, LA Bahureksa, PT Sadtler, KM Quick, et al.

  2. Combining Brain Perturbation and Neuroimaging in Non-human Primates

    Neuroimage, March 29, 2021

    PC Klink, JF Aubry, VP Ferrera, AS Fox, S Froudist-Walsh, B Jarraya, et al.

  3. The connectome predicts resting-state functional connectivity across the Drosophila brain

    Curr Biol, March 23, 2021

    MH Turner, K Mann, and Thomas R. Clandinin

  4. Experience-dependent contextual codes in the hippocampus

    Nat Neurosci, March 22, 2021

    MH Plitt and Lisa Giocomo

  5. Prefrontal cortex represents heuristics that shape choice bias and its integration into future behavior

    Curr Biol, March 22, 2021

    G Mochol, Roozbeh Kiani, and R Moreno-Bote

  6. Nonequilibrium Green's Functions for Functional Connectivity in the Brain

    Phys Rev Lett, March 19, 2021

    Francesco Randi and Andrew Leifer

  7. Synaptic plasticity as Bayesian inference

    Nat Neurosci, March 11, 2021

    L Aitchison, J Jegminat, JA Menendez, JP Pfister, Alexandre Pouget, and Peter Latham

  8. BARcode DEmixing through Non-negative Spatial Regression (BarDensr)

    PLoS Comput Biol, March 8, 2021

    S Chen, J Loper, X Chen, A Vaughan, Anthony Zador, and Liam Paninski

  9. Limited Evidence for Sensory Prediction Error Responses in Visual Cortex of Macaques and Humans

    Cereb Cortex, March 4, 2021

    SS Solomon, H Tang, E Sussman, and Adam Kohn

  10. Nonlinear convergence boosts information coding in circuits with parallel outputs

    Proc Natl Acad Sci U S A, February 23, 2021

    GJ Gutierrez, Fred Rieke, and ET Shea-Brown

  11. Independent generation of sequence elements by motor cortex

    Nat Neuro, February 22, 2021

    AJ Zimnik and Mark M. Churchland

  12. Distributed chromatic processing at the interface between retina and brain in the larval zebrafish

    Curr Biol, February 19, 2021

    DA Guggiana Nilo, C Riegler, M Hübener, and Florian Engert

  13. Topography in the Bursting Dynamics of Entorhinal Neurons

    Cell Rep, February 18, 2021

    JS Bant, K Hardcastle, SA Ocko, and Lisa Giocomo

  14. Extracting the dynamics of behavior in sensory decision-making experiments

    Neuron, February 17, 2021

    NA Roy, JH Bak, International Brain Laboratory, A Akrami, Carlos Brody, and Jonathan Pillow

  15. Investigating the representation of uncertainty in neuronal circuits

    PLoS Comput Biol, February 12, 2021

    GP Dehaene, R Coen-Cagli, and Alexandre Pouget

  16. Implanting and Recycling Neuropixels Probes for Recordings in Freely Moving Mice

    Bio Protoc, February 5, 2021

    AL Juavinett, G Bekheet, and Anne K. Churchland

  17. Spatial modulation of visual responses arises in cortex with active navigation

    Elife, February 4, 2021

    EM Diamanti, CB Reddy, S Schröder, T Muzzu, AB Saleem, and Matteo Carandini

  18. Systems Neuroscience of Natural Behaviors in Rodents

    J Neurosci, February 3, 2021

    EJ Dennis, A Hady, A Michaiel, A Clemens, DRG Tervo, J Voigts, et al.

  19. DYNAMICS OF HEADING AND CHOICE-RELATED SIGNALS IN THE PARIETO-INSULAR VESTIBULAR CORTEX OF MACAQUE MONKEYS

    J Neurosci, February 2, 2021

    A Chen, F Zeng, GC DeAngelis, and Dora Angelaki

  20. New role for circuit expansion for learning in neural networks

    Phys Rev E, February 1, 2021

    J Steinberg, M Advani, and Haim Sompolinsky

  21. Modelling and prediction of the dynamic responses of large-scale brain networks during direct electrical stimulation

    Nat Biomed Eng, February 1, 2021

    Y Yang, S Qiao, OG Sani, JI Sedillo, B Ferrentino, Bijan Pesaran, et al.

  22. Mouse entorhinal cortex encodes a diverse repertoire of self-motion signals

    Nat Commun., January 28, 2021

    CS Mallory, K Hardcastle, MG Campbell, A Attinger, IIC Low, Jennifer Raymond, et al.

  23. Measurement, manipulation and modeling of brain-wide neural population dynamics

    Nat Commun., January 27, 2021

    Krishna Shenoy and JC Kao

  24. Multiscale low-dimensional motor cortical state dynamics predict naturalistic reach-and-grasp behavior

    Nat Commun., January 27, 2021

    H Abbaspourazad, M Choudhury, YT Wong, Bijan Pesaran, and MM Shanechi

  25. Targeted photostimulation uncovers circuit motifs supporting short-term memory

    Nat Neurosci., January 25, 2021

    K Daie, Karel Svoboda, and Shaul Druckmann

  26. The Neural Representation of Force across Grasp Types in Motor Cortex of Humans with Tetraplegia

    eNeuro, January 22, 2021

    A Rastogi, FR Willett, J Abreu, DC Crowder, BA Murphy, WD Memberg, et al.

  27. Decoding and perturbing decision states in real time

    Nature, January 20, 2021

    D Peixoto, JR Verhein, Roozbeh Kiani, JC Kao, P Nuyujukian, C Chandrasekaran, et al.

  28. Striatal activity topographically reflects cortical activity

    Nature, January 20, 2021

    AJ Peters, JMJ Fabre, Nick Steinmetz, and Matteo Carandini

  29. Unsupervised neural network models of the ventral visual stream

    Proc Natl Acad Sci U S A., January 19, 2021

    C Zhuang, S Yan, A Nayebi, M Schrimpf, MC Frank, James DiCarlo, et al.

  30. The geometry of neuronal representations during rule learning reveals complementary roles of cingulate cortex and putamen

    Neuron, January 16, 2021

    Y Cohen, Elad Schneidman, and R Paz

  31. Supporting generalization in non-human primate behavior by tapping into structural knowledge: Examples from sensorimotor mappings, inference, and decision-making

    Prog Neurobiol., January 14, 2021

    JP Noel, B Caziot, S Bruni, NE Fitzgerald, E Avila, and Dora Angelaki

  32. Recurrent network dynamics shape direction selectivity in primary auditory cortex

    Nat Commun., January 12, 2021

    DA Aponte, G Handy, AM Kline, H Tsukano, Brent Doiron, and HK Kato

  33. Lapses in perceptual decisions reflect exploration

    Elife, January 11, 2021

    S Pisupati, L Chartarifsky-Lynn, A Khanal, and Anne K. Churchland

  34. Citric Acid Water as an Alternative to Water Restriction for High-Yield Mouse Behavior

    eNeuro, January 8, 2021

    AE Urai, V Aguillon-Rodriguez, IC Laranjeira, F Cazettes, International Brain Lab, Zachary Mainen, et al.

  35. Social isolation uncovers a circuit underlying context-dependent territory-covering micturition

    Proc Natl Acad Sci U S A, January 5, 2021

    M Hyun, J Taranda, G Radeljic, L Miner, W Wang, N Ochandarena, et al.

  36. Multiregional communication and the channel modulation hypothesis

    Curr Opin Neurobiol., December 24, 2020

    Bijan Pesaran, M Hagan, S Qiao, and R Shewcraft

  37. NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans

    Cell, December 23, 2020

    E Yemini, A Lin, A Nejatbakhsh, E Varol, R Sun, GE Mena, et al.

  38. A Disinhibitory Circuit for Contextual Modulation in Primary Visual Cortex

    Neuron, December 23, 2020

    AJ Kellar, M Dipoppa, MM Roth, MS Caudill, A Ingrosso, Kenneth Miller, et al.

  39. A circuit logic for sexually shared and dimorphic aggressive behaviors in Drosophila

    Cell, December 22, 2020

    H Chiu, ED Hoopfer, ML Coughlan, and David J. Anderson

  40. Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation

    Cell Rep., December 22, 2020

    S Tsutsumi, O Chadney, TL Yiu, E Bäumler, L Faraggiana, M Beau, et al.

  41. Neural Encoding and Representation of Time for Sensorimotor Control and Learning

    J Neurosci., December 21, 2020

    R Balasubramaniam, S Haegens, Mehrdad Jazayeri, H Merchant, D Sternad, and JH Song

  42. Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task

    Elife, December 21, 2020

    I Tsutsui-Kimura, H Matsumoto, K Akiti, MM Yamada, Naoshige Uchida, and M Watabe-Uchida

  43. A Network Perspective on Sensorimotor Learning

    Trends Neurosci., December 18, 2020

    H Sohn, N Meirhaeghe, R Rajalingham, and Mehrdad Jazayeri

  44. High-fidelity musculoskeletal modeling reveals a motor planning contribution to the speed-accuracy tradeoff

    Elife., December 16, 2020

    M AI Borno, S Vyas, KV Shenoy, and SL Delp

  45. The sensory representation of causally controlled objects

    Neuron, December 15, 2020

    KB Clancy and Thomas Mrsic-Flogel

  46. A Comparison of Dopaminergic and Cholinergic Populations Reveals Unique Contributions of VTA Dopamine Neurons to Short-Term Memory

    Cell Rep., December 15, 2020

    JY Choi, HJ Jang, S Ornelas, WT Fleming, D Fürth, J Au, et al.

  47. The connectome of the adult Drosophila mushroom body provides insights into function

    Elife., December 14, 2020

    F Li, JW Lindsey, EC Marin, N Otto, M Dreher, G Dempsey, et al.

  48. Modeling statistical dependencies in multi-region spike train data

    Curr Opin Neurobiol., December 14, 2020

    Sl Keeley, DM Zoltowski, MC Aoi, and Jonathan Pillow

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