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  • Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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Bringing people and ideas together to fund, conduct, and share transformative science.

Our grants advance knowledge and strengthen connections between science and society.

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Founded by Jim and Marilyn Simons, we’re a private philanthropy advancing mathematics and basic science.

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The Flatiron Institute is a research center that uses computational science to advance fields like physics, biology, and astronomy.

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  1. miRNATissueAtlas2: an update to the human miRNA tissue atlas

    Nucleic Acids Res, September 27, 2021

    A Keller, L Gröger, T Tschernig, J Solomon, O Laham, N Schaum, et al.

  2. Hippocampal replay of experience at real-world speeds

    Elife, September 27, 2021

    EL Denovellis, Anna Gillespie, ME Coulter, M Sosa, JE Chung, Uri Eden, et al.

  3. A stable population code for attention in prefrontal cortex leads a dynamic attention code in visual cortex

    J Neurosci, September 27, 2021

    AC Snyder, Byron Yu, and MA Smith

  4. Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

    Science, September 24, 2021

    RE Mukamel, RE Handsaker, MA Sherman, AR Barton, Y Zheng, Steven McCarroll, et al.

  5. Protein-coding repeat polymorphisms strongly shape diverse human phenotypes [Update]

    Science, September 24, 2021

    RE Mukamel, SE Handsaker, MA Sherman, AR Barton, Y Zheng, Steven McCarroll, et al.

  6. Partitioning variability in animal behavioral videos using semi-supervised variational autoencoders

    PLoS Comput Biol, September 22, 2021

    MR Whiteway, D Biderman, Y Friedman, M Dipoppa, EK Buchanan, A Wu, et al.

  7. Cognitive, Systems, and Computational Neurosciences of the Self in Motion

    Annu Rev Psychol, September 21, 2021

    JP Noel and Dora Angelaki

  8. Improving rigor and reproducibility in nonhuman primate research

    Am J Primatol, September 20, 2021

    E Bliss-Moreau, RR Amara, Elizabeth A. Buffalo, RJ Colman, ME Embers, JH Morrison, et al.

  9. A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging

    Nat Neurosci, September 16, 2021

    P Rupprecht, S Carta, A Hoffmann, M Echizen, A Blot, AC Kwan, et al.

  10. Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation

    PLoS Biol, September 16, 2021

    JY Yu and Loren Frank

  11. Interpreting neural computations by examining intrinsic and embedding dimensionality of neural activity

    Curr Opin Neurobiol, September 16, 2021

    Mehrdad Jazayeri and S Ostojic

  12. The Glymphatic System: A Novel Component of Fundamental Neurobiology

    J Neurosci, September 15, 2021

    LM Hablitz and Maiken Nedergaard

  13. A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex

    Neuron, September 15, 2021

    S Froudist-Walsh, DP Bliss, X Ding, L Rapan, M Niu, K Knoblauch, et al.

  14. A precise and adaptive neural mechanism for predictive temporal processing in the frontal cortex

    Neuron, September 15, 2021

    N Meirhaeghe, H Sohn, and Mehrdad Jazayeri

  15. Distinct population code for movement kinematics and changes of ongoing movements in human subthalamic nucleus

    Elife, September 14, 2021

    D London, A Fazl, K Katlowitz, M Soula, M Pourfar, A Mogilner, et al.

  16. Predictive encoding of motion begins in the primate retina

    Nat Neurosci, September 13, 2021

    B Liu, A Hong, Fred Rieke, and MB Manookin

  17. Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response

    Prog Neurobiol, September 12, 2021

    JR Polimeni and Laura Lewis

  18. Fasting blood glucose as a predictor of mortality: Lost in translation

    Cell Metab, September 8, 2021

    DL Palliyaguru, EJ Shiroma, JK Nam, E Duregon, C Vieira Ligo Teixeira, NL Price, et al.

  19. Distance-tuned neurons drive specialized path integration calculations in medial entorhinal cortex

    Cell Rep, September 7, 2021

    MG Campbell, A Attinger, SA Ocko, Surya Ganguli, and Lisa Giocomo

  20. GDF11 expressed in the adult brain negatively regulates hippocampal neurogenesis

    Mol Brain, September 6, 2021

    BA Mayweather, SM Buchanan, and Lee Rubin

  21. Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells

    PLoS One, September 2, 2021

    C Sadegh, W Ebina, AC Arvanites, LS Davidow, Lee Rubin, and JD Macklis

  22. Electrode pooling can boost the yield of extracellular recordings with switchable silicon probes

    Nat Commun, September 2, 2021

    KH Lee, YL Ni, J Colonell, B Karsh, J Putzeys, M Pachitariu, et al.

  23. Mechanosensory input during circuit formation shapes Drosophila motor behavior through patterned spontaneous network activity

    Curr Biol, September 1, 2021

    A Carreira-Rosario, RA York, M Choi, CQ Doe, and Thomas R. Clandinin

  24. Chronically implantable LED arrays for behavioral optogenetics in primates

    Nat Methods, August 30, 2021

    R Rajalingham, M Sorenson, R Azadi, S Bohn, James DiCarlo, and A Afraz

  25. What is the dynamical regime of cerebral cortex?

    Neuron, August 30, 2021

    Y Ahmadian and Kenneth Miller

  26. Decoding locomotion from population neural activity in moving C. elegans

    Elife, August 29, 2021

    KM Hallinen, R Dempsey, M Scholz, X Yu, A Linder, F Randi, et al.

  27. NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory C. elegans mutants

    Elife, August 27, 2021

    GA Guerrero, MJ Derisbourg, FA Mayr, LE Wester, M Giorda, JE Dinort, et al.

  28. The grid code for ordered experience

    Nat Rev Neurosci, August 27, 2021

    JW Rueckemann, M Sosa, Lisa Giocomo, and Elizabeth A. Buffalo

  29. What is the dynamical regime of cerebral cortex?

    Neuron, August 26, 2021

    Y Ahmadian and Kenneth Miller

  30. Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease

    JAMA Neurol, August 23, 2021

    EJ Davis, CW Solsberg, CC White, E Miñones-Moyano, M Sirota, L Chibnik, et al.

  31. Hippocampal replay reflects specific past experiences rather than a plan for subsequent choice

    Neuron, August 23, 2021

    Anna Gillespie, DA Astudillo Maya, EL Denovellis, DF Liu, DB Kastner, ME Coulter, et al.

  32. Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease

    JAMA Neurol, August 23, 2021

    EJ Davis, CW Solsberg, CC White, E Miñones-Moyano, M Sirota, L Chibnik, et al.

  33. Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models

    Neuron, August 18, 2021

    DS Roy, Y Zhang, T Aida, S Choi, Q Chen, Y Hou, et al.

  34. Using focal cooling to link neural dynamics and behavior

    Neuron, August 18, 2021

    A Banerjee, R Egger, and Michael A. Long

  35. Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models

    Neuron, August 18, 2021

    DS Roy, Y Zhang, T Aida, S Choi, Q Chen, Y Hou, et al.

  36. Cardiovascular brain impulses in Alzheimer's disease

    Brain, August 17, 2021

    Z Rajna, H Mattila, N Huotari, T Tuovinen, J Krüger, SC Holst, et al.

  37. Joint encoding of facial identity, orientation, gaze, and expression in the middle dorsal face area

    Proc Natl Acad Sci U S A, August 17, 2021

    Z Yang and Winrich Freiwald

  38. Locally ordered representation of 3D space in the entorhinal cortex

    Nature, August 11, 2021

    G Ginosar, J Aljadeff, Y Burak, Haim Sompolinsky, L Las, and N Ulanovsky

  39. Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by non-visual input

    J Neurophysiol, August 4, 2021

    A Fanning, A Shakhawat, and Jennifer Raymond

  40. The role of the Cer1 transposon in horizontal transfer of transgenerational memory

    Cell, August 3, 2021

    RS Moore, R Kaletsky, C Lesnik, V Cota, E Blackman, LR Parsons, et al.

  41. Multi-omic profiling of primary mouse neutrophils predicts a pattern of sex and age-related functional regulation

    Nat Aging, August 2, 2021

    RJ Lu, S Taylor, K Contrepois, M Kim, JI Bravo, M Ellenberger, et al.

  42. Predictive encoding of motion begins in the primate retina

    Nat Neurosci, August 2, 2021

    B Liu, A Hong, Fred Rieke, and MB Manookin

  43. A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging

    Nat Neurosci, August 2, 2021

    P Rupprecht, S Carta, A Hoffmann, M Echizen, A Blot, AC Kwan, et al.

  44. Sensory coding and the causal impact of mouse cortex in a visual decision

    Elife, July 30, 2021

    P Zatka-Haas, Nick Steinmetz, and Matteo Carandini

  45. Dynamic and reversible remapping of network representations in an unchanging environment

    Neuron, July 30, 2021

    IIC Low, AH Williams, MG Campbell, Scott Linderman, and Lisa Giocomo

  46. Interrogating theoretical models of neural computation with emergent property inference

    Elife, July 29, 2021

    SR Bittner, Agostina Palmigiano, AT Piet, Chunyu Ann Duan, Carlos Brody, Kenneth Miller, et al.

  47. Active dendrites enable strong but sparse inputs to determine orientation selectivity

    Proc Natl Acad Sci U S A., July 27, 2021

    L Goetz, A Roth, and Michael Hausser

  48. Peripheral B-cells repress B-cell regeneration in aging through a TNFα/IGFBP-1/IGF1 immune-endocrine axis

    Blood, July 23, 2021

    R Dowery, D Benhamou, E Benchetrit, O Harel, A Nevelsky, S Zisman-Rozen, et al.

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