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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. Meta-learning synaptic plasticity and memory addressing for continual familiarity detection

    Neuron, November 24, 2021

    D Tyulmankov, GR Yang, and Larry Abbott

  2. Wide-field calcium imaging of cortex-wide activity in awake, head-fixed mice

    STAR Protoc, November 20, 2021

    C Ren and Takaki Komiyama

  3. Neural population geometry: An approach for understanding biological and artificial neural networks

    Curr Opin Neurobiol, November 19, 2021

    S Chung and Larry Abbott

  4. Context-dependent persistency as a coding mechanism for robust and widely distributed value coding

    Neuron, November 18, 2021

    R Hattori and Takaki Komiyama

  5. Flexible simultaneous mesoscale two-photon imaging of neural activity at high speeds

    Nat Commun, November 17, 2021

    M Clough, IA Chen, SW Park, AM Ahrens, JN Stirman, Spencer Smith, et al.

  6. Diesel2p mesoscope with dual independent scan engines for flexible capture of dynamics in distributed neural circuitry

    Nat Commun, November 17, 2021

    CH Yu, JN Stirman, Y Yu, R Hira, and Spencer Smith

  7. Revealing nonlinear neural decoding by analyzing choices

    Nature Communications, November 16, 2021

    Q Yang, E Walker, RJ Cotton, AS Tolias, and Xaq Pitkow

  8. Protocol for analysis of mouse neutrophil NETosis by flow cytometry

    STAR Protoc, November 13, 2021

    CJ McGill, RJ Lu, and Bérénice Benayoun

  9. Sequential and efficient neural-population coding of complex task information

    Neuron, November 13, 2021

    SA Koay, AS Charles, SY Thiberge, Carlos Brody, and David W. Tank

  10. Primary visual cortex straightens natural video trajectories

    Nat Commun, November 13, 2021

    OJ Hénaff, Y Bai, JA Charlton, I Nauhaus, Eero P. Simoncelli, and RLT Goris

  11. An oligomeric semiconducting nanozyme with ultrafast electron transfers alleviates acute brain injury

    Sci Adv, November 12, 2021

    X Mu, J Wang, H He, Q Li, B Yang, J Wang, et al.

  12. Accurate Localization of Linear Probe Electrode Arrays across Multiple Brains

    eNeuro, November 12, 2021

    LD Liu, S Chen, H Hou, SJ West, M Faulkner, MN Economo, et al.

  13. CD4 + T cells contribute to neurodegeneration in Lewy body dementia

    Science, November 12, 2021

    D Gate, E Tapp, O Leventhal, M Shahid, TJ Nonninger, AC Yang, et al.

  14. How pushing the spatiotemporal resolution of fMRI can advance neuroscience

    Prog Neurobiol, November 9, 2021

    L Vizioli, E Yacoub, and Laura Lewis

  15. Unsupervised deep learning identifies semantic disentanglement in single inferotemporal face patch neurons

    Nat Commun, November 9, 2021

    I Higgins, L Chang, V Langston, D Hassabis, C Summerfield, Doris Tsao, et al.

  16. Context-dependent representations of movement in Drosophila dopaminergic reinforcement pathways

    Nat Neurosci, November 9, 2021

    A Zolin, R Cohn, R Pang, AF Siliciano, Adrienne Fairhall, and Vanessa Ruta

  17. Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics

    Am J Hum Genet, November 5, 2021

    Z He, Y Le Guen, L Liu, J Lee, S Ma, AC Yang, et al.

  18. Novel small molecule inhibition of IKK/NF-κB activation reduces markers of senescence and improves healthspan in mouse models of aging

    Aging Cell, November 3, 2021

    L Zhang, J Zhao, X Mu, SJ McGowan, L Angelini, RD O'Kelly, et al.

  19. Striatal indirect pathway mediates exploration via collicular competition

    Nature, November 3, 2021

    J Lee and Bernardo Sabatini

  20. Reverse engineering recurrent neural networks with Jacobian switching linear dynamical systems

    Advances in Neural Information Processing Systems (NeurIPS), November 1, 2021

    JTH Smith, SW Linderman, and David Sussillo

  21. 50 years of mnemonic persistent activity: quo vadis?

    Trends Neurosci, November 1, 2021

    Xiao-Jing Wang

  22. Supervised multisensory calibration signals are evident in VIP but not MSTd

    J Neurosci, October 29, 2021

    A Zaidel, J Laurens, GC DeAngelis, and Dora Angelaki

  23. Metastable attractors explain the variable timing of stable behavioral action sequences

    Neuron, October 29, 2021

    S Recanatesi, U Pereira-Obilinovic, M Murakami, Zachary Mainen, and L Mazzucato

  24. Individual bitter-sensing neurons in Drosophila exhibit both ON and OFF responses that influence synaptic plasticity

    Curr Biol, October 28, 2021

    AV Devineni, JU Deere, B Sun, and Richard Axel

  25. The interconnected causes and consequences of sleep in the brain

    Science, October 28, 2021

    Laura Lewis

  26. Value representation in the monkey hippocampus

    Trends Cogn Sci, October 27, 2021

    SM Landi and Elizabeth A. Buffalo

  27. Olfactory landmarks and path integration converge to form a cognitive spatial map

    Neuron, October 25, 2021

    W Fischler-Ruiz, DG Clark, N Joshi, V Devi-Chou, L Kitch, Mark Schnitzer, et al.

  28. Subpopulations of neurons in lOFC encode previous and current rewards at time of choice

    Elife, October 25, 2021

    DL Hocker, Carlos Brody, C Savin, and CM Constantinople

  29. The glymphatic system

    Curr Biol, October 25, 2021

    LM Hablitz and Maiken Nedergaard

  30. Rats use memory confidence to guide decisions

    Curr Biol, October 25, 2021

    HR Joo, H Liang, JE Chung, C Geaghan-Breiner, JL Fan, BP Nachman, et al.

  31. Can we make drug discovery targeting fundamental mechanisms of aging a reality?

    Expert Opin Drug Discov, October 22, 2021

    DG Le Couteur, Rozalyn Anderson, and R de Cabo

  32. Can we make drug discovery targeting fundamental mechanisms of aging a reality?

    Expert Opin Drug Discov, October 22, 2021

    DG Le Couteur, Rozalyn Anderson, and R de Cabo

  33. Attention improves information flow between neuronal populations without changing the communication subspace

    Curr Biol, October 20, 2021

    R Srinath, DA Ruff, and Marlene Cohen

  34. Sex-Stratified Single-Cell RNA-Seq Analysis Identifies Sex-Specific and Cell Type-Specific Transcriptional Responses in Alzheimer's Disease Across Two Brain Regions

    Mol Neurobiol, October 20, 2021

    SA Belonwu, Y Li, D Bunis, AA Rao, CW Solsberg, A Tang, et al.

  35. Flexible filtering by neural inputs supports motion computation across states and stimuli

    Curr Biol, October 14, 2021

    JR Kohn, JP Portes, MP Christenson, Larry Abbott, and R Behnia

  36. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

    Nat Commun, October 8, 2021

    I Pediaditakis, KR Kodella, DV Manatakis, CY Le, CD Hinojosa, W Tien-Street, et al.

  37. How learning unfolds in the brain: toward an optimization view

    Neuron, October 8, 2021

    JA Hennig, ER Oby, DM Losey, AP Batista, Byron Yu, and SM Chase

  38. Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

    Nat Commun, October 8, 2021

    I Pediaditakis, KR Kodella, DV Manatakis, CY Le, CD Hinojosa, W Tien-Street, et al.

  39. A multimodal cell census and atlas of the mammalian primary motor cortex

    Nature, October 7, 2021

    BRAIN Initiative Cell Census Network (BICCN)

  40. Cellular anatomy of the mouse primary motor cortex

    Nature, October 7, 2021

    R Muñoz-Castañeda, et al.

  41. Comparative cellular analysis of motor cortex in human, marmoset and mouse

    Nature, October 7, 2021

    TE Bakken, et al.

  42. Evolving the olfactory system with machine learning

    Neuron, October 6, 2021

    PY Wang, Y Sun, Richard Axel, Larry Abbott, and GR Yang

  43. The Learning Salon: Toward a new participatory science

    Neuron, October 6, 2021

    I Momennejad, JW Krakauer, C Sun, E Yezerets, Kanaka Rajan, JT Vogelstein, et al.

  44. Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS Heterozygotes

    J Alzheimers Dis, October 4, 2021

    I Driscoll, Y Ma, CL Gallagher, SC Johnson, S Asthana, BP Hermann, et al.

  45. Spatial modulation of hippocampal activity in freely moving macaques

    Neuron, October 1, 2021

    D Mao, E Avila, B Caziot, J Laurens, JD Dickman, and Dora Angelaki

  46. Bayesian inference with incomplete knowledge explains perceptual confidence and its deviations from accuracy

    Nat Commun, September 29, 2021

    K Khalvati, Roozbeh Kiani, and RPN Rao

  47. Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

    Brain, September 28, 2021

    T Du, H Mestre, BT Kress, G Liu, AM Sweeney, AJ Samson, et al.

  48. CeAid: a smartphone application for logging and plotting Caenorhabditis elegans assays

    G3 (Bethesda), September 27, 2021

    S Sohrabi, RS Moore, and Coleen T. Murphy

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